Ikarian Capital, LLC

In its 13F for Q2 2025 (holdings as of June 30, 2025, filed August 14, 2025), Ikarian Capital, LLC reported 103 stock positions worth $302.2 million. Its top holding was Cidara Therapeutics (CDTX) at 7.5% of the portfolio, followed by Alnylam Pharmaceuticals (ALNY, 6.1%) and Insmed (INSM, 5.5%). Compared with Q1 2025, it opened 20 new positions, sold out of 33, added to 14 and reduced 28. The biggest buy was Cidara Therapeutics (CDTX, shares +87%) and the biggest sale Tarsus Pharmaceuticals (TARS, shares −59%).

Most Recent 13F
Q2 2026
Location
DALLAS, TX
CIK
0001778253
Portfolio Value
$302.2M (Q2 2025)
SEC Filing
0001420506-25-002181 ↗ filed Aug 14, 2025

Holdings Value

0$200.0M$400.0M$600.0M$800.0M Q1 2024: $367.7M Q1 2024 Q2 2024: $320.5M Q2 2024 Q3 2024: $322.0M Q3 2024 Q4 2024: $350.2M Q4 2024 Q1 2025: $306.9M Q1 2025 Q2 2025: $302.2M $302.2M Q2 2025 Q3 2025: $494.3M Q3 2025 Q4 2025: $772.6M Q4 2025 Q1 2026: $699.0M Q1 2026 Q2 2026: $610.9M Q2 2026

