Sectoral Asset Management Inc.
In its 13F for Q1 2025 (holdings as of March 31, 2025, filed May 15, 2025), Sectoral Asset Management Inc. reported 84 stock positions worth $128.5 million. Its top holding was Lenz Therapeutics (LENZ) at 19.6% of the portfolio, followed by Eli Lilly (LLY, 6.1%) and Unitedhealth (UNH, 5.3%). Compared with Q4 2024, it opened 13 new positions, sold out of 15, added to 31 and reduced 37. The biggest buy was Intuitive Surgical (ISRG, shares +72%) and the biggest sale an exit from Sarepta Therapeutics (SRPT).
- Most Recent 13F
- Q2 2026
- Location
- MONTREAL, A8
- CIK
- 0001274413
- Portfolio Value
- $128.5M (Q1 2025)
- SEC Filing
- 0001104659-25-049125 ↗ filed May 15, 2025
Holdings Value
Holdings 84 stocks · $128.5M
| LENZ Lenz Therapeutics Inc. | 19.56% | 977,245 | $25.1M | No change |
| LLY Eli Lilly & Co. | 6.05% | 9,416 | $7.8M | Reduce -24.9% |
| UNH Unitedhealth Group Inc. | 5.26% | 12,895 | $6.8M | Reduce -11.8% |
| MLYS Mineralys Therapeutics Inc. | 4.58% | 370,513 | $5.9M | Reduce -2.7% |
| CTNM Contineum Therapeutics Inc. Class A | 4.35% | 800,787 | $5.6M | No change |
| JNJ Johnson & Johnson | 2.81% | 21,800 | $3.6M | Reduce -4.8% |
| GILD Gilead Sciences Inc. | 2.79% | 32,020 | $3.6M | Reduce -37.6% |
| AMGN Amgen Inc. | 2.52% | 10,385 | $3.2M | Reduce -17.3% |
| ABBV Abbvie Inc. | 2.41% | 14,800 | $3.1M | Reduce -21.3% |
| ISRG Intuitive Surgical Inc. | 2.02% | 5,250 | $2.6M | Add +72.1% |
| ABT Abbott Laboratories | 1.93% | 18,698 | $2.5M | Reduce -23.4% |
| BSX Boston Scientific Corp. | 1.90% | 24,226 | $2.4M | Reduce -25.5% |
| MRK Merck & Co. Inc. | 1.88% | 26,900 | $2.4M | Add +9.8% |
| VRTX Vertex Pharmaceuticals Inc. | 1.78% | 4,725 | $2.3M | Add +28.8% |
| SYK Stryker Corp. | 1.77% | 6,100 | $2.3M | Reduce -4.7% |
| DHR Danaher Corp. | 1.69% | 10,575 | $2.2M | Add +45.4% |
| MDT Medtronic PLC | 1.67% | 23,850 | $2.1M | Reduce -9.5% |
| ARGX Argenx SE - ADR | 1.43% | 3,103 | $1.8M | Reduce -9.5% |
| REGN Regeneron Pharmaceuticals | 1.37% | 2,773 | $1.8M | Reduce -18.4% |
| BMRN Biomarin Pharmaceutical Inc. | 1.29% | 23,530 | $1.7M | Reduce -20.0% |
| TMO Thermo Fisher Scientific Inc. | 1.26% | 3,250 | $1.6M | Reduce -31.6% |
| BNTX Biontech SE-ADR | 1.22% | 17,175 | $1.6M | Reduce -9.4% |
| PFE Pfizer Inc. | 1.18% | 59,650 | $1.5M | Reduce -23.2% |
| ALNY Alnylam Pharmaceuticals Inc. | 1.09% | 5,205 | $1.4M | Reduce -37.3% |
| AZN Astrazeneca PLC-Spons ADR | 1.07% | 18,790 | $1.4M | Add +28.3% |
| SMMT Summit Therapeutics Inc. | 1.04% | 69,240 | $1.3M | Add +130.8% |
