Sectoral Asset Management Inc.
In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 9, 2026), Sectoral Asset Management Inc. reported 74 stock positions worth $124.8 million. Its top holding was Evommune (EVMN) at 8.1% of the portfolio, followed by Contineum Therapeutics Class A (CTNM, 7.3%) and Eli Lilly (LLY, 6.3%). Compared with Q3 2025, it opened 6 new positions, sold out of 14, added to 20 and reduced 44. The biggest buy was a new position in Evommune (EVMN) and the biggest sale an exit from Anaptysbio (ANAB).
- Most Recent 13F
- Q2 2026
- Location
- MONTREAL, A8
- CIK
- 0001274413
- Portfolio Value
- $124.8M (Q4 2025)
- SEC Filing
- 0001104659-26-011921 ↗ filed Feb 9, 2026
Holdings Value
Holdings 74 stocks · $124.8M
| EVMN Evommune Inc. | 8.08% | 589,005 | $10.1M | New |
| CTNM Contineum Therapeutics Inc. Class A | 7.34% | 800,787 | $9.2M | No change |
| LLY Eli Lilly & Co. | 6.27% | 7,276 | $7.8M | Reduce -22.4% |
| SI Shoulder Innovations Inc. | 5.64% | 492,435 | $7.0M | Add +14.4% |
| UNH Unitedhealth Group Inc. | 3.60% | 13,595 | $4.5M | Add +0.4% |
| AMGN Amgen Inc. | 3.43% | 13,070 | $4.3M | Add +26.4% |
| JNJ Johnson & Johnson | 3.37% | 20,300 | $4.2M | Add +32.7% |
| ABBV Abbvie Inc. | 3.08% | 16,800 | $3.8M | Add +13.5% |
| VRTX Vertex Pharmaceuticals Inc. | 2.91% | 8,005 | $3.6M | Add +3.8% |
| ABT Abbott Laboratories | 2.36% | 23,498 | $2.9M | Add +36.6% |
| REGN Regeneron Pharmaceuticals | 2.30% | 3,715 | $2.9M | Reduce -6.4% |
| ISRG Intuitive Surgical Inc. | 2.20% | 4,850 | $2.7M | Reduce -15.7% |
| BSX Boston Scientific Corp. | 2.11% | 27,626 | $2.6M | Add +24.9% |
| ARGX Argenx SE - ADR | 1.95% | 2,894 | $2.4M | Reduce -25.6% |
| DHR Danaher Corp. | 1.94% | 10,575 | $2.4M | No change |
| SYK Stryker Corp. | 1.85% | 6,550 | $2.3M | Add +52.3% |
| TMO Thermo Fisher Scientific Inc. | 1.81% | 3,900 | $2.3M | No change |
| MRK Merck & Co. Inc. | 1.81% | 21,400 | $2.3M | Add +30.5% |
| GILD Gilead Sciences Inc. | 1.76% | 17,885 | $2.2M | Reduce -8.5% |
| INSM Insmed Inc. | 1.56% | 11,182 | $1.9M | Reduce -16.7% |
| DXCM Dexcom Inc. | 1.53% | 28,700 | $1.9M | Add +38.6% |
| VERA Vera Therapeutics Inc. | 1.50% | 36,858 | $1.9M | Add +22.1% |
| GPCR Structure Therapeutics Inc. | 1.33% | 23,872 | $1.7M | Reduce -89.2% |
| BNTX Biontech SE-ADR | 1.31% | 17,218 | $1.6M | Reduce -2.5% |
| EW Edwards Lifesciences Corp. | 1.18% | 17,250 | $1.5M | Add +15.0% |
| AZN Astrazeneca PLC-Spons ADR | 1.12% | 15,232 | $1.4M | Reduce -18.8% |
| SMMT Summit Therapeutics Inc. | 1.12% | 79,625 | $1.4M | Add +7.5% |
| RCUS Arcus Biosciences Inc. | 1.09% | 56,945 | $1.4M | Reduce -84.5% |
| SNDX Syndax Pharmaceuticals Inc. | 1.03% | 61,200 | $1.3M | Reduce -22.9% |
| TARS Tarsus Pharmaceuticals Inc. | 0.97% | 14,740 | $1.2M | Reduce -19.9% |
| ALNY Alnylam Pharmaceuticals Inc. | 0.95% | 2,990 | $1.2M | Reduce -8.7% |
| RAPP Rapport Therapeutics Inc. | 0.95% | 38,925 | $1.2M | Reduce -10.5% |
| COGT Cogent Biosciences Inc. | 0.93% | 32,685 | $1.2M | New |
| MLYS Mineralys Therapeutics Inc. | 0.92% | 31,625 | $1.1M | Reduce -6.7% |
| TRVI Trevi Therapeutics Inc. | 0.85% | 84,255 | $1.1M | Reduce -20.5% |
| ROIV Roivant Sciences Ltd. | 0.79% | 45,347 | $984K | Reduce -9.3% |
| TECX Tectonic Therapeutic Inc. | 0.71% | 42,255 | $881K | Reduce -78.1% |
