Edgewise TherapeuticsEWTX
13F holders, Q4 2025 (December 31)199holders +26
37new positions
19sold out
4famous investors
$24.81avg. 13F price*
At the end of Q4 2025, 199 institutions reported holding Edgewise Therapeutics Inc. (EWTX) in their 13F filings, up 26 from Q3 2025. 37 opened new positions and 19 sold out. The largest holders were Orbimed Advisors LLC ($385.1M), Ra Capital Management, L.P. ($258.8M) and BlackRock, Inc. ($164.5M). 4 famous investors held it, including David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Edgewise Therapeutics Inc.
- CUSIP
- 28036F105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 37 | $90.6M |
| Exits | 19 | $16.5M |
All 13F filers, Q3 2025 → Q4 2025: 16,367,454 shares bought and 6,838,640 shares sold, net +9,528,814 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 199 holders
| Orbimed Advisors LLC | 7.88% | No change | 15,518,492 | $385.1M |
| Ra Capital Management, L.P. | 2.65% | No change | 10,428,437 | $258.8M |
| BlackRock, Inc. | 0.00% | Add +4.4% | 6,630,576 | $164.5M |
| Baker Bros. Advisors LP | 0.96% | Reduce -10.0% | 6,575,940 | $163.2M |
| Paradigm Biocapital Advisors LP | 4.35% | Add +6.0% | 6,541,210 | $162.3M |
| Novo Holdings A/S | 10.31% | No change | 5,350,000 | $132.8M |
| Braidwell LP | 4.95% | No change | 5,210,831 | $129.3M |
| Vanguard Group Inc. | 0.00% | Add +1.4% | 4,871,624 | $120.9M |
| Janus Henderson Group PLC | 0.05% | Reduce -8.3% | 4,566,850 | $113.3M |
| Siren, L.L.C. | 3.35% | Add +16.2% | 4,529,990 | $112.4M |
| Perceptive Advisors LLC | 2.03% | Add +17.4% | 4,457,974 | $110.6M |
| Driehaus Capital Management LLC | 0.71% | Add +88.1% | 4,191,193 | $104.0M |
| Cormorant Asset Management, LP | 4.62% | Reduce -18.1% | 3,285,000 | $81.5M |
| Morgan Stanley | 0.00% | Add +234.7% | 2,910,881 | $72.2M |
| UBS Group AG | 0.01% | Add +1755.0% | 2,117,073 | $52.5M |
| Geode Capital Management, LLC | 0.00% | Add +1.7% | 1,746,222 | $43.3M |
| State Street Corp. | 0.00% | Add +1.0% | 1,717,343 | $42.6M |
| MPM Bioimpact LLC | 4.70% | Reduce -3.8% | 1,655,256 | $41.1M |
| First Light Asset Management, LLC | 2.99% | Add +11.2% | 1,573,701 | $39.1M |
| Bellevue Group AG | 0.72% | Reduce -44.9% | 1,528,518 | $37.9M |
| Integral Health Asset Management, LLC | 1.89% | No change | 1,500,000 | $37.2M |
| Bank of America Corp. | 0.00% | Add +359.3% | 1,474,797 | $36.6M |
| Dimensional Fund Advisors LP | 0.01% | Add +2.6% | 1,213,657 | $30.1M |
| American Century Companies Inc. | 0.01% | Add +8.3% | 1,186,467 | $29.4M |
| Alliancebernstein L.P. | 0.01% | Add +1241.2% | 1,036,170 | $25.7M |
| Soleus Capital Management, L.P. | 0.96% | New | 910,000 | $22.6M |
| Aberdeen Group plc | 0.03% | Add +32.6% | 821,940 | $20.4M |
| Deerfield Management Company, L.P. | 0.28% | No change | 765,694 | $19.0M |
| Norges Bank | 0.00% | — | 751,355 | $18.6M |
| Victory Capital Management Inc. | 0.01% | Add +49.7% | 746,562 | $18.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +36.1% | 718,372 | $17.8M |
| Artisan Partners Limited Partnership | 0.03% | Reduce -2.0% | 704,077 | $17.5M |
| FMR LLC | 0.00% | Add +173.5% | 692,955 | $17.2M |
| Marshall Wace, LLP | 0.02% | New | 681,921 | $16.9M |
| Healthcare of Ontario Pension Plan Trust Fund | 0.03% | New | 640,400 | $15.9M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +2.3% | 611,384 | $15.2M |
| Eventide Asset Management, LLC | 0.22% | No change | 568,310 | $14.1M |
| Northern Trust Corp. | 0.00% | Reduce -4.8% | 559,649 | $13.9M |
| Candriam S.C.A. | 0.06% | Add +126.6% | 501,214 | $12.4M |
| Opaleye Management Inc. | 1.64% | No change | 500,000 | $12.4M |
| Sofinnova Investments, Inc. | 0.47% | Reduce -15.8% | 437,819 | $10.9M |
| Parkman Healthcare Partners LLC | 1.01% | Reduce -22.3% | 427,690 | $10.6M |
| D. E. Shaw & Co. | 0.01% | Reduce -41.8% | 394,695 | $9.8M |
| Barclays PLC | 0.00% | Add +58.9% | 372,738 | $9.2M |
| Stempoint Capital LP | 1.54% | New | 360,876 | $9.0M |
