Lexeo TherapeuticsLXEO
13F holders, Q4 2025 (December 31)146holders +37
44new positions
9sold out
6famous investors
$9.93avg. 13F price*
At the end of Q4 2025, 146 institutions reported holding Lexeo Therapeutics Inc. (LXEO) in their 13F filings, up 37 from Q3 2025. 44 opened new positions and 9 sold out. The largest holders were Janus Henderson Group PLC ($54.7M), Ra Capital Management, L.P. ($49.6M) and BlackRock, Inc. ($48.7M). 6 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Lexeo Therapeutics Inc.
- CUSIP
- 52886X107
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 44 | $207.9M |
| Exits | 9 | $7.9M |
All 13F filers, Q3 2025 → Q4 2025: 33,921,738 shares bought and 6,956,694 shares sold, net +26,965,044 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 146 holders
| Janus Henderson Group PLC | 0.02% | Reduce -9.8% | 5,509,635 | $54.7M |
| Ra Capital Management, L.P. | 0.51% | New | 5,000,000 | $49.6M |
| BlackRock, Inc. | 0.00% | Add +126.0% | 4,907,563 | $48.7M |
| Paradigm Biocapital Advisors LP | 1.27% | New | 4,763,198 | $47.3M |
| Vestal Point Capital, LP | 1.63% | Add +37.7% | 4,475,000 | $44.4M |
| Frazier Life Sciences Management, L.P. | 1.18% | No change | 4,424,725 | $43.9M |
| Vanguard Group Inc. | 0.00% | Add +74.9% | 3,894,310 | $38.7M |
| Citadel Advisors | 0.03% | Add +1.5% | 3,774,317 | $37.5M |
| Avoro Capital Advisors LLC | 0.32% | New | 3,300,000 | $32.8M |
| Affinity Asset Advisors, LLC | 2.36% | Reduce -17.3% | 3,200,000 | $31.8M |
| Woodline Partners LP | 0.12% | Add +24.3% | 3,197,760 | $31.8M |
| State Street Corp. | 0.00% | Add +485.1% | 3,187,722 | $31.7M |
| Orbimed Advisors LLC | 0.43% | New | 2,125,000 | $21.1M |
| Point72 Asset Management | 0.03% | Reduce -2.4% | 1,894,722 | $18.8M |
| Octagon Capital Advisors LP | 2.14% | New | 1,725,000 | $17.1M |
| Balyasny Asset Management L.P. | 0.03% | Reduce -58.2% | 1,635,026 | $16.2M |
| Geode Capital Management, LLC | 0.00% | Add +100.3% | 1,445,887 | $14.4M |
| ADAR1 Capital Management, LLC | 1.03% | Reduce -9.1% | 1,393,161 | $13.8M |
| Montanova Capital, LLC | 0.31% | New | 1,250,000 | $12.4M |
| 683 Capital Management, LLC | 0.97% | Add +21.4% | 1,120,000 | $11.1M |
| Nantahala Capital Management, LLC | 0.59% | New | 1,000,000 | $9.9M |
| Millennium Management | 0.01% | Reduce -60.8% | 908,024 | $9.0M |
| Blackstone Inc. | 0.04% | Reduce -19.6% | 904,959 | $9.0M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -5.4% | 862,892 | $8.6M |
| Goldman Sachs Group Inc. | 0.00% | Add +449.1% | 781,855 | $7.8M |
| Siren, L.L.C. | 0.21% | Add +19.4% | 720,622 | $7.2M |
| Silverarc Capital Management, LLC | 0.89% | Reduce -20.7% | 617,608 | $6.1M |
| Ikarian Capital, LLC | 0.66% | Reduce -9.6% | 513,011 | $5.1M |
| D. E. Shaw & Co. | 0.00% | Add +3646.3% | 480,205 | $4.8M |
| Invesco Ltd. | 0.00% | New | 463,029 | $4.6M |
| Northern Trust Corp. | 0.00% | Add +93.3% | 457,052 | $4.5M |
| Verition Fund Management LLC | 0.02% | Add +3.3% | 428,458 | $4.3M |
| Two Sigma Investments, LP | 0.01% | Add +372.6% | 400,567 | $4.0M |
| DAFNA Capital Management LLC | 0.80% | Reduce -4.8% | 340,859 | $3.4M |
| AQR Capital Management | 0.00% | Reduce -3.0% | 337,386 | $3.4M |
| UBS Group AG | 0.00% | Add +12.5% | 281,083 | $2.8M |
| BNP Paribas Financial Markets | 0.00% | Add +737.8% | 257,417 | $2.6M |
| Ameriprise Financial Inc. | 0.00% | Add +46.1% | 243,294 | $2.4M |
| Y-Intercept (Hong Kong) Ltd | 0.05% | New | 231,163 | $2.3M |
| Renaissance Technologies | 0.00% | Add +45.9% | 217,772 | $2.2M |
| Nuveen, LLC | 0.00% | Add +539.0% | 211,529 | $2.1M |
| Privium Fund Management B.V. | 0.35% | Add +0.1% | 192,550 | $1.9M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +81.7% | 192,210 | $1.9M |
| Barclays PLC | 0.00% | Add +69.2% | 188,754 | $1.9M |
