Spero TherapeuticsSPRO
13F holders, Q1 2025 (March 31)At the end of Q1 2025, 38 institutions reported holding Spero Therapeutics Inc. (SPRO) in their 13F filings, down 12 from Q4 2024. 1 opened new positions and 12 sold out. The largest holders were Anson Funds Management LP ($2.7M), Pfizer Inc ($1.7M) and Vanguard Group Inc. ($1.3M). 2 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Spero Therapeutics Inc.
- CUSIP
- 84833T103
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024 → Q1 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 1 | $12K |
| Exits | 12 | $225K |
All 13F filers, Q4 2024 → Q1 2025: 145,218 shares bought and 714,587 shares sold, net −569,369 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 38 holders
| Anson Funds Management LP | 0.66% | Reduce -1.1% | 3,798,932 | $2.7M |
| Pfizer Inc | 0.34% | No change | 2,362,348 | $1.7M |
| Vanguard Group Inc. | 0.00% | No change | 1,763,620 | $1.3M |
| Renaissance Technologies | 0.00% | Reduce -12.2% | 970,907 | $699K |
| Alphabet Inc. | 0.04% | No change | 889,979 | $641K |
| Murchinson Ltd. | 0.11% | No change | 873,910 | $629K |
| Acadian Asset Management LLC | 0.00% | Reduce -16.2% | 871,212 | $626K |
| ADAR1 Capital Management, LLC | 0.11% | No change | 801,277 | $577K |
| Geode Capital Management, LLC | 0.00% | Add +9.1% | 524,869 | $378K |
| BlackRock, Inc. | 0.00% | Reduce -0.7% | 482,082 | $347K |
| Monimus Capital Management, LP | 0.19% | No change | 310,908 | $224K |
| Atlas Venture Life Science Advisors, LLC | 0.04% | No change | 305,255 | $220K |
| Mackenzie Financial Corp. | 0.00% | Add +11.4% | 209,031 | $151K |
| Bridgeway Capital Management, LLC | 0.00% | Reduce -16.2% | 154,800 | $111K |
| State Street Corp. | 0.00% | No change | 148,911 | $107K |
| DAFNA Capital Management LLC | 0.03% | No change | 125,000 | $90K |
| Northern Trust Corp. | 0.00% | Add +16.8% | 100,924 | $73K |
| Squarepoint Ops LLC | 0.00% | Add +68.8% | 92,939 | $67K |
| Citadel Advisors | 0.00% | Reduce -64.5% | 61,316 | $44K |
| JPMorgan Chase & Co. | 0.00% | Reduce -1.3% | 60,817 | $44K |
| Prudential Financial Inc. | 0.00% | Add +13.8% | 56,000 | $40K |
| Three Seasons Wealth, LLC | 0.01% | No change | 30,000 | $22K |
| DLK Investment Management, LLC | 0.01% | Add +3.0% | 29,825 | $21K |
| Charles Schwab Investment Management Inc. | 0.00% | No change | 28,565 | $21K |
| EP Wealth Advisors, LLC | 0.00% | New | 16,500 | $12K |
| Texas Yale Capital Corp. | 0.00% | No change | 10,000 | $7K |
| Morgan Stanley | 0.00% | No change | 6,971 | $5K |
| Bank of America Corp. | 0.00% | Add +0.3% | 5,565 | $4K |
| FMR LLC | 0.00% | Add +17.9% | 5,056 | $4K |
| Simplex Trading, LLC | 0.00% | Reduce -0.2% | 5,098 | $3K |
| UBS Group AG | 0.00% | Add +1904.3% | 2,826 | $2K |
| Cullen/Frost Bankers, Inc. | 0.00% | No change | 2,000 | $1K |
| Wells Fargo & Company | 0.00% | No change | 200 | $144 |
| US Bancorp \de | 0.00% | Reduce -97.1% | 151 | $109 |
| NewEdge Advisors, LLC | 0.00% | No change | 100 | $72 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -71.8% | 60 | $43 |
| CoreCap Advisors, LLC | 0.00% | No change | 50 | $36 |
| BNP Paribas Financial Markets | 0.00% | No change | 12 | $9 |
"% of holder's portfolio" is SPRO's weight in each manager's 13F, not the share of Spero Therapeutics Inc. the manager owns.