Spyre TherapeuticsSYRE
13F holders, Q2 2025 (June 30)129holders
18new positions
17sold out
2famous investors
$14.97avg. 13F price*
At the end of Q2 2025, 129 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, unchanged from Q1 2025. 18 opened new positions and 17 sold out. The largest holders were FMR LLC ($135.5M), Fairmount Funds Management LLC ($60.2M) and BlackRock, Inc. ($60.0M). 2 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 18 | $17.2M |
| Exits | 17 | $10.9M |
All 13F filers, Q1 2025 → Q2 2025: 5,693,805 shares bought and 4,176,998 shares sold, net +1,516,807 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 129 holders
| FMR LLC | 0.01% | Add +0.2% | 9,053,034 | $135.5M |
| Fairmount Funds Management LLC | 7.79% | No change | 4,018,101 | $60.2M |
| BlackRock, Inc. | 0.00% | Add +12.2% | 4,007,296 | $60.0M |
| RTW Investments, LP | 0.77% | No change | 3,621,996 | $54.2M |
| Tang Capital Management LLC | 2.42% | Add +56.1% | 3,200,000 | $47.9M |
| Vanguard Group Inc. | 0.00% | Add +5.8% | 3,066,586 | $45.9M |
| Venrock Adviser, LLC | 3.01% | No change | 2,685,448 | $40.2M |
| Braidwell LP | 1.85% | No change | 2,578,404 | $38.6M |
| Capital International Investors | 0.01% | No change | 2,392,541 | $35.8M |
| Driehaus Capital Management LLC | 0.25% | Reduce -23.3% | 2,085,590 | $31.2M |
| Commodore Capital LP | 2.10% | No change | 1,988,084 | $29.8M |
| Paradigm Biocapital Advisors LP | 1.20% | Reduce -12.1% | 1,870,445 | $28.0M |
| State Street Corp. | 0.00% | Reduce -6.0% | 1,595,291 | $23.9M |
| Perceptive Advisors LLC | 0.86% | Reduce -33.9% | 1,529,445 | $22.9M |
| Wellington Management Group LLP | 0.00% | Reduce -5.0% | 1,513,478 | $22.7M |
| Jefferies Financial Group Inc. | 0.36% | Add +11.2% | 1,388,854 | $20.8M |
| Geode Capital Management, LLC | 0.00% | Add +15.8% | 1,227,232 | $18.4M |
| Pictet Asset Management Holding SA | 0.02% | Add +1.0% | 1,079,443 | $16.2M |
| T. Rowe Price Associates Inc. | 0.00% | Add +274.4% | 930,481 | $13.9M |
| Franklin Resources Inc. | 0.00% | Add +4.6% | 795,275 | $11.9M |
| Polar Capital Holdings Plc | 0.06% | Reduce -9.7% | 745,000 | $11.2M |
| Morgan Stanley | 0.00% | Add +100.0% | 671,044 | $10.0M |
| Baker Bros. Advisors LP | 0.09% | New | 626,703 | $9.4M |
| Deerfield Management Company, L.P. | 0.19% | Add +36.4% | 613,665 | $9.2M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | Reduce -24.0% | 610,200 | $9.1M |
| Affinity Asset Advisors, LLC | 1.40% | Add +25.9% | 606,678 | $9.1M |
| Emerald Advisers, LLC | 0.31% | Add +3.3% | 565,863 | $8.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +165.6% | 523,416 | $7.8M |
| Blackstone Inc. | 0.03% | No change | 489,248 | $7.3M |
| Woodline Partners LP | 0.04% | Add +0.1% | 465,152 | $7.0M |
| UBS Group AG | 0.00% | Reduce -16.2% | 462,863 | $6.9M |
| Northern Trust Corp. | 0.00% | Add +15.0% | 436,947 | $6.5M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +9.4% | 418,503 | $6.3M |
| Bank of America Corp. | 0.00% | Reduce -7.2% | 396,351 | $5.9M |
| Siren, L.L.C. | 0.29% | No change | 368,598 | $5.5M |
| Victory Capital Management Inc. | 0.00% | Add +40.6% | 354,116 | $5.3M |