| SPRY Ars Pharmaceuticals Inc. | 0.98% | 100,205 | $1.3M | Reduce -5.5% |
| LEGN Legend Biotech Corp.-ADR | 0.95% | 35,965 | $1.2M | Add +20.7% |
| THC Tenet Healthcare Corp. | 0.94% | 9,000 | $1.2M | New |
| BMY Bristol-Myers Squibb Co. | 0.93% | 19,500 | $1.2M | Reduce -55.7% |
| INSM Insmed Inc. | 0.90% | 15,230 | $1.2M | Add +106.6% |
| SWTX Springworks Therapeutics Inc. | 0.87% | 25,325 | $1.1M | Add +360.4% |
| ZLAB Zai Lab Ltd.-ADR | 0.84% | 29,920 | $1.1M | Reduce -33.2% |
| BOLD Boundless Bio Inc. | 0.80% | 678,574 | $1.0M | No change |
| DXCM Dexcom Inc. | 0.80% | 15,000 | $1.0M | New |
| BPMC Blueprint Medicines Corp. | 0.77% | 11,235 | $994K | Reduce -10.6% |
| RDNT Radnet Inc. | 0.77% | 20,000 | $994K | New |
| TARS Tarsus Pharmaceuticals Inc. | 0.69% | 17,250 | $886K | Reduce -15.0% |
| FOLD Amicus Therapeutics Inc. | 0.68% | 107,585 | $878K | Reduce -20.7% |
| PHR Phreesia Inc. | 0.68% | 34,000 | $869K | New |
| CVRX CVRX Inc. | 0.65% | 68,500 | $838K | New |
| ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD | 0.62% | 2,927 | $797K | Add +45.6% |
| PCVX Vaxcyte Inc. | 0.62% | 21,040 | $794K | Add +11.0% |
| CYTK Cytokinetics Inc. | 0.57% | 18,068 | $726K | Reduce -26.3% |
| ICLR Icon PLC | 0.54% | 4,000 | $700K | New |
| VERA Vera Therapeutics Inc. | 0.53% | 28,348 | $681K | Add +397.3% |
| CLOV Clover Health Investments Co. | 0.51% | 183,000 | $657K | Reduce -33.5% |
| ELV Elevance Health Inc. | 0.51% | 1,500 | $652K | New |
| QURE Uniqure NV | 0.47% | 57,550 | $610K | Reduce -19.5% |
| MLTX Moonlake Immunotherapeutics | 0.46% | 15,108 | $590K | Reduce -36.2% |
| GPCR Structure Therapeutics Inc. | 0.45% | 33,695 | $583K | Reduce -31.6% |
| BBIO Bridgebio Pharma Inc. | 0.43% | 16,085 | $556K | Add +39.9% |
| TRVI Trevi Therapeutics Inc. | 0.40% | 81,800 | $515K | New |
| ROIV Roivant Sciences Ltd. | 0.38% | 48,907 | $493K | Add +41.8% |
| COGT Cogent Biosciences Inc. | 0.37% | 79,020 | $473K | Add +7.1% |
| PTCT PTC Therapeutics Inc. | 0.33% | 8,350 | $426K | Add +44.0% |
| BIIB Biogen Inc. | 0.30% | 2,855 | $391K | Reduce -25.9% |
| INCY Incyte Corp. | 0.29% | 6,145 | $372K | Add +145.8% |
| SGOV iShares 0-3 Month Treasury B | 0.28% | 3,589 | $361K | Reduce -55.1% |
| ASND Ascendis Pharma A/S | 0.25% | 2,091 | $326K | Add +30.7% |
| NBIX Neurocrine Biosciences Inc. | 0.25% | 2,905 | $321K | Reduce -75.4% |
| RCKT Rocket Pharmaceuticals Inc. | 0.23% | 44,383 | $296K | Add +10.4% |
| ILMN Illumina Inc. | 0.23% | 3,682 | $292K | Reduce -15.7% |
