Ikarian Capital, LLC

In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 18, 2026), Ikarian Capital, LLC reported 135 stock positions worth $772.6 million. Its top holding was Terns Pharmaceuticals (TERN) at 8.3% of the portfolio, followed by Cidara Therapeutics (CDTX, 7.8%) and Abivax SA-ADR (ABVX, 3.8%). Compared with Q3 2025, it opened 44 new positions, sold out of 25, added to 26 and reduced 60. The biggest buy was Terns Pharmaceuticals (TERN, shares +872%) and the biggest sale an exit from Genmab A/S -SP ADR (GMAB).

Most Recent 13F
Q2 2026
Location
DALLAS, TX
CIK
0001778253
Portfolio Value
$772.6M (Q4 2025)
SEC Filing
0001420506-26-000592 ↗ filed Feb 18, 2026

Holdings Value

0$200.0M$400.0M$600.0M$800.0M Q1 2024: $367.7M Q1 2024 Q2 2024: $320.5M Q2 2024 Q3 2024: $322.0M Q3 2024 Q4 2024: $350.2M Q4 2024 Q1 2025: $306.9M Q1 2025 Q2 2025: $302.2M Q2 2025 Q3 2025: $494.3M Q3 2025 Q4 2025: $772.6M $772.6M Q4 2025 Q1 2026: $699.0M Q1 2026 Q2 2026: $610.9M Q2 2026

