ZymeworksZYME
13F holders, Q4 2025 (December 31)210holders +26
41new positions
19sold out
7famous investors
$26.33avg. 13F price*
At the end of Q4 2025, 210 institutions reported holding Zymeworks Inc. (ZYME) in their 13F filings, up 26 from Q3 2025. 41 opened new positions and 19 sold out. The largest holders were EcoR1 Capital, LLC ($604.8M), Rubric Capital Management LP ($151.4M) and BlackRock, Inc. ($121.0M). 7 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Zymeworks Inc.
- CUSIP
- 98985Y108
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 41 | $149.1M |
| Exits | 19 | $46.1M |
All 13F filers, Q3 2025 → Q4 2025: 11,635,585 shares bought and 13,803,837 shares sold, net −2,168,252 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 210 holders
| EcoR1 Capital, LLC | 27.72% | No change | 22,970,388 | $604.8M |
| Rubric Capital Management LP | 1.81% | Add +22.1% | 5,750,000 | $151.4M |
| BlackRock, Inc. | 0.00% | Add +15.2% | 4,595,548 | $121.0M |
| BVF Inc. | 3.49% | No change | 3,938,641 | $103.7M |
| Perceptive Advisors LLC | 1.58% | Add +56.0% | 3,261,850 | $85.9M |
| Morgan Stanley | 0.00% | Reduce -34.9% | 2,593,080 | $68.3M |
| Vanguard Group Inc. | 0.00% | Add +8.1% | 2,328,727 | $61.3M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.06% | New | 1,822,048 | $48.0M |
| Siren, L.L.C. | 1.32% | New | 1,680,121 | $44.2M |
| Deutsche Bank AG | 0.01% | Add +3.3% | 1,595,833 | $42.0M |
| Dimensional Fund Advisors LP | 0.01% | Reduce -2.7% | 1,159,215 | $30.5M |
| Nextech Invest Ltd. | 2.84% | No change | 1,113,946 | $29.3M |
| State Street Corp. | 0.00% | Reduce -4.0% | 1,037,642 | $27.3M |
| Capricorn Fund Managers Ltd | 6.49% | New | 1,022,840 | $26.9M |
| Vestal Point Capital, LP | 0.84% | Reduce -51.0% | 865,000 | $22.8M |
| Arrowstreet Capital, Limited Partnership | 0.01% | Add +123.1% | 700,002 | $18.4M |
| Adage Capital Partners Gp, L.L.C. | 0.03% | Add +17.6% | 663,546 | $17.5M |
| Nuveen, LLC | 0.00% | Add +14.7% | 648,326 | $17.1M |
| Geode Capital Management, LLC | 0.00% | Reduce -4.5% | 647,970 | $17.1M |
| Assenagon Asset Management S.A. | 0.03% | Reduce -51.2% | 647,374 | $17.0M |
| FMR LLC | 0.00% | Add +15838.7% | 560,086 | $14.7M |
| Prosight Management, LP | 2.89% | Reduce -29.2% | 530,393 | $14.0M |
| Redmile Group, LLC | 0.95% | Reduce -86.7% | 491,654 | $12.9M |
| Qube Research & Technologies Ltd | 0.02% | Add +86.0% | 474,290 | $12.5M |
| Algert Global LLC | 0.17% | Add +103.8% | 423,646 | $11.2M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -5.3% | 420,207 | $11.1M |
| Millennium Management | 0.01% | Reduce -65.5% | 381,621 | $10.0M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -81.3% | 320,261 | $8.4M |
| Northern Trust Corp. | 0.00% | Reduce -11.6% | 307,979 | $8.1M |
| Schonfeld Strategic Advisors LLC | 0.04% | Add +167.7% | 288,571 | $7.6M |
| UBS Group AG | 0.00% | Add +437.9% | 278,854 | $7.3M |
| Invesco Ltd. | 0.00% | Add +175.0% | 257,580 | $6.8M |
| Citadel Advisors | 0.00% | Add +23.4% | 255,351 | $6.7M |