| RPRX Royalty Pharma PLC Class A | 0.22% | 9,280 | $289K | Add +28.9% |
| IONS Ionis Pharmaceuticals Inc. | 0.22% | 9,440 | $285K | Add +31.1% |
| JAZZ Jazz Pharmaceuticals PLC | 0.22% | 2,274 | $282K | Add +29.9% |
| MDGL Madrigal Pharmaceuticals Inc. | 0.19% | 730 | $242K | Add +28.1% |
| UTHR United Therapeutics Corp. | 0.18% | 765 | $236K | Add +28.6% |
| RVMD Revolution Medicines Inc. | 0.17% | 6,240 | $221K | Add +27.4% |
| RCUS Arcus Biosciences Inc. | 0.16% | 26,870 | $211K | Reduce -61.4% |
| NVO Novo-Nordisk A/S-Spons ADR | 0.15% | 2,850 | $198K | Add +29.6% |
| CRNX Crinetics Pharmaceuticals Inc. | 0.15% | 5,710 | $192K | Add +29.8% |
| AVBP Arrivent Biopharma Inc. | 0.15% | 10,090 | $187K | New |
| VTRS Viatris Inc. | 0.13% | 19,800 | $172K | Add +26.9% |
| MEDP Medpace Holdings Inc. | 0.13% | 531 | $162K | Reduce -36.0% |
| MRNA Moderna Inc. | 0.12% | 5,600 | $159K | Add +28.7% |
| AXSM Axsome Therapeutics Inc. | 0.09% | 1,020 | $119K | Add +24.4% |
| ORIC Oric Pharmaceuticals Inc. | 0.09% | 20,000 | $112K | New |
| TEM Tempus AI Inc. Class A | 0.08% | 2,160 | $104K | New |
| IOBTQ Io Biotech Inc. | 0.08% | 95,000 | $104K | Add +26.7% |
| ARVN Arvinas Inc. | 0.07% | 12,930 | $91K | Reduce -57.1% |
| CRSP Crispr Therapeutics AG | 0.07% | 2,540 | $86K | New |
| RXRX Recursion Pharmaceuticals-A | 0.05% | 11,500 | $61K | New |
| ENGN Engene Holdings Inc. | 0.04% | 11,700 | $52K | Reduce -85.2% |
Portfolio Sells Q4 2024 → Q1 2025
| SRPT Sarepta Therapeutics Inc. | Sold out | 0.00% | −0.89 |
| NBIX Neurocrine Biosciences Inc. | Reduce -75.4% | 0.25% | −0.82 |
| HCAT Health Catalyst Inc. | Sold out | 0.00% | −0.76 |
| BMY Bristol-Myers Squibb Co. | Reduce -55.7% | 0.93% | −0.74 |
| PRVA Privia Health Group Inc. | Sold out | 0.00% | −0.68 |
| CVS CVS Health Corp. | Sold out | 0.00% | −0.66 |
| RCUS Arcus Biosciences Inc. | Reduce -61.4% | 0.16% | −0.53 |
| NARI Inari Medical Inc. | Sold out | 0.00% | −0.52 |
| GPCR Structure Therapeutics Inc. | Reduce -31.6% | 0.45% | −0.44 |
| CI The Cigna Group | Sold out | 0.00% | −0.41 |
| LLY Eli Lilly & Co. | Reduce -24.9% | 6.05% | −0.41 |
| IOVA Iovance Biotherapeutics Inc. | Sold out | 0.00% | −0.40 |
| MLTX Moonlake Immunotherapeutics | Reduce -36.2% | 0.46% | −0.40 |
| TMO Thermo Fisher Scientific Inc. | Reduce -31.6% | 1.26% | −0.39 |
| EW Edwards Lifesciences Corp. | Sold out | 0.00% | −0.39 |
| GILD Gilead Sciences Inc. | Reduce -37.6% | 2.79% | −0.37 |
| QURE Uniqure NV | Reduce -19.5% | 0.47% | −0.37 |
| ARVN Arvinas Inc. | Reduce -57.1% | 0.07% | −0.32 |