Holdings 135 stocks · $772.6M

TERN Terns Pharmaceuticals Inc. 8.35% 1,596,378 $64.5M Add +872.2%
CDTX Cidara Therapeutics Inc. 7.81% 273,243 $60.4M Reduce -1.6%
ABVX Abivax SA-ADR 3.77% 205,985 $29.1M Reduce -48.0%
JAZZ Jazz Pharmaceuticals PLC 3.53% 160,367 $27.3M Add +106.1%
MAZE Maze Therapeutics Inc. 3.46% 644,680 $26.7M Reduce -13.0%
PRAX Praxis Precision Medicines I 3.30% 86,581 $25.5M Add +203.0%
RAPT Rapt Therapeutics Inc. 2.92% 665,271 $22.5M Add +8.2%
KOD Kodiak Sciences Inc. 2.60% 719,787 $20.1M Add +73.9%
OLMA Olema Pharmaceuticals Inc. 2.46% 758,654 $19.0M New
PCVX Vaxcyte Inc. 2.26% 378,682 $17.5M Add +21.5%
CAPR Capricor Therapeutics Inc. 2.16% 578,015 $16.7M Add +118.4%
IONS Ionis Pharmaceuticals Inc. 2.07% 202,038 $16.0M Reduce -51.3%
FULC Fulcrum Therapeutics Inc. 2.01% 1,375,472 $15.6M Add +6.7%
LLY Eli Lilly & Co. 1.92% 13,815 $14.8M New
RLMD Relmada Therapeutics Inc. 1.92% 3,068,359 $14.8M Add +66.5%
AMGN Amgen Inc. 1.91% 45,000 $14.7M New
CTMX Cytomx Therapeutics Inc. 1.75% 3,172,616 $13.5M Reduce -5.9%
PHVS Pharvaris NV 1.75% 486,856 $13.5M Add +131.7%
CNTB Connect Biopharma Holdings L 1.75% 4,788,486 $13.5M New
DRUG Bright Minds Biosciences Inc. 1.61% 159,421 $12.4M Add +933.1%
TENX Tenax Therapeutics Inc. 1.53% 967,600 $11.8M No change
RVMD Revolution Medicines Inc. 1.42% 138,142 $11.0M New
CYTK Cytokinetics Inc. 1.42% 172,672 $11.0M Reduce -22.5%
SPRB Spruce Biosciences Inc. 1.37% 121,356 $10.6M Add +810.3%
CELC Celcuity Inc. 1.36% 105,545 $10.5M New
ANRO Alto Neuroscience Inc. 1.19% 515,000 $9.2M Add +368.2%
PTCT PTC Therapeutics Inc. 1.17% 118,657 $9.0M Reduce -57.7%
HROW Harrow Inc. 1.16% 183,347 $9.0M New
VTYX Ventyx Biosciences Inc. 1.12% 958,704 $8.7M Reduce -26.8%
CGON CG Oncology Inc. 1.07% 199,473 $8.3M Reduce -20.0%
FBRX Forte Biosciences Inc. 1.06% 300,000 $8.2M No change
PTHS Pelthos Therapeutics Inc. 1.03% 255,758 $7.9M Add +309.5%
NBIX Neurocrine Biosciences Inc. 0.99% 54,062 $7.7M New
MLYS Mineralys Therapeutics Inc. 0.94% 200,000 $7.3M New
ACOG Alpha Cognition Inc. 0.89% 1,056,259 $6.9M Add +11.6%
DMRA Damora Therapeutics Inc. filed as GALECTO INC 0.85% 285,710 $6.6M New
IVVD Invivyd Inc. 0.85% 2,656,570 $6.6M Add +27.8%
CORT Corcept Therapeutics Inc. 0.84% 185,593 $6.5M New
NUVL Nuvalent Inc. Class A 0.78% 59,594 $6.0M New
LXEO Lexeo Therapeutics Inc. 0.66% 513,011 $5.1M Reduce -9.6%
LEGN Legend Biotech Corp.-ADR 0.64% 226,888 $4.9M New
JBIO Jade Biosciences Inc. 0.60% 300,000 $4.6M New
EPRX Eupraxia Pharmaceuticals Inc. 0.60% 610,000 $4.6M New
DCTH Delcath Systems Inc. 0.56% 431,251 $4.4M No change
CMPX Compass Therapeutics Inc. 0.56% 800,000 $4.3M New
ADMA Adma Biologics Inc. 0.55% 234,854 $4.3M Add +46.9%
ARVN Arvinas Inc. 0.55% 358,257 $4.2M Add +58.3%
ZURA Zura Bio Ltd. 0.54% 802,322 $4.2M Reduce -62.4%
KPTI Karyopharm Therapeutics Inc. 0.52% 544,554 $4.0M Add +1897.8%
