Puma BiotechnologyPBYI
13F holders, Q4 2025 (December 31)151holders +19
30new positions
14sold out
5famous investors
$5.95avg. 13F price*
At the end of Q4 2025, 151 institutions reported holding Puma Biotechnology Inc. (PBYI) in their 13F filings, up 19 from Q3 2025. 30 opened new positions and 14 sold out. The largest holders were Acorn Capital Advisors, LLC ($24.6M), Vanguard Group Inc. ($22.6M) and BlackRock, Inc. ($21.7M). 5 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Cliff Asness (0.0% of AQR Capital Management's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Puma Biotechnology Inc.
- CUSIP
- 74587V107
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 30 | $4.1M |
| Exits | 14 | $6.9M |
All 13F filers, Q3 2025 → Q4 2025: 4,122,171 shares bought and 3,363,675 shares sold, net +758,496 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 151 holders
| Acorn Capital Advisors, LLC | 8.33% | No change | 4,131,299 | $24.6M |
| Vanguard Group Inc. | 0.00% | Add +2.9% | 3,797,748 | $22.6M |
| BlackRock, Inc. | 0.00% | Add +1.8% | 3,642,588 | $21.7M |
| Renaissance Technologies | 0.02% | Reduce -1.3% | 2,123,813 | $12.6M |
| Acadian Asset Management LLC | 0.02% | Reduce -1.4% | 2,024,823 | $12.0M |
| American Century Companies Inc. | 0.00% | Add +11.3% | 1,650,137 | $9.8M |
| Dimensional Fund Advisors LP | 0.00% | Add +5.3% | 1,339,603 | $8.0M |
| O'shaughnessy Asset Management, LLC | 0.04% | Add +35.3% | 1,120,329 | $6.7M |
| Geode Capital Management, LLC | 0.00% | Add +1.1% | 994,345 | $5.9M |
| State Street Corp. | 0.00% | Add +17.1% | 877,077 | $5.2M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.01% | Reduce -7.2% | 875,301 | $5.2M |
| Kennedy Capital Management LLC | 0.11% | Add +0.1% | 868,315 | $5.2M |
| Goldman Sachs Group Inc. | 0.00% | Add +238.4% | 793,962 | $4.7M |
| Bridgeway Capital Management, LLC | 0.10% | Add +78.4% | 773,485 | $4.6M |
| Ritholtz Wealth Management | 0.08% | Add +47.4% | 694,001 | $4.1M |
| AQR Capital Management | 0.00% | Add +410.1% | 666,605 | $4.0M |
| Northern Trust Corp. | 0.00% | Add +17.0% | 616,197 | $3.7M |
| Arrowstreet Capital, Limited Partnership | 0.00% | Add +17.9% | 547,853 | $3.3M |
| Globeflex Capital L P | 0.41% | No change | 452,606 | $2.7M |
| Sei Investments Co. | 0.00% | Add +23.8% | 429,925 | $2.6M |
| LSV Asset Management | 0.01% | Reduce -27.7% | 404,802 | $2.4M |
| D. E. Shaw & Co. | 0.00% | Reduce -24.1% | 378,296 | $2.3M |
| Bank of New York Mellon Corp | 0.00% | Reduce -1.0% | 351,881 | $2.1M |
| Morgan Stanley | 0.00% | Reduce -13.6% | 326,774 | $1.9M |
| Prudential Financial Inc. | 0.00% | Add +29.7% | 286,509 | $1.7M |
| Russell Investments Group, Ltd. | 0.00% | Reduce -73.9% | 251,653 | $1.5M |
| Federated Hermes, Inc. | 0.00% | Add +20.1% | 237,857 | $1.4M |
| Panagora Asset Management Inc. | 0.00% | Add +17.5% | 194,887 | $1.2M |
| Empowered Funds, LLC | 0.02% | Add +55.7% | 186,185 | $1.1M |
| Prospera Financial Services Inc | 0.02% | Reduce -2.2% | 185,496 | $1.1M |
| Franklin Resources Inc. | 0.00% | Add +5.2% | 182,706 | $1.1M |
| FMR LLC | 0.00% | Add +12.8% | 163,870 | $975K |
| Citadel Advisors | 0.00% | New | 162,670 | $968K |
| Two Sigma Investments, LP | 0.00% | Add +189.3% | 162,351 | $966K |
| Mackenzie Financial Corp. | 0.00% | Reduce -8.1% | 160,973 | $966K |
| Los Angeles Capital Management LLC | 0.00% | Reduce -46.0% | 148,132 | $809K |
| State of Wisconsin Investment Board | 0.00% | Add +146.3% | 133,774 | $796K |
| UBS Group AG | 0.00% | Reduce -66.2% | 127,312 | $758K |
| Charles Schwab Investment Management Inc. | 0.00% | No change | 125,372 | $746K |
| First Trust Advisors LP | 0.00% | Add +2.5% | 122,800 | $731K |
| Qube Research & Technologies Ltd | 0.00% | Reduce -28.3% | 111,520 | $664K |
| Invesco Ltd. | 0.00% | Add +69.7% | 108,301 | $644K |
| Round Rock Advisors LLC | 0.09% | Add +60.6% | 105,042 | $625K |
