Design TherapeuticsDSGN
13F holders, Q4 2025 (December 31)117holders +22
27new positions
8sold out
6famous investors
$9.38avg. 13F price*
At the end of Q4 2025, 117 institutions reported holding Design Therapeutics Inc. (DSGN) in their 13F filings, up 22 from Q3 2025. 27 opened new positions and 8 sold out. The largest holders were SR One Capital Management, LP ($61.2M), Point72 Asset Management ($50.4M) and Logos Global Management LP ($23.4M). 6 famous investors held it, including Steve Cohen (0.1% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Design Therapeutics Inc.
- CUSIP
- 25056L103
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 27 | $30.8M |
| Exits | 8 | $18.5M |
All 13F filers, Q3 2025 → Q4 2025: 8,984,218 shares bought and 5,602,239 shares sold, net +3,381,979 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 117 holders
| SR One Capital Management, LP | 8.67% | No change | 6,526,476 | $61.2M |
| Point72 Asset Management | 0.08% | Add +60.8% | 5,372,004 | $50.4M |
| Logos Global Management LP | 1.56% | Reduce -31.6% | 2,500,000 | $23.4M |
| Baker Bros. Advisors LP | 0.12% | Add +30.4% | 2,233,099 | $20.9M |
| BlackRock, Inc. | 0.00% | Add +3.6% | 2,117,156 | $19.9M |
| Vanguard Group Inc. | 0.00% | Add +13.0% | 1,630,910 | $15.3M |
| Vivo Capital, LLC | 0.98% | New | 1,612,903 | $15.1M |
| Almitas Capital LLC | 3.18% | No change | 1,530,435 | $14.4M |
| Ra Capital Management, L.P. | 0.14% | Add +207.2% | 1,461,381 | $13.7M |
| Driehaus Capital Management LLC | 0.08% | Add +9.6% | 1,179,817 | $11.1M |
| Woodline Partners LP | 0.03% | Add +54.1% | 944,039 | $8.9M |
| Kynam Capital Management, LP | 0.48% | Reduce -23.8% | 784,606 | $7.4M |
| FMR LLC | 0.00% | Add +4.1% | 771,268 | $7.2M |
| Morgan Stanley | 0.00% | Add +299.1% | 702,306 | $6.6M |
| Geode Capital Management, LLC | 0.00% | Reduce -2.3% | 679,590 | $6.4M |
| State Street Corp. | 0.00% | Add +2.1% | 647,636 | $6.1M |
| Acadian Asset Management LLC | 0.01% | Reduce -0.8% | 612,768 | $5.7M |
| Frazier Life Sciences Management, L.P. | 0.13% | Reduce -73.3% | 521,000 | $4.9M |
| Citadel Advisors | 0.00% | Reduce -17.0% | 459,874 | $4.3M |
| D. E. Shaw & Co. | 0.00% | Add +17.6% | 438,894 | $4.1M |
| Invesco Ltd. | 0.00% | Add +1995.8% | 305,757 | $2.9M |
| Dimensional Fund Advisors LP | 0.00% | Add +6.5% | 297,921 | $2.8M |
| Renaissance Technologies | 0.00% | Add +4.7% | 287,100 | $2.7M |
| Northern Trust Corp. | 0.00% | Reduce -3.4% | 286,572 | $2.7M |
| Goldman Sachs Group Inc. | 0.00% | Add +3.5% | 270,654 | $2.5M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -4.5% | 236,863 | $2.2M |
| Jane Street Group, LLC | 0.00% | Add +92.2% | 226,512 | $2.1M |
| Marshall Wace, LLP | 0.00% | New | 225,528 | $2.1M |
| Elmind Capital, LP | 0.58% | — | 207,900 | $2.0M |
| Jacobs Levy Equity Management, Inc. | 0.01% | New | 194,611 | $1.8M |
| Algert Global LLC | 0.03% | New | 187,769 | $1.8M |
| Millennium Management | 0.00% | Add +162.8% | 180,866 | $1.7M |
| Ameriprise Financial Inc. | 0.00% | New | 158,383 | $1.5M |
| Acuta Capital Partners, LLC | 0.96% | New | 150,906 | $1.4M |
| Nuveen, LLC | 0.00% | Reduce -5.8% | 125,260 | $1.2M |
| Raymond James Financial Inc. | 0.00% | New | 109,763 | $1.0M |
| Diadema Partners LP | 0.56% | New | 100,320 | $941K |
| Trexquant Investment LP | 0.01% | New | 99,967 | $938K |
| BNP Paribas Financial Markets | 0.00% | Add +1747.4% | 94,828 | $889K |
| Barclays PLC | 0.00% | Reduce -1.3% | 87,060 | $817K |
| Bank of New York Mellon Corp | 0.00% | Reduce -2.9% | 84,975 | $797K |
| Informed Momentum Co LLC | 0.08% | New | 78,949 | $741K |
| Bridgeway Capital Management, LLC | 0.02% | Reduce -58.3% | 78,500 | $736K |
| Lynx1 Capital Management LP | 0.13% | Add +5.4% | 69,516 | $652K |
