Protalix BiotherapeuticsPLX
13F holders, Q4 2025 (December 31)83holders +6
12new positions
5sold out
2famous investors
$1.80avg. 13F price*
At the end of Q4 2025, 83 institutions reported holding Protalix Biotherapeutics Inc. (PLX) in their 13F filings, up 6 from Q3 2025. 12 opened new positions and 5 sold out. The largest holders were BlackRock, Inc. ($6.6M), Opaleye Management Inc. ($4.5M) and Renaissance Technologies ($2.3M). 2 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Protalix Biotherapeutics Inc.
- CUSIP
- 74365A309
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 12 | $1.3M |
| Exits | 5 | $135K |
All 13F filers, Q3 2025 → Q4 2025: 1,736,211 shares bought and 688,846 shares sold, net +1,047,365 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 83 holders
| BlackRock, Inc. | 0.00% | Add +2.7% | 3,647,106 | $6.6M |
| Opaleye Management Inc. | 0.59% | Reduce -4.0% | 2,478,176 | $4.5M |
| Renaissance Technologies | 0.00% | Reduce -4.0% | 1,263,300 | $2.3M |
| Northern Trust Corp. | 0.00% | Reduce -4.1% | 865,708 | $1.6M |
| Geode Capital Management, LLC | 0.00% | Add +1.3% | 830,054 | $1.5M |
| State Street Corp. | 0.00% | Add +17.4% | 585,261 | $1.1M |
| Stratos Wealth Partners, LTD. | 0.01% | No change | 500,000 | $900K |
| Vanguard Group Inc. | 0.00% | Add +5.2% | 488,552 | $879K |
| Citadel Advisors | 0.00% | Add +751.4% | 317,628 | $572K |
| Jane Street Group, LLC | 0.00% | New | 289,917 | $522K |
| Goldman Sachs Group Inc. | 0.00% | Add +74.2% | 262,809 | $473K |
| UBS Group AG | 0.00% | Add +38.0% | 262,520 | $473K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | Reduce -42.0% | 232,093 | $418K |
| Main Street Financial Solutions, LLC | 0.03% | Add +65.8% | 214,100 | $385K |
| Bank of New York Mellon Corp | 0.00% | Add +52.2% | 210,867 | $380K |
| Bridgeway Capital Management, LLC | 0.01% | No change | 189,100 | $340K |
| Charles Schwab Investment Management Inc. | 0.00% | No change | 175,070 | $315K |
| Commonwealth Equity Services, LLC | 0.00% | No change | 171,772 | $309K |
| Evergreen Capital Management LLC | 0.01% | No change | 171,338 | $308K |
| Round Rock Advisors LLC | 0.04% | New | 155,102 | $279K |
| Diametric Capital, LP | 0.07% | Reduce -22.8% | 138,929 | $250K |
| Morgan Stanley | 0.00% | Add +85.8% | 131,987 | $238K |
| Barclays PLC | 0.00% | Add +10.9% | 112,849 | $203K |
| Nuveen, LLC | 0.00% | No change | 90,188 | $162K |
| Wells Fargo & Company | 0.00% | Add +84.5% | 79,002 | $142K |
| Lazard Asset Management LLC | 0.00% | New | 71,393 | $129K |
| HRT Financial LP | 0.00% | New | 64,610 | $116K |
| Orin Green Financial, LLC | 0.04% | Add +0.4% | 61,433 | $111K |
| Invesco Ltd. | 0.00% | Add +12.3% | 50,563 | $91K |
| Bank of America Corp. | 0.00% | Add +130.4% | 46,352 | $83K |
| Rhumbline Advisers | 0.00% | Reduce -31.9% | 44,369 | $80K |
| Two Sigma Securities, LLC | 0.01% | New | 39,811 | $72K |
| Susquehanna International Group, LLP | 0.00% | Reduce -47.2% | 38,518 | $69K |
| T. Rowe Price Associates Inc. | 0.00% | No change | 35,278 | $64K |
| XTX Topco Ltd | 0.00% | Reduce -60.0% | 34,296 | $62K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +3.1% | 33,246 | $60K |