| Capital World Investors | 0.00% | No change | 350,774 | $5.3M |
| Emerald Mutual Fund Advisers Trust | 0.30% | Reduce -15.4% | 329,430 | $4.9M |
| Voloridge Investment Management, LLC | 0.02% | Add +8.3% | 278,920 | $4.2M |
| Candriam S.C.A. | 0.02% | No change | 246,030 | $3.7M |
| BNP Paribas Financial Markets | 0.00% | Add +300.0% | 223,320 | $3.3M |
| Deep Track Capital, LP | 0.11% | No change | 219,015 | $3.3M |
| Barclays PLC | 0.00% | Add +0.9% | 216,646 | $3.2M |
| Capitolis Liquid Global Markets LLC | 0.02% | New | 183,000 | $2.7M |
| Armistice Capital, LLC | 0.10% | Reduce -14.0% | 172,000 | $2.6M |
| Nuveen, LLC | 0.00% | Reduce -3.6% | 135,068 | $2.0M |
| Bank of New York Mellon Corp | 0.00% | Add +15.7% | 132,150 | $2.0M |
| Schroder Investment Management Group | 0.00% | Add +19.4% | 129,558 | $2.0M |
| TD Asset Management Inc | 0.00% | Add +409.5% | 113,968 | $1.7M |
| HighVista Strategies LLC | 0.62% | Add +18.5% | 112,805 | $1.7M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Reduce -9.2% | 109,284 | $1.6M |
| Mercer Global Advisors Inc. | 0.00% | New | 106,142 | $1.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +64.4% | 85,702 | $1.3M |
| ExodusPoint Capital Management, LP | 0.02% | Add +451.2% | 82,977 | $1.2M |
| B Group, Inc. | 1.03% | Add +14.3% | 80,000 | $1.2M |
| Manufacturers Life Insurance Company, The | 0.00% | Add +48.2% | 79,896 | $1.2M |
| Rhumbline Advisers | 0.00% | Add +30.6% | 73,168 | $1.1M |
| Foresite Capital Management VI LLC | 0.59% | New | 70,000 | $1.0M |
| Swiss National Bank | 0.00% | No change | 68,600 | $1.0M |
| Verition Fund Management LLC | 0.01% | New | 65,042 | $974K |
| Susquehanna International Group, LLP | 0.00% | Add +1.9% | 59,816 | $895K |
| F/m Investments LLC | 0.03% | Add +1.4% | 52,546 | $787K |
| Rafferty Asset Management, LLC | 0.00% | Reduce -27.5% | 50,957 | $763K |
| JPMorgan Chase & Co. | 0.00% | Add +13.8% | 47,279 | $708K |
| Alliancebernstein L.P. | 0.00% | No change | 36,230 | $542K |
| State of Wisconsin Investment Board | 0.00% | Add +0.4% | 35,046 | $525K |
| Legal & General Group Plc | 0.00% | Reduce -7.6% | 34,969 | $523K |
| Invesco Ltd. | 0.00% | Add +37.6% | 34,680 | $519K |
| Wells Fargo & Company | 0.00% | Add +14.6% | 34,409 | $515K |
| ADAR1 Capital Management, LLC | 0.08% | Add +126.5% | 34,051 | $510K |
| Deutsche Bank AG | 0.00% | Add +19.1% | 33,938 | $508K |
| California State Teachers Retirement System | 0.00% | Add +1.9% | 33,201 | $497K |
| Renaissance Technologies | 0.00% | New | 30,936 | $463K |
| Squarepoint Ops LLC | 0.00% | Reduce -58.3% | 30,046 | $450K |
| MetLife Investment Management, LLC | 0.00% | Add +26.1% | 29,918 | $448K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +10.3% | 29,812 | $447K |
| Citigroup Inc. | 0.00% | Reduce -64.9% | 29,261 | $438K |
| Teachers Retirement System of the State of Kentucky | 0.00% | No change | 25,799 | $386K |
| Intech Investment Management LLC | 0.00% | Add +22.1% | 24,945 | $373K |
| Natixis | 0.00% | New | 20,040 | $355K |
| Assenagon Asset Management S.A. | 0.00% | Reduce -2.6% | 22,136 | $331K |
