Lyra TherapeuticsLYRA
13F holders, Q4 2024 (December 31)54holders −8
7new positions
15sold out
1famous investor
$0.21avg. 13F price*
At the end of Q4 2024, 54 institutions reported holding Lyra Therapeutics Inc. (LYRA) in their 13F filings, down 8 from Q3 2024. 7 opened new positions and 15 sold out. The largest holders were Perceptive Advisors LLC ($2.6M), BlackRock, Inc. ($642K) and Samsara Biocapital, LLC ($406K). One famous investor held it Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Lyra Therapeutics Inc.
- CUSIP
- 55234L105
- Latest filing quarter
- Q2 2025
History
Number of 13F holders
Total Exit/New Position Q3 2024 → Q4 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 7 | $247K |
| Exits | 15 | $1.4M |
All 13F filers, Q3 2024 → Q4 2024: 2,253,812 shares bought and 7,891,013 shares sold, net −5,637,201 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 54 holders
| Perceptive Advisors LLC | 0.07% | No change | 12,757,562 | $2.6M |
| BlackRock, Inc. | 0.00% | Add +3.9% | 3,109,798 | $642K |
| Samsara Biocapital, LLC | 0.06% | Reduce -29.3% | 1,965,689 | $406K |
| Vanguard Group Inc. | 0.00% | Add +0.5% | 1,787,422 | $368K |
| Ikarian Capital, LLC | 0.06% | Add +0.1% | 1,058,148 | $218K |
| Geode Capital Management, LLC | 0.00% | Add +15.3% | 885,966 | $183K |
| Goldman Sachs Group Inc. | 0.00% | Add +1.5% | 555,508 | $115K |
| ADAR1 Capital Management, LLC | 0.02% | New | 533,200 | $110K |
| State Street Corp. | 0.00% | No change | 488,720 | $101K |
| UBS Group AG | 0.00% | Add +1605.7% | 424,965 | $88K |
| Two Sigma Advisers, LP | 0.00% | Reduce -16.3% | 385,500 | $80K |
| Qube Research & Technologies Ltd | 0.00% | New | 342,159 | $71K |
| Northern Trust Corp. | 0.00% | Add +56.2% | 286,310 | $59K |
| BNP Paribas Financial Markets | 0.00% | New | 244,920 | $51K |
| Boothbay Fund Management, LLC | 0.00% | Add +0.6% | 233,989 | $48K |
| Morgan Stanley | 0.00% | Reduce -66.8% | 216,485 | $45K |
| Two Sigma Investments, LP | 0.00% | Reduce -25.7% | 209,997 | $43K |
| JPMorgan Chase & Co. | 0.00% | Add +161.8% | 156,442 | $32K |
| New York State Common Retirement Fund | 0.00% | No change | 154,800 | $32K |
| Charles Schwab Investment Management Inc. | 0.00% | No change | 111,609 | $23K |
| Susquehanna International Group, LLP | 0.00% | Add +701.0% | 103,430 | $21K |
| FMR LLC | 0.00% | Add +147.8% | 99,791 | $21K |
| Sei Investments Co. | 0.00% | Reduce -91.6% | 84,075 | $17K |
| Bank of New York Mellon Corp | 0.00% | No change | 75,966 | $16K |
| Barclays PLC | 0.00% | Add +18.9% | 75,254 | $16K |
| Bank of Montreal | 0.00% | Reduce -54.7% | 54,130 | $11K |
| Bank of America Corp. | 0.00% | Add +7.0% | 52,664 | $11K |
| Virtu Financial LLC | 0.00% | New | 42,069 | $9K |
| Rhumbline Advisers | 0.00% | No change | 41,258 | $8K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +163.1% | 39,785 | $8K |
| Citigroup Inc. | 0.00% | Add +8.8% | 38,102 | $8K |
| SG Americas Securities, LLC | 0.00% | Reduce -12.4% | 31,907 | $7K |
| Alliancebernstein L.P. | 0.00% | No change | 33,120 | $7K |
| AQR Capital Management | 0.00% | Reduce -46.9% | 28,713 | $6K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +4.6% | 27,770 | $6K |
| Wells Fargo & Company | 0.00% | Add +40.6% | 24,744 | $5K |
| Corebridge Financial, Inc. | 0.00% | Reduce -7.0% | 24,061 | $5K |
| Invesco Ltd. | 0.00% | Add +4.3% | 23,626 | $5K |
| T. Rowe Price Associates Inc. | 0.00% | No change | 17,541 | $4K |
| Abel Hall, LLC | 0.00% | New | 17,647 | $4K |
| ProShare Advisors LLC | 0.00% | New | 13,631 | $3K |
| Royal Bank of Canada | 0.00% | Reduce -14.2% | 5,294 | $2K |
| Cwm, LLC | 0.00% | Add +628.8% | 5,371 | $1K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 4,741 | $979 |
| SBI Securities Co., Ltd. | 0.00% | — | 4,269 | $881 |
| California State Teachers Retirement System | 0.00% | No change | 3,507 | $724 |
| Comerica Bank | 0.00% | No change | 1,159 | $239 |
| Wilmington Savings Fund Society, FSB | 0.00% | No change | 1,025 | $212 |
| Jones Financial Companies LLLP | 0.00% | No change | 500 | $103 |
| Nisa Investment Advisors, LLC | 0.00% | Add +1251.3% | 500 | $103 |
| EverSource Wealth Advisors, LLC | 0.00% | New | 119 | $25 |
| Sterling Capital Management LLC | 0.00% | No change | 88 | $18 |
| Amalgamated Bank | 0.00% | No change | 1,674 | $0 |
| Simplex Trading, LLC | 0.00% | Reduce -91.3% | 363 | $0 |
"% of holder's portfolio" is LYRA's weight in each manager's 13F, not the share of Lyra Therapeutics Inc. the manager owns.