KRYS Krystal Biotech Inc. 0.47% 14,814 $3.7M Reduce -39.3%
TGTX TG Therapeutics Inc. 0.45% 117,903 $3.5M Reduce -32.6%
VIR Vir Biotechnology Inc. 0.45% 575,712 $3.5M Reduce -3.0%
NXTC Nextcure Inc. 0.44% 238,303 $3.4M New
ALEC Alector Inc. 0.42% 2,082,606 $3.2M Add +174.0%
CTNM Contineum Therapeutics Inc. Class A 0.42% 282,874 $3.2M New
SLNO Soleno Therapeutics Inc. 0.41% 68,823 $3.2M Add +23.0%
AGIO Agios Pharmaceuticals Inc. 0.41% 115,489 $3.1M Reduce -9.1%
FRNM Freenome Inc. filed as PERCEPTIVE CAP SOLUTIONS COR 0.41% 240,951 $3.1M New
QNRX Quoin Pharmaceuticals LT-ADR 0.40% 211,538 $3.1M New
KLRS Kalaris Therapeutics Inc. 0.39% 360,000 $3.0M New
PRQR Proqr Therapeutics NV 0.39% 1,492,229 $3.0M Add +67.3%
PEPG Pepgen Inc. 0.38% 447,165 $2.9M Reduce -16.6%
CMPS Compass Pathways PLC 0.36% 400,000 $2.8M New
BBOT Bridgebio Oncology Therapeut 0.36% 220,231 $2.8M Reduce -10.2%
ERAS Erasca Inc. 0.35% 735,396 $2.7M New
TARS Tarsus Pharmaceuticals Inc. 0.33% 31,166 $2.6M Reduce -57.7%
GUTS Fractyl Health Inc. 0.31% 1,100,000 $2.4M Reduce -38.9%
BHVN Biohaven Ltd. 0.31% 212,481 $2.4M New
IVA Inventiva SA - ADR 0.30% 502,601 $2.3M New
NMRA Neumora Therapeutics Inc. 0.30% 1,278,408 $2.3M Add +10128.9%
CPIX Cumberland Pharmaceuticals 0.29% 555,932 $2.2M No change
QURE Uniqure NV 0.28% 91,060 $2.2M Add +55.4%
DBVT DBV Technologies SA-Spon ADR 0.27% 525,000 $2.1M New
CABA Cabaletta Bio Inc. 0.26% 900,000 $2.0M New
DERM Journey Medical Corp. 0.25% 251,436 $1.9M New
IBIO Ibio Inc. 0.24% 957,062 $1.8M Add +55.0%
APLS Apellis Pharmaceuticals Inc. 0.23% 71,747 $1.8M Reduce -84.1%
SLN Silence Therapeutics PLC-ADR 0.22% 865,784 $1.7M Reduce -3.9%
VSTM Verastem Inc. 0.21% 213,865 $1.7M New
INSM Insmed Inc. 0.21% 9,337 $1.6M Reduce -32.1%
NAMS Newamsterdam Pharma Co. NV 0.21% 45,830 $1.6M Reduce -57.1%
LPCN Lipocine Inc. 0.21% 199,542 $1.6M New
SRZN Surrozen Inc. 0.19% 65,788 $1.5M New
WVE Wave Life Sciences Ltd. 0.19% 85,285 $1.4M Reduce -11.1%
CPRX Catalyst Pharmaceuticals Inc. 0.17% 57,388 $1.3M Reduce -50.7%
LYEL Lyell Immunopharma Inc. 0.16% 41,081 $1.3M Reduce -6.2%
ANNX Annexon Inc. 0.15% 230,244 $1.2M New
HELP Cybin Inc. 0.14% 132,153 $1.1M Reduce -5.9%
STIM Neuronetics Inc. 0.13% 701,182 $968K Reduce -22.6%
SLDB Solid Biosciences Inc. 0.12% 160,409 $905K Reduce -9.2%
LABD Dire DLY SP BT Be 3X ETF-Usd 0.11% 40,822 $860K Reduce -55.6%
IOBTQ Io Biotech Inc. 0.11% 1,386,565 $844K Reduce -9.1%
MIND MEDICINE MINDMED INC 0.10% 58,803 $787K Reduce -6.2%
TRAW Traws Pharma Inc. 0.10% 678,142 $766K Add +2280.0%
PALI Palisade Bio Inc. 0.08% 274,978 $646K New
KZR Kezar Life Sciences Inc. 0.08% 102,211 $643K Reduce -4.4%
KALV Kalvista Pharmaceuticals Inc. 0.07% 35,119 $567K New
AVTX Avalo Therapeutics Inc. 0.07% 31,106 $565K Reduce -80.5%
ABOS Acumen Pharmaceuticals Inc. 0.07% 254,312 $537K Reduce -4.3%
SGMOQ Sangamo Therapeutics Inc. 0.07% 1,218,671 $512K Reduce -5.9%

