Eton PharmaceuticalsETON
13F holders, Q4 2025 (December 31)104holders +1
20new positions
19sold out
5famous investors
$16.91avg. 13F price*
At the end of Q4 2025, 104 institutions reported holding Eton Pharmaceuticals Inc. (ETON) in their 13F filings, up 1 from Q3 2025. 20 opened new positions and 19 sold out. The largest holders were Opaleye Management Inc. ($48.4M), EcoR1 Capital, LLC ($34.3M) and BlackRock, Inc. ($29.4M). 5 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Eton Pharmaceuticals Inc.
- CUSIP
- 29772L108
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 20 | $4.7M |
| Exits | 19 | $22.1M |
All 13F filers, Q3 2025 → Q4 2025: 960,015 shares bought and 2,752,075 shares sold, net −1,792,060 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 104 holders
| Opaleye Management Inc. | 6.38% | No change | 2,860,000 | $48.4M |
| EcoR1 Capital, LLC | 1.57% | No change | 2,030,544 | $34.3M |
| BlackRock, Inc. | 0.00% | Add +2.0% | 1,738,907 | $29.4M |
| Vanguard Group Inc. | 0.00% | Add +0.3% | 1,348,668 | $22.8M |
| Nantahala Capital Management, LLC | 1.19% | No change | 1,175,951 | $19.9M |
| Geode Capital Management, LLC | 0.00% | Reduce -1.6% | 565,051 | $9.6M |
| State Street Corp. | 0.00% | Add +14.5% | 501,925 | $8.5M |
| Morgan Stanley | 0.00% | Reduce -15.7% | 493,914 | $8.4M |
| National Philanthropic Trust | 0.08% | No change | 492,112 | $8.3M |
| Westside Investment Management, Inc. | 1.27% | Reduce -0.3% | 470,940 | $8.0M |
| Oberweis Asset Management Inc./ | 0.27% | Add +124.2% | 431,300 | $7.3M |
| Thompson Siegel & Walmsley LLC | 0.12% | Reduce -2.4% | 408,541 | $6.9M |
| BNP Paribas Financial Markets | 0.00% | Add +20.7% | 277,458 | $4.7M |
| Northern Trust Corp. | 0.00% | Reduce -5.4% | 231,849 | $3.9M |
| Cannell Capital LLC | 2.34% | Reduce -52.4% | 216,917 | $3.7M |
| Renaissance Technologies | 0.01% | Reduce -36.6% | 205,700 | $3.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +3.2% | 196,263 | $3.3M |
| Diametric Capital, LP | 0.88% | Add +94.5% | 193,155 | $3.3M |
| JPMorgan Chase & Co. | 0.00% | Reduce -47.2% | 185,439 | $3.1M |
| Lumbard & Kellner, LLC | 1.04% | Reduce -0.8% | 174,944 | $3.0M |
| Aristides Capital LLC | 0.95% | Reduce -3.7% | 161,436 | $2.7M |
| Bank of New York Mellon Corp | 0.00% | Reduce -1.1% | 127,700 | $2.2M |
| UBS Group AG | 0.00% | Reduce -42.5% | 126,674 | $2.1M |
| Jefferies Financial Group Inc. | 0.02% | Add +33.8% | 118,300 | $2.0M |
| Bank of America Corp. | 0.00% | Add +40.4% | 104,796 | $1.8M |
| Woodline Partners LP | 0.01% | New | 95,487 | $1.6M |
| Bridgeway Capital Management, LLC | 0.03% | Reduce -22.9% | 84,020 | $1.4M |
| Wellington Management Group LLP | 0.00% | Reduce -8.0% | 81,201 | $1.4M |
| Millennium Management | 0.00% | Add +400.1% | 79,331 | $1.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -0.1% | 77,212 | $1.3M |
| Two Sigma Investments, LP | 0.00% | Reduce -73.3% | 76,602 | $1.3M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | Reduce -46.8% | 76,586 | $1.3M |
| Citadel Advisors | 0.00% | New | 74,144 | $1.3M |
| Nuveen, LLC | 0.00% | No change | 58,917 | $996K |
| Jane Street Group, LLC | 0.00% | Reduce -18.2% | 58,056 | $982K |
| Barclays PLC | 0.00% | Add +39.8% | 51,448 | $870K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -9.4% | 49,694 | $840K |
| Prelude Capital Management, LLC | 0.06% | Add +8.2% | 45,325 | $766K |
| Anchor Capital Advisors LLC | 0.02% | Add +10.6% | 40,668 | $688K |
| XTX Topco Ltd | 0.01% | Add +33.3% | 32,527 | $550K |
| Blair William & Co. | 0.00% | No change | 32,400 | $548K |
| Rhumbline Advisers | 0.00% | Reduce -15.8% | 30,436 | $515K |
| Wells Fargo & Company | 0.00% | Add +69.3% | 28,293 | $478K |
| State of Wisconsin Investment Board | 0.00% | New | 24,615 | $416K |
| Guilbault Capital LLC | 0.44% | — | 23,225 | $393K |
| Aquatic Capital Management LLC | 0.01% | Reduce -37.2% | 22,802 | $386K |