Holdings 103 stocks · $302.2M

CDTX Cidara Therapeutics Inc. 7.49% 464,488 $22.6M Add +86.6%
ALNY Alnylam Pharmaceuticals Inc. 6.11% 56,594 $18.5M Add +79.1%
INSM Insmed Inc. 5.45% 163,751 $16.5M Add +93.1%
VRNA Verona Pharma Ltd. 4.59% 146,831 $13.9M Add +12.9%
CRNX Crinetics Pharmaceuticals Inc. 4.12% 433,431 $12.5M Reduce -17.2%
AKRO Akero Therapeutics Inc. 3.88% 220,000 $11.7M Reduce -10.2%
PRAX Praxis Precision Medicines I 3.85% 276,950 $11.6M Add +90.3%
APGE Apogee Therapeutics Inc. 3.33% 232,047 $10.1M New
PCVX Vaxcyte Inc. 3.28% 305,000 $9.9M Add +52.5%
ACOG Alpha Cognition Inc. 2.83% 917,867 $8.6M Reduce -5.2%
TARS Tarsus Pharmaceuticals Inc. 2.63% 196,536 $8.0M Reduce -59.5%
CYTK Cytokinetics Inc. 2.55% 233,464 $7.7M Add +55.7%
SRPT Sarepta Therapeutics Inc. 2.54% 449,087 $7.7M Add +165.6%
TGTX TG Therapeutics Inc. 2.50% 209,938 $7.6M Reduce -0.1%
COGT Cogent Biosciences Inc. 2.46% 1,035,528 $7.4M New
VRDN Viridian Therapeutics Inc. 2.17% 469,949 $6.6M Reduce -5.0%
ARVN Arvinas Inc. 2.07% 850,000 $6.3M Add +269.7%
FBRX Forte Biosciences Inc. 2.04% 476,443 $6.2M Reduce -21.8%
VIR Vir Biotechnology Inc. 1.78% 1,068,062 $5.4M No change
CPRX Catalyst Pharmaceuticals Inc. 1.51% 209,649 $4.5M Reduce -16.0%
DCTH Delcath Systems Inc. 1.45% 322,390 $4.4M Add +221.2%
JAZZ Jazz Pharmaceuticals PLC 1.40% 40,000 $4.2M New
CGON CG Oncology Inc. 1.33% 155,000 $4.0M New
STIM Neuronetics Inc. 1.27% 1,099,700 $3.8M Reduce -0.0%
GPCR Structure Therapeutics Inc. 1.26% 183,085 $3.8M Reduce -30.7%
NAMS Newamsterdam Pharma Co. NV 1.24% 206,800 $3.7M New
DYN Dyne Therapeutics Inc. 1.15% 363,837 $3.5M Add +1.4%
TECX Tectonic Therapeutic Inc. 1.08% 163,696 $3.3M Reduce -39.2%
MAZE Maze Therapeutics Inc. 1.07% 262,740 $3.2M Reduce -18.6%
JANX Janux Therapeutics Inc. 0.99% 129,691 $3.0M No change
FULC Fulcrum Therapeutics Inc. 0.98% 428,521 $2.9M Add +114.2%
ELDN Eledon Pharmaceuticals Inc. 0.90% 1,000,221 $2.7M Reduce -2.4%
BIIB Biogen Inc. 0.89% 21,516 $2.7M New
VKTX Viking Therapeutics Inc. 0.88% 100,000 $2.7M Add +100.0%
RLAY Relay Therapeutics Inc. 0.85% 743,308 $2.6M No change
ARCT Arcturus Therapeutics Holdin 0.75% 175,000 $2.3M No change
GERN Geron Corp. 0.75% 1,600,000 $2.3M Add +966.7%
KALV Kalvista Pharmaceuticals Inc. 0.74% 198,528 $2.2M New
KOD Kodiak Sciences Inc. 0.74% 599,534 $2.2M Reduce -7.7%
LXEO Lexeo Therapeutics Inc. 0.73% 550,029 $2.2M No change
MTSR Metsera Inc. 0.73% 77,316 $2.2M Reduce -48.5%
VTYX Ventyx Biosciences Inc. 0.69% 967,590 $2.1M Reduce -20.5%
CPIX Cumberland Pharmaceuticals 0.66% 595,932 $2.0M Reduce -19.5%
PRQR Proqr Therapeutics NV 0.59% 868,069 $1.8M New
SRRK Scholar Rock Holding Corp. 0.58% 49,179 $1.7M Reduce -79.9%
DRUG Bright Minds Biosciences Inc. 0.57% 65,431 $1.7M No change
QURE Uniqure NV 0.55% 119,986 $1.7M New
SLN Silence Therapeutics PLC-ADR 0.46% 873,568 $1.4M New
RCUS Arcus Biosciences Inc. 0.44% 163,363 $1.3M No change
APLS Apellis Pharmaceuticals Inc. 0.43% 75,000 $1.3M No change
