ZymeworksZYME
13F holders, Q2 2025 (June 30)182holders −3
27new positions
29sold out
7famous investors
$12.55avg. 13F price*
At the end of Q2 2025, 182 institutions reported holding Zymeworks Inc. (ZYME) in their 13F filings, down 3 from Q1 2025. 27 opened new positions and 29 sold out. The largest holders were EcoR1 Capital, LLC ($288.3M), Rubric Capital Management LP ($59.1M) and BVF Inc. ($54.1M). 7 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Zymeworks Inc.
- CUSIP
- 98985Y108
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 27 | $17.6M |
| Exits | 29 | $26.5M |
All 13F filers, Q1 2025 → Q2 2025: 11,900,485 shares bought and 6,714,901 shares sold, net +5,185,584 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 182 holders
| EcoR1 Capital, LLC | 17.11% | Add +33.1% | 22,970,388 | $288.3M |
| Rubric Capital Management LP | 0.95% | Add +8.6% | 4,710,551 | $59.1M |
| BVF Inc. | 1.93% | No change | 4,308,935 | $54.1M |
| Morgan Stanley | 0.00% | Add +2.6% | 4,177,614 | $52.4M |
| Redmile Group, LLC | 5.54% | Reduce -13.3% | 4,150,627 | $52.1M |
| BlackRock, Inc. | 0.00% | Reduce -7.2% | 3,794,272 | $47.6M |
| Vanguard Group Inc. | 0.00% | Add +39.5% | 2,464,693 | $30.9M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Reduce -36.6% | 2,459,513 | $30.9M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.06% | Reduce -7.2% | 2,039,656 | $25.6M |
| Blackstone Inc. | 0.09% | Add +19.8% | 1,656,790 | $20.8M |
| Deutsche Bank AG | 0.01% | Reduce -0.5% | 1,544,763 | $19.4M |
| Prosight Management, LP | 4.01% | Add +36.8% | 1,309,904 | $16.4M |
| Perceptive Advisors LLC | 0.60% | Reduce -31.6% | 1,275,274 | $16.0M |
| Dimensional Fund Advisors LP | 0.00% | Add +10.5% | 1,192,432 | $15.0M |
| Vestal Point Capital, LP | 0.76% | Add +130.0% | 1,150,000 | $14.4M |
| Nextech Invest Ltd. | 2.65% | No change | 1,113,946 | $14.0M |
| Tang Capital Management LLC | 0.70% | No change | 1,100,000 | $13.8M |
| State Street Corp. | 0.00% | Add +0.3% | 1,088,459 | $13.7M |
| Geode Capital Management, LLC | 0.00% | Add +0.1% | 705,364 | $8.9M |
| Nuveen, LLC | 0.00% | Add +229.4% | 654,916 | $8.2M |
| Renaissance Technologies | 0.01% | Add +18.4% | 533,300 | $6.7M |
| Assenagon Asset Management S.A. | 0.01% | Reduce -0.5% | 492,780 | $6.2M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | New | 476,000 | $6.0M |
| JPMorgan Chase & Co. | 0.00% | Add +1050.0% | 441,690 | $5.5M |
| Goldman Sachs Group Inc. | 0.00% | Add +114.4% | 428,857 | $5.4M |
| Granahan Investment Management, LLC | 0.19% | Reduce -6.6% | 380,783 | $4.8M |
| Jupiter Asset Management Ltd. | 0.04% | No change | 369,499 | $4.6M |
| Northern Trust Corp. | 0.00% | Reduce -9.6% | 349,799 | $4.4M |
| Samsara Biocapital, LLC | 0.80% | Reduce -53.5% | 310,300 | $3.9M |
| Schroder Investment Management Group | 0.00% | Reduce -5.4% | 304,666 | $3.8M |
| Silvercrest Asset Management Group LLC | 0.02% | No change | 280,726 | $3.5M |
| Susquehanna International Group, LLP | 0.01% | Reduce -26.2% | 259,137 | $3.3M |
| D. E. Shaw & Co. | 0.00% | Add +304.6% | 255,291 | $3.2M |
| UBS Group AG | 0.00% | Add +17.4% | 251,510 | $3.2M |
| Citadel Advisors | 0.00% | Add +36.3% | 246,155 | $3.1M |
| Platinum Investment Management Ltd. | 0.20% | Reduce -14.4% | 238,391 | $3.0M |