| Squadron Capital Management LLC | 3.88% | — | 350,000 | $8.7M |
| Eversept Partners, LP | 0.47% | Reduce -32.8% | 337,340 | $8.4M |
| Qube Research & Technologies Ltd | 0.01% | Reduce -46.7% | 296,208 | $7.4M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Add +104.8% | 271,385 | $6.7M |
| Kennedy Capital Management LLC | 0.13% | Reduce -3.6% | 241,509 | $6.0M |
| Sio Capital Management, LLC | 0.98% | Reduce -22.7% | 237,481 | $5.9M |
| Granahan Investment Management, LLC | 0.25% | Reduce -31.6% | 232,295 | $5.8M |
| Woodline Partners LP | 0.02% | Add +0.0% | 224,192 | $5.6M |
| Citigroup Inc. | 0.00% | Reduce -58.5% | 223,294 | $5.5M |
| Deutsche Bank AG | 0.00% | Add +38.6% | 214,769 | $5.3M |
| Ameriprise Financial Inc. | 0.00% | New | 202,297 | $5.0M |
| Bank of New York Mellon Corp | 0.00% | Reduce -2.8% | 198,614 | $4.9M |
| Ally Bridge Group (NY) LLC | 7.68% | New | 195,000 | $4.8M |
| HighVista Strategies LLC | 1.09% | Reduce -17.8% | 171,137 | $4.2M |
| Nuveen, LLC | 0.00% | Reduce -1.9% | 169,466 | $4.2M |
| DAFNA Capital Management LLC | 0.93% | Reduce -25.3% | 159,736 | $4.0M |
| Balyasny Asset Management L.P. | 0.01% | New | 151,905 | $3.8M |
| JPMorgan Chase & Co. | 0.00% | Add +112.5% | 146,038 | $3.6M |
| Schroder Investment Management Group | 0.00% | Reduce -3.8% | 145,286 | $3.6M |
| KVP Capital Advisors, LP | 3.41% | — | 133,000 | $3.3M |
| Neuberger Berman Group LLC | 0.00% | Reduce -42.1% | 127,136 | $3.2M |
| Millennium Management | 0.00% | Reduce -82.6% | 126,436 | $3.1M |
| Citadel Advisors | 0.00% | Add +451.6% | 123,097 | $3.1M |
| Jain Global LLC | 0.03% | New | 113,856 | $2.8M |
| Wellington Management Group LLP | 0.00% | Reduce -2.8% | 111,387 | $2.8M |
| Quantum Private Wealth, LLC | 0.77% | Add +0.1% | 106,024 | $2.6M |
| Swiss National Bank | 0.00% | Add +2.0% | 103,900 | $2.6M |
| Exome Asset Management LLC | 1.23% | Reduce -42.3% | 100,046 | $2.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -29.5% | 98,063 | $2.4M |
| ADAR1 Capital Management, LLC | 0.17% | Add +127.5% | 90,999 | $2.3M |
| New York State Common Retirement Fund | 0.00% | Add +6.6% | 88,937 | $2.2M |
| SG Americas Securities, LLC | 0.00% | Add +797.9% | 88,723 | $2.2M |
| Alps Advisors Inc. | 0.01% | Add +70.1% | 86,929 | $2.2M |
| Rhumbline Advisers | 0.00% | Reduce -18.8% | 85,075 | $2.1M |
| Federated Hermes, Inc. | 0.00% | Add +38.5% | 82,096 | $2.0M |
| Jump Financial, LLC | 0.03% | Reduce -1.1% | 79,915 | $2.0M |
| Wells Fargo & Company | 0.00% | Add +78.8% | 75,442 | $1.9M |
| Invesco Ltd. | 0.00% | Add +14.2% | 75,438 | $1.9M |
| Susquehanna International Group, LLP | 0.00% | Add +53.8% | 70,196 | $1.7M |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 80,000 | $1.6M |
| Schonfeld Strategic Advisors LLC | 0.01% | Add +14.1% | 59,326 | $1.5M |
| Ishara Investments LP | 1.68% | — | 58,000 | $1.4M |
| T. Rowe Price Associates Inc. | 0.00% | Add +11.5% | 57,315 | $1.4M |
| XTX Topco Ltd | 0.04% | New | 55,620 | $1.4M |
| HighMark Wealth Management LLC | 0.54% | No change | 53,179 | $1.3M |
| Legal & General Group Plc | 0.00% | Reduce -5.7% | 52,747 | $1.3M |
| Two Sigma Investments, LP | 0.00% | Add +93.6% | 50,848 | $1.3M |
| California State Teachers Retirement System | 0.00% | Reduce -0.8% | 50,392 | $1.3M |
| Franklin Resources Inc. | 0.00% | Reduce -10.5% | 43,145 | $1.1M |
| Moody Aldrich Partners LLC | 0.20% | Reduce -48.0% | 43,134 | $1.1M |
| Silverarc Capital Management, LLC | 0.15% | New | 42,052 | $1.0M |
| Prelude Capital Management, LLC | 0.08% | Reduce -15.5% | 41,584 | $1.0M |
| State of Wisconsin Investment Board | 0.00% | Add +9.2% | 39,997 | $993K |
| Voya Investment Management LLC | 0.00% | Add +219.3% | 39,648 | $984K |
| Knights of Columbus Asset Advisors LLC | 0.05% | New | 38,676 | $960K |
"% of holder's portfolio" is EWTX's weight in each manager's 13F, not the share of Edgewise Therapeutics Inc. the manager owns.