| Picton Mahoney Asset Management | 0.07% | Add +18.6% | 244,798 | $6.4M |
| Hillsdale Investment Management Inc. | 0.17% | Add +9.9% | 237,922 | $6.3M |
| Granahan Investment Management, LLC | 0.25% | Reduce -35.0% | 224,408 | $5.9M |
| SummitTX Capital, L.P. | 0.18% | New | 224,268 | $5.9M |
| D. E. Shaw & Co. | 0.00% | Add +76.3% | 223,786 | $5.9M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +14.3% | 220,909 | $5.8M |
| Renaissance Technologies | 0.01% | Reduce -48.8% | 220,877 | $5.8M |
| Wells Fargo & Company | 0.00% | Add +17.9% | 208,313 | $5.5M |
| Raymond James Financial Inc. | 0.00% | Add +52.8% | 187,685 | $4.9M |
| Silvercrest Asset Management Group LLC | 0.03% | Reduce -33.4% | 181,790 | $4.8M |
| Wellington Management Group LLP | 0.00% | Add +7.7% | 181,705 | $4.8M |
| Susquehanna International Group, LLP | 0.01% | Add +238.3% | 176,088 | $4.6M |
| Federated Hermes, Inc. | 0.01% | Reduce -16.5% | 152,689 | $4.0M |
| Kennedy Capital Management LLC | 0.08% | Reduce -0.6% | 145,534 | $3.8M |
| Bank of New York Mellon Corp | 0.00% | Reduce -6.8% | 128,131 | $3.4M |
| Jupiter Asset Management Ltd. | 0.03% | Reduce -64.2% | 125,506 | $3.3M |
| HRT Financial LP | 0.01% | Add +76.8% | 121,064 | $3.2M |
| Ameriprise Financial Inc. | 0.00% | Add +49.0% | 113,141 | $3.0M |
| Citigroup Inc. | 0.00% | Reduce -5.6% | 111,207 | $2.9M |
| Opaleye Management Inc. | 0.38% | Add +8.9% | 108,929 | $2.9M |
| Platinum Investment Management Ltd. | 0.64% | Reduce -15.7% | 105,184 | $2.8M |
| Trexquant Investment LP | 0.02% | New | 101,274 | $2.7M |
| Soleus Capital Management, L.P. | 0.11% | New | 100,000 | $2.6M |
| Susquehanna Portfolio Strategies, LLC | 0.04% | Add +18.5% | 99,795 | $2.6M |
| Schroder Investment Management Group | 0.00% | Reduce -39.4% | 97,907 | $2.6M |
| XTX Topco Ltd | 0.06% | New | 93,469 | $2.5M |
| AQR Capital Management | 0.00% | Reduce -40.3% | 91,075 | $2.4M |
| Bank of America Corp. | 0.00% | Add +18.9% | 89,524 | $2.4M |
| Kornitzer Capital Management Inc. | 0.05% | New | 88,800 | $2.3M |
| Acuta Capital Partners, LLC | 1.43% | No change | 80,143 | $2.1M |
| Barclays PLC | 0.00% | Reduce -59.8% | 79,966 | $2.1M |
| Panagora Asset Management Inc. | 0.01% | Reduce -26.1% | 78,336 | $2.1M |
| NEOS Investment Management LLC | 0.01% | Add +21.1% | 77,115 | $2.0M |
| Tema ETFs LLC | 0.16% | Add +19.3% | 75,975 | $2.0M |
| Stifel Financial Corp. | 0.00% | Add +4.6% | 75,847 | $2.0M |
| State of Wisconsin Investment Board | 0.00% | Add +34.3% | 75,566 | $2.0M |
| Rhumbline Advisers | 0.00% | Reduce -12.1% | 75,498 | $2.0M |
| Man Group plc | 0.00% | Reduce -52.5% | 75,318 | $2.0M |
| Credit Agricole S A | 0.01% | New | 75,000 | $2.0M |
| Pictet Asset Management Holding SA | 0.00% | New | 73,627 | $2.0M |
| Swiss National Bank | 0.00% | Add +1.5% | 74,200 | $2.0M |
| Jane Street Group, LLC | 0.00% | Reduce -51.5% | 70,445 | $1.9M |
| Fisher Asset Management | 0.00% | Reduce -5.3% | 68,197 | $1.8M |