| STRS Ohio | 0.00% | Reduce -20.4% | 99,400 | $591K |
| WINTON GROUP Ltd | 0.02% | Add +58.4% | 97,159 | $578K |
| Evergreen Capital Management LLC | 0.01% | No change | 96,000 | $571K |
| Haven Private, LLC | 0.24% | New | 92,083 | $548K |
| OpenArc Corporate Advisory, LLC | 0.01% | — | 89,361 | $532K |
| Barclays PLC | 0.00% | Add +1.9% | 81,434 | $485K |
| Nuveen, LLC | 0.00% | No change | 79,101 | $471K |
| Canada Pension Plan Investment Board | 0.00% | New | 75,200 | $447K |
| Two Sigma Advisers, LP | 0.00% | Reduce -2.9% | 71,100 | $423K |
| Nomura Asset Management International Inc. | 0.00% | — | 61,255 | $364K |
| Lazard Asset Management LLC | 0.00% | Reduce -5.7% | 59,575 | $354K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Add +16.7% | 59,317 | $353K |
| Verdad Advisers, LP | 0.38% | — | 55,542 | $330K |
| Rhumbline Advisers | 0.00% | Reduce -10.2% | 53,895 | $321K |
| State of Wyoming | 0.03% | Add +317.3% | 53,155 | $316K |
| Bank of America Corp. | 0.00% | Add +16.5% | 52,385 | $312K |
| D'Orazio & Associates, Inc. | 0.04% | Add +56.0% | 49,807 | $296K |
| Wells Fargo & Company | 0.00% | Add +48.4% | 48,281 | $287K |
| Man Group plc | 0.00% | New | 47,324 | $282K |
| Virtus Advisers, LLC | 0.14% | No change | 47,172 | $281K |
| Metis Global Partners, LLC | 0.01% | Reduce -23.7% | 42,586 | $253K |
| LPL Financial LLC | 0.00% | Reduce -21.2% | 40,442 | $241K |
| Vise Technologies, Inc. | 0.00% | New | 40,298 | $240K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Reduce -80.2% | 39,308 | $234K |
| Jane Street Group, LLC | 0.00% | Reduce -73.8% | 36,362 | $216K |
| Baron Wealth Management LLC | 0.06% | Add +62.6% | 35,392 | $211K |
| EntryPoint Capital, LLC | 0.08% | New | 35,389 | $211K |
| Prelude Capital Management, LLC | 0.01% | Reduce -16.3% | 32,148 | $191K |
| Stokes Family Office, LLC | 0.02% | New | 28,091 | $167K |
| State Board of Administration of Florida Retirement System | 0.00% | New | 27,335 | $163K |
| Kathmere Capital Management, LLC | 0.01% | Reduce -2.9% | 27,131 | $161K |
| T. Rowe Price Associates Inc. | 0.00% | Add +19.9% | 25,936 | $155K |
| MetLife Investment Management, LLC | 0.00% | Add +67.8% | 24,412 | $145K |
| C2C Wealth Management, LLC | 0.12% | No change | 23,020 | $137K |
| Brandywine Global Investment Management, LLC | 0.00% | New | 21,800 | $130K |
| JPMorgan Chase & Co. | 0.00% | Add +22.1% | 21,108 | $126K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -0.3% | 20,159 | $120K |
| Heron Bay Capital Management | 0.02% | New | 20,056 | $119K |
| One Wealth Advisors, LLC | 0.01% | New | 19,389 | $115K |
| Intech Investment Management LLC | 0.00% | No change | 18,900 | $112K |
| Engineers Gate Manager LP | 0.00% | New | 18,786 | $112K |
| Millennium Management | 0.00% | Reduce -84.3% | 16,614 | $99K |
| Axq Capital, LP | 0.02% | New | 16,592 | $99K |
| Caprock Group, LLC | 0.00% | Add +39.8% | 16,448 | $98K |
| Headlands Technologies LLC | 0.01% | Reduce -45.2% | 15,976 | $95K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +88.9% | 15,719 | $94K |
| Alliancebernstein L.P. | 0.00% | No change | 13,800 | $82K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -11.4% | 13,427 | $80K |
| Causeway Capital Management LLC | 0.00% | Reduce -5.6% | 13,310 | $79K |
| Cwm, LLC | 0.00% | Add +43.6% | 12,813 | $76K |
| Perkins Capital Management Inc. | 0.06% | Add +2.5% | 12,500 | $74K |
| Osaic Holdings, Inc. | 0.00% | Reduce -33.4% | 12,169 | $72K |
| Cerity Partners LLC | 0.00% | Add +18.2% | 12,072 | $72K |
| PFG Investments, LLC | 0.00% | Reduce -20.0% | 12,000 | $71K |
| Royce & Associates LP | 0.00% | Reduce -36.4% | 11,914 | $71K |
| Ieq Capital, LLC | 0.00% | New | 11,495 | $68K |
| Abel Hall, LLC | 0.01% | New | 10,793 | $64K |
"% of holder's portfolio" is PBYI's weight in each manager's 13F, not the share of Puma Biotechnology Inc. the manager owns.