Allostery Investments LP

In its 13F for Q2 2025 (holdings as of June 30, 2025, filed August 14, 2025), Allostery Investments LP reported 20 stock positions worth $7.9 million. Its top holding was Abivax SA-ADR (ABVX) at 16.3% of the portfolio, followed by Akero Therapeutics (AKRO, 15.3%) and Amylyx Pharmaceuticals (AMLX, 9.8%). Compared with Q1 2025, it opened 5 new positions, sold out of 26, added to 1 and reduced 14. The biggest buy was Akero Therapeutics (AKRO, shares +25%) and the biggest sale an exit from Alkermes (ALKS).

Most Recent 13F
Q3 2025
Location
Stamford, CT
CIK
0001978599
Portfolio Value
$7.9M (Q2 2025)
SEC Filing
0001013594-25-001022 ↗ filed Aug 14, 2025

Holdings Value

0$20.0M$40.0M$60.0M$80.0M Q4 2024: $50.9M Q4 2024 Q1 2025: $69.3M Q1 2025 Q2 2025: $7.9M $7.9M Q2 2025 Q3 2025: $0 Q3 2025

Holdings 20 stocks · $7.9M
ABVX Abivax SA-ADR 16.31% 167,350 $1.3M Reduce -84.8%
AKRO Akero Therapeutics Inc. 15.29% 22,500 $1.2M Add +25.0%
AMLX Amylyx Pharmaceuticals Inc. 9.81% 120,119 $770K Reduce -54.9%
CNTA Centessa Pharmaceuticals Ltd. 8.79% 52,500 $690K Reduce -86.3%
EOLS Evolus Inc. 7.04% 60,000 $553K Reduce -85.5%
RZLT Rezolute Inc. 6.78% 119,294 $532K New
MRUS Merus NV 6.03% 9,000 $473K Reduce -92.8%
KALV Kalvista Pharmaceuticals Inc. 5.76% 40,000 $452K Reduce -91.3%
FULC Fulcrum Therapeutics Inc. 3.54% 40,353 $278K New
APGE Apogee Therapeutics Inc. 3.32% 6,000 $261K Reduce -94.5%
VRNA Verona Pharma Ltd. 3.01% 2,500 $236K Reduce -80.0%
TNGX Tango Therapeutics Inc. 2.61% 40,000 $205K New
BBIO Bridgebio Pharma Inc. 2.20% 4,000 $173K Reduce -95.0%
CYTK Cytokinetics Inc. 2.10% 5,000 $165K Reduce -92.9%
TRML Tourmaline Bio Inc. 1.91% 9,356 $150K New
LEGN Legend Biotech Corp.-ADR 1.81% 4,000 $142K Reduce -15.8%
NKTR Nektar Therapeutics 1.32% 4,000 $103K New
PMN Promis Neurosciences Inc. 0.97% 155,720 $76K Reduce -33.4%
ACLX Arcellx Inc. 0.84% 1,000 $66K Reduce -97.7%
AVTX Avalo Therapeutics Inc. 0.57% 9,000 $45K Reduce -91.6%

Portfolio Sells Q1 2025 → Q2 2025
ALKS Alkermes PLC Sold out 0.00% −5.48
AEROVATE THERAPEUTICS INC Sold out 0.00% −5.15
ZURA Zura Bio Ltd. Sold out 0.00% −4.33
SWTX Springworks Therapeutics Inc. Sold out 0.00% −3.34
ACLX Arcellx Inc. Reduce -97.7% 0.84% −3.32
BEAM Beam Therapeutics Inc. Sold out 0.00% −2.61
APGE Apogee Therapeutics Inc. Reduce -94.5% 3.32% −2.61
SLNO Soleno Therapeutics Inc. Sold out 0.00% −2.06
CYTK Cytokinetics Inc. Reduce -92.9% 2.10% −1.95
KALV Kalvista Pharmaceuticals Inc. Reduce -91.3% 5.76% −1.87
BBIO Bridgebio Pharma Inc. Reduce -95.0% 2.20% −1.79
PCVX Vaxcyte Inc. Sold out 0.00% −1.74
MRUS Merus NV Reduce -92.8% 6.03% −1.54
IONS Ionis Pharmaceuticals Inc. Sold out 0.00% −1.52
XENE Xenon Pharmaceuticals Inc. Sold out 0.00% −1.45
INSM Insmed Inc. Sold out 0.00% −1.10
TARS Tarsus Pharmaceuticals Inc. Sold out 0.00% −1.01
GOSS Gossamer Bio Inc. Sold out 0.00% −0.97
PLRX Pliant Therapeutics Inc. Sold out 0.00% −0.86
CNTX Context Therapeutics Inc. Sold out 0.00% −0.84
BIOMX INC Sold out 0.00% −0.75
RLYB Rallybio Corp. Sold out 0.00% −0.71
AVTX Avalo Therapeutics Inc. Reduce -91.6% 0.57% −0.67
ELDN Eledon Pharmaceuticals Inc. Sold out 0.00% −0.49
CLYM Climb Bio Inc. Sold out 0.00% −0.43
ORKA Oruka Therapeutics Inc. Sold out 0.00% −0.30
MDGL Madrigal Pharmaceuticals Inc. Sold out 0.00% −0.29
ETNB 89BIO Inc. Sold out 0.00% −0.26
VIR Vir Biotechnology Inc. Sold out 0.00% −0.21
WVE Wave Life Sciences Ltd. Sold out 0.00% −0.20
ARQT Arcutis Biotherapeutics Inc. Sold out 0.00% −0.17
EOLS Evolus Inc. Reduce -85.5% 7.04% −0.12
EWTX Edgewise Therapeutics Inc. Sold out 0.00% −0.10
LXEO Lexeo Therapeutics Inc. Sold out 0.00% −0.03
PMN Promis Neurosciences Inc. Reduce -33.4% 0.97% +0.73
CNTA Centessa Pharmaceuticals Ltd. Reduce -86.3% 8.79% +0.85
LEGN Legend Biotech Corp.-ADR Reduce -15.8% 1.81% +1.58
VRNA Verona Pharma Ltd. Reduce -80.0% 3.01% +1.87
ABVX Abivax SA-ADR Reduce -84.8% 16.31% +6.40
AMLX Amylyx Pharmaceuticals Inc. Reduce -54.9% 9.81% +8.45

Portfolio Buys Q1 2025 → Q2 2025
AKRO Akero Therapeutics Inc. Add +25.0% 15.29% +14.24
RZLT Rezolute Inc. New 6.78% +6.78
FULC Fulcrum Therapeutics Inc. New 3.54% +3.54
TNGX Tango Therapeutics Inc. New 2.61% +2.61
TRML Tourmaline Bio Inc. New 1.91% +1.91
NKTR Nektar Therapeutics New 1.32% +1.32

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q3 2025 0$0
Q2 2025 20$7.9MABVX, AKRO, AMLX, CNTA, EOLS
Q1 2025 41$69.3MABVX, CNTA, KALV, MRUS, EOLS
Q4 2024 30$50.9MCNTA, EOLS, APGE, ABVX, KALV