Show all 135 holdings

Options reported separately and not counted above: XBI puts ($103.6M), CDTX puts ($66.3M), AMGN puts ($65.5M), JAZZ PHARMACEUTICALS PLC calls ($28.9M), HROW calls ($25.0M), SLNO calls ($24.5M), CYTK calls ($18.5M), CRNX puts ($17.2M), ABVX calls ($16.9M), OMER puts ($16.3M), RAPT calls ($9.8M), OMER calls ($9.4M), and 27 more.

Portfolio Sells Q3 2025 → Q4 2025

GMAB Genmab A/S -SP ADR Sold out 0.00% −10.73
IONS Ionis Pharmaceuticals Inc. Reduce -51.3% 2.07% −3.43
ABVX Abivax SA-ADR Reduce -48.0% 3.77% −2.99
DNTH Dianthus Therapeutics Inc. Sold out 0.00% −2.75
PTCT PTC Therapeutics Inc. Reduce -57.7% 1.17% −2.32
AKRO Akero Therapeutics Inc. Sold out 0.00% −1.99
APLS Apellis Pharmaceuticals Inc. Reduce -84.1% 0.23% −1.84
ZURA Zura Bio Ltd. Reduce -62.4% 0.54% −1.32
CRNX Crinetics Pharmaceuticals Inc. Sold out 0.00% −1.10
VRDN Viridian Therapeutics Inc. Sold out 0.00% −1.07
CYTK Cytokinetics Inc. Reduce -22.5% 1.42% −1.06
SNDX Syndax Pharmaceuticals Inc. Sold out 0.00% −1.04
CGON CG Oncology Inc. Reduce -20.0% 1.07% −0.96
TVTX Travere Therapeutics Inc. Sold out 0.00% −0.92
GPCR Structure Therapeutics Inc. Reduce -97.0% 0.04% −0.88
ARGX Argenx SE - ADR Sold out 0.00% −0.87
TGTX TG Therapeutics Inc. Reduce -32.6% 0.45% −0.82
PVLA Palvella Therapeutics Inc. Sold out 0.00% −0.82
LABD Dire DLY SP BT Be 3X ETF-Usd Reduce -55.6% 0.11% −0.64
MLTX Moonlake Immunotherapeutics Sold out 0.00% −0.63
AGIO Agios Pharmaceuticals Inc. Reduce -9.1% 0.41% −0.62
UPB Upstream Bio Inc. Sold out 0.00% −0.61
TARS Tarsus Pharmaceuticals Inc. Reduce -57.7% 0.33% −0.55
BBIO Bridgebio Pharma Inc. Sold out 0.00% −0.55
RLAY Relay Therapeutics Inc. Sold out 0.00% −0.49
MAZE Maze Therapeutics Inc. Reduce -13.0% 3.46% −0.43
CTMX Cytomx Therapeutics Inc. Reduce -5.9% 1.75% −0.43
NAMS Newamsterdam Pharma Co. NV Reduce -57.1% 0.21% −0.41
VTGN Vistagen Therapeutics Inc. Reduce -16.4% 0.04% −0.40
KRYS Krystal Biotech Inc. Reduce -39.3% 0.47% −0.40
STIM Neuronetics Inc. Reduce -22.6% 0.13% −0.38
AVTX Avalo Therapeutics Inc. Reduce -80.5% 0.07% −0.34
ANAB Anaptysbio Inc. Sold out 0.00% −0.30
DYN Dyne Therapeutics Inc. Sold out 0.00% −0.29
CPRX Catalyst Pharmaceuticals Inc. Reduce -50.7% 0.17% −0.29
JANX Janux Therapeutics Inc. Sold out 0.00% −0.27
GUTS Fractyl Health Inc. Reduce -38.9% 0.31% −0.27
ZYME Zymeworks Inc. Sold out 0.00% −0.25
VIR Vir Biotechnology Inc. Reduce -3.0% 0.45% −0.24
OVID Ovid Therapeutics Inc. Reduce -77.4% 0.05% −0.24
BBOT Bridgebio Oncology Therapeut Reduce -10.2% 0.36% −0.22
IFRX Inflarx NV Sold out 0.00% −0.20
INSM Insmed Inc. Reduce -32.1% 0.21% −0.19
MBX MBX Biosciences Inc. Sold out 0.00% −0.17
PRME Prime Medicine Inc. Sold out 0.00% −0.17
SONN Sonnet Biotherapeutics Holdi Sold out 0.00% −0.14
PEPG Pepgen Inc. Reduce -16.6% 0.38% −0.12
IMUX Immunic Inc. Reduce -26.2% 0.05% −0.12
SGMOQ Sangamo Therapeutics Inc. Reduce -5.9% 0.07% −0.11
SLDB Solid Biosciences Inc. Reduce -9.2% 0.12% −0.10