| Trexquant Investment LP | 0.03% | Add +0.1% | 220,982 | $2.8M |
| Opaleye Management Inc. | 0.54% | Add +20.0% | 210,000 | $2.6M |
| Picton Mahoney Asset Management | 0.04% | Reduce -0.2% | 207,602 | $2.6M |
| Hillsdale Investment Management Inc. | 0.10% | Reduce -13.5% | 205,022 | $2.6M |
| Norges Bank | 0.00% | No change | 201,700 | $2.5M |
| Tejara Capital Ltd | 1.16% | Add +5.7% | 200,150 | $2.5M |
| Federated Hermes, Inc. | 0.00% | Add +0.2% | 182,270 | $2.3M |
| Wellington Management Group LLP | 0.00% | Reduce -0.8% | 180,690 | $2.3M |
| AXA S.A. | 0.01% | New | 175,121 | $2.2M |
| Wells Fargo & Company | 0.00% | Add +65.9% | 166,428 | $2.1M |
| AQR Capital Management | 0.00% | Add +242.7% | 166,143 | $2.1M |
| Citigroup Inc. | 0.00% | Add +278.6% | 155,998 | $2.0M |
| Squarepoint Ops LLC | 0.00% | Add +144.6% | 155,599 | $2.0M |
| Kennedy Capital Management LLC | 0.04% | Add +7.8% | 146,954 | $1.8M |
| Bank of New York Mellon Corp | 0.00% | Add +10.2% | 133,090 | $1.7M |
| Raymond James Financial Inc. | 0.00% | Add +6.6% | 124,435 | $1.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -7.1% | 124,204 | $1.6M |
| Barclays PLC | 0.00% | Add +62.8% | 122,820 | $1.5M |
| Cubist Systematic Strategies, LLC | 0.02% | New | 119,962 | $1.5M |
| Algert Global LLC | 0.03% | New | 118,104 | $1.5M |
| Millennium Management | 0.00% | Reduce -60.7% | 116,102 | $1.5M |
| Dark Forest Capital Management LP | 0.05% | Reduce -8.3% | 96,989 | $1.2M |
| North Growth Management Ltd. | 0.23% | No change | 97,000 | $1.2M |
| Bank of America Corp. | 0.00% | Add +45.5% | 90,378 | $1.1M |
| Invesco Ltd. | 0.00% | Add +14.3% | 89,371 | $1.1M |
| Rhumbline Advisers | 0.00% | Add +4.0% | 86,083 | $1.1M |
| Susquehanna Portfolio Strategies, LLC | 0.02% | New | 85,728 | $1.1M |
| Acuta Capital Partners, LLC | 1.47% | Add +22.2% | 83,655 | $1.0M |
| Swiss National Bank | 0.00% | Reduce -8.7% | 73,100 | $917K |
| Royal Bank of Canada | 0.00% | Add +28.6% | 72,983 | $915K |
| Fisher Asset Management | 0.00% | Add +0.0% | 71,979 | $903K |
| Qube Research & Technologies Ltd | 0.00% | New | 69,874 | $877K |
| Stifel Financial Corp. | 0.00% | Add +4.0% | 69,730 | $875K |
| Weiss Asset Management LP | 0.01% | New | 54,171 | $680K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | Add +22.4% | 54,075 | $679K |
| Tema ETFs LLC | 0.17% | Add +57.1% | 51,855 | $651K |
| NEOS Investment Management LLC | 0.01% | Add +57.1% | 51,855 | $651K |
| ExodusPoint Capital Management, LP | 0.01% | Reduce -61.2% | 51,669 | $648K |
| Alliancebernstein L.P. | 0.00% | No change | 50,030 | $628K |
| STRS Ohio | 0.00% | New | 46,300 | $581K |
| Prudential Financial Inc. | 0.00% | Add +5.6% | 44,965 | $564K |
| Legal & General Group Plc | 0.00% | Reduce -6.5% | 43,763 | $549K |
| California State Teachers Retirement System | 0.00% | Reduce -2.1% | 42,873 | $538K |
| O'shaughnessy Asset Management, LLC | 0.00% | Reduce -57.2% | 41,224 | $517K |
| HSBC Holdings PLC | 0.00% | New | 36,497 | $461K |
| Man Group plc | 0.00% | Add +226.1% | 35,406 | $444K |
| Victory Capital Management Inc. | 0.00% | Reduce -21.8% | 34,610 | $434K |
| Tudor Investment Corporation | 0.00% | New | 34,293 | $430K |
| Panagora Asset Management Inc. | 0.00% | New | 33,559 | $421K |
| MetLife Investment Management, LLC | 0.00% | No change | 33,309 | $418K |