| Penserra Capital Management LLC | 0.02% | New | 60,146 | $1.6M |
| Franklin Resources Inc. | 0.00% | Add +74.4% | 58,987 | $1.6M |
| American Century Companies Inc. | 0.00% | Add +15.3% | 58,832 | $1.5M |
| Russell Investments Group, Ltd. | 0.00% | Add +1.6% | 58,350 | $1.5M |
| Royal Bank of Canada | 0.00% | Reduce -5.0% | 55,055 | $1.4M |
| Alliancebernstein L.P. | 0.00% | No change | 50,030 | $1.3M |
| Dana Investment Advisors, Inc. | 0.04% | New | 48,318 | $1.3M |
| Simplex Trading, LLC | 0.04% | Add +67.0% | 48,040 | $1.3M |
| Mackenzie Financial Corp. | 0.00% | Reduce -19.4% | 45,460 | $1.2M |
| North Growth Management Ltd. | 0.18% | Reduce -45.1% | 45,000 | $1.2M |
| O'shaughnessy Asset Management, LLC | 0.01% | Add +3.1% | 43,052 | $1.1M |
| Victory Capital Management Inc. | 0.00% | Add +24.3% | 42,905 | $1.1M |
| Envestnet Asset Management Inc. | 0.00% | Add +180.0% | 40,812 | $1.1M |
| California State Teachers Retirement System | 0.00% | Add +7.2% | 37,761 | $994K |
| JPMorgan Chase & Co. | 0.00% | Add +3.3% | 35,008 | $922K |
| Tang Capital Management LLC | 0.04% | Reduce -96.8% | 34,631 | $912K |
| Campbell & CO Investment Adviser LLC | 0.04% | Add +3.4% | 33,588 | $884K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +7.8% | 32,815 | $864K |
| SBI Okasan Asset Management Co.Ltd. | 0.05% | — | 32,000 | $856K |
| Legal & General Group Plc | 0.00% | Add +13.3% | 32,149 | $846K |
| Two Sigma Advisers, LP | 0.00% | New | 31,415 | $827K |
| Tudor Investment Corporation | 0.00% | Reduce -19.3% | 30,324 | $798K |
| Journey Strategic Wealth LLC | 0.02% | No change | 29,050 | $765K |
| Quantinno Capital Management LP | 0.00% | New | 28,883 | $760K |
| T. Rowe Price Associates Inc. | 0.00% | Add +7.3% | 28,784 | $758K |
| MetLife Investment Management, LLC | 0.00% | Reduce -14.1% | 28,630 | $754K |
| Creative Planning | 0.00% | Add +3.6% | 28,293 | $745K |
| Massachusetts Financial Services Co. | 0.00% | Reduce -3.2% | 28,083 | $739K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | Reduce -50.1% | 27,935 | $736K |
| STRS Ohio | 0.00% | Reduce -35.0% | 26,600 | $700K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -16.5% | 26,095 | $687K |
| Ritholtz Wealth Management | 0.01% | Reduce -1.6% | 24,338 | $641K |
| Aquatic Capital Management LLC | 0.02% | New | 24,103 | $635K |
| Brevan Howard Capital Management LP | 0.01% | Add +60.7% | 23,333 | $614K |
| BNP Paribas Financial Markets | 0.00% | Add +50.7% | 23,298 | $613K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +0.7% | 23,109 | $608K |
| Quadrature Capital Ltd | 0.01% | New | 23,017 | $606K |
| Y-Intercept (Hong Kong) Ltd | 0.01% | New | 22,643 | $596K |
| Seven Fleet Capital Management LP | 0.37% | — | 20,600 | $542K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Reduce -31.3% | 20,421 | $538K |
| Intech Investment Management LLC | 0.00% | Add +19.7% | 20,330 | $535K |
| PSP Research LLC | 0.47% | — | 20,312 | $535K |
| Duncan Williams Asset Management, LLC | 0.13% | No change | 22,095 | $511K |
