MPM Asset Management LLC

In its 13F for Q1 2024 (holdings as of March 31, 2024, filed May 15, 2024), MPM Asset Management LLC reported 6 stock positions worth $245.2 million. Its top holding was Dyne Therapeutics (DYN) at 40.0% of the portfolio, followed by Entrada Therapeutics (TRDA, 25.6%) and Iteos Therapeutics (ITOS, 15.2%). Compared with Q4 2023, it sold out of 1 and reduced 1. The biggest sale was an exit from Harpoon Therapeutics (HARP).

Most Recent 13F
Q3 2025
Location
BOSTON, MA
CIK
0001263048
Portfolio Value
$245.2M (Q1 2024)
SEC Filing
0000950123-24-005709 ↗ filed May 15, 2024

Holdings Value

0$50.0M$100.0M$150.0M$200.0M$250.0M Q1 2024: $245.2M $245.2M Q1 2024 Q2 2024: $182.1M Q2 2024 Q3 2024: $145.3M Q3 2024 Q4 2024: $124.4M Q4 2024 Q1 2025: $69.4M Q1 2025 Q2 2025: $43.3M Q2 2025 Q3 2025: $44.5M Q3 2025

Holdings 6 stocks · $245.2M

DYN Dyne Therapeutics Inc. 39.97% 3,451,303 $98.0M Reduce -30.3%
TRDA Entrada Therapeutics Inc. 25.58% 4,425,784 $62.7M No change
ITOS Iteos Therapeutics Inc. 15.24% 2,738,785 $37.4M No change
HOWL Werewolf Therapeutics Inc. 11.32% 4,284,172 $27.8M No change
RPTX Repare Therapeutics Inc. 4.31% 2,242,636 $10.6M No change
ADAPY Adaptimmune Therapeutics-ADR 3.58% 5,555,461 $8.8M No change

Portfolio Sells Q4 2023 → Q1 2024

HARP Harpoon Therapeutics Inc. Sold out 0.00% −1.75
DYN Dyne Therapeutics Inc. Reduce -30.3% 39.97% +7.61

Portfolio Buys Q4 2023 → Q1 2024

None this quarter.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q3 2025 4$44.5MTRDA, DYN, HOWL, RPTX
Q2 2025 5$43.3MTRDA, DYN, HOWL, RPTX, ADAPY
Q1 2025 6$69.4MTRDA, ITOS, DYN, HOWL, RPTX
Q4 2024 6$124.4MTRDA, ITOS, DYN, HOWL, ADAPY
Q3 2024 6$145.3MTRDA, ITOS, DYN, HOWL, RPTX
Q2 2024 6$182.1MTRDA, DYN, ITOS, HOWL, RPTX
Q1 2024 6$245.2MDYN, TRDA, ITOS, HOWL, RPTX