| Novo Holdings A/S | 5.03% | New | 3,686,622 | $64.8M |
| FCPM III Services B.V. | 7.43% | New | 3,226,400 | $56.7M |
| T. Rowe Price Investment Management, Inc. | 0.03% | New | 2,799,180 | $49.2M |
| Goldman Sachs Group Inc. | 0.00% | New | 1,937,168 | $34.0M |
| BlackRock, Inc. | 0.00% | New | 1,095,514 | $19.2M |
| Nan Fung Group Holdings Ltd | 15.27% | New | 971,253 | $17.1M |
| 5AM Venture Management, LLC | 5.25% | New | 950,011 | $16.7M |
| Sanofi | 5.16% | New | 912,041 | $16.0M |
| Vanguard Group Inc. | 0.00% | New | 869,668 | $15.3M |
| Pivotal bioVenture Partners Investment Advisor LLC | 4.15% | New | 611,447 | $10.7M |
| Perceptive Advisors LLC | 0.18% | New | 550,000 | $9.7M |
| Velan Capital Investment Management LP | 5.34% | New | 522,305 | $9.2M |
| Siren, L.L.C. | 0.24% | New | 450,000 | $7.9M |
| Geode Capital Management, LLC | 0.00% | New | 389,026 | $6.8M |
| Vestal Point Capital, LP | 0.25% | New | 385,000 | $6.8M |
| Baker Bros. Advisors LP | 0.04% | New | 364,705 | $6.4M |
| Jain Global LLC | 0.06% | New | 327,693 | $5.8M |
| Blue Owl Capital Holdings LP | 1.79% | New | 327,058 | $5.7M |
| State Street Corp. | 0.00% | New | 229,484 | $4.0M |
| Lazard Asset Management LLC | 0.01% | New | 207,494 | $3.6M |
| Board of Trustees of The Leland Stanford Junior University | 0.71% | New | 199,233 | $3.5M |
| Citadel Advisors | 0.00% | New | 190,139 | $3.3M |
| Freestone Grove Partners LP | 0.02% | New | 183,771 | $3.2M |
| Tetragon Partners GP Ltd | 0.61% | New | 164,525 | $2.9M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | New | 147,930 | $2.6M |
| DAFNA Capital Management LLC | 0.59% | New | 143,764 | $2.5M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 138,427 | $2.4M |
| Northern Trust Corp. | 0.00% | New | 119,557 | $2.1M |
| Stempoint Capital LP | 0.30% | New | 100,000 | $1.8M |
| Seven Grand Managers, LLC | 0.13% | New | 100,000 | $1.8M |
| Burkehill Global Management, LP | 0.09% | New | 75,000 | $1.3M |
| Ameriprise Financial Inc. | 0.00% | New | 66,872 | $1.2M |
| Diadema Partners LP | 0.67% | New | 63,791 | $1.1M |
| Orbimed Advisors LLC | 0.02% | New | 56,000 | $952K |
| Tudor Investment Corporation | 0.00% | New | 47,840 | $840K |
| Marshall Wace, LLP | 0.00% | New | 39,659 | $697K |
| Bank of America Corp. | 0.00% | New | 37,820 | $664K |
| TD Asset Management Inc | 0.00% | New | 36,960 | $649K |
| Bank of New York Mellon Corp | 0.00% | New | 35,857 | $630K |
| Barclays PLC | 0.00% | New | 26,415 | $464K |
| Morgan Stanley | 0.00% | New | 23,222 | $408K |
| Persistent Asset Partners Ltd | 0.18% | New | 21,766 | $382K |
| Nuveen, LLC | 0.00% | New | 20,197 | $355K |
| Ghisallo Capital Management LLC | 0.02% | New | 20,000 | $351K |
| Wells Fargo & Company | 0.00% | New | 18,687 | $328K |
| UBS Group AG | 0.00% | New | 18,290 | $321K |
| Oxford Asset Management LLP | 0.11% | New | 17,763 | $312K |
| Millennium Management | 0.00% | New | 13,945 | $245K |
| Rhumbline Advisers | 0.00% | New | 13,642 | $240K |
| Lynx1 Capital Management LP | 0.05% | New | 13,477 | $237K |
| Invesco Ltd. | 0.00% | New | 12,970 | $228K |
| Deutsche Bank AG | 0.00% | New | 11,928 | $210K |
| Walleye Capital LLC | 0.00% | New | 11,686 | $205K |
| LMR Partners LLP | 0.00% | New | 10,000 | $176K |
| MetLife Investment Management, LLC | 0.00% | New | 9,798 | $172K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 7,815 | $137K |
| JPMorgan Chase & Co. | 0.00% | New | 6,743 | $118K |
| New York State Common Retirement Fund | 0.00% | New | 5,300 | $93K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 3,986 | $70K |
| BNP Paribas Financial Markets | 0.00% | New | 3,455 | $61K |
| STRS Ohio | 0.00% | New | 3,000 | $53K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 2,870 | $50K |
| Legal & General Group Plc | 0.00% | New | 1,649 | $29K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,371 | $24K |
| Russell Investments Group, Ltd. | 0.00% | New | 1,337 | $23K |
| California State Teachers Retirement System | 0.00% | New | 1,040 | $18K |
| FMR LLC | 0.00% | New | 904 | $16K |
| SBI Securities Co., Ltd. | 0.00% | New | 607 | $11K |
| Royal Bank of Canada | 0.00% | New | 582 | $10K |
| Sterling Capital Management LLC | 0.00% | New | 519 | $9K |
| Amalgamated Bank | 0.00% | New | 530 | $9K |
| Federation des caisses Desjardins du Quebec | 0.00% | New | 500 | $9K |
| Citigroup Inc. | 0.00% | New | 383 | $7K |
| Farther Finance Advisors, LLC | 0.00% | New | 120 | $2K |