Allostery Investments LP
In its 13F for Q1 2025 (holdings as of March 31, 2025, filed May 15, 2025), Allostery Investments LP reported 41 stock positions worth $69.3 million. Its top holding was Abivax SA-ADR (ABVX) at 9.9% of the portfolio, followed by Centessa Pharmaceuticals (CNTA, 7.9%) and Kalvista Pharmaceuticals (KALV, 7.6%). Compared with Q4 2024, it opened 16 new positions, sold out of 5, added to 11 and reduced 5. The biggest buy was Merus (MRUS, shares +474%) and the biggest sale Ionis Pharmaceuticals (IONS, shares −46%).
- Most Recent 13F
- Q3 2025
- Location
- Stamford, CT
- CIK
- 0001978599
- Portfolio Value
- $69.3M (Q1 2025)
- SEC Filing
- 0001013594-25-000654 ↗ filed May 15, 2025
Holdings Value
Holdings 41 stocks · $69.3M
| ABVX Abivax SA-ADR | 9.91% | 1,099,654 | $6.9M | Add +86.0% |
| CNTA Centessa Pharmaceuticals Ltd. | 7.93% | 382,524 | $5.5M | Add +34.5% |
| KALV Kalvista Pharmaceuticals Inc. | 7.63% | 458,302 | $5.3M | Reduce -4.3% |
| MRUS Merus NV | 7.57% | 124,657 | $5.2M | Add +473.5% |
| EOLS Evolus Inc. | 7.16% | 412,754 | $5.0M | Reduce -4.3% |
| APGE Apogee Therapeutics Inc. | 5.93% | 110,000 | $4.1M | Add +10.0% |
| ALKS Alkermes PLC | 5.48% | 115,000 | $3.8M | Reduce -4.2% |
| AEROVATE THERAPEUTICS INC | 5.15% | 1,421,568 | $3.6M | Add +67.1% |
| ZURA Zura Bio Ltd. | 4.33% | 2,329,384 | $3.0M | Add +53.7% |
| ACLX Arcellx Inc. | 4.16% | 44,000 | $2.9M | Add +25.7% |
| CYTK Cytokinetics Inc. | 4.06% | 70,000 | $2.8M | Add +7.7% |
| BBIO Bridgebio Pharma Inc. | 3.99% | 80,000 | $2.8M | New |
| SWTX Springworks Therapeutics Inc. | 3.34% | 52,500 | $2.3M | New |
| BEAM Beam Therapeutics Inc. | 2.61% | 92,754 | $1.8M | New |
| SLNO Soleno Therapeutics Inc. | 2.06% | 20,000 | $1.4M | New |
| PCVX Vaxcyte Inc. | 1.74% | 32,000 | $1.2M | New |
| IONS Ionis Pharmaceuticals Inc. | 1.52% | 35,000 | $1.1M | Reduce -46.1% |
| XENE Xenon Pharmaceuticals Inc. | 1.45% | 30,000 | $1.0M | No change |
| AMLX Amylyx Pharmaceuticals Inc. | 1.36% | 266,099 | $942K | New |
| AVTX Avalo Therapeutics Inc. | 1.24% | 107,141 | $858K | Add +46.1% |
| VRNA Verona Pharma Ltd. | 1.14% | 12,500 | $794K | New |
| INSM Insmed Inc. | 1.10% | 10,000 | $763K | No change |
| AKRO Akero Therapeutics Inc. | 1.05% | 18,000 | $729K | New |
| TARS Tarsus Pharmaceuticals Inc. | 1.01% | 13,600 | $699K | No change |
| GOSS Gossamer Bio Inc. | 0.97% | 613,028 | $674K | No change |
| PLRX Pliant Therapeutics Inc. | 0.86% | 441,686 | $596K | New |
| CNTX Context Therapeutics Inc. | 0.84% | 950,166 | $582K | No change |
| BIOMX INC | 0.75% | 940,629 | $523K | Add +46.1% |
| RLYB Rallybio Corp. | 0.71% | 752,235 | $492K | Reduce -6.4% |
| ELDN Eledon Pharmaceuticals Inc. | 0.49% | 100,000 | $339K | No change |
| CLYM Climb Bio Inc. | 0.43% | 244,988 | $299K | No change |
| ORKA Oruka Therapeutics Inc. | 0.30% | 20,000 | $205K | No change |
| MDGL Madrigal Pharmaceuticals Inc. | 0.29% | 600 | $199K | New |
| ETNB 89BIO Inc. | 0.26% | 25,000 | $182K | New |
| PMN Promis Neurosciences Inc. | 0.24% | 233,703 | $165K | Add +19.8% |
| LEGN Legend Biotech Corp.-ADR | 0.23% | 4,750 | $161K | New |
| VIR Vir Biotechnology Inc. | 0.21% | 22,202 | $144K | New |
| WVE Wave Life Sciences Ltd. | 0.20% | 17,500 | $141K | New |
