Design TherapeuticsDSGN
13F holders, Q3 2025 (September 30)95holders +3
14new positions
12sold out
6famous investors
$7.53avg. 13F price*
At the end of Q3 2025, 95 institutions reported holding Design Therapeutics Inc. (DSGN) in their 13F filings, up 3 from Q2 2025. 14 opened new positions and 12 sold out. The largest holders were SR One Capital Management, LP ($49.1M), Logos Global Management LP ($27.5M) and Point72 Asset Management ($25.2M). 6 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Design Therapeutics Inc.
- CUSIP
- 25056L103
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 14 | $5.1M |
| Exits | 12 | $764K |
All 13F filers, Q2 2025 → Q3 2025: 2,382,077 shares bought and 2,419,957 shares sold, net −37,880 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 95 holders
| SR One Capital Management, LP | 7.11% | No change | 6,526,476 | $49.1M |
| Logos Global Management LP | 2.72% | Reduce -13.3% | 3,655,000 | $27.5M |
| Point72 Asset Management | 0.06% | Add +84.8% | 3,340,552 | $25.2M |
| BlackRock, Inc. | 0.00% | Reduce -14.7% | 2,044,388 | $15.4M |
| Frazier Life Sciences Management, L.P. | 0.44% | No change | 1,953,547 | $14.7M |
| Tang Capital Management LLC | 0.52% | No change | 1,780,975 | $13.4M |
| Baker Bros. Advisors LP | 0.09% | No change | 1,712,882 | $12.9M |
| Almitas Capital LLC | 2.64% | No change | 1,530,435 | $11.5M |
| Vanguard Group Inc. | 0.00% | Reduce -1.9% | 1,443,701 | $10.9M |
| Driehaus Capital Management LLC | 0.06% | No change | 1,076,236 | $8.1M |
| Kynam Capital Management, LP | 0.58% | No change | 1,029,579 | $7.8M |
| FMR LLC | 0.00% | Reduce -22.1% | 740,849 | $5.6M |
| Geode Capital Management, LLC | 0.00% | Reduce -12.4% | 695,613 | $5.2M |
| State Street Corp. | 0.00% | Reduce -11.8% | 634,397 | $4.8M |
| Acadian Asset Management LLC | 0.01% | Reduce -1.6% | 617,489 | $4.6M |
| Woodline Partners LP | 0.02% | Reduce -21.2% | 612,712 | $4.6M |
| MPM Bioimpact LLC | 0.68% | No change | 555,187 | $4.2M |
| Citadel Advisors | 0.00% | Reduce -34.1% | 554,020 | $4.2M |
| Ra Capital Management, L.P. | 0.04% | New | 475,699 | $3.6M |
| D. E. Shaw & Co. | 0.00% | Reduce -4.5% | 373,276 | $2.8M |
| Northern Trust Corp. | 0.00% | Reduce -18.2% | 296,529 | $2.2M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -10.7% | 279,817 | $2.1M |
| Renaissance Technologies | 0.00% | Add +2.4% | 274,300 | $2.1M |
| Goldman Sachs Group Inc. | 0.00% | Add +9.2% | 261,445 | $2.0M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -1.2% | 247,934 | $1.9M |
| Bridgeway Capital Management, LLC | 0.03% | No change | 188,200 | $1.4M |
| Morgan Stanley | 0.00% | Reduce -17.6% | 175,991 | $1.3M |
| Nuveen, LLC | 0.00% | No change | 133,028 | $1.0M |
| Jane Street Group, LLC | 0.00% | Add +279.1% | 117,833 | $887K |
| Barclays PLC | 0.00% | Reduce -19.5% | 88,176 | $664K |
| Bank of New York Mellon Corp | 0.00% | Reduce -7.5% | 87,475 | $659K |
| Millennium Management | 0.00% | New | 68,823 | $518K |
| Lynx1 Capital Management LP | 0.10% | No change | 65,954 | $497K |
| Two Sigma Investments, LP | 0.00% | Reduce -33.7% | 59,237 | $446K |
| Palumbo Wealth Management LLC | 0.13% | Reduce -14.0% | 52,081 | $392K |
| American Century Companies Inc. | 0.00% | Add +9.6% | 50,852 | $383K |
| DLD Asset Management, LP | 0.16% | New | 50,000 | $377K |
| Rhumbline Advisers | 0.00% | Reduce -4.1% | 46,334 | $349K |
| Alliancebernstein L.P. | 0.00% | Add +2.4% | 46,120 | $347K |
| Prudential Financial Inc. | 0.00% | Reduce -22.6% | 44,825 | $338K |
| Two Sigma Advisers, LP | 0.00% | Reduce -62.7% | 40,500 | $305K |
| China Universal Asset Management Co., Ltd. | 0.02% | Add +206.8% | 34,982 | $263K |
