Spyre TherapeuticsSYRE
13F holders, Q1 2024 (March 31)102holders
4famous investors
$37.83avg. 13F price*
At the end of Q1 2024, 102 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings. The largest holders were FMR LLC ($246.6M), Perceptive Advisors LLC ($97.0M) and RTW Investments, LP ($84.7M). 4 famous investors held it, including George Soros (0.0% of Soros Fund Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 53 | $143.7M |
| Exits | 6 | $47.5M |
Ownership 102 holders
| FMR LLC | 0.02% | Add +73.9% | 6,583,755 | $246.6M |
| Perceptive Advisors LLC | 1.71% | Reduce -1.9% | 2,556,679 | $97.0M |
| RTW Investments, LP | 1.25% | No change | 2,232,760 | $84.7M |
| Venrock Adviser, LLC | 3.92% | Reduce -8.5% | 2,171,782 | $82.4M |
| Commodore Capital LP | 4.78% | No change | 1,884,084 | $71.5M |
| Avoro Capital Advisors LLC | 0.81% | No change | 1,839,138 | $69.8M |
| Deep Track Capital, LP | 1.32% | Reduce -37.9% | 1,213,420 | $46.0M |
| Adage Capital Partners Gp, L.L.C. | 0.08% | Add +10.5% | 1,105,200 | $41.9M |
| Wellington Management Group LLP | 0.01% | Add +27.9% | 812,860 | $30.8M |
| Franklin Resources Inc. | 0.01% | Add +8.0% | 741,904 | $28.1M |
| Citadel Advisors | 0.03% | Add +22.7% | 707,590 | $26.8M |
| Driehaus Capital Management LLC | 0.26% | Reduce -11.0% | 687,080 | $26.1M |
| BlackRock Inc. | 0.00% | Add +2717.0% | 556,691 | $21.1M |
| Braidwell LP | 1.10% | No change | 515,000 | $19.5M |
| Polar Capital Holdings Plc | 0.10% | No change | 500,000 | $19.0M |
| Vanguard Group Inc. | 0.00% | Add +1160.4% | 497,181 | $18.9M |
| Darwin Global Management, Ltd. | 2.39% | New | 473,200 | $17.9M |
| Farallon Capital Management, L.L.C. | 0.11% | New | 466,000 | $17.7M |
| First Turn Management, LLC | 2.64% | New | 464,435 | $17.6M |
| Affinity Asset Advisors, LLC | 2.72% | Reduce -20.8% | 410,000 | $15.6M |
| Fairmount Funds Management LLC | 1.56% | No change | 378,421 | $14.4M |
| Geode Capital Management, LLC | 0.00% | Add +988.9% | 330,225 | $12.5M |
| Millennium Management | 0.01% | Add +194.6% | 319,563 | $12.1M |
| Logos Global Management LP | 1.00% | Add +66.7% | 250,000 | $9.5M |
| Boxer Capital, LLC | 0.47% | No change | 250,000 | $9.5M |
| Cormorant Asset Management, LP | 0.42% | Reduce -73.3% | 250,000 | $9.5M |
| Goldman Sachs Group Inc. | 0.00% | New | 239,915 | $9.1M |
| Voloridge Investment Management, LLC | 0.03% | New | 188,053 | $7.1M |
| Montanova Capital, LLC | 0.26% | No change | 162,395 | $6.2M |
| Marshall Wace, LLP | 0.01% | Add +699.5% | 161,921 | $6.1M |
| HighVista Strategies LLC | 2.09% | Reduce -73.3% | 154,381 | $5.9M |
| Invesco Ltd. | 0.00% | New | 152,578 | $5.8M |
| State Street Corp. | 0.00% | New | 134,426 | $5.1M |
| Great Point Partners LLC | 0.74% | No change | 125,000 | $4.7M |
| Walleye Capital LLC | 0.05% | New | 111,478 | $4.2M |
| Candriam S.C.A. | 0.03% | New | 105,000 | $4.0M |
| Susquehanna International Group, LLP | 0.01% | New | 101,503 | $3.9M |
| Woodline Partners LP | 0.04% | New | 100,527 | $3.8M |
| Ghost Tree Capital, LLC | 1.22% | New | 100,000 | $3.8M |
| Integral Health Asset Management, LLC | 0.37% | New | 100,000 | $3.8M |
| Nicholas Investment Partners, LP | 0.39% | New | 89,962 | $3.4M |
| HRT Financial LP | 0.02% | New | 78,996 | $3.0M |
| T. Rowe Price Associates Inc. | 0.00% | New | 78,529 | $3.0M |
| Northern Trust Corp. | 0.00% | New | 66,340 | $2.5M |
| Assenagon Asset Management S.A. | 0.01% | New | 64,400 | $2.4M |
| Stempoint Capital LP | 0.63% | Reduce -83.6% | 62,253 | $2.4M |