ALEC Alector Inc. 0.42% 900,000 $1.3M Reduce -5.3%
NUVB Nuvation Bio Inc. 0.40% 619,258 $1.2M No change
VTGN Vistagen Therapeutics Inc. 0.40% 601,703 $1.2M No change
HELP Cybin Inc. 0.39% 140,475 $1.2M Reduce -64.6%
TRML Tourmaline Bio Inc. 0.36% 67,927 $1.1M No change
WVE Wave Life Sciences Ltd. 0.35% 161,137 $1.0M New
VERU Veru Inc. 0.27% 1,425,239 $829K No change
ORKA Oruka Therapeutics Inc. 0.25% 68,574 $769K Reduce -60.8%
IBB iShares Biotechnology ETF 0.24% 5,755 $728K New
SGMOQ Sangamo Therapeutics Inc. 0.23% 1,260,179 $682K Reduce -32.3%
IMUX Immunic Inc. 0.21% 914,170 $638K No change
INBX Inhibrx Biosciences Inc. 0.20% 42,122 $601K No change
IFRX Inflarx NV 0.18% 705,010 $557K New
KZR Kezar Life Sciences Inc. 0.16% 106,901 $490K No change
VYNE THERAPEUTICS INC 0.16% 290,000 $479K New
IBIO Ibio Inc. 0.15% 599,913 $458K No change
MIND MEDICINE MINDMED INC 0.13% 62,691 $407K No change
BIOMX INC 0.13% 892,976 $402K No change
LYEL Lyell Immunopharma Inc. 0.13% 43,799 $387K No change
NYXH Nyxoah SA 0.13% 50,627 $379K New
ANAB Anaptysbio Inc. 0.12% 15,662 $348K New
VERA Vera Therapeutics Inc. 0.11% 14,096 $332K New
ZYME Zymeworks Inc. 0.10% 25,000 $314K New
ABOS Acumen Pharmaceuticals Inc. 0.10% 265,769 $308K No change
IMTX Immatics NV 0.09% 49,396 $266K New
VIGL Vigil Neuroscience Inc. 0.08% 31,360 $249K Reduce -87.5%
CMMB Chemomab Therapeutics Ltd. 0.08% 213,052 $247K No change
ANRO Alto Neuroscience Inc. 0.08% 110,000 $242K Reduce -37.1%
RNAC Cartesian Therapeutics Inc. 0.08% 22,166 $230K No change
ANEB Anebulo Pharmaceuticals Inc. 0.08% 157,720 $227K No change
TERN Terns Pharmaceuticals Inc. 0.07% 58,491 $218K Reduce -81.0%
EVAX Evaxion A/S 0.06% 80,000 $196K No change
FTH Faeth Therapeutics Inc. filed as SENSEI BIOTHERAPEUTICS INC 0.06% 22,497 $193K No change
LYRA Lyra Therapeutics Inc. 0.06% 21,161 $190K No change
AETHLON MED INC 0.06% 153,659 $184K No change
AVTX Avalo Therapeutics Inc. 0.06% 35,300 $176K Reduce -82.3%
VYGR Voyager Therapeutics Inc. 0.06% 55,766 $173K No change
LXRX Lexicon Pharmaceuticals Inc. 0.06% 176,479 $167K Reduce -87.5%
PEPG Pepgen Inc. 0.06% 150,000 $167K No change
JSPR Jasper Therapeutics Inc. 0.05% 25,107 $139K No change
KPTI Karyopharm Therapeutics Inc. 0.04% 27,257 $117K No change
MGNX Macrogenics Inc. 0.03% 80,071 $97K No change
SGMT Sagimet Biosciences Inc. Class A 0.03% 11,984 $91K No change
AIRS Airsculpt Technologies Inc. 0.03% 17,951 $87K New
SPRB Spruce Biosciences Inc. 0.02% 1,000,000 $73K No change
TKNO Alpha Teknova Inc. 0.02% 14,008 $69K No change
HOOK Hookipa Pharma Inc. 0.02% 52,996 $67K No change
TOVX Theriva Biologics Inc. 0.02% 120,031 $52K No change
TRAW Traws Pharma Inc. 0.01% 28,493 $42K No change
AUTONOMIX MED INC 0.01% 20,000 $31K No change
SYBX Synlogic Inc. 0.01% 20,422 $26K No change
RLMD Relmada Therapeutics Inc. 0.01% 40,270 $24K No change
NMRA Neumora Therapeutics Inc. 0.00% 12,498 $9K Reduce -19.1%

