Spyre TherapeuticsSYRE
13F holders, Q1 2026 (March 31)198holders +45
51new positions
10sold out
4famous investors
$50.37avg. 13F price*
At the end of Q1 2026, 198 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, up 45 from Q4 2025. 51 opened new positions and 10 sold out. The largest holders were FMR LLC ($594.2M), BlackRock, Inc. ($278.5M) and RTW Investments, LP ($210.4M). 4 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 51 | $119.3M |
| Exits | 10 | $50.7M |
All 13F filers, Q4 2025 → Q1 2026: 8,115,595 shares bought and 6,568,207 shares sold, net +1,547,388 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 198 holders
| FMR LLC | 0.03% | Add +1.2% | 11,781,024 | $594.2M |
| BlackRock, Inc. | 0.00% | Reduce -0.0% | 5,521,221 | $278.5M |
| RTW Investments, LP | 2.09% | No change | 4,171,996 | $210.4M |
| Fairmount Funds Management LLC | 14.64% | No change | 4,018,101 | $202.7M |
| Perceptive Advisors LLC | 3.78% | Add +23.3% | 3,783,225 | $190.8M |
| Venrock Adviser, LLC | 6.94% | No change | 3,685,448 | $185.9M |
| Vanguard Capital Management LLC | 0.00% | — | 3,057,401 | $154.2M |
| Driehaus Capital Management LLC | 1.03% | Reduce -3.2% | 2,790,785 | $140.8M |
| State Street Corp. | 0.00% | Add +15.2% | 2,607,031 | $131.5M |
| Paradigm Biocapital Advisors LP | 2.02% | Add +33.4% | 1,957,266 | $98.7M |
| Commodore Capital LP | 5.58% | Reduce -19.9% | 1,912,380 | $96.5M |
| TCG Crossover Management, LLC | 2.74% | No change | 1,900,582 | $95.9M |
| Tang Capital Management LLC | 4.85% | No change | 1,892,200 | $95.4M |
| Wellington Management Group LLP | 0.02% | Add +17.8% | 1,824,811 | $92.0M |
| Capital International Investors | 0.02% | Reduce -50.0% | 1,746,129 | $88.1M |
| Geode Capital Management, LLC | 0.01% | Add +3.7% | 1,720,912 | $86.8M |
| Janus Henderson Group PLC | 0.04% | Reduce -9.4% | 1,656,164 | $83.6M |
| Ra Capital Management, L.P. | 0.87% | No change | 1,621,620 | $81.8M |
| T. Rowe Price Associates Inc. | 0.01% | Reduce -0.2% | 1,598,730 | $80.6M |
| Remedium Capital Partners, LLC | 26.13% | No change | 1,456,231 | $73.5M |
| Affinity Asset Advisors, LLC | 3.86% | Reduce -10.7% | 1,279,134 | $64.5M |
| Bank of America Corp. | 0.00% | Add +192.6% | 1,228,093 | $61.9M |
| Baker Bros. Advisors LP | 0.29% | No change | 1,000,000 | $50.4M |
| Braidwell LP | 1.79% | Reduce -42.9% | 932,823 | $47.1M |
| Franklin Resources Inc. | 0.01% | Reduce -20.4% | 882,833 | $44.5M |
| JPMorgan Chase & Co. | 0.00% | Add +1455.7% | 979,299 | $44.5M |
| Caligan Partners LP | 3.13% | New | 878,127 | $44.3M |
| Siren, L.L.C. | 1.14% | No change | 818,598 | $41.3M |
| Polar Capital Holdings Plc | 0.17% | Add +7.1% | 792,847 | $40.0M |
| UBS Group AG | 0.01% | Reduce -1.4% | 671,235 | $33.9M |
| Capital World Investors | 0.00% | Add +233.0% | 666,564 | $33.6M |
| Emerald Advisers, LLC | 0.98% | Reduce -3.6% | 613,365 | $30.9M |
| Candriam S.C.A. | 0.16% | Add +43.4% | 610,282 | $30.8M |
| Vanguard Portfolio Management LLC | 0.00% | — | 585,130 | $29.5M |
| Northern Trust Corp. | 0.00% | Add +3.2% | 578,907 | $29.2M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -2.1% | 562,653 | $28.4M |
| Pictet Asset Management Holding SA | 0.03% | Reduce -46.2% | 491,649 | $24.8M |
| Vanguard Fiduciary Trust Co. | 0.01% | — | 464,651 | $23.4M |
| Emerald Mutual Fund Advisers Trust | 1.00% | Reduce -1.0% | 408,113 | $20.6M |
| Samlyn Capital, LLC | 0.34% | New | 396,661 | $20.0M |
| ADAR1 Capital Management, LLC | 1.03% | Add +893.6% | 338,323 | $17.1M |
| Blackstone Inc. | 0.06% | Reduce -41.5% | 292,847 | $14.8M |
| Victory Capital Management Inc. | 0.01% | Add +100.0% | 292,126 | $14.7M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -1.9% | 269,938 | $13.6M |
| Woodline Partners LP | 0.05% | No change | 265,892 | $13.4M |
