AnaptysbioANAB
13F holders, Q4 2025 (December 31)179holders +13
33new positions
24sold out
8famous investors
$48.47avg. 13F price*
At the end of Q4 2025, 179 institutions reported holding Anaptysbio Inc. (ANAB) in their 13F filings, up 13 from Q3 2025. 33 opened new positions and 24 sold out. The largest holders were EcoR1 Capital, LLC ($382.0M), Point72 Asset Management ($93.7M) and BlackRock, Inc. ($84.1M). 8 famous investors held it, including Steve Cohen (0.2% of Point72 Asset Management's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Anaptysbio Inc.
- CUSIP
- 032724106
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 33 | $55.2M |
| Exits | 24 | $63.6M |
All 13F filers, Q3 2025 → Q4 2025: 3,036,423 shares bought and 5,458,371 shares sold, net −2,421,948 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 179 holders
| EcoR1 Capital, LLC | 17.51% | No change | 7,880,094 | $382.0M |
| Point72 Asset Management | 0.15% | Reduce -14.7% | 1,932,890 | $93.7M |
| BlackRock, Inc. | 0.00% | Add +0.7% | 1,734,430 | $84.1M |
| Vanguard Group Inc. | 0.00% | Add +4.5% | 1,544,037 | $74.9M |
| Tang Capital Management LLC | 3.19% | Reduce -0.1% | 1,332,087 | $64.6M |
| State Street Corp. | 0.00% | Add +20.6% | 1,053,474 | $51.1M |
| Morgan Stanley | 0.00% | Reduce -33.5% | 1,034,562 | $50.2M |
| Sanofi | 12.84% | No change | 821,917 | $39.8M |
| Millennium Management | 0.03% | Reduce -46.5% | 813,571 | $39.4M |
| Palo Alto Investors LP | 4.66% | Add +2.5% | 690,032 | $33.5M |
| D. E. Shaw & Co. | 0.03% | Add +91.9% | 670,288 | $32.5M |
| 683 Capital Management, LLC | 2.75% | Add +18.5% | 648,093 | $31.4M |
| First Light Asset Management, LLC | 2.40% | Reduce -34.7% | 646,238 | $31.3M |
| Arrowstreet Capital, Limited Partnership | 0.02% | Add +51.1% | 559,744 | $27.1M |
| Woodline Partners LP | 0.09% | No change | 501,023 | $24.3M |
| Geode Capital Management, LLC | 0.00% | Reduce -0.9% | 469,494 | $22.8M |
| Affinity Asset Advisors, LLC | 1.60% | New | 444,692 | $21.6M |
| Goldman Sachs Group Inc. | 0.00% | Add +20.9% | 398,914 | $19.3M |
| Two Sigma Advisers, LP | 0.03% | Reduce -4.5% | 356,700 | $17.3M |
| Nuveen, LLC | 0.00% | Reduce -6.7% | 316,685 | $15.4M |
| Federated Hermes, Inc. | 0.02% | Add +54.9% | 299,416 | $14.5M |
| Sofinnova Investments, Inc. | 0.60% | Add +13.1% | 287,690 | $13.9M |
| Two Sigma Investments, LP | 0.02% | Add +0.1% | 256,635 | $12.4M |
| Voloridge Investment Management, LLC | 0.04% | Add +2358.3% | 229,137 | $11.1M |
| Ensign Peak Advisors, Inc | 0.02% | No change | 215,454 | $10.4M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -3.8% | 198,660 | $9.6M |
| Northern Trust Corp. | 0.00% | Reduce -7.0% | 181,884 | $8.8M |
| BNP Paribas Financial Markets | 0.01% | Add +56.0% | 164,823 | $8.0M |
| Squarepoint Ops LLC | 0.02% | Add +136.3% | 160,731 | $7.8M |
| Soleus Capital Management, L.P. | 0.28% | Reduce -78.4% | 135,000 | $6.5M |
| Bank of America Corp. | 0.00% | Add +2.8% | 130,767 | $6.3M |
| Granahan Investment Management, LLC | 0.26% | Reduce -14.8% | 125,855 | $6.1M |
| Invesco Ltd. | 0.00% | Add +192.6% | 124,006 | $6.0M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.02% | New | 122,476 | $5.9M |
| Eversept Partners, LP | 0.33% | New | 120,927 | $5.9M |
| Jump Financial, LLC | 0.08% | Add +46.5% | 120,217 | $5.8M |
| Victory Capital Management Inc. | 0.00% | Reduce -45.8% | 110,583 | $5.4M |
| Citadel Advisors | 0.00% | Add +313.5% | 109,483 | $5.3M |
| Qube Research & Technologies Ltd | 0.01% | New | 108,965 | $5.3M |
| HighMark Wealth Management LLC | 1.86% | Reduce -30.4% | 94,050 | $4.6M |
| Nomura Asset Management International Inc. | 0.01% | — | 93,732 | $4.5M |
| Jane Street Group, LLC | 0.00% | Reduce -53.4% | 84,447 | $4.1M |
| ExodusPoint Capital Management, LP | 0.04% | Add +214.4% | 83,313 | $4.0M |
| Renaissance Technologies | 0.01% | Reduce -38.1% | 76,300 | $3.7M |