Portfolio Buys Q3 2025 → Q4 2025

TERN Terns Pharmaceuticals Inc. Add +872.2% 8.35% +8.10
PRAX Praxis Precision Medicines I Add +203.0% 3.30% +3.00
OLMA Olema Pharmaceuticals Inc. New 2.46% +2.46
LLY Eli Lilly & Co. New 1.92% +1.92
AMGN Amgen Inc. New 1.91% +1.91
CAPR Capricor Therapeutics Inc. Add +118.4% 2.16% +1.77
CNTB Connect Biopharma Holdings L New 1.75% +1.75
JAZZ Jazz Pharmaceuticals PLC Add +106.1% 3.53% +1.45
RVMD Revolution Medicines Inc. New 1.42% +1.42
DRUG Bright Minds Biosciences Inc. Add +933.1% 1.61% +1.42
CELC Celcuity Inc. New 1.36% +1.36
SPRB Spruce Biosciences Inc. Add +810.3% 1.37% +1.34
KOD Kodiak Sciences Inc. Add +73.9% 2.60% +1.23
RLMD Relmada Therapeutics Inc. Add +66.5% 1.92% +1.17
HROW Harrow Inc. New 1.16% +1.16
ANRO Alto Neuroscience Inc. Add +368.2% 1.19% +1.10
NBIX Neurocrine Biosciences Inc. New 0.99% +0.99
MLYS Mineralys Therapeutics Inc. New 0.94% +0.94
DMRA Damora Therapeutics Inc. New 0.85% +0.85
CORT Corcept Therapeutics Inc. New 0.84% +0.84
NUVL Nuvalent Inc. Class A New 0.78% +0.78
PHVS Pharvaris NV Add +131.7% 1.75% +0.69
PTHS Pelthos Therapeutics Inc. Add +309.5% 1.03% +0.67
LEGN Legend Biotech Corp.-ADR New 0.64% +0.64
JBIO Jade Biosciences Inc. New 0.60% +0.60
EPRX Eupraxia Pharmaceuticals Inc. New 0.60% +0.60
CMPX Compass Therapeutics Inc. New 0.56% +0.56
KPTI Karyopharm Therapeutics Inc. Add +1897.8% 0.52% +0.48
NXTC Nextcure Inc. New 0.44% +0.44
CTNM Contineum Therapeutics Inc. Class A New 0.42% +0.42
FRNM Freenome Inc. New 0.41% +0.41
QNRX Quoin Pharmaceuticals LT-ADR New 0.40% +0.40
KLRS Kalaris Therapeutics Inc. New 0.39% +0.39
IVVD Invivyd Inc. Add +27.8% 0.85% +0.39
CMPS Compass Pathways PLC New 0.36% +0.36
ERAS Erasca Inc. New 0.35% +0.35
BHVN Biohaven Ltd. New 0.31% +0.31
IVA Inventiva SA - ADR New 0.30% +0.30
NMRA Neumora Therapeutics Inc. Add +10128.9% 0.30% +0.29
DBVT DBV Technologies SA-Spon ADR New 0.27% +0.27
CABA Cabaletta Bio Inc. New 0.26% +0.26
DERM Journey Medical Corp. New 0.25% +0.25
VSTM Verastem Inc. New 0.21% +0.21
LPCN Lipocine Inc. New 0.21% +0.21
SRZN Surrozen Inc. New 0.19% +0.19
ARVN Arvinas Inc. Add +58.3% 0.55% +0.16
ANNX Annexon Inc. New 0.15% +0.15
IBIO Ibio Inc. Add +55.0% 0.24% +0.14
TRAW Traws Pharma Inc. Add +2280.0% 0.10% +0.09
PALI Palisade Bio Inc. New 0.08% +0.08