| Intech Investment Management LLC | 0.00% | Reduce -0.4% | 31,133 | $56K |
| New York State Common Retirement Fund | 0.00% | Reduce -24.7% | 31,100 | $56K |
| JPMorgan Chase & Co. | 0.00% | Add +2.9% | 30,874 | $56K |
| Dimensional Fund Advisors LP | 0.00% | Add +68.8% | 28,744 | $51K |
| Aptus Capital Advisors, LLC | 0.00% | Add +3.4% | 26,610 | $48K |
| Earned Wealth Advisors, LLC | 0.00% | No change | 25,975 | $47K |
| Smartleaf Asset Management LLC | 0.00% | New | 25,975 | $45K |
| Prelude Capital Management, LLC | 0.00% | Reduce -55.3% | 22,243 | $40K |
| State of Alaska, Department of Revenue | 0.00% | New | 21,831 | $39K |
| Lido Advisors, LLC | 0.00% | No change | 15,554 | $35K |
| Marshall Wace, LLP | 0.00% | New | 19,079 | $34K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 18,554 | $33K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -23.1% | 18,498 | $33K |
| SG Americas Securities, LLC | 0.00% | New | 17,155 | $31K |
| BNP Paribas Financial Markets | 0.00% | Add +11.9% | 17,021 | $31K |
| R Squared Ltd | 0.01% | New | 14,632 | $26K |
| ProShare Advisors LLC | 0.00% | Add +10.2% | 13,137 | $24K |
| Two Sigma Advisers, LP | 0.00% | Add +25.2% | 12,900 | $23K |
| Altshuler Shaham Ltd | 0.00% | No change | 12,142 | $22K |
| Cascade Financial Partners, LLC | 0.00% | Reduce -29.4% | 12,000 | $22K |
| Alliancebernstein L.P. | 0.00% | No change | 11,720 | $21K |
| Equitable Holdings, Inc. | 0.00% | New | 11,150 | $20K |
| LPL Financial LLC | 0.00% | No change | 10,291 | $19K |
| Harbour Investment Management LLC | 0.01% | No change | 10,100 | $18K |
| Kestra Advisory Services, LLC | 0.00% | Reduce -9.1% | 10,000 | $18K |
| Russell Investments Group, Ltd. | 0.00% | Reduce -2.6% | 7,267 | $13K |
| Legal & General Group Plc | 0.00% | Reduce -7.2% | 7,201 | $13K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 7,119 | $13K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +13.1% | 6,233 | $11K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 6,000 | $11K |
| California State Teachers Retirement System | 0.00% | Add +2.1% | 4,443 | $8K |
| Royal Bank of Canada | 0.00% | Add +217.2% | 3,404 | $6K |
| FMR LLC | 0.00% | Add +428.5% | 2,315 | $4K |
| Amalgamated Bank | 0.00% | Reduce -4.7% | 2,269 | $4K |
| Citigroup Inc. | 0.00% | Reduce -75.3% | 1,634 | $3K |
| Osaic Holdings, Inc. | 0.00% | Add +71.4% | 1,200 | $2K |
| Investment Research & Advisory Group, Inc. | 0.00% | No change | 1,000 | $2K |
| Deutsche Bank AG | 0.00% | Reduce -98.7% | 846 | $2K |
| Sterling Capital Management LLC | 0.00% | Add +168.1% | 453 | $815 |
| GAMMA Investing LLC | 0.00% | New | 355 | $639 |
| Activest Wealth Management | 0.00% | No change | 300 | $540 |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 250 | $450 |
| Y.D. More Investments Ltd | 0.00% | No change | 220 | $383 |
| Arax Advisory Partners | 0.00% | Reduce -86.8% | 39 | $71 |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -42.9% | 20 | $36 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -99.5% | 1 | $2 |
| Cwm, LLC | 0.00% | Add +24.5% | 203 | $0 |
"% of holder's portfolio" is PLX's weight in each manager's 13F, not the share of Protalix Biotherapeutics Inc. the manager owns.