| ARQT Arcutis Biotherapeutics Inc. | 0.17% | 7,500 | $117K | New |
| EWTX Edgewise Therapeutics Inc. | 0.10% | 3,000 | $66K | New |
| LXEO Lexeo Therapeutics Inc. | 0.03% | 5,054 | $18K | No change |
Portfolio Sells Q4 2024 → Q1 2025
| IONS Ionis Pharmaceuticals Inc. | Reduce -46.1% | 1.52% | −2.94 |
| EOLS Evolus Inc. | Reduce -4.3% | 7.16% | −2.18 |
| MIND MEDICINE MINDMED INC | Sold out | 0.00% | −1.78 |
| ALKS Alkermes PLC | Reduce -4.2% | 5.48% | −1.30 |
| DNTH Dianthus Therapeutics Inc. | Sold out | 0.00% | −1.07 |
| CRNX Crinetics Pharmaceuticals Inc. | Sold out | 0.00% | −0.97 |
| JSPR Jasper Therapeutics Inc. | Sold out | 0.00% | −0.92 |
| RLYB Rallybio Corp. | Reduce -6.4% | 0.71% | −0.80 |
| ELEV Elevation Oncology Inc. | Sold out | 0.00% | −0.48 |
| KALV Kalvista Pharmaceuticals Inc. | Reduce -4.3% | 7.63% | −0.34 |
Portfolio Buys Q4 2024 → Q1 2025
| MRUS Merus NV | Add +473.5% | 7.57% | +5.77 |
| BBIO Bridgebio Pharma Inc. | New | 3.99% | +3.99 |
| SWTX Springworks Therapeutics Inc. | New | 3.34% | +3.34 |
| BEAM Beam Therapeutics Inc. | New | 2.61% | +2.61 |
| SLNO Soleno Therapeutics Inc. | New | 2.06% | +2.06 |
| PCVX Vaxcyte Inc. | New | 1.74% | +1.74 |
| ABVX Abivax SA-ADR | Add +86.0% | 9.91% | +1.42 |
| AMLX Amylyx Pharmaceuticals Inc. | New | 1.36% | +1.36 |
| VRNA Verona Pharma Ltd. | New | 1.14% | +1.14 |
| AKRO Akero Therapeutics Inc. | New | 1.05% | +1.05 |
| PLRX Pliant Therapeutics Inc. | New | 0.86% | +0.86 |
| AEROVATE THERAPEUTICS INC | Add +67.1% | 5.15% | +0.72 |
| MDGL Madrigal Pharmaceuticals Inc. | New | 0.29% | +0.29 |
| ETNB 89BIO Inc. | New | 0.26% | +0.26 |
| LEGN Legend Biotech Corp.-ADR | New | 0.23% | +0.23 |
| VIR Vir Biotechnology Inc. | New | 0.21% | +0.21 |
| WVE Wave Life Sciences Ltd. | New | 0.20% | +0.20 |
| ARQT Arcutis Biotherapeutics Inc. | New | 0.17% | +0.17 |
| AVTX Avalo Therapeutics Inc. | Add +46.1% | 1.24% | +0.17 |
| EWTX Edgewise Therapeutics Inc. | New | 0.10% | +0.10 |
| PMN Promis Neurosciences Inc. | Add +19.8% | 0.24% | −0.12 |
| BIOMX INC | Add +46.1% | 0.75% | −0.17 |
| ACLX Arcellx Inc. | Add +25.7% | 4.16% | −1.11 |
| CNTA Centessa Pharmaceuticals Ltd. | Add +34.5% | 7.93% | −1.42 |
| CYTK Cytokinetics Inc. | Add +7.7% | 4.06% | −1.95 |
| APGE Apogee Therapeutics Inc. | Add +10.0% | 5.93% | −2.97 |
| ZURA Zura Bio Ltd. | Add +53.7% | 4.33% | −3.10 |
Options Activity Q4 2024 → Q1 2025
| XBI SS SPDR S&P Biotech ETF | call | Sold out | 175,000 | $15.8Mbefore exit |
| QQQ Invesco QQQ Trust Series 1 | put | Sold out | 25,000 | $12.8Mbefore exit |
| TLT iShares 20+ Year Treasury BD | put | Sold out | 100,000 | $8.7Mbefore exit |
| APLS Apellis Pharmaceuticals Inc. | call | Sold out | 80,000 | $2.6Mbefore exit |
| TGTX TG Therapeutics Inc. | call | Sold out | 75,000 | $2.3Mbefore exit |
| NVAX Novavax Inc. | put | Sold out | 150,000 | $1.2Mbefore exit |
| ANAB Anaptysbio Inc. | call | Sold out | 50,000 | $662Kbefore exit |
| OLMA Olema Pharmaceuticals Inc. | call | Sold out | 90,000 | $525Kbefore exit |
| ZURA Zura Bio Ltd. | call | Sold out | 100,000 | $250Kbefore exit |
| VRDN Viridian Therapeutics Inc. | put | Sold out | 3,600 | $69Kbefore exit |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.