| Citigroup Inc. | 0.00% | Add +4.1% | 73,453 | $3.6M |
| HRT Financial LP | 0.01% | Add +180.2% | 70,130 | $3.4M |
| UBS Group AG | 0.00% | Reduce -7.0% | 70,032 | $3.4M |
| Wellington Management Group LLP | 0.00% | Reduce -8.3% | 61,187 | $3.0M |
| Barclays PLC | 0.00% | Reduce -6.0% | 59,654 | $2.9M |
| Trexquant Investment LP | 0.03% | Reduce -47.4% | 58,809 | $2.9M |
| Fisher Asset Management | 0.00% | Reduce -3.9% | 56,564 | $2.7M |
| Penserra Capital Management LLC | 0.03% | New | 56,352 | $2.7M |
| Bank of New York Mellon Corp | 0.00% | Reduce -3.0% | 55,345 | $2.7M |
| Jacobs Levy Equity Management, Inc. | 0.01% | Reduce -85.4% | 55,088 | $2.7M |
| Moody Aldrich Partners LLC | 0.43% | Reduce -4.6% | 47,601 | $2.3M |
| Bleakley Financial Group, LLC | 0.04% | Add +8.9% | 43,547 | $2.1M |
| PDT Partners, LLC | 0.14% | No change | 43,001 | $2.1M |
| Credit Agricole S A | 0.01% | New | 40,000 | $1.9M |
| XTX Topco Ltd | 0.05% | Add +113.3% | 38,637 | $1.9M |
| Susquehanna Portfolio Strategies, LLC | 0.03% | Add +1.4% | 35,948 | $1.7M |
| Rafferty Asset Management, LLC | 0.01% | Add +17.4% | 35,310 | $1.7M |
| DCF Advisers, LLC | 0.56% | Reduce -26.6% | 35,250 | $1.7M |
| Y-Intercept (Hong Kong) Ltd | 0.04% | New | 33,101 | $1.6M |
| Alliancebernstein L.P. | 0.00% | No change | 30,520 | $1.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -8.3% | 30,508 | $1.5M |
| Osaic Holdings, Inc. | 0.00% | Add +1427.4% | 27,737 | $1.3M |
| Swiss National Bank | 0.00% | Reduce -2.8% | 27,600 | $1.3M |
| FMR LLC | 0.00% | Reduce -49.0% | 27,108 | $1.3M |
| AQR Capital Management | 0.00% | Add +0.5% | 26,309 | $1.3M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -91.3% | 26,005 | $1.3M |
| Campbell & CO Investment Adviser LLC | 0.06% | Add +38.8% | 25,368 | $1.2M |
| Headlands Technologies LLC | 0.10% | New | 25,278 | $1.2M |
| Rhumbline Advisers | 0.00% | Reduce -14.4% | 25,032 | $1.2M |
| Schonfeld Strategic Advisors LLC | 0.01% | New | 24,431 | $1.2M |
| Quadrature Capital Ltd | 0.01% | New | 24,280 | $1.2M |
| Mackenzie Financial Corp. | 0.00% | New | 24,228 | $1.2M |
| NEOS Investment Management LLC | 0.01% | Add +108.6% | 22,895 | $1.1M |
| Tema ETFs LLC | 0.08% | Add +105.6% | 22,560 | $1.1M |
| Wells Fargo & Company | 0.00% | Add +61.6% | 22,207 | $1.1M |
| Panagora Asset Management Inc. | 0.00% | Reduce -67.3% | 20,872 | $1.0M |
| Russell Investments Group, Ltd. | 0.00% | Reduce -42.1% | 19,714 | $956K |
| Legal & General Group Plc | 0.00% | Reduce -6.8% | 18,180 | $881K |
| Tudor Investment Corporation | 0.00% | Add +24.8% | 17,305 | $839K |
| Algert Global LLC | 0.01% | Reduce -80.4% | 16,400 | $795K |
| Creative Planning | 0.00% | Reduce -8.7% | 15,254 | $740K |
| Cresset Asset Management, LLC | 0.00% | Reduce -4.0% | 15,121 | $733K |
| Orion Porfolio Solutions, LLC | 0.01% | Add +7.0% | 14,697 | $713K |
| Deutsche Bank AG | 0.00% | Add +13.4% | 14,381 | $697K |
| California State Teachers Retirement System | 0.00% | Reduce -0.5% | 14,138 | $685K |
| Profund Advisors LLC | 0.02% | Add +99.4% | 13,088 | $635K |
| Voya Investment Management LLC | 0.00% | Reduce -1.6% | 12,760 | $619K |
| Los Angeles Capital Management LLC | 0.00% | Add +1.5% | 15,101 | $551K |
| JPMorgan Chase & Co. | 0.00% | Reduce -26.5% | 10,916 | $529K |
| Engineers Gate Manager LP | 0.01% | Reduce -62.7% | 10,880 | $527K |
| Gsa Capital Partners LLP | 0.04% | Reduce -71.3% | 10,695 | $518K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -0.2% | 10,641 | $515K |
| SG Americas Securities, LLC | 0.00% | New | 10,428 | $506K |
| MetLife Investment Management, LLC | 0.00% | Reduce -13.4% | 10,327 | $501K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +42.9% | 9,286 | $450K |
| New York State Common Retirement Fund | 0.00% | Reduce -14.2% | 9,088 | $441K |
"% of holder's portfolio" is ANAB's weight in each manager's 13F, not the share of Anaptysbio Inc. the manager owns.