| Morgan Stanley | 0.00% | Add +35.0% | 246,719 | $12.4M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +233.2% | 207,314 | $10.5M |
| Boothbay Fund Management, LLC | 0.23% | New | 193,031 | $9.7M |
| Bank of New York Mellon Corp | 0.00% | Reduce -0.7% | 191,395 | $9.7M |
| Silverarc Capital Management, LLC | 1.11% | Reduce -0.6% | 186,618 | $9.4M |
| First Trust Advisors LP | 0.01% | New | 178,389 | $9.0M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.01% | Reduce -0.5% | 170,381 | $8.6M |
| Stempoint Capital LP | 1.63% | Add +417.7% | 167,606 | $8.5M |
| Ameriprise Financial Inc. | 0.00% | Add +316.2% | 159,217 | $8.0M |
| Nuveen, LLC | 0.00% | Add +1.9% | 153,899 | $7.8M |
| Ensign Peak Advisors, Inc | 0.01% | New | 148,537 | $7.5M |
| Millennium Management | 0.01% | Add +92.5% | 146,639 | $7.4M |
| HighVista Strategies LLC | 2.04% | Reduce -22.3% | 146,264 | $7.4M |
| Marshall Wace, LLP | 0.01% | New | 139,259 | $7.0M |
| TD Asset Management Inc | 0.01% | Reduce -8.3% | 137,390 | $6.9M |
| Invesco Ltd. | 0.00% | Reduce -12.3% | 132,390 | $6.7M |
| Deutsche Bank AG | 0.00% | Add +6.0% | 129,242 | $6.5M |
| Armistice Capital, LLC | 0.20% | Reduce -38.4% | 120,931 | $6.1M |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -12.5% | 112,841 | $5.7M |
| Citadel Advisors | 0.00% | Add +69.2% | 108,135 | $5.5M |
| B Group, Inc. | 3.74% | No change | 100,000 | $5.0M |
| Seven Grand Managers, LLC | 0.34% | No change | 100,000 | $5.0M |
| F/m Investments LLC | 0.33% | Reduce -4.1% | 99,460 | $5.0M |
| Swiss National Bank | 0.00% | No change | 96,500 | $4.9M |
| ExodusPoint Capital Management, LP | 0.04% | Add +129.9% | 87,065 | $4.4M |
| Rhumbline Advisers | 0.00% | Add +2.6% | 85,121 | $4.3M |
| Mercer Global Advisors Inc. | 0.01% | Reduce -33.1% | 71,091 | $3.6M |
| Atle Fund Management AB | 1.13% | New | 62,735 | $3.5M |
| Rockefeller Capital Management L.P. | 0.01% | Add +11557.9% | 64,002 | $3.2M |
| Alps Advisors Inc. | 0.02% | Add +0.4% | 63,939 | $3.2M |
| Prudential Financial Inc. | 0.00% | New | 59,555 | $3.0M |
| Fred Alger Management, LLC | 0.01% | New | 59,453 | $3.0M |
| California State Teachers Retirement System | 0.00% | Add +23.3% | 59,242 | $3.0M |
| Schroder Investment Management Group | 0.00% | Add +3.4% | 63,684 | $2.9M |
| Rafferty Asset Management, LLC | 0.01% | Add +6.6% | 56,920 | $2.9M |
| Balyasny Asset Management L.P. | 0.01% | Reduce -24.5% | 55,477 | $2.8M |
| Voya Investment Management LLC | 0.00% | Add +97.9% | 53,970 | $2.7M |
| Susquehanna Portfolio Strategies, LLC | 0.04% | No change | 53,101 | $2.7M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -38.3% | 47,697 | $2.4M |
| Alliancebernstein L.P. | 0.00% | Add +5.0% | 70,900 | $2.3M |
| Barclays PLC | 0.00% | Reduce -74.9% | 45,786 | $2.3M |
| Legal & General Group Plc | 0.00% | Reduce -20.6% | 44,792 | $2.3M |
| MetLife Investment Management, LLC | 0.01% | Add +1.0% | 38,407 | $1.9M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +3.4% | 36,323 | $1.8M |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | — | 33,232 | $1.7M |
| Wells Fargo & Company | 0.00% | Reduce -59.7% | 33,208 | $1.7M |
| Vanguard Global Advisers, LLC | 0.00% | — | 31,141 | $1.6M |
| Susquehanna International Group, LLP | 0.00% | Add +373.9% | 28,962 | $1.5M |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.01% | Add +10.4% | 27,550 | $1.4M |
| Cinctive Capital Management LP | 0.09% | Reduce -23.7% | 27,430 | $1.4M |
| State of Wisconsin Investment Board | 0.00% | Reduce -2.7% | 26,523 | $1.3M |
| Profund Advisors LLC | 0.05% | Add +26.5% | 26,043 | $1.3M |
| Waverly Advisors, LLC | 0.01% | Add +0.1% | 25,966 | $1.3M |
| Teachers Retirement System of the State of Kentucky | 0.01% | No change | 25,799 | $1.3M |
| XTX Topco Ltd | 0.02% | New | 24,435 | $1.2M |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.