Spero TherapeuticsSPRO
13F holders, Q4 2024 (December 31)At the end of Q4 2024, 50 institutions reported holding Spero Therapeutics Inc. (SPRO) in their 13F filings, up 4 from Q3 2024. 8 opened new positions and 8 sold out. The largest holders were Anson Funds Management LP ($4.0M), Pfizer Inc ($2.4M) and Vanguard Group Inc. ($1.8M). 2 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Spero Therapeutics Inc.
- CUSIP
- 84833T103
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2024 → Q4 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 8 | $1.2M |
| Exits | 8 | $1.2M |
All 13F filers, Q3 2024 → Q4 2024: 1,759,075 shares bought and 1,096,463 shares sold, net +662,612 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 50 holders
| Anson Funds Management LP | 0.50% | Add +2.4% | 3,839,886 | $4.0M |
| Pfizer Inc | 0.09% | — | 2,362,348 | $2.4M |
| Vanguard Group Inc. | 0.00% | No change | 1,763,620 | $1.8M |
| Renaissance Technologies | 0.00% | Add +13.4% | 1,105,591 | $1.1M |
| Acadian Asset Management LLC | 0.00% | Reduce -3.0% | 1,039,922 | $1.1M |
| Alphabet Inc. | 0.05% | No change | 889,979 | $917K |
| Murchinson Ltd. | 0.43% | New | 873,910 | $900K |
| ADAR1 Capital Management, LLC | 0.18% | Add +7.8% | 801,277 | $825K |
| BlackRock, Inc. | 0.00% | Add +0.1% | 485,352 | $500K |
| Geode Capital Management, LLC | 0.00% | Reduce -0.0% | 481,128 | $496K |
| Monimus Capital Management, LP | 0.30% | — | 310,908 | $320K |
| Atlas Venture Life Science Advisors, LLC | 0.04% | Reduce -24.2% | 305,255 | $314K |
| Mackenzie Financial Corp. | 0.00% | Add +487.9% | 187,559 | $193K |
| Bridgeway Capital Management, LLC | 0.00% | No change | 184,800 | $190K |
| Citadel Advisors | 0.00% | Add +112.3% | 172,872 | $178K |
| State Street Corp. | 0.00% | Add +14.1% | 148,911 | $153K |
| DAFNA Capital Management LLC | 0.03% | No change | 125,000 | $129K |
| Northern Trust Corp. | 0.00% | Reduce -22.5% | 86,447 | $89K |
| JPMorgan Chase & Co. | 0.00% | Add +26011.9% | 61,624 | $63K |
| Squarepoint Ops LLC | 0.00% | New | 55,051 | $57K |
| Jane Street Group, LLC | 0.00% | New | 52,869 | $54K |
| Prudential Financial Inc. | 0.00% | New | 49,200 | $51K |
| Virtu Financial LLC | 0.00% | New | 46,046 | $47K |
| XTX Topco Ltd | 0.00% | New | 30,138 | $31K |
| Three Seasons Wealth, LLC | 0.02% | No change | 30,000 | $31K |
| Susquehanna International Group, LLP | 0.00% | Reduce -32.7% | 29,755 | $31K |
| DLK Investment Management, LLC | 0.01% | Reduce -7.7% | 28,955 | $30K |
| Charles Schwab Investment Management Inc. | 0.00% | No change | 28,565 | $29K |
| PFG Investments, LLC | 0.00% | Add +75.5% | 24,534 | $25K |
| HRT Financial LP | 0.00% | New | 14,692 | $15K |
| Dimensional Fund Advisors LP | 0.00% | No change | 10,003 | $10K |
| Texas Yale Capital Corp. | 0.00% | New | 10,000 | $10K |
| National Bank of Canada | 0.00% | No change | 10,000 | $10K |
| Morgan Stanley | 0.00% | No change | 6,971 | $7K |
| Bank of America Corp. | 0.00% | Reduce -1.9% | 5,547 | $6K |
| US Bancorp \de | 0.00% | Add +3311.3% | 5,151 | $5K |
| Simplex Trading, LLC | 0.00% | Add +454.8% | 5,110 | $5K |
| FMR LLC | 0.00% | Add +36.6% | 4,289 | $4K |
| WR Wealth Planners, LLC | 0.00% | No change | 2,600 | $3K |
| Cullen/Frost Bankers, Inc. | 0.00% | No change | 2,000 | $2K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +245.3% | 929 | $957 |
| Osaic Holdings, Inc. | 0.00% | No change | 295 | $304 |
| SBI Securities Co., Ltd. | 0.00% | — | 213 | $219 |
| Wells Fargo & Company | 0.00% | No change | 200 | $206 |
| Richards, Merrill & Peterson, Inc. | 0.00% | — | 150 | $155 |
| UBS Group AG | 0.00% | Reduce -99.2% | 141 | $145 |
| NewEdge Advisors, LLC | 0.00% | No change | 100 | $103 |
| CoreCap Advisors, LLC | 0.00% | Reduce -74.0% | 50 | $52 |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 30 | $31 |
| BNP Paribas Financial Markets | 0.00% | No change | 12 | $12 |
"% of holder's portfolio" is SPRO's weight in each manager's 13F, not the share of Spero Therapeutics Inc. the manager owns.