| TD Asset Management Inc | 0.00% | New | 60,968 | $2.3M |
| Qube Research & Technologies Ltd | 0.00% | New | 57,678 | $2.2M |
| Morgan Stanley | 0.00% | Add +127870.0% | 51,188 | $1.9M |
| ADAR1 Capital Management, LLC | 0.51% | Add +668.6% | 49,500 | $1.9M |
| Renaissance Technologies | 0.00% | Add +1.9% | 49,468 | $1.9M |
| Cubist Systematic Strategies, LLC | 0.02% | Add +88.5% | 49,303 | $1.9M |
| Barclays PLC | 0.00% | Add +1.0% | 45,962 | $1.7M |
| Swiss National Bank | 0.00% | New | 39,100 | $1.5M |
| Bank of America Corp. | 0.00% | New | 36,332 | $1.4M |
| Schonfeld Strategic Advisors LLC | 0.01% | New | 35,500 | $1.3M |
| NBW Capital LLC | 0.27% | New | 34,360 | $1.3M |
| Balyasny Asset Management L.P. | 0.00% | New | 32,397 | $1.2M |
| Allianz Asset Management GmbH | 0.00% | New | 31,800 | $1.2M |
| Citigroup Inc. | 0.00% | Add +208.4% | 31,757 | $1.2M |
| Soros Fund Management | 0.04% | New | 30,038 | $1.1M |
| Manufacturers Life Insurance Company, The | 0.00% | New | 24,657 | $935K |
| ExodusPoint Capital Management, LP | 0.01% | Reduce -6.6% | 24,472 | $928K |
| Jump Financial, LLC | 0.02% | New | 22,800 | $865K |
| Credit Suisse AG/ | 0.00% | New | 22,056 | $837K |
| Blackstone Inc. | 0.00% | No change | 19,991 | $758K |
| Global Endowment Management, LP | 0.07% | Reduce -96.5% | 18,184 | $690K |
| Fred Alger Management, LLC | 0.00% | New | 18,158 | $689K |
| Informed Momentum Co LLC | 0.11% | New | 17,938 | $680K |
| California State Teachers Retirement System | 0.00% | New | 17,803 | $675K |
| Legal & General Group Plc | 0.00% | New | 17,032 | $646K |
| Virtu Financial LLC | 0.05% | New | 16,213 | $615K |
| Engineers Gate Manager LP | 0.02% | New | 15,653 | $594K |
| Charles Schwab Investment Management Inc. | 0.00% | New | 15,000 | $569K |
| New York State Common Retirement Fund | 0.00% | Add +3919.2% | 14,670 | $556K |
| State of Wisconsin Investment Board | 0.00% | New | 14,632 | $555K |
| Janus Henderson Group PLC | 0.00% | New | 13,977 | $530K |
| Two Sigma Investments, LP | 0.00% | Reduce -52.5% | 13,355 | $507K |
| Scientech Research LLC | 0.26% | New | 13,143 | $499K |
| Legato Capital Management LLC | 0.05% | New | 11,458 | $435K |
| EFG Asset Management (North America) Corp. | 0.07% | New | 11,151 | $423K |
| LMR Partners LLP | 0.02% | New | 11,093 | $421K |
| Polymer Capital Management (HK) LTD | 0.10% | New | 10,520 | $399K |
| Carlyle Group Inc. | 0.02% | No change | 9,620 | $365K |
| Squarepoint Ops LLC | 0.00% | New | 8,161 | $310K |
| Susquehanna Fundamental Investments, LLC | 0.01% | New | 8,075 | $306K |
| Jane Street Group, LLC | 0.00% | New | 7,210 | $273K |
| Chartwell Investment Partners, LLC | 0.01% | New | 6,835 | $259K |
| Bank of New York Mellon Corp | 0.00% | New | 6,050 | $229K |
| Virtus Advisers, LLC | 0.12% | Reduce -6.4% | 5,838 | $221K |
| Arizona State Retirement System | 0.00% | New | 5,445 | $207K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +48.4% | 3,828 | $145K |
| UBS Group AG | 0.00% | Reduce -30.2% | 2,601 | $99K |
| Wells Fargo & Company | 0.00% | Add +9647.8% | 2,242 | $85K |
| Deutsche Bank AG | 0.00% | New | 298 | $11K |
| IFP Advisors, Inc | 0.00% | No change | 114 | $4K |
| Osaic Holdings, Inc. | 0.00% | Reduce -70.7% | 83 | $3K |
| Royal Bank of Canada | 0.00% | New | 56 | $2K |
| Point72 (DIFC) Ltd | 0.00% | — | 22 | $847 |
| JPMorgan Chase & Co. | 0.00% | Reduce -73.2% | 11 | $417 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.