| Commodore Capital LP | 3.17% | New | 4,657,345 | $46.4M |
| Janus Henderson Group PLC | 0.02% | New | 4,443,667 | $44.0M |
| BlackRock Inc. | 0.00% | New | 3,485,946 | $34.8M |
| Avidity Partners Management LP | 1.29% | New | 3,037,668 | $30.3M |
| Vanguard Group Inc. | 0.00% | New | 2,921,268 | $29.1M |
| Deerfield Management Company, L.P. | 0.54% | New | 2,817,763 | $28.1M |
| Octagon Capital Advisors LP | 2.60% | New | 1,580,249 | $15.8M |
| Marshall Wace, LLP | 0.02% | New | 1,283,942 | $12.8M |
| Geode Capital Management, LLC | 0.00% | New | 1,034,550 | $10.3M |
| State Street Corp. | 0.00% | New | 997,427 | $9.9M |
| Ghost Tree Capital, LLC | 3.21% | New | 925,000 | $9.2M |
| Paradigm Biocapital Advisors LP | 0.35% | New | 919,692 | $9.2M |
| Sphera Funds Management LTD. | 1.28% | New | 786,909 | $7.8M |
| ExodusPoint Capital Management, LP | 0.07% | New | 596,054 | $5.9M |
| Citadel Advisors | 0.01% | New | 575,549 | $5.7M |
| Affinity Asset Advisors, LLC | 0.95% | New | 550,000 | $5.5M |
| Schonfeld Strategic Advisors LLC | 0.04% | New | 525,800 | $5.2M |
| Walleye Capital LLC | 0.06% | New | 512,823 | $5.1M |
| Orbimed Advisors LLC | 0.10% | New | 492,670 | $4.9M |
| Rock Springs Capital Management LP | 0.12% | New | 401,196 | $4.0M |
| Ally Bridge Group (NY) LLC | 2.35% | New | 396,242 | $4.0M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | New | 381,640 | $3.8M |
| Stempoint Capital LP | 1.01% | New | 343,810 | $3.4M |
| Eagle Asset Management Inc. | 0.01% | New | 241,679 | $2.7M |
| Nuveen Asset Management, LLC | 0.00% | New | 260,927 | $2.6M |
| Silverarc Capital Management, LLC | 0.64% | New | 260,009 | $2.6M |
| Millennium Management | 0.00% | New | 246,558 | $2.5M |
| DAFNA Capital Management LLC | 0.56% | New | 231,634 | $2.3M |
| Point72 Asset Management | 0.01% | New | 202,572 | $2.0M |
| Altium Capital Management LLC | 0.79% | New | 191,450 | $1.9M |
| WealthPLAN Partners, LLC | 0.18% | New | 169,963 | $1.7M |
| Morgan Stanley | 0.00% | New | 151,896 | $1.5M |
| Atika Capital Management LLC | 0.16% | New | 142,499 | $1.4M |
| HighTower Advisors, LLC | 0.00% | New | 141,236 | $1.4M |
| Northern Trust Corp. | 0.00% | New | 137,840 | $1.4M |
| Bank of New York Mellon Corp | 0.00% | New | 137,268 | $1.4M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 134,744 | $1.3M |
| FMR LLC | 0.00% | New | 134,430 | $1.3M |
| Sofinnova Investments, Inc. | 0.08% | New | 132,089 | $1.3M |
| HighVista Strategies LLC | 0.41% | New | 113,550 | $1.1M |
| Sandler Capital Management | 0.21% | New | 106,697 | $1.1M |
| Osterweis Capital Management Inc. | 0.06% | New | 91,293 | $910K |
| Superstring Capital Management LP | 1.10% | New | 87,638 | $874K |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0.03% | New | 85,013 | $848K |
| WINTON GROUP Ltd | 0.06% | New | 84,363 | $841K |
| Qube Research & Technologies Ltd | 0.00% | New | 83,346 | $831K |
| AlphaCentric Advisors LLC | 0.60% | New | 82,000 | $818K |
| Jane Street Group, LLC | 0.00% | New | 78,660 | $784K |