Options Activity Q3 2025 → Q4 2025

XBI SS SPDR S&P Biotech ETF put Add +13.3% 850,000 $103.6M
UTHR United Therapeutics Corp. put Sold out 209,800 $88.0Mbefore exit
CDTX Cidara Therapeutics Inc. put New 300,000 $66.3M
AMGN Amgen Inc. put New 200,000 $65.5M
BMY Bristol-Myers Squibb Co. put Sold out 800,000 $36.1Mbefore exit
JAZZ PHARMACEUTICALS PLC call Add +140.4% 170,000 $28.9M
HROW Harrow Inc. call Add +75.9% 509,700 $25.0M
SLNO Soleno Therapeutics Inc. call Add +200.3% 528,900 $24.5M
SRRK Scholar Rock Holding Corp. call Sold out 561,600 $20.9Mbefore exit
CYTK Cytokinetics Inc. call Add +162.3% 290,900 $18.5M
CRNX Crinetics Pharmaceuticals Inc. put New 368,500 $17.2M
ABVX Abivax SA-ADR call New 125,100 $16.9M
OMER Omeros Corp. put New 950,000 $16.3M
INSM Insmed Inc. put Sold out 100,000 $14.4Mbefore exit
PTCT PTC Therapeutics Inc. call Sold out 213,000 $13.1Mbefore exit
BIOHAVEN LTD call Sold out 796,400 $12.0Mbefore exit
CRNX Crinetics Pharmaceuticals Inc. call Sold out 257,700 $10.7Mbefore exit
RAPT Rapt Therapeutics Inc. call Add +65.7% 290,000 $9.8M
OMER Omeros Corp. call New 550,000 $9.4M
DXCM Dexcom Inc. call New 137,500 $9.1M
NVO Novo-Nordisk A/S-Spons ADR call Sold out 150,000 $8.3Mbefore exit
CORT Corcept Therapeutics Inc. put New 236,700 $8.2M
APLS Apellis Pharmaceuticals Inc. call Reduce -9.1% 325,600 $8.2M
IONS Ionis Pharmaceuticals Inc. call Add +611.3% 94,600 $7.5M
CNTA Centessa Pharmaceuticals Ltd. call Sold out 307,700 $7.5Mbefore exit
NBIX Neurocrine Biosciences Inc. call New 51,000 $7.2M
ANIP Ani Pharmaceuticals Inc. call New 82,800 $6.5M
RARE Ultragenyx Pharmaceutical Inc. put Add +175.5% 255,100 $5.9M
RARE Ultragenyx Pharmaceutical Inc. call New 250,000 $5.8M
CORT Corcept Therapeutics Inc. call New 163,800 $5.7M
SPRY Ars Pharmaceuticals Inc. call Sold out 562,400 $5.7Mbefore exit
PRAX Praxis Precision Medicines I call Sold out 100,000 $5.3Mbefore exit
OLMA Olema Pharmaceuticals Inc. call New 200,000 $5.0M
ANAB Anaptysbio Inc. call Sold out 161,100 $4.9Mbefore exit
ANAB Anaptysbio Inc. put Sold out 161,100 $4.9Mbefore exit
KALV Kalvista Pharmaceuticals Inc. call Sold out 400,000 $4.9Mbefore exit
LQDA Liquidia Corp. call Sold out 200,000 $4.5Mbefore exit
MTSR Metsera Inc. put Sold out 86,000 $4.5Mbefore exit
MTSR Metsera Inc. call Sold out 86,000 $4.5Mbefore exit
MLTX Moonlake Immunotherapeutics call Sold out 612,200 $4.4Mbefore exit
ARCT Arcturus Therapeutics Holdin call Sold out 227,200 $4.2Mbefore exit
TEVA Teva Pharmaceutical-SP ADR call Sold out 200,000 $4.0Mbefore exit
ALT Altimmune Inc. call Sold out 1,000,000 $3.8Mbefore exit
AGIO Agios Pharmaceuticals Inc. call Reduce -8.5% 137,200 $3.7M
SRRK Scholar Rock Holding Corp. put Sold out 96,200 $3.6Mbefore exit
MBX MBX Biosciences Inc. put Sold out 200,000 $3.5Mbefore exit
MBX MBX Biosciences Inc. call Sold out 200,000 $3.5Mbefore exit
SLNO Soleno Therapeutics Inc. put Sold out 50,000 $3.4Mbefore exit
AQST Aquestive Therapeutics Inc. put New 500,000 $3.2M
MLTX Moonlake Immunotherapeutics put Sold out 450,000 $3.2Mbefore exit

Showing the first 50 of 76.

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 126$610.9MABVX, KOD, ALMS, PRAX, PCVX
Q1 2026 127$699.0MTERN, KOD, ALMS, PCVX, PRAX
Q4 2025 135$772.6MTERN, CDTX, ABVX, JAZZ, MAZE
Q3 2025 116$494.3MGMAB, ABVX, IONS, CDTX, MAZE
Q2 2025 103$302.2MCDTX, ALNY, INSM, VRNA, CRNX
Q1 2025 116$306.9MTARS, CRNX, SPY, SRPT, BPMC
Q4 2024 122$350.2MTARS, CRNX, SRRK, BPMC, FBRX
Q3 2024 96$322.0MTARS, CRNX, ELVN, RCUS, VRDN
Q2 2024 85$320.5MSRPT, CRNX, TARS, SLNO, CRBP
Q1 2024Amended 82$367.7MCRNX, TARS, SLNO, CRBP, SRPT