Spyre TherapeuticsSYRE
13F holders, Q2 2026 (June 30)265holders +67
88new positions
20sold out
5famous investors
$88.89avg. 13F price*
At the end of Q2 2026, 265 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, up 67 from Q1 2026. 88 opened new positions and 20 sold out. The largest holders were FMR LLC ($1.2B), BlackRock, Inc. ($577.7M) and Perceptive Advisors LLC ($383.5M). 5 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2026 → Q2 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 88 | $552.2M |
| Exits | 20 | $390.1M |
All 13F filers, Q1 2026 → Q2 2026: 24,436,048 shares bought and 11,830,012 shares sold, net +12,606,036 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 265 holders
| FMR LLC | 0.05% | Add +10.6% | 13,026,187 | $1.2B |
| BlackRock, Inc. | 0.01% | Add +17.9% | 6,506,605 | $577.7M |
| Perceptive Advisors LLC | 5.97% | Add +14.2% | 4,319,496 | $383.5M |
| RTW Investments, LP | 3.22% | Add +1.9% | 4,251,996 | $377.5M |
| Paradigm Biocapital Advisors LP | 6.38% | Add +96.2% | 3,840,778 | $341.0M |
| Vanguard Capital Management LLC | 0.01% | Add +12.8% | 3,448,681 | $306.2M |
| State Street Corp. | 0.01% | Add +17.3% | 3,057,416 | $271.4M |
| Venrock Adviser, LLC | 8.04% | Reduce -19.0% | 2,985,448 | $265.0M |
| T. Rowe Price Associates Inc. | 0.03% | Add +85.2% | 2,960,855 | $262.9M |
| Driehaus Capital Management LLC | 1.44% | Add +0.3% | 2,799,166 | $248.5M |
| Geode Capital Management, LLC | 0.01% | Add +48.9% | 2,562,265 | $239.3M |
| Vanguard Portfolio Management LLC | 0.01% | Add +298.2% | 2,330,098 | $206.9M |
| Capital World Investors | 0.02% | Add +247.4% | 2,315,553 | $205.6M |
| Jupiter Topco LLC | 0.08% | — | 2,206,936 | $195.9M |
| TCG Crossover Management, LLC | 4.06% | No change | 1,900,582 | $168.7M |
| Tang Capital Management LLC | 7.67% | No change | 1,892,200 | $168.0M |
| Bank of America Corp. | 0.01% | Add +44.8% | 1,777,854 | $157.8M |
| Adage Capital Partners Gp, L.L.C. | 0.21% | New | 1,722,300 | $152.9M |
| Wellington Management Group LLP | 0.02% | Reduce -13.3% | 1,581,505 | $140.4M |
| Goldman Sachs Group Inc. | 0.01% | Add +447.6% | 1,478,059 | $131.2M |
| Franklin Resources Inc. | 0.03% | Add +66.8% | 1,472,943 | $130.8M |
| Remedium Capital Partners, LLC | 28.78% | Add +0.6% | 1,464,169 | $130.0M |
| Affinity Asset Advisors, LLC | 5.65% | No change | 1,279,134 | $113.6M |
| JPMorgan Chase & Co. | 0.01% | Add +11.6% | 1,093,026 | $98.9M |
| Holocene Advisors, LP | 0.21% | New | 1,015,170 | $90.1M |
| Marshall Wace, LLP | 0.07% | Add +612.1% | 991,693 | $88.0M |
| Polar Capital Holdings Plc | 0.25% | Add +24.6% | 988,009 | $87.7M |
| Siren, L.L.C. | 1.75% | Add +18.3% | 968,598 | $86.0M |
| Capital International Investors | 0.02% | Reduce -45.3% | 955,196 | $84.8M |
| Braidwell LP | 3.00% | Reduce -5.7% | 879,467 | $78.1M |
| Commodore Capital LP | 4.48% | Reduce -55.7% | 846,786 | $75.2M |
| UBS Group AG | 0.01% | Add +25.6% | 843,071 | $74.8M |
| Northern Trust Corp. | 0.01% | Add +16.5% | 674,529 | $59.9M |
| Charles Schwab Investment Management Inc. | 0.01% | Add +16.1% | 652,958 | $58.0M |
| Pictet Asset Management Holding SA | 0.05% | Add +27.8% | 628,138 | $55.8M |
| Emerald Advisers, LLC | 1.19% | Reduce -7.5% | 567,430 | $50.4M |
| Victory Capital Management Inc. | 0.03% | Add +89.6% | 553,980 | $49.2M |
| Vanguard Fiduciary Trust Co. | 0.01% | Add +18.7% | 551,389 | $49.0M |
| Candriam S.C.A. | 0.22% | Reduce -10.5% | 546,312 | $48.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Add +151.8% | 522,071 | $46.3M |
| Morgan Stanley | 0.00% | Add +102.6% | 499,963 | $44.4M |
| Voya Investment Management LLC | 0.04% | Add +699.9% | 431,694 | $38.3M |
| Emerald Mutual Fund Advisers Trust | 1.25% | Reduce -1.7% | 401,271 | $35.6M |
| Samlyn Capital, LLC | 0.59% | Add +0.9% | 400,075 | $35.5M |