| Vinva Investment Management Ltd | 0.01% | Reduce -16.3% | 12,216 | $484K |
| CreativeOne Wealth, LLC | 0.01% | New | 18,264 | $481K |
| Janus Henderson Group PLC | 0.00% | No change | 18,200 | $479K |
| HSBC Holdings PLC | 0.00% | Reduce -52.5% | 17,868 | $476K |
| SG Americas Securities, LLC | 0.00% | Add +28.9% | 17,557 | $462K |
| Bank of Montreal | 0.00% | Reduce -36.8% | 17,468 | $460K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -0.8% | 17,433 | $459K |
| New York State Common Retirement Fund | 0.00% | Add +29.9% | 17,371 | $457K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 15,340 | $404K |
| Agf Management Ltd. | 0.00% | New | 15,000 | $395K |
| Lazard Asset Management LLC | 0.00% | Reduce -10.0% | 13,776 | $363K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Reduce -3.5% | 13,702 | $361K |
| Walleye Capital LLC | 0.00% | Add +17882.9% | 13,667 | $360K |
| Walleye Trading LLC | 0.01% | New | 13,252 | $349K |
| Prudential Financial Inc. | 0.00% | Reduce -61.8% | 12,755 | $336K |
| ProShare Advisors LLC | 0.00% | Add +10.6% | 12,387 | $326K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -7.5% | 12,195 | $321K |
| Northwest & Ethical Investments L.P. | 0.01% | Add +20.1% | 12,044 | $320K |
| WINTON GROUP Ltd | 0.01% | New | 11,180 | $294K |
| Janney Montgomery Scott LLC | 0.00% | No change | 11,067 | $291K |
| Ewing Morris & Co. Investment Partners Ltd. | 0.13% | No change | 10,850 | $289K |
| James Investment Research, Inc. | 0.03% | Add +3.3% | 10,925 | $288K |
| State of Wyoming | 0.03% | New | 10,875 | $286K |
| Virtus Investment Advisers, LLC | 0.07% | Add +20.2% | 10,441 | $275K |
| Arizona State Retirement System | 0.00% | Reduce -6.0% | 10,395 | $274K |
| Abacus Wealth Partners, LLC | 0.03% | New | 10,222 | $269K |
| Baader Bank Aktiengesellschaft | 0.02% | New | 10,013 | $264K |
| VARCOV Co. | 0.10% | — | 9,818 | $259K |
| Voya Investment Management LLC | 0.00% | New | 9,234 | $243K |
| Group One Trading LLC | 0.01% | Add +28.7% | 8,841 | $233K |
| AlphaQuest LLC | 0.01% | Reduce -1.9% | 8,313 | $219K |
| Brooklyn Investment Group | 0.01% | New | 8,020 | $214K |
| Cresset Asset Management, LLC | 0.00% | New | 8,120 | $214K |
| KLP Kapitalforvaltning As | 0.00% | Add +9.6% | 8,000 | $211K |
| Apollon Wealth Management, LLC | 0.00% | New | 7,875 | $207K |
| Allspring Global Investments Holdings, LLC | 0.00% | New | 7,707 | $205K |
| Persistent Asset Partners Ltd | 0.09% | New | 7,346 | $193K |
| Cwm, LLC | 0.00% | Add +0.1% | 6,975 | $184K |
| Cygnus Capital Advisors, LLC | 0.12% | — | 5,997 | $158K |
| Ameritas Investment Partners, Inc. | 0.00% | No change | 4,164 | $110K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +25.1% | 3,637 | $96K |
| CFG Wealth Management Services, Inc. | 0.08% | — | 3,080 | $81K |
| Osaic Holdings, Inc. | 0.00% | Add +223.9% | 2,510 | $66K |
| Amalgamated Bank | 0.00% | Reduce -16.7% | 1,566 | $41K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -9.1% | 1,470 | $39K |