| Essex Investment Management Co. LLC | 0.05% | No change | 20,182 | $341K |
| Invesco Ltd. | 0.00% | Add +46.1% | 19,691 | $333K |
| Juncture Wealth Strategies, LLC | 0.11% | Add +11.9% | 18,996 | $321K |
| Bridge City Capital, LLC | 0.09% | Add +11.6% | 18,600 | $315K |
| Deutsche Bank AG | 0.00% | Add +4.9% | 18,249 | $309K |
| CHICAGO TRUST Co NA | 0.04% | No change | 16,700 | $282K |
| Los Angeles Capital Management LLC | 0.00% | New | 14,631 | $267K |
| Voleon Capital Management LP | 0.01% | Add +42.3% | 15,582 | $263K |
| MetLife Investment Management, LLC | 0.00% | No change | 15,537 | $263K |
| T. Rowe Price Associates Inc. | 0.00% | Add +13.6% | 15,369 | $260K |
| D. E. Shaw & Co. | 0.00% | New | 15,331 | $259K |
| PDT Partners, LLC | 0.02% | No change | 14,891 | $252K |
| Two Sigma Advisers, LP | 0.00% | Reduce -91.3% | 14,700 | $249K |
| Squarepoint Ops LLC | 0.00% | Reduce -77.4% | 13,482 | $228K |
| Point72 Asset Management | 0.00% | New | 12,925 | $219K |
| Canada Pension Plan Investment Board | 0.00% | New | 12,500 | $211K |
| Intech Investment Management LLC | 0.00% | Add +11.1% | 12,421 | $210K |
| Raymond James Financial Inc. | 0.00% | Reduce -85.9% | 12,250 | $207K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -1.2% | 11,864 | $201K |
| Quantum Private Wealth, LLC | 0.06% | No change | 11,500 | $194K |
| Envestnet Asset Management Inc. | 0.00% | Reduce -3.8% | 10,944 | $185K |
| Jump Financial, LLC | 0.00% | New | 10,551 | $178K |
| Man Group plc | 0.00% | Reduce -17.2% | 10,473 | $177K |
| Northwestern Mutual Wealth Management Co. | 0.00% | No change | 10,000 | $169K |
| Quantbot Technologies LP | 0.01% | Reduce -18.9% | 9,357 | $158K |
| State of Wyoming | 0.02% | Add +50.0% | 8,161 | $138K |
| New York State Common Retirement Fund | 0.00% | No change | 8,100 | $137K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 7,209 | $122K |
| State of Alaska, Department of Revenue | 0.00% | Add +388.6% | 6,943 | $117K |
| SG Americas Securities, LLC | 0.00% | New | 6,471 | $109K |
| China Universal Asset Management Co., Ltd. | 0.01% | New | 4,370 | $74K |
| AlphaQuest LLC | 0.00% | Reduce -0.0% | 4,149 | $70K |
| FMR LLC | 0.00% | Reduce -46.0% | 3,076 | $52K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +208.3% | 2,994 | $51K |
| Caitong International Asset Management Co., Ltd | 0.01% | New | 2,939 | $50K |
| Legal & General Group Plc | 0.00% | Reduce -4.2% | 2,731 | $46K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 2,167 | $37K |
| California State Teachers Retirement System | 0.00% | Reduce -1.4% | 1,578 | $27K |
| Citigroup Inc. | 0.00% | Add +19.8% | 1,451 | $25K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | New | 1,303 | $22K |
| Truvestments Capital LLC | 0.00% | No change | 1,183 | $20K |
| Royal Bank of Canada | 0.00% | Reduce -99.8% | 1,018 | $17K |
| Amalgamated Bank | 0.00% | Reduce -8.1% | 805 | $14K |
| GF Fund Management Co. LTD. | 0.00% | New | 527 | $9K |
| Group One Trading LLC | 0.00% | Reduce -34.4% | 500 | $8K |
| Jones Financial Companies LLLP | 0.00% | New | 221 | $4K |
| Osaic Holdings, Inc. | 0.00% | No change | 200 | $3K |
| Sterling Capital Management LLC | 0.00% | Add +169.3% | 167 | $3K |
| Vermillion & White Wealth Management Group, LLC | 0.00% | No change | 150 | $3K |
| Farther Finance Advisors, LLC | 0.00% | New | 146 | $2K |
| Daiwa Securities Group Inc. | 0.00% | New | 89 | $2K |
| US Bancorp \de | 0.00% | New | 54 | $913 |
| PNC Financial Services Group, Inc. | 0.00% | Add +200.0% | 51 | $862 |
| GAMMA Investing LLC | 0.00% | New | 23 | $389 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -92.2% | 10 | $169 |
| Allworth Financial LP | 0.00% | New | 7 | $119 |
| Hughes Financial Services, LLC | 0.00% | New | 1 | $17 |
| Cwm, LLC | 0.00% | Reduce -16.1% | 26 | $0 |
"% of holder's portfolio" is ETON's weight in each manager's 13F, not the share of Eton Pharmaceuticals Inc. the manager owns.