Spruce BiosciencesSPRB

13F holders, Q4 2025 (December 31)

32holders +23

24new positions

2sold out

1famous investor

$87.02avg. 13F price*

At the end of Q4 2025, 32 institutions reported holding Spruce Biosciences Inc. (SPRB) in their 13F filings, up 23 from Q3 2025. 24 opened new positions and 2 sold out. The largest holders were Ikarian Capital, LLC ($10.6M), Squadron Capital Management LLC ($6.1M) and Citadel Advisors ($6.1M). One famous investor held it Ken Griffin (0.0% of Citadel Advisors's portfolio).

Company: Spruce Biosciences Inc.
CUSIP: 85209E208
Latest filing quarter: Q2 2026

History

Number of 13F holders

Total Exit/New Position Q3 2025 → Q4 2025

	Institutions	Total Value
New Positions	24	$45.1M
Exits	2	$240K

All 13F filers, Q3 2025 → Q4 2025: 630,657 shares bought and 2,884,697 shares sold, net −2,254,040 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.

Ownership 32 holders


Ikarian Capital, LLC	1.37%	Add +810.3%	121,356	$10.6M
Squadron Capital Management LLC	2.72%	—	70,000	$6.1M
Citadel Advisors	0.00%	New	69,999	$6.1M
Wellington Management Group LLP	0.00%	New	58,949	$5.1M
ADAR1 Capital Management, LLC	0.38%	New	58,000	$5.1M
Alyeska Investment Group, L.P.	0.01%	New	51,671	$4.5M
Boothbay Fund Management, LLC	0.11%	New	47,933	$4.2M
Balyasny Asset Management L.P.	0.01%	New	40,000	$3.5M
Carlyle Group Inc.	0.02%	Reduce -98.7%	38,620	$3.3M
ExodusPoint Capital Management, LP	0.02%	New	25,271	$2.2M
Schonfeld Strategic Advisors LLC	0.01%	New	24,767	$2.2M
Quinn Opportunity Partners LLC	0.09%	New	22,810	$2.0M
Caligan Partners LP	0.16%	New	20,514	$1.8M
Stonepine Capital Management, LLC	1.36%	New	19,742	$1.7M
Vanguard Group Inc.	0.00%	New	17,873	$1.6M
BlackRock, Inc.	0.00%	New	16,938	$1.5M
Geode Capital Management, LLC	0.00%	New	12,732	$1.1M
Superstring Capital Management LP	0.57%	New	12,137	$1.1M
State Street Corp.	0.00%	New	6,400	$558K
UBS Group AG	0.00%	Add +3613.6%	4,902	$427K
Resolute Capital Asset Partners LLC	0.17%	New	4,000	$348K
SkyView Investment Advisors, LLC	0.03%	New	3,000	$261K
Northern Trust Corp.	0.00%	New	2,422	$211K
BNP Paribas Financial Markets	0.00%	New	2,000	$174K
Lion Point Capital, LP	0.45%	No change	1,000	$87K
Morgan Stanley	0.00%	Add +295.9%	388	$34K
Sound Income Strategies, LLC	0.00%	New	200	$15K
Bank of America Corp.	0.00%	Add +3000.0%	93	$8K
Jones Financial Companies LLLP	0.00%	New	84	$7K
Royal Bank of Canada	0.00%	New	40	$3K
Caldwell Sutter Capital, Inc.	0.00%	No change	13	$1K
Tower Research Capital LLC (TRC)	0.00%	New	1	$87

"% of holder's portfolio" is SPRB's weight in each manager's 13F, not the share of Spruce Biosciences Inc. the manager owns.