| Caitong International Asset Management Co., Ltd | 0.01% | New | 1,399 | $37K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -88.0% | 1,353 | $36K |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 3,843 | $35K |
| Optiver Holding B.V. | 0.00% | Reduce -24.0% | 1,148 | $30K |
| GAMMA Investing LLC | 0.00% | Add +22.4% | 985 | $26K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 968 | $25K |
| PNC Financial Services Group, Inc. | 0.00% | Add +149.5% | 781 | $21K |
| Lanark Financial, Inc. | 0.00% | New | 623 | $16K |
| Thurston, Springer, Miller, Herd & Titak, Inc. | 0.01% | New | 610 | $16K |
| Federation des caisses Desjardins du Quebec | 0.00% | Reduce -34.5% | 570 | $15K |
| National Bank of Canada | 0.00% | Reduce -0.7% | 545 | $14K |
| UMB Bank, n.a. | 0.00% | New | 466 | $12K |
| Huntington National Bank | 0.00% | New | 364 | $10K |
| Sterling Capital Management LLC | 0.00% | Add +173.6% | 331 | $9K |
| Parallel Advisors, LLC | 0.00% | No change | 329 | $9K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 311 | $8K |
| US Bancorp \de | 0.00% | Add +15.7% | 287 | $8K |
| Los Angeles Capital Management LLC | 0.00% | New | 387 | $7K |
| Farther Finance Advisors, LLC | 0.00% | Add +350.0% | 279 | $7K |
| Truvestments Capital LLC | 0.00% | No change | 231 | $6K |
| HighMark Wealth Management LLC | 0.00% | Reduce -17.9% | 230 | $6K |
| Comerica Bank | 0.00% | No change | 211 | $6K |
| Daiwa Securities Group Inc. | 0.00% | Reduce -35.0% | 186 | $5K |
| EverSource Wealth Advisors, LLC | 0.00% | No change | 182 | $5K |
| Arax Advisory Partners | 0.00% | Reduce -94.3% | 169 | $4K |
| Allworth Financial LP | 0.00% | Add +4.3% | 146 | $4K |
| IFP Advisors, Inc | 0.00% | No change | 96 | $3K |
| Quarry LP | 0.00% | Reduce -96.9% | 90 | $2K |
| Kilter Group LLC | 0.00% | No change | 66 | $2K |
| Bare Financial Services, Inc | 0.00% | No change | 64 | $2K |
| True Wealth Design, LLC | 0.00% | No change | 58 | $2K |
| Rothschild Investment LLC | 0.00% | Add +1.8% | 56 | $1K |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 53 | $1K |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 51 | $1K |
| Signaturefd, LLC | 0.00% | New | 42 | $1K |
| Covestor Ltd | 0.00% | Add +1.9% | 54 | $1K |
| Sunbelt Securities, Inc. | 0.00% | No change | 27 | $711 |
| International Assets Investment Management, LLC | 0.00% | New | 25 | $658 |
| Jones Financial Companies LLLP | 0.00% | New | 20 | $527 |
| CoreCap Advisors, LLC | 0.00% | No change | 18 | $474 |
| Smartleaf Asset Management LLC | 0.00% | No change | 12 | $318 |
| Essential Partners LLC | 0.00% | No change | 12 | $316 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -8.3% | 11 | $290 |
| Innovative Advisory Group, LLC | 0.00% | No change | 8 | $211 |
| Larson Financial Group LLC | 0.00% | New | 6 | $158 |
| MAI Capital Management | 0.00% | New | 5 | $132 |
"% of holder's portfolio" is ZYME's weight in each manager's 13F, not the share of Zymeworks Inc. the manager owns.