Options reported separately and not counted above: CDTX puts ($24.4M), RARE calls ($20.5M), SLNO calls ($16.8M), SLNO puts ($16.8M), CDTX calls ($15.6M), CAPR puts ($13.5M), UNIQURE NV calls ($11.2M), RARE puts ($10.9M), PRAX calls ($10.2M), VKTX calls ($9.3M), MLTX puts ($9.2M), CAPR calls ($7.0M), and 18 more.

Portfolio Sells Q1 2025 → Q2 2025

TARS Tarsus Pharmaceuticals Inc. Reduce -59.5% 2.63% −5.48
SPY SS SPDR S&P 500 ETF Trust-US Sold out 0.00% −4.56
BPMC Blueprint Medicines Corp. Sold out 0.00% −3.28
RARE Ultragenyx Pharmaceutical Inc. Sold out 0.00% −2.56
EWTX Edgewise Therapeutics Inc. Sold out 0.00% −2.01
SRRK Scholar Rock Holding Corp. Reduce -79.9% 0.58% −1.98
ELVN Enliven Therapeutics Inc. Sold out 0.00% −1.86
CRNX Crinetics Pharmaceuticals Inc. Reduce -17.2% 4.12% −1.60
TRVI Trevi Therapeutics Inc. Sold out 0.00% −1.18
BBIO Bridgebio Pharma Inc. Sold out 0.00% −1.02
KROS Keros Therapeutics Inc. Sold out 0.00% −0.91
ABEO Abeona Therapeutics Inc. Sold out 0.00% −0.83
EOLS Evolus Inc. Sold out 0.00% −0.76
MTSR Metsera Inc. Reduce -48.5% 0.73% −0.60
VERV Verve Therapeutics Inc. Sold out 0.00% −0.53
RCKT Rocket Pharmaceuticals Inc. Sold out 0.00% −0.48
TECX Tectonic Therapeutic Inc. Reduce -39.2% 1.08% −0.48
CPRX Catalyst Pharmaceuticals Inc. Reduce -16.0% 1.51% −0.47
AVTX Avalo Therapeutics Inc. Reduce -82.3% 0.06% −0.46
HELP Cybin Inc. Reduce -64.6% 0.39% −0.43
TDOC Teladoc Health Inc. Sold out 0.00% −0.39
CPIX Cumberland Pharmaceuticals Reduce -19.5% 0.66% −0.36
OKUR Onkure Therapeutics Inc. Class A Sold out 0.00% −0.36
NKTR Nektar Therapeutics Sold out 0.00% −0.35
ORKA Oruka Therapeutics Inc. Reduce -60.8% 0.25% −0.33
SLDB Solid Biosciences Inc. Sold out 0.00% −0.28
ETNB 89BIO Inc. Sold out 0.00% −0.24
ELDN Eledon Pharmaceuticals Inc. Reduce -2.4% 0.90% −0.24
OLMA Olema Pharmaceuticals Inc. Sold out 0.00% −0.24
GPCR Structure Therapeutics Inc. Reduce -30.7% 1.26% −0.23
GLUE Monte Rosa Therapeutics Inc. Sold out 0.00% −0.21
TERN Terns Pharmaceuticals Inc. Reduce -81.0% 0.07% −0.21
CHANNEL THERAPEUTICS CORPORA Sold out 0.00% −0.20
TGTX TG Therapeutics Inc. Reduce -0.1% 2.50% −0.20
PYXS Pyxis Oncology Inc. Sold out 0.00% −0.20
SWTX Springworks Therapeutics Inc. Sold out 0.00% −0.18
SGMOQ Sangamo Therapeutics Inc. Reduce -32.3% 0.23% −0.17
LXRX Lexicon Pharmaceuticals Inc. Reduce -87.5% 0.06% −0.16
ITOS Iteos Therapeutics Inc. Sold out 0.00% −0.15
THRD Third Harmonic Bio Inc. Sold out 0.00% −0.11
DNA Ginkgo Bioworks Holdings Inc. Sold out 0.00% −0.11
TYRA Tyra Biosciences Inc. Sold out 0.00% −0.11
MAZE Maze Therapeutics Inc. Reduce -18.6% 1.07% −0.09
ALLK Allakos LLC Sold out 0.00% −0.09
ACRS Aclaris Therapeutics Inc. Sold out 0.00% −0.08
MNPR Monopar Therapeutics Inc. Sold out 0.00% −0.07
CLYM Climb Bio Inc. Sold out 0.00% −0.07
VIGL Vigil Neuroscience Inc. Reduce -87.5% 0.08% −0.06
ELEV Elevation Oncology Inc. Sold out 0.00% −0.06
STIM Neuronetics Inc. Reduce -0.0% 1.27% −0.05