| HRT Financial LP | 0.00% | Reduce -49.9% | 32,758 | $411K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -14.5% | 32,170 | $404K |
| American Century Companies Inc. | 0.00% | No change | 31,147 | $391K |
| XTX Topco Ltd | 0.02% | Add +53.5% | 31,021 | $389K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Add +22.0% | 29,934 | $376K |
| Journey Strategic Wealth LLC | 0.01% | Add +0.3% | 29,040 | $364K |
| Russell Investments Group, Ltd. | 0.00% | Add +827.4% | 28,312 | $355K |
| Bank of Montreal | 0.00% | Add +6.7% | 27,642 | $347K |
| Massachusetts Financial Services Co. | 0.00% | Add +1.3% | 27,109 | $340K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -17.1% | 26,863 | $337K |
| T. Rowe Price Associates Inc. | 0.00% | Add +11.2% | 26,816 | $337K |
| Landscape Capital Management, L.L.C. | 0.03% | New | 26,667 | $335K |
| Creative Planning | 0.00% | Add +114.8% | 25,389 | $319K |
| Ritholtz Wealth Management | 0.01% | Reduce -58.3% | 25,235 | $317K |
| Ikarian Capital, LLC | 0.10% | New | 25,000 | $314K |
| Intech Investment Management LLC | 0.00% | Reduce -42.5% | 23,163 | $291K |
| Duncan Williams Asset Management, LLC | 0.09% | No change | 22,095 | $277K |
| State of Wisconsin Investment Board | 0.00% | Reduce -41.7% | 22,035 | $277K |
| Graham Capital Management, L.P. | 0.01% | New | 21,660 | $272K |
| Mackenzie Financial Corp. | 0.00% | New | 21,355 | $268K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -6.8% | 19,070 | $239K |
| Engineers Gate Manager LP | 0.00% | Add +52.8% | 18,941 | $238K |
| Janus Henderson Group PLC | 0.00% | No change | 18,200 | $229K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 15,340 | $193K |
| Campbell & CO Investment Adviser LLC | 0.01% | New | 14,985 | $188K |
| Voya Investment Management LLC | 0.00% | Reduce -4.9% | 14,887 | $187K |
| Envestnet Asset Management Inc. | 0.00% | Reduce -70.5% | 14,606 | $183K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | New | 14,300 | $179K |
| Ieq Capital, LLC | 0.00% | New | 14,169 | $178K |
| AlphaQuest LLC | 0.02% | Reduce -55.7% | 14,026 | $176K |
| China Universal Asset Management Co., Ltd. | 0.02% | Add +1.3% | 13,996 | $176K |
| New York State Common Retirement Fund | 0.00% | No change | 13,371 | $168K |
| ProShare Advisors LLC | 0.00% | Reduce -15.1% | 12,665 | $159K |
| Jane Street Group, LLC | 0.00% | Reduce -90.8% | 12,549 | $157K |
| Magnetar Financial LLC | 0.00% | Reduce -2.3% | 12,168 | $153K |
| Cresset Asset Management, LLC | 0.00% | Reduce -43.0% | 12,153 | $153K |
| Quantinno Capital Management LP | 0.00% | Reduce -17.5% | 11,746 | $147K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | No change | 11,669 | $146K |
| Janney Montgomery Scott LLC | 0.00% | No change | 11,567 | $145K |
| Arizona State Retirement System | 0.00% | Reduce -5.8% | 11,159 | $140K |
| Brevan Howard Capital Management LP | 0.00% | New | 10,628 | $133K |
| James Investment Research, Inc. | 0.02% | No change | 10,578 | $133K |
| Teacher Retirement System of Texas | 0.00% | Reduce -7.2% | 10,368 | $130K |
| BNP Paribas Financial Markets | 0.00% | Add +157.7% | 10,307 | $129K |
| TPG Financial Advisors, LLC | 0.05% | No change | 10,017 | $126K |
| Northwest & Ethical Investments L.P. | 0.00% | No change | 10,030 | $125K |