| ADAR1 Capital Management, LLC | 0.14% | New | 69,985 | $698K |
| Swiss National Bank | 0.00% | New | 69,260 | $691K |
| Bank of America Corp. | 0.00% | New | 67,655 | $675K |
| Y-Intercept (Hong Kong) Ltd | 0.03% | New | 63,581 | $634K |
| Rhumbline Advisers | 0.00% | New | 63,170 | $630K |
| Renaissance Technologies | 0.00% | New | 61,660 | $615K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 55,467 | $553K |
| ClariVest Asset Management LLC | 0.06% | New | 54,199 | $540K |
| Alpine Global Management, LLC | 0.09% | New | 44,714 | $446K |
| Sykon Capital LLC | 0.14% | New | 37,932 | $378K |
| AMG National Trust Bank | 0.01% | New | 37,330 | $372K |
| Legal & General Group Plc | 0.00% | New | 36,375 | $363K |
| California State Teachers Retirement System | 0.00% | New | 35,364 | $353K |
| Informed Momentum Co LLC | 0.05% | New | 32,631 | $325K |
| Corebridge Financial, Inc. | 0.00% | — | 25,333 | $253K |
| State of Wisconsin Investment Board | 0.00% | New | 24,390 | $243K |
| Alliancebernstein L.P. | 0.00% | New | 24,320 | $242K |
| Moneta Group Investment Advisors LLC | 0.00% | New | 23,707 | $236K |
| Invesco Ltd. | 0.00% | New | 23,523 | $235K |
| JPMorgan Chase & Co. | 0.00% | New | 20,068 | $200K |
| New York State Common Retirement Fund | 0.00% | New | 19,000 | $189K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 18,842 | $188K |
| UBS Group AG | 0.00% | New | 18,302 | $182K |
| Creative Planning | 0.00% | New | 17,520 | $175K |
| Wealth Effects LLC | 0.06% | New | 17,350 | $173K |
| Barclays PLC | 0.00% | New | 16,582 | $165K |
| Wells Fargo & Company | 0.00% | New | 16,119 | $161K |
| Voloridge Investment Management, LLC | 0.00% | New | 15,963 | $159K |
| Voya Investment Management LLC | 0.00% | New | 15,869 | $158K |
| Bridgeway Capital Management, LLC | 0.00% | New | 13,400 | $134K |
| MetLife Investment Management, LLC | 0.00% | New | 12,028 | $120K |
| Point72 (DIFC) Ltd | 0.01% | New | 11,842 | $118K |
| Victory Capital Management Inc. | 0.00% | New | 11,770 | $117K |
| Sectoral Asset Management Inc. | 0.04% | New | 11,000 | $110K |
| Citigroup Inc. | 0.00% | New | 10,305 | $103K |
| STRS Ohio | 0.00% | New | 8,700 | $87K |
| Virtus Advisers, LLC | 0.04% | New | 7,803 | $78K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 4,613 | $46K |
| Royal Bank of Canada | 0.00% | New | 4,429 | $44K |
| BNP Paribas Financial Markets | 0.00% | New | 3,391 | $34K |
| US Bancorp \de | 0.00% | New | 2,710 | $27K |
| Amalgamated Bank | 0.00% | New | 1,629 | $16K |
| Carolinas Wealth Consulting LLC | 0.00% | New | 1,097 | $11K |
| Deutsche Bank AG | 0.00% | New | 948 | $9K |
| Mendota Financial Group, LLC | 0.00% | New | 750 | $7K |
| State of Wyoming | 0.00% | New | 572 | $6K |
| Lazard Asset Management LLC | 0.00% | New | 523 | $5K |
| JNBA Financial Advisors | 0.00% | New | 500 | $5K |
| Farther Finance Advisors, LLC | 0.00% | New | 348 | $4K |
| TD Waterhouse Canada Inc. | 0.00% | New | 200 | $2K |
| Headlands Technologies LLC | 0.00% | New | 152 | $2K |
| Planning Capital Management Corp | 0.00% | New | 110 | $1K |