| Waverly Advisors, LLC | 0.00% | Add +0.1% | 19,453 | $291K |
| NBW Capital LLC | 0.06% | No change | 19,430 | $291K |
| Global Endowment Management, LP | 0.04% | No change | 18,184 | $272K |
| AQR Capital Management | 0.00% | New | 17,973 | $269K |
| New York State Common Retirement Fund | 0.00% | Add +61.4% | 16,565 | $248K |
| Voya Investment Management LLC | 0.00% | Add +31.3% | 13,589 | $203K |
| Janus Henderson Group PLC | 0.00% | Reduce -98.8% | 13,000 | $194K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | New | 12,873 | $193K |
| ProShare Advisors LLC | 0.00% | Add +9.7% | 12,479 | $187K |
| China Universal Asset Management Co., Ltd. | 0.02% | Add +0.3% | 12,122 | $181K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +31.5% | 11,525 | $173K |
| Profund Advisors LLC | 0.01% | Reduce -24.7% | 11,043 | $165K |
| Man Group plc | 0.00% | New | 10,843 | $162K |
| Arizona State Retirement System | 0.00% | Add +4.9% | 10,512 | $157K |
| Royal Bank of Canada | 0.00% | Add +290.1% | 8,474 | $126K |
| KLP Kapitalforvaltning As | 0.00% | No change | 7,800 | $117K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +182.2% | 5,769 | $86K |
| Virtus Investment Advisers, LLC | 0.03% | Reduce -22.6% | 5,310 | $79K |
| Ameritas Investment Partners, Inc. | 0.00% | Add +25.8% | 5,091 | $76K |
| AlphaQuest LLC | 0.01% | Add +30.8% | 4,174 | $62K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +15.6% | 2,331 | $35K |
| Cwm, LLC | 0.00% | Add +357.8% | 1,712 | $26K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 1,589 | $24K |
| GF Fund Management Co. LTD. | 0.00% | No change | 1,502 | $22K |
| Huntington National Bank | 0.00% | No change | 1,470 | $22K |
| Amalgamated Bank | 0.00% | No change | 1,379 | $21K |
| Nisa Investment Advisors, LLC | 0.00% | Add +196.7% | 546 | $8K |
| Sterling Capital Management LLC | 0.00% | Reduce -16.7% | 524 | $8K |
| Brooklyn Investment Group | 0.00% | New | 520 | $8K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.00% | New | 377 | $6K |
| Osaic Holdings, Inc. | 0.00% | Add +26.1% | 300 | $4K |
| Daiwa Securities Group Inc. | 0.00% | No change | 206 | $3K |
| GAMMA Investing LLC | 0.00% | Reduce -35.6% | 174 | $3K |
| Meeder Asset Management Inc. | 0.00% | New | 170 | $3K |
| Signaturefd, LLC | 0.00% | New | 165 | $2K |
| Russell Investments Group, Ltd. | 0.00% | New | 142 | $2K |
| Rothschild Investment LLC | 0.00% | Add +180.0% | 140 | $2K |
| Simplex Trading, LLC | 0.00% | New | 145 | $2K |
| Caitong International Asset Management Co., Ltd | 0.00% | Add +264.3% | 102 | $2K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +170.8% | 65 | $973 |
| Parkside Financial Bank & Trust | 0.00% | New | 35 | $524 |
| Allworth Financial LP | 0.00% | Add +130.8% | 30 | $450 |
| IFP Advisors, Inc | 0.00% | Reduce -78.9% | 23 | $374 |
| Raymond James Financial Inc. | 0.00% | New | 16 | $240 |
| SBI Securities Co., Ltd. | 0.00% | Add +120.0% | 11 | $165 |
| US Bancorp \de | 0.00% | Add +11.1% | 10 | $150 |
| Larson Financial Group LLC | 0.00% | Reduce -86.4% | 6 | $90 |
| Covestor Ltd | 0.00% | Add +50.0% | 6 | $0 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.