| ENGN Engene Holdings Inc. | Reduce -85.2% | 0.04% | −0.31 |
| ITCI Intra-Cellular Therapies Inc. | Sold out | 0.00% | −0.27 |
| HUM Humana Inc. | Sold out | 0.00% | −0.27 |
| SGOV iShares 0-3 Month Treasury B | Reduce -55.1% | 0.28% | −0.25 |
| REGN Regeneron Pharmaceuticals | Reduce -18.4% | 1.37% | −0.25 |
| OLMA Olema Pharmaceuticals Inc. | Sold out | 0.00% | −0.24 |
| BNTX Biontech SE-ADR | Reduce -9.4% | 1.22% | −0.22 |
| ALNY Alnylam Pharmaceuticals Inc. | Reduce -37.3% | 1.09% | −0.21 |
| CYTK Cytokinetics Inc. | Reduce -26.3% | 0.57% | −0.20 |
| PFE Pfizer Inc. | Reduce -23.2% | 1.18% | −0.20 |
| TSBX Turnstone Biologics Corp. | Sold out | 0.00% | −0.17 |
| FOLD Amicus Therapeutics Inc. | Reduce -20.7% | 0.68% | −0.17 |
| ILMN Illumina Inc. | Reduce -15.7% | 0.23% | −0.16 |
| GERN Geron Corp. | Sold out | 0.00% | −0.15 |
| BIIB Biogen Inc. | Reduce -25.9% | 0.30% | −0.09 |
| CRGX Cargo Therapeutics Inc. | Sold out | 0.00% | −0.08 |
| EXEL Exelixis Inc. | Sold out | 0.00% | −0.08 |
| CLOV Clover Health Investments Co. | Reduce -33.5% | 0.51% | −0.07 |
| TARS Tarsus Pharmaceuticals Inc. | Reduce -15.0% | 0.69% | −0.06 |
| MEDP Medpace Holdings Inc. | Reduce -36.0% | 0.13% | −0.06 |
| BSX Boston Scientific Corp. | Reduce -25.5% | 1.90% | −0.04 |
| BMRN Biomarin Pharmaceutical Inc. | Reduce -20.0% | 1.29% | +0.00 |
| ARGX Argenx SE - ADR | Reduce -9.5% | 1.43% | +0.02 |
| BPMC Blueprint Medicines Corp. | Reduce -10.6% | 0.77% | +0.04 |
| ZLAB Zai Lab Ltd.-ADR | Reduce -33.2% | 0.84% | +0.06 |
| ABT Abbott Laboratories | Reduce -23.4% | 1.93% | +0.09 |
| ABBV Abbvie Inc. | Reduce -21.3% | 2.41% | +0.18 |
| SYK Stryker Corp. | Reduce -4.7% | 1.77% | +0.23 |
| SPRY Ars Pharmaceuticals Inc. | Reduce -5.5% | 0.98% | +0.23 |
| MDT Medtronic PLC | Reduce -9.5% | 1.67% | +0.25 |
| UNH Unitedhealth Group Inc. | Reduce -11.8% | 5.26% | +0.32 |
| AMGN Amgen Inc. | Reduce -17.3% | 2.52% | +0.34 |
Portfolio Buys Q4 2024 → Q1 2025
| ISRG Intuitive Surgical Inc. | Add +72.1% | 2.02% | +0.96 |
| THC Tenet Healthcare Corp. | New | 0.94% | +0.94 |
| DXCM Dexcom Inc. | New | 0.80% | +0.80 |
| VRTX Vertex Pharmaceuticals Inc. | Add +28.8% | 1.78% | +0.80 |
| RDNT Radnet Inc. | New | 0.77% | +0.77 |
| SWTX Springworks Therapeutics Inc. | Add +360.4% | 0.87% | +0.74 |
| SMMT Summit Therapeutics Inc. | Add +130.8% | 1.04% | +0.68 |
| PHR Phreesia Inc. | New | 0.68% | +0.68 |
| CVRX CVRX Inc. | New | 0.65% | +0.65 |
| DHR Danaher Corp. | Add +45.4% | 1.69% | +0.57 |
| INSM Insmed Inc. | Add +106.6% | 0.90% | +0.56 |