| Shell Asset Management Co. | 0.00% | Reduce -23.2% | 9,296 | $117K |
| SG Americas Securities, LLC | 0.00% | Reduce -91.2% | 8,671 | $109K |
| Cwm, LLC | 0.00% | Add +272.8% | 8,570 | $108K |
| KLP Kapitalforvaltning As | 0.00% | Reduce -29.1% | 7,300 | $92K |
| Virtus Investment Advisers, LLC | 0.03% | Reduce -44.8% | 7,178 | $90K |
| Simplex Trading, LLC | 0.00% | Add +54.6% | 6,445 | $80K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.01% | New | 6,311 | $79K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 5,616 | $70K |
| Clearstead Advisors, LLC | 0.00% | No change | 5,000 | $63K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +29.6% | 4,947 | $62K |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 3,843 | $48K |
| FMR LLC | 0.00% | Reduce -75.8% | 3,110 | $39K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +15.5% | 2,692 | $34K |
| Amalgamated Bank | 0.00% | No change | 1,880 | $24K |
| GF Fund Management Co. LTD. | 0.00% | No change | 1,763 | $22K |
| Nisa Investment Advisors, LLC | 0.00% | Add +191.6% | 968 | $12K |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 870 | $11K |
| GAMMA Investing LLC | 0.00% | Add +49.2% | 810 | $10K |
| Osaic Holdings, Inc. | 0.00% | Add +65.2% | 669 | $8K |
| Caitong International Asset Management Co., Ltd | 0.01% | New | 564 | $7K |
| National Bank of Canada | 0.00% | Reduce -9.9% | 472 | $6K |
| PNC Financial Services Group, Inc. | 0.00% | Add +47.0% | 338 | $4K |
| Parallel Advisors, LLC | 0.00% | No change | 329 | $4K |
| Daiwa Securities Group Inc. | 0.00% | No change | 286 | $4K |
| Truvestments Capital LLC | 0.00% | No change | 309 | $4K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 311 | $4K |
| HighMark Wealth Management LLC | 0.00% | No change | 280 | $4K |
| US Bancorp \de | 0.00% | Reduce -41.4% | 248 | $3K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +1292.3% | 181 | $2K |
| Allworth Financial LP | 0.00% | Add +10.9% | 122 | $2K |
| Sterling Capital Management LLC | 0.00% | Reduce -87.3% | 119 | $1K |
| Brooklyn Investment Group | 0.00% | Reduce -61.6% | 111 | $1K |
| Group One Trading LLC | 0.00% | No change | 100 | $1K |
| IFP Advisors, Inc | 0.00% | Add +0.0% | 96 | $1K |
| Point72 (DIFC) Ltd | 0.00% | New | 77 | $966 |
| Kilter Group LLC | 0.00% | New | 66 | $829 |
| Rothschild Investment LLC | 0.00% | Reduce -45.0% | 55 | $690 |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 53 | $665 |
| Physician Wealth Advisors, Inc. | 0.00% | New | 51 | $641 |
| Bare Financial Services, Inc | 0.00% | New | 45 | $565 |
| Cornerstone Planning Group LLC | 0.00% | New | 35 | $439 |
| Farther Finance Advisors, LLC | 0.00% | Reduce -82.0% | 25 | $314 |
| Ameriflex Group, Inc. | 0.00% | No change | 20 | $247 |
| CoreCap Advisors, LLC | 0.00% | No change | 18 | $226 |
| Essential Partners LLC | 0.00% | — | 14 | $176 |
| Northwestern Mutual Wealth Management Co. | 0.00% | New | 14 | $176 |
| SBI Securities Co., Ltd. | 0.00% | No change | 10 | $126 |
| Innovative Advisory Group, LLC | 0.00% | No change | 8 | $100 |
| True Wealth Design, LLC | 0.00% | Reduce -65.0% | 7 | $88 |
| Covestor Ltd | 0.00% | Reduce -3.7% | 26 | $0 |
"% of holder's portfolio" is ZYME's weight in each manager's 13F, not the share of Zymeworks Inc. the manager owns.