| Palumbo Wealth Management LLC | 0.16% | Add +33.2% | 69,377 | $651K |
| Susquehanna International Group, LLP | 0.00% | Add +341.1% | 61,852 | $580K |
| American Century Companies Inc. | 0.00% | Add +13.7% | 57,798 | $542K |
| Canada Pension Plan Investment Board | 0.00% | New | 54,600 | $512K |
| Sei Investments Co. | 0.00% | New | 52,730 | $495K |
| State of Wisconsin Investment Board | 0.00% | Add +87.2% | 50,657 | $475K |
| Kennedy Capital Management LLC | 0.01% | Add +70.1% | 50,023 | $469K |
| Alps Advisors Inc. | 0.00% | New | 46,771 | $439K |
| Two Sigma Investments, LP | 0.00% | Reduce -21.9% | 46,237 | $434K |
| Squarepoint Ops LLC | 0.00% | New | 46,142 | $433K |
| Alliancebernstein L.P. | 0.00% | No change | 46,120 | $433K |
| Prudential Financial Inc. | 0.00% | Reduce -4.7% | 42,710 | $401K |
| XTX Topco Ltd | 0.01% | Add +197.3% | 35,284 | $331K |
| Persistent Asset Partners Ltd | 0.16% | New | 34,989 | $328K |
| Rhumbline Advisers | 0.00% | Reduce -24.9% | 34,778 | $326K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -2.0% | 34,282 | $322K |
| Bank of America Corp. | 0.00% | Add +14.8% | 27,446 | $257K |
| Corient Private Wealth LP | 0.00% | New | 26,965 | $253K |
| Wells Fargo & Company | 0.00% | Add +46.2% | 26,786 | $251K |
| UBS Group AG | 0.00% | Add +12.5% | 25,537 | $240K |
| Two Sigma Advisers, LP | 0.00% | Reduce -37.5% | 25,300 | $237K |
| Russell Investments Group, Ltd. | 0.00% | Add +295.7% | 25,234 | $237K |
| STRS Ohio | 0.00% | Add +11.5% | 25,200 | $236K |
| Virtu Financial LLC | 0.01% | New | 22,651 | $212K |
| AlphaCentric Advisors LLC | 0.19% | — | 20,262 | $190K |
| Velan Capital Investment Management LP | 0.11% | No change | 20,000 | $188K |
| Baader Bank Aktiengesellschaft | 0.02% | New | 20,000 | $188K |
| 9823 Capital, L.P. | 0.12% | — | 19,197 | $180K |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -3.7% | 15,711 | $148K |
| Deutsche Bank AG | 0.00% | New | 15,541 | $146K |
| MetLife Investment Management, LLC | 0.00% | Add +47.8% | 15,249 | $143K |
| JPMorgan Chase & Co. | 0.00% | Reduce -37.8% | 14,451 | $136K |
| Engineers Gate Manager LP | 0.00% | New | 14,012 | $131K |
| AQR Capital Management | 0.00% | Add +0.5% | 13,730 | $129K |
| Mariner, LLC | 0.00% | Reduce -20.3% | 12,822 | $120K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 11,824 | $111K |
| Axq Capital, LP | 0.02% | New | 11,728 | $110K |
| Two Sigma Securities, LLC | 0.01% | New | 11,396 | $107K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +3.4% | 11,091 | $104K |
| Public Employees Retirement System of Ohio | 0.00% | New | 7,093 | $67K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 6,598 | $62K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +118.1% | 4,273 | $40K |
| Caz Investments LP | 0.06% | Reduce -30.0% | 3,500 | $33K |
| Citigroup Inc. | 0.00% | Add +95.8% | 3,113 | $29K |
| Torren Management, LLC | 0.01% | — | 2,820 | $26K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +25.7% | 2,768 | $26K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 2,570 | $24K |
| Legal & General Group Plc | 0.00% | No change | 2,077 | $19K |
| New York State Common Retirement Fund | 0.00% | No change | 2,026 | $19K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -0.4% | 1,816 | $17K |
| California State Teachers Retirement System | 0.00% | Reduce -25.3% | 1,471 | $14K |
| Sterling Capital Management LLC | 0.00% | Reduce -16.4% | 1,377 | $13K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | No change | 1,227 | $12K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -7.8% | 1,118 | $10K |
| GAMMA Investing LLC | 0.00% | Add +69.3% | 750 | $7K |
| Amalgamated Bank | 0.00% | Reduce -36.1% | 751 | $7K |
"% of holder's portfolio" is DSGN's weight in each manager's 13F, not the share of Design Therapeutics Inc. the manager owns.