| Spruce Street Capital LP | 0.57% | — | 175,000 | $1.7M |
| Bank of New York Mellon Corp | 0.00% | Add +132.6% | 166,749 | $1.7M |
| Bank of America Corp. | 0.00% | Add +466.8% | 160,288 | $1.6M |
| Morgan Stanley | 0.00% | Add +43.0% | 140,181 | $1.4M |
| Jane Street Group, LLC | 0.00% | Add +8.2% | 140,096 | $1.4M |
| Perceptive Advisors LLC | 0.03% | No change | 139,835 | $1.4M |
| Boothbay Fund Management, LLC | 0.04% | Reduce -24.6% | 136,377 | $1.4M |
| Qube Research & Technologies Ltd | 0.00% | New | 133,257 | $1.3M |
| Burkehill Global Management, LP | 0.09% | New | 125,000 | $1.2M |
| Rafferty Asset Management, LLC | 0.00% | New | 102,159 | $1.0M |
| Squarepoint Ops LLC | 0.00% | New | 92,608 | $920K |
| Wellington Management Group LLP | 0.00% | New | 83,230 | $826K |
| Two Sigma Advisers, LP | 0.00% | New | 81,300 | $807K |
| Wells Fargo & Company | 0.00% | Add +267.2% | 70,736 | $702K |
| Rhumbline Advisers | 0.00% | Add +118.4% | 69,369 | $689K |
| Atom Investors LP | 0.05% | New | 68,491 | $680K |
| Alliancebernstein L.P. | 0.00% | Add +110.5% | 61,810 | $614K |
| Deutsche Bank AG | 0.00% | Add +135.0% | 57,166 | $568K |
| Acadian Asset Management LLC | 0.00% | New | 50,909 | $505K |
| American Century Companies Inc. | 0.00% | Add +27.2% | 45,988 | $457K |
| Profund Advisors LLC | 0.01% | New | 38,054 | $378K |
| Susquehanna International Group, LLP | 0.00% | Add +27.9% | 37,009 | $367K |
| MetLife Investment Management, LLC | 0.00% | New | 35,721 | $355K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +207.8% | 35,257 | $349K |
| Panagora Asset Management Inc. | 0.00% | No change | 34,297 | $341K |
| T. Rowe Price Associates Inc. | 0.00% | Add +183.1% | 33,872 | $337K |
| Graham Capital Management, L.P. | 0.02% | New | 32,898 | $327K |
| JPMorgan Chase & Co. | 0.00% | Add +108.0% | 29,861 | $297K |
| Virtus Investment Advisers, LLC | 0.07% | New | 27,230 | $270K |
| WINTON GROUP Ltd | 0.01% | New | 26,900 | $267K |
| Susquehanna Portfolio Strategies, LLC | 0.00% | Add +14.4% | 26,205 | $260K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | New | 26,209 | $252K |
| Ieq Capital, LLC | 0.00% | Reduce -26.5% | 24,692 | $245K |
| Cerity Partners LLC | 0.00% | Reduce -4.9% | 22,439 | $223K |
| Pale Fire Capital SE | 0.03% | Reduce -33.7% | 22,302 | $221K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 20,900 | $208K |
| Soltis Investment Advisors LLC | 0.01% | No change | 20,000 | $199K |
| New York State Common Retirement Fund | 0.00% | Add +375.0% | 19,887 | $197K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 19,147 | $190K |
| Cwm, LLC | 0.00% | Add +0.5% | 18,953 | $188K |
| SG Americas Securities, LLC | 0.00% | New | 18,640 | $185K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Reduce -1.0% | 16,436 | $163K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +171.1% | 16,373 | $163K |
| Persistent Asset Partners Ltd | 0.08% | New | 16,025 | $159K |
| Citigroup Inc. | 0.00% | Add +105.8% | 15,293 | $152K |
| ProShare Advisors LLC | 0.00% | New | 14,752 | $146K |
| Intech Investment Management LLC | 0.00% | Add +19.5% | 14,188 | $141K |
| Caxton Corp. | 3.24% | Reduce -19.6% | 13,943 | $138K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Add +0.6% | 14,330 | $136K |
| Bridgeway Capital Management, LLC | 0.00% | Reduce -72.3% | 13,400 | $133K |
| FMR LLC | 0.00% | Reduce -0.3% | 13,388 | $133K |
| Simplex Trading, LLC | 0.00% | Add +2511.4% | 13,031 | $129K |
| Raymond James Financial Inc. | 0.00% | New | 12,538 | $125K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +25.6% | 11,893 | $118K |
| AlphaQuest LLC | 0.01% | New | 11,726 | $116K |
| Gsa Capital Partners LLP | 0.01% | New | 11,463 | $114K |
"% of holder's portfolio" is LXEO's weight in each manager's 13F, not the share of Lexeo Therapeutics Inc. the manager owns.