| SLNO Soleno Therapeutics Inc. | 28.31% | 8,418,093 | $360.3M | No change |
| GERN Geron Corp. | 7.06% | 27,225,292 | $89.8M | Add +12.8% |
| HRMY Harmony Biosciences Holdings | 6.88% | 2,606,247 | $87.5M | No change |
| SVA Sinovac Biotech Ltd. | 6.00% | 11,800,000 | $76.3M | New |
| AVDL Avadel Pharmaceuticals plc | 5.27% | 3,972,099 | $67.1M | Reduce -3.0% |
| VRNA Verona Pharma Ltd. | 4.56% | 3,610,177 | $58.1M | Reduce -15.1% |
| ALXO Alx Oncology Holdings Inc. | 3.70% | 4,220,048 | $47.1M | No change |
| DYN Dyne Therapeutics Inc. | 3.65% | 1,635,136 | $46.4M | Add +58.0% |
| TERN Terns Pharmaceuticals Inc. | 3.43% | 6,657,992 | $43.7M | No change |
| ATXS Astria Therapeutics Inc. | 2.58% | 2,329,027 | $32.8M | Reduce -6.2% |
| VRDN Viridian Therapeutics Inc. | 2.31% | 1,678,207 | $29.4M | No change |
| SLN Silence Therapeutics PLC-ADR | 1.88% | 1,105,454 | $23.9M | Add +116.7% |
| OLMA Olema Pharmaceuticals Inc. | 1.67% | 1,873,704 | $21.2M | No change |
| ADVM Adverum Biotechnologies Inc. | 1.67% | 1,500,000 | $21.2M | New |
| ALPN Alpine Immune Sciences Inc. | 1.63% | 520,505 | $20.8M | Reduce -36.5% |
| TARS Tarsus Pharmaceuticals Inc. | 1.62% | 565,550 | $20.6M | Reduce -68.3% |
| VSTM Verastem Inc. | 1.43% | 1,538,461 | $18.2M | No change |
| CRNX Crinetics Pharmaceuticals Inc. | 1.29% | 350,000 | $16.4M | No change |
| COGT Cogent Biosciences Inc. | 1.19% | 2,244,941 | $15.1M | No change |
| SERA Sera Prognostics Inc. Class A | 1.18% | 1,650,440 | $15.0M | No change |
| RGLS Regulus Therapeutics Inc. | 1.13% | 5,000,000 | $14.4M | New |
| TRML Tourmaline Bio Inc. | 1.07% | 591,882 | $13.6M | No change |
| CMPS Compass Pathways PLC | 1.05% | 1,608,000 | $13.4M | No change |
| ORIC Oric Pharmaceuticals Inc. | 0.92% | 849,681 | $11.7M | No change |
| ENGN Engene Holdings Inc. | 0.90% | 678,705 | $11.5M | No change |
| GTH Genetron Holdings Ltd.-ADR | 0.86% | 2,708,056 | $10.9M | No change |
| IOBTQ Io Biotech Inc. | 0.84% | 6,173,439 | $10.7M | No change |
| SVRA Savara Inc. | 0.82% | 2,088,323 | $10.4M | No change |
| ZLAB Zai Lab Ltd.-ADR | 0.67% | 531,198 | $8.5M | Add +29.0% |
| DCTH Delcath Systems Inc. | 0.62% | 1,666,746 | $8.0M | Add +94.9% |
| RZLT Rezolute Inc. | 0.56% | 2,797,704 | $7.1M | Reduce -13.7% |
| CMPX Compass Therapeutics Inc. | 0.55% | 3,556,023 | $7.0M | No change |
| TIL Instil Bio Inc. | 0.53% | 624,338 | $6.7M | Reduce 0.0% |
| QTTB Q32 Bio Inc. | 0.50% | 370,068 | $6.3M | New |
| BOLT Bolt Biotherapeutics Inc. | 0.39% | 3,521,291 | $4.9M | No change |
| UNICYCIVE THERAPEUTICS INC | 0.38% | 3,470,152 | $4.8M | No change |
| ALLK Allakos LLC | 0.30% | 2,988,000 | $3.8M | No change |
| ALGS Aligos Therapeutics Inc. | 0.27% | 3,547,030 | $3.5M | No change |
| DBV TECHNOLOGIES S A | 0.16% | 2,708,875 | $2.0M | No change |
| CDXS Codexis Inc. | 0.11% | 388,144 | $1.4M | No change |
| WHWK Whitehawk Therapeutics Inc. filed as AADI BIOSCIENCE INC | 0.09% | 509,572 | $1.2M | No change |
| DTIL Precision Biosciences Inc. | 0.01% | 4,675 | $63K | No change |