| SLNO Soleno Therapeutics Inc. | 27.58% | 7,316,851 | $298.5M | Reduce -13.1% |
| GERN Geron Corp. | 10.66% | 27,225,292 | $115.4M | No change |
| HRMY Harmony Biosciences Holdings | 7.26% | 2,606,247 | $78.6M | No change |
| SVA Sinovac Biotech Ltd. | 7.05% | 11,800,000 | $76.3M | No change |
| DYN Dyne Therapeutics Inc. | 5.33% | 1,635,136 | $57.7M | No change |
| AVDL Avadel Pharmaceuticals plc | 5.16% | 3,972,099 | $55.8M | No change |
| VRNA Verona Pharma Ltd. | 4.74% | 3,549,758 | $51.3M | Reduce -1.7% |
| TERN Terns Pharmaceuticals Inc. | 3.89% | 6,182,992 | $42.1M | Reduce -7.1% |
| ALXO Alx Oncology Holdings Inc. | 2.35% | 4,220,048 | $25.4M | No change |
| VRDN Viridian Therapeutics Inc. | 2.02% | 1,678,207 | $21.8M | No change |
| ATXS Astria Therapeutics Inc. | 1.96% | 2,329,027 | $21.2M | No change |
| SLN Silence Therapeutics PLC-ADR | 1.94% | 1,105,454 | $21.0M | No change |
| OLMA Olema Pharmaceuticals Inc. | 1.87% | 1,873,704 | $20.3M | No change |
| COGT Cogent Biosciences Inc. | 1.75% | 2,244,941 | $18.9M | No change |
| ERAS Erasca Inc. | 1.47% | 6,756,756 | $15.9M | New |
| TARS Tarsus Pharmaceuticals Inc. | 1.42% | 565,550 | $15.4M | No change |
| DCTH Delcath Systems Inc. | 1.29% | 1,666,746 | $14.0M | No change |
| RZLT Rezolute Inc. | 1.11% | 2,797,704 | $12.0M | No change |
| CELC Celcuity Inc. | 0.92% | 610,500 | $10.0M | New |
| SERA Sera Prognostics Inc. Class A | 0.90% | 1,650,440 | $9.8M | No change |
| CMPS Compass Pathways PLC | 0.90% | 1,608,000 | $9.7M | No change |
| ZLAB Zai Lab Ltd.-ADR | 0.85% | 531,198 | $9.2M | No change |
| ORIC Oric Pharmaceuticals Inc. | 0.83% | 1,269,676 | $9.0M | Add +49.4% |
| RGLS Regulus Therapeutics Inc. | 0.82% | 5,000,000 | $8.9M | No change |
| ABEO Abeona Therapeutics Inc. | 0.72% | 1,842,751 | $7.8M | New |
| TRML Tourmaline Bio Inc. | 0.70% | 591,882 | $7.6M | No change |
| CRBP Corbus Pharmaceuticals Holdi | 0.70% | 166,794 | $7.5M | New |
| IOBTQ Io Biotech Inc. | 0.67% | 6,173,439 | $7.2M | No change |
| TIL Instil Bio Inc. | 0.59% | 624,339 | $6.4M | Add +0.0% |
| ENGN Engene Holdings Inc. | 0.59% | 678,705 | $6.4M | No change |
| VSTM Verastem Inc. | 0.42% | 1,538,461 | $4.6M | No change |
| CMPX Compass Therapeutics Inc. | 0.33% | 3,556,023 | $3.6M | No change |
| ALLK Allakos LLC | 0.28% | 2,988,000 | $3.0M | No change |
| BOLT Bolt Biotherapeutics Inc. | 0.24% | 3,521,291 | $2.6M | No change |
| UNICYCIVE THERAPEUTICS INC | 0.16% | 3,470,152 | $1.7M | No change |
| ALGS Aligos Therapeutics Inc. | 0.11% | 3,547,030 | $1.2M | No change |
| CDXS Codexis Inc. | 0.11% | 388,144 | $1.2M | No change |
| DBV TECHNOLOGIES S A | 0.10% | 1,354,437 | $1.1M | No change |
| ADVM Adverum Biotechnologies Inc. | 0.08% | 833,333 | $833K | Reduce -44.4% |
| WHWK Whitehawk Therapeutics Inc. filed as AADI BIOSCIENCE INC | 0.07% | 509,572 | $744K | No change |
| QTTB Q32 Bio Inc. | 0.03% | 20,559 | $369K | Reduce -94.4% |
| DTIL Precision Biosciences Inc. | 0.00% | 4,675 | $45K | No change |