| Ameriprise Financial Inc. | 0.01% | Add +123.7% | 356,082 | $31.6M |
| Integral Health Asset Management, LLC | 1.18% | New | 325,000 | $28.9M |
| Woodline Partners LP | 0.08% | Add +15.1% | 306,049 | $27.2M |
| Jennison Associates LLC | 0.02% | New | 303,180 | $26.9M |
| ADAR1 Capital Management, LLC | 1.19% | Reduce -16.1% | 283,982 | $25.2M |
| BNP Paribas Financial Markets | 0.01% | Add +1295.2% | 259,923 | $23.1M |
| Bank of New York Mellon Corp | 0.00% | Add +28.1% | 245,193 | $21.8M |
| Bellevue Group AG | 0.43% | New | 229,931 | $20.4M |
| Cormorant Asset Management, LP | 1.02% | New | 225,000 | $20.0M |
| Seven Grand Managers, LLC | 0.81% | Add +125.0% | 225,000 | $20.0M |
| Eventide Asset Management, LLC | 0.24% | New | 201,616 | $17.9M |
| Millennium Management | 0.01% | Add +34.1% | 196,712 | $17.5M |
| Orbimed Advisors LLC | 0.31% | New | 186,145 | $16.5M |
| Frontier Capital Management Co. LLC | 0.15% | New | 182,931 | $16.2M |
| Nuveen, LLC | 0.00% | Add +17.7% | 181,105 | $16.1M |
| Neuberger Berman Group LLC | 0.01% | New | 180,884 | $16.1M |
| Deutsche Bank AG | 0.00% | Add +35.0% | 174,459 | $15.5M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.02% | Add +1.5% | 172,923 | $15.4M |
| Balyasny Asset Management L.P. | 0.02% | Add +165.1% | 147,042 | $13.1M |
| Soleus Capital Management, L.P. | 0.45% | New | 147,000 | $13.1M |
| Squarepoint Ops LLC | 0.02% | New | 139,605 | $12.4M |
| Armistice Capital, LLC | 0.34% | Add +13.8% | 137,588 | $12.2M |
| Russell Investments Group, Ltd. | 0.01% | Add +1256.9% | 134,757 | $12.0M |
| Ensign Peak Advisors, Inc | 0.02% | Reduce -14.8% | 126,620 | $11.2M |
| Invesco Ltd. | 0.00% | Reduce -8.9% | 120,541 | $10.7M |
| Blackstone Inc. | 0.04% | Reduce -59.0% | 120,177 | $10.7M |
| Rhenman & Partners Asset Management AB | 1.00% | New | 119,300 | $10.6M |
| TD Asset Management Inc | 0.01% | Reduce -15.6% | 115,990 | $10.3M |
| Swiss National Bank | 0.01% | Add +16.6% | 112,500 | $10.0M |
| Stempoint Capital LP | 1.64% | Reduce -36.2% | 106,926 | $9.5M |
| Manufacturers Life Insurance Company, The | 0.01% | Reduce -7.4% | 104,516 | $9.3M |
| Citadel Advisors | 0.01% | Reduce -4.7% | 103,100 | $9.2M |
| Boxer Capital Management, LLC | 0.67% | New | 100,000 | $8.9M |
| Rhumbline Advisers | 0.01% | Add +11.3% | 94,763 | $8.4M |
| Barclays PLC | 0.00% | Add +105.5% | 94,069 | $8.4M |
| F/m Investments LLC | 0.42% | Reduce -6.9% | 92,618 | $8.2M |
| Prudential Financial Inc. | 0.01% | Add +46.7% | 87,370 | $7.8M |
| Federated Hermes, Inc. | 0.01% | New | 85,950 | $7.6M |
| Granahan Investment Management, LLC | 0.26% | New | 82,991 | $7.4M |
| Citigroup Inc. | 0.00% | Add +587.9% | 82,593 | $7.3M |
| Wells Fargo & Company | 0.00% | Add +148.4% | 82,506 | $7.3M |
| HighVista Strategies LLC | 1.57% | Reduce -46.8% | 77,807 | $6.9M |
| Mercer Global Advisors Inc. | 0.01% | Add +0.1% | 71,145 | $6.3M |
| B Group, Inc. | 3.53% | Reduce -30.0% | 70,000 | $6.2M |
| Trexquant Investment LP | 0.04% | New | 67,007 | $5.9M |
| California State Teachers Retirement System | 0.01% | Add +9.2% | 64,687 | $5.7M |
| Informed Momentum Co LLC | 0.48% | New | 60,393 | $5.4M |
| Silverarc Capital Management, LLC | 0.59% | Reduce -67.9% | 59,959 | $5.3M |
| Principal Financial Group Inc. | 0.00% | Add +1289.8% | 59,747 | $5.3M |
| Hudson Bay Capital Management LP | 0.03% | New | 58,387 | $5.2M |
| Atle Fund Management AB | 1.36% | Reduce -9.1% | 57,030 | $5.1M |
| Raymond James Financial Inc. | 0.00% | Add +171.5% | 53,627 | $4.8M |
| Susquehanna Portfolio Strategies, LLC | 0.08% | No change | 53,101 | $4.7M |
| Alliancebernstein L.P. | 0.00% | Add +30.5% | 92,540 | $4.7M |
| Royce & Associates LP | 0.04% | New | 51,789 | $4.6M |
| XTX Topco Ltd | 0.06% | Add +106.6% | 50,483 | $4.5M |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.