Portfolio Buys Q1 2025 → Q2 2025

CDTX Cidara Therapeutics Inc. Add +86.6% 7.49% +5.74
INSM Insmed Inc. Add +93.1% 5.45% +3.35
APGE Apogee Therapeutics Inc. New 3.33% +3.33
ALNY Alnylam Pharmaceuticals Inc. Add +79.1% 6.11% +3.33
COGT Cogent Biosciences Inc. New 2.46% +2.46
PRAX Praxis Precision Medicines I Add +90.3% 3.85% +2.06
VRNA Verona Pharma Ltd. Add +12.9% 4.59% +1.91
ARVN Arvinas Inc. Add +269.7% 2.07% +1.54
JAZZ Jazz Pharmaceuticals PLC New 1.40% +1.40
CGON CG Oncology Inc. New 1.33% +1.33
NAMS Newamsterdam Pharma Co. NV New 1.24% +1.24
DCTH Delcath Systems Inc. Add +221.2% 1.45% +1.03
BIIB Biogen Inc. New 0.89% +0.89
PCVX Vaxcyte Inc. Add +52.5% 3.28% +0.82
FULC Fulcrum Therapeutics Inc. Add +114.2% 0.98% +0.79
KALV Kalvista Pharmaceuticals Inc. New 0.74% +0.74
GERN Geron Corp. Add +966.7% 0.75% +0.67
CYTK Cytokinetics Inc. Add +55.7% 2.55% +0.59
PRQR Proqr Therapeutics NV New 0.59% +0.59
QURE Uniqure NV New 0.55% +0.55
VKTX Viking Therapeutics Inc. Add +100.0% 0.88% +0.48
SLN Silence Therapeutics PLC-ADR New 0.46% +0.46
WVE Wave Life Sciences Ltd. New 0.35% +0.35
IBB iShares Biotechnology ETF New 0.24% +0.24
IFRX Inflarx NV New 0.18% +0.18
VYNE THERAPEUTICS INC New 0.16% +0.16
NYXH Nyxoah SA New 0.13% +0.13
ANAB Anaptysbio Inc. New 0.12% +0.12
VERA Vera Therapeutics Inc. New 0.11% +0.11
ZYME Zymeworks Inc. New 0.10% +0.10
IMTX Immatics NV New 0.09% +0.09
AIRS Airsculpt Technologies Inc. New 0.03% +0.03
DYN Dyne Therapeutics Inc. Add +1.4% 1.15% −0.08
SRPT Sarepta Therapeutics Inc. Add +165.6% 2.54% −0.97