| HRT Financial LP | 0.00% | New | 31,903 | $240K |
| Kennedy Capital Management LLC | 0.00% | Add +95.9% | 29,411 | $221K |
| State of Wisconsin Investment Board | 0.00% | Reduce -5.6% | 27,062 | $204K |
| Bank of America Corp. | 0.00% | Reduce -2.9% | 23,907 | $180K |
| JPMorgan Chase & Co. | 0.00% | Add +26.7% | 23,221 | $175K |
| UBS Group AG | 0.00% | Reduce -17.0% | 22,693 | $171K |
| STRS Ohio | 0.00% | No change | 22,600 | $170K |
| Sphera Funds Management LTD. | 0.04% | New | 21,918 | $165K |
| Velan Capital Investment Management LP | 0.14% | No change | 20,000 | $151K |
| Wells Fargo & Company | 0.00% | Reduce -9.7% | 18,317 | $138K |
| T. Rowe Price Associates Inc. | 0.00% | No change | 16,314 | $123K |
| Mariner, LLC | 0.00% | Add +2.2% | 16,081 | $121K |
| Invesco Ltd. | 0.00% | Add +1.6% | 14,589 | $110K |
| Intech Investment Management LLC | 0.00% | Reduce -28.0% | 14,155 | $107K |
| Susquehanna International Group, LLP | 0.00% | Reduce -63.3% | 14,023 | $106K |
| AQR Capital Management | 0.00% | Reduce -52.4% | 13,664 | $103K |
| XTX Topco Ltd | 0.00% | New | 11,868 | $89K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 11,824 | $89K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -40.3% | 10,724 | $81K |
| MetLife Investment Management, LLC | 0.00% | New | 10,320 | $78K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 6,598 | $50K |
| Russell Investments Group, Ltd. | 0.00% | Add +69.7% | 6,377 | $48K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.01% | New | 5,702 | $43K |
| BNP Paribas Financial Markets | 0.00% | Add +34.3% | 5,133 | $39K |
| Caz Investments LP | 0.07% | Reduce -33.3% | 5,000 | $38K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 2,570 | $19K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +0.4% | 2,202 | $17K |
| Legal & General Group Plc | 0.00% | Reduce -32.5% | 2,077 | $16K |
| New York State Common Retirement Fund | 0.00% | No change | 2,026 | $15K |
| California State Teachers Retirement System | 0.00% | New | 1,969 | $15K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -79.8% | 1,959 | $15K |
| PNC Financial Services Group, Inc. | 0.00% | Add +9.1% | 1,823 | $14K |
| Sterling Capital Management LLC | 0.00% | Add +96.0% | 1,648 | $12K |
| Citigroup Inc. | 0.00% | Reduce -88.3% | 1,590 | $12K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Reduce -32.5% | 1,227 | $9K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -16.3% | 1,213 | $9K |
| Amalgamated Bank | 0.00% | No change | 1,176 | $9K |
| Clearstead Advisors, LLC | 0.00% | No change | 610 | $5K |
| Private Wealth Management Group, LLC | 0.00% | No change | 558 | $4K |
| Royal Bank of Canada | 0.00% | Reduce -88.3% | 445 | $4K |
| GAMMA Investing LLC | 0.00% | New | 443 | $3K |
| Farther Finance Advisors, LLC | 0.00% | Add +1926.3% | 385 | $3K |
| Optiver Holding B.V. | 0.00% | New | 328 | $2K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 268 | $2K |
| Cwm, LLC | 0.00% | Reduce -18.1% | 222 | $2K |
| MassMutual Private Wealth & Trust, FSB | 0.00% | No change | 239 | $2K |
| EverSource Wealth Advisors, LLC | 0.00% | No change | 235 | $2K |
| Arax Advisory Partners | 0.00% | New | 194 | $1K |
| Daiwa Securities Group Inc. | 0.00% | Reduce -71.4% | 100 | $1K |
| Rise Advisors, LLC | 0.00% | No change | 130 | $979 |
| Versant Capital Management, Inc | 0.00% | New | 71 | $535 |
| Larson Financial Group LLC | 0.00% | New | 3 | $23 |
| Capital Advisors, Ltd. LLC | 0.00% | No change | 12 | $0 |
"% of holder's portfolio" is DSGN's weight in each manager's 13F, not the share of Design Therapeutics Inc. the manager owns.