| ICLR Icon PLC | New | 0.54% | +0.54 |
| ELV Elevance Health Inc. | New | 0.51% | +0.51 |
| AZN Astrazeneca PLC-Spons ADR | Add +28.3% | 1.07% | +0.43 |
| TRVI Trevi Therapeutics Inc. | New | 0.40% | +0.40 |
| ONC Beone Medicines Ltd.-ADR | Add +45.6% | 0.62% | +0.37 |
| VERA Vera Therapeutics Inc. | Add +397.3% | 0.53% | +0.37 |
| LEGN Legend Biotech Corp.-ADR | Add +20.7% | 0.95% | +0.30 |
| MRK Merck & Co. Inc. | Add +9.8% | 1.88% | +0.25 |
| BBIO Bridgebio Pharma Inc. | Add +39.9% | 0.43% | +0.22 |
| INCY Incyte Corp. | Add +145.8% | 0.29% | +0.17 |
| PTCT PTC Therapeutics Inc. | Add +44.0% | 0.33% | +0.16 |
| AVBP Arrivent Biopharma Inc. | New | 0.15% | +0.15 |
| ROIV Roivant Sciences Ltd. | Add +41.8% | 0.38% | +0.11 |
| ASND Ascendis Pharma A/S | Add +30.7% | 0.25% | +0.11 |
| RPRX Royalty Pharma PLC Class A | Add +28.9% | 0.22% | +0.10 |
| ORIC Oric Pharmaceuticals Inc. | New | 0.09% | +0.09 |
| TEM Tempus AI Inc. Class A | New | 0.08% | +0.08 |
| JAZZ Jazz Pharmaceuticals PLC | Add +29.9% | 0.22% | +0.08 |
| MDGL Madrigal Pharmaceuticals Inc. | Add +28.1% | 0.19% | +0.07 |
| CRSP Crispr Therapeutics AG | New | 0.07% | +0.07 |
| IONS Ionis Pharmaceuticals Inc. | Add +31.1% | 0.22% | +0.05 |
| RXRX Recursion Pharmaceuticals-A | New | 0.05% | +0.05 |
| AXSM Axsome Therapeutics Inc. | Add +24.4% | 0.09% | +0.05 |
| UTHR United Therapeutics Corp. | Add +28.6% | 0.18% | +0.04 |
| IOBTQ Io Biotech Inc. | Add +26.7% | 0.08% | +0.03 |
| RVMD Revolution Medicines Inc. | Add +27.4% | 0.17% | +0.03 |
| NVO Novo-Nordisk A/S-Spons ADR | Add +29.6% | 0.15% | +0.03 |
| VTRS Viatris Inc. | Add +26.9% | 0.13% | +0.00 |
| MRNA Moderna Inc. | Add +28.7% | 0.12% | +0.00 |
| CRNX Crinetics Pharmaceuticals Inc. | Add +29.8% | 0.15% | −0.00 |
| COGT Cogent Biosciences Inc. | Add +7.1% | 0.37% | −0.02 |
| RCKT Rocket Pharmaceuticals Inc. | Add +10.4% | 0.23% | −0.11 |
| PCVX Vaxcyte Inc. | Add +11.0% | 0.62% | −0.42 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 82 | $143.3M | CTNM, SI, LLY, UNH, JNJ |
| Q1 2026 | 77 | $120.7M | EVMN, CTNM, SI, LLY, JNJ |
| Q4 2025 | 74 | $124.8M | EVMN, CTNM, LLY, SI, UNH |
| Q3 2025 | 82 | $162.0M | CTNM, LLY, GPCR, ANAB, SI |
| Q2 2025 | 94 | $151.5M | LENZ, LLY, UNH, MLYS, CTNM |
| Q1 2025 | 84 | $128.5M | LENZ, LLY, UNH, MLYS, CTNM |
| Q4 2024 | 86 | $149.8M | LENZ, CTNM, LLY, UNH, GILD |
| Q3 2024 | 90 | $169.3M | LENZ, CTNM, LLY, UNH, GILD |
| Q2 2024 | 97 | $246.1M | LLY, LENZ, CTNM, UNH, MRK |
| Q1 2024 | 92 | $254.4M | LENZ, LLY, BOLD, UNH, MRK |