Options Activity Q1 2025 → Q2 2025

SPY SS SPDR S&P 500 ETF Trust-US put Sold out 320,000 $179.0Mbefore exit
LLY Eli Lilly & Co. put Sold out 150,000 $123.9Mbefore exit
CORT Corcept Therapeutics Inc. put Sold out 287,900 $32.9Mbefore exit
CDTX Cidara Therapeutics Inc. put New 501,600 $24.4M
BBIO Bridgebio Pharma Inc. call Sold out 655,400 $22.7Mbefore exit
RARE Ultragenyx Pharmaceutical Inc. call Add +397.9% 563,100 $20.5M
SLNO Soleno Therapeutics Inc. put Add +100.0% 200,000 $16.8M
SLNO Soleno Therapeutics Inc. call Reduce -17.7% 200,000 $16.8M
CDTX Cidara Therapeutics Inc. call New 321,000 $15.6M
CAPR Capricor Therapeutics Inc. put New 1,360,200 $13.5M
CORT Corcept Therapeutics Inc. call Sold out 100,000 $11.4Mbefore exit
UNIQURE NV call New 800,000 $11.2M
RARE Ultragenyx Pharmaceutical Inc. put Add +200.0% 300,000 $10.9M
PRAX Praxis Precision Medicines I call New 242,400 $10.2M
VKTX Viking Therapeutics Inc. call Add +133.3% 350,000 $9.3M
MLTX Moonlake Immunotherapeutics put Add +105.8% 194,500 $9.2M
RNAM Avidity Biosciences Inc. put Sold out 300,000 $8.9Mbefore exit
BHVN Biohaven Ltd. call Sold out 348,200 $8.4Mbefore exit
TRUP Trupanion Inc. call Sold out 200,000 $7.5Mbefore exit
ACLX Arcellx Inc. put Sold out 111,600 $7.3Mbefore exit
CAPR Capricor Therapeutics Inc. call Add +75.0% 700,000 $7.0M
IMVT Immunovant Inc. put Sold out 400,000 $6.8Mbefore exit
SRPT Sarepta Therapeutics Inc. call New 332,100 $5.7M
CYTK Cytokinetics Inc. call New 150,000 $5.0M
PTGX Protagonist Therapeutics Inc. put Sold out 100,000 $4.8Mbefore exit
PTGX Protagonist Therapeutics Inc. call Sold out 100,000 $4.8Mbefore exit
KALV Kalvista Pharmaceuticals Inc. call New 400,000 $4.5M
BIOHAVEN LTD call New 300,000 $4.2M
FULC Fulcrum Therapeutics Inc. call New 534,000 $3.7M
INCY Incyte Corp. call Sold out 60,400 $3.7Mbefore exit
VERA Vera Therapeutics Inc. call New 153,200 $3.6M
APGE Apogee Therapeutics Inc. put Add +11.9% 79,100 $3.4M
ALT Altimmune Inc. call New 827,500 $3.2M
QURE Uniqure NV call Sold out 300,000 $3.2Mbefore exit
KYMR Kymera Therapeutics Inc. call Sold out 100,000 $2.7Mbefore exit
CNTA Centessa Pharmaceuticals Ltd. call New 200,000 $2.6M
AKRO Akero Therapeutics Inc. call New 44,400 $2.4M
DYN Dyne Therapeutics Inc. call Sold out 187,000 $2.0Mbefore exit
COGT Cogent Biosciences Inc. call New 262,600 $1.9M
ARCT Arcturus Therapeutics Holdin call Sold out 150,000 $1.6Mbefore exit
HROW Harrow Inc. call Sold out 58,300 $1.6Mbefore exit
TRUP Trupanion Inc. put Sold out 40,000 $1.5Mbefore exit
CMPX Compass Therapeutics Inc. call Sold out 662,200 $1.3Mbefore exit
CMPX Compass Therapeutics Inc. put Sold out 662,200 $1.3Mbefore exit
ALT Altimmune Inc. put Sold out 240,000 $1.2Mbefore exit
CRVS Corvus Pharmaceuticals Inc. call Sold out 338,100 $1.1Mbefore exit
IMUX Immunic Inc. call Sold out 635,800 $693Kbefore exit
IRON Disc Medicine Inc. call Sold out 11,900 $591Kbefore exit
MLYS Mineralys Therapeutics Inc. call Sold out 34,300 $545Kbefore exit
KYMR Kymera Therapeutics Inc. put Reduce -94.3% 10,000 $436K

Showing the first 50 of 57.

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 126$610.9MABVX, KOD, ALMS, PRAX, PCVX
Q1 2026 127$699.0MTERN, KOD, ALMS, PCVX, PRAX
Q4 2025 135$772.6MTERN, CDTX, ABVX, JAZZ, MAZE
Q3 2025 116$494.3MGMAB, ABVX, IONS, CDTX, MAZE
Q2 2025 103$302.2MCDTX, ALNY, INSM, VRNA, CRNX
Q1 2025 116$306.9MTARS, CRNX, SPY, SRPT, BPMC
Q4 2024 122$350.2MTARS, CRNX, SRRK, BPMC, FBRX
Q3 2024 96$322.0MTARS, CRNX, ELVN, RCUS, VRDN
Q2 2024 85$320.5MSRPT, CRNX, TARS, SLNO, CRBP
Q1 2024Amended 82$367.7MCRNX, TARS, SLNO, CRBP, SRPT