| VTYX Ventyx Biosciences Inc. | 0.70% | 96,945 | $875K | Reduce -91.2% |
| BBIO Bridgebio Pharma Inc. | 0.68% | 11,170 | $854K | Reduce -18.2% |
| UTHR United Therapeutics Corp. | 0.67% | 1,723 | $840K | Add +125.2% |
| BOLD Boundless Bio Inc. | 0.65% | 678,574 | $814K | No change |
| ONC Beone Medicines Ltd.-ADR | 0.65% | 2,665 | $810K | Reduce -63.0% |
| RDNT Radnet Inc. | 0.63% | 11,000 | $785K | Add +10.0% |
| AVBP Arrivent Biopharma Inc. | 0.62% | 38,255 | $770K | Reduce -2.5% |
| QURE Uniqure NV | 0.59% | 30,585 | $732K | Reduce -0.5% |
| ASND Ascendis Pharma A/S | 0.56% | 3,254 | $694K | Reduce -9.6% |
| LENZ Lenz Therapeutics Inc. | 0.55% | 42,500 | $680K | New |
| PFE Pfizer Inc. | 0.54% | 27,150 | $676K | Reduce -64.8% |
| INSP Inspire Medical Systems Inc. | 0.53% | 7,200 | $664K | New |
| IONS Ionis Pharmaceuticals Inc. | 0.53% | 8,365 | $662K | Reduce -9.1% |
| IMTX Immatics NV | 0.53% | 63,015 | $662K | Reduce -88.8% |
| HNGE Hinge Health Inc. Class A | 0.53% | 14,206 | $660K | Add +26.8% |
| BMRN Biomarin Pharmaceutical Inc. | 0.52% | 10,880 | $647K | Reduce -56.5% |
| ALHC Alignment Healthcare Inc. | 0.50% | 31,500 | $622K | Reduce -42.2% |
| FOLD Amicus Therapeutics Inc. | 0.49% | 43,300 | $617K | Reduce -63.6% |
| PRVA Privia Health Group Inc. | 0.49% | 26,000 | $616K | Reduce -28.8% |
| CARL Carlsmed Inc. | 0.47% | 47,700 | $589K | New |
| PTCT PTC Therapeutics Inc. | 0.47% | 7,715 | $586K | Reduce -9.6% |
| OMDA Omada Health Inc. | 0.46% | 36,500 | $576K | Add +32.7% |
| NKTR Nektar Therapeutics | 0.46% | 13,485 | $570K | New |
| KURA Kura Oncology Inc. | 0.45% | 54,110 | $562K | Reduce -86.3% |
| NBIX Neurocrine Biosciences Inc. | 0.30% | 2,675 | $379K | Reduce -9.6% |
| BIIB Biogen Inc. | 0.30% | 2,155 | $379K | Reduce -9.3% |
| CYTK Cytokinetics Inc. | 0.30% | 5,893 | $374K | Reduce -42.4% |
| JAZZ Jazz Pharmaceuticals PLC | 0.28% | 2,049 | $348K | Reduce -8.7% |
| SPRY Ars Pharmaceuticals Inc. | 0.28% | 29,803 | $347K | Reduce -63.6% |
| RPRX Royalty Pharma PLC Class A | 0.26% | 8,470 | $327K | Reduce -8.7% |
| ILMN Illumina Inc. | 0.26% | 2,472 | $324K | Reduce -9.3% |
| AXSM Axsome Therapeutics Inc. | 0.25% | 1,740 | $318K | Add +70.6% |
| INCY Incyte Corp. | 0.22% | 2,750 | $272K | Reduce -9.2% |
| TEM Tempus AI Inc. Class A | 0.21% | 4,500 | $266K | Add +19.7% |
| MDGL Madrigal Pharmaceuticals Inc. | 0.16% | 352 | $205K | Reduce -51.8% |
| ORIC Oric Pharmaceuticals Inc. | 0.15% | 22,480 | $184K | Reduce -93.2% |
| MRNA Moderna Inc. | 0.12% | 5,005 | $148K | Reduce -10.6% |
Portfolio Sells Q3 2025 → Q4 2025
| ANAB Anaptysbio Inc. | Sold out | 0.00% | −3.68 |
| BCAX Bicara Therapeutics Inc. | Sold out | 0.00% | −2.60 |
| GPCR Structure Therapeutics Inc. | Reduce -89.2% | 1.33% | −2.50 |
| IMTX Immatics NV | Reduce -88.8% | 0.53% | −2.42 |
| SLDB Solid Biosciences Inc. | Sold out | 0.00% | −2.41 |
| ORIC Oric Pharmaceuticals Inc. | Reduce -93.2% | 0.15% | −2.29 |
| MBX MBX Biosciences Inc. | Sold out | 0.00% | −2.11 |
| XBI SS SPDR S&P Biotech ETF | Sold out | 0.00% | −2.10 |
| ZBIO Zenas Biopharma Inc. | Sold out | 0.00% | −2.08 |
| RCUS Arcus Biosciences Inc. | Reduce -84.5% | 1.09% | −2.00 |
| PVLA Palvella Therapeutics Inc. | Sold out | 0.00% | −1.90 |
| TIL Instil Bio Inc. | Sold out | 0.00% | −1.78 |
| KURA Kura Oncology Inc. | Reduce -86.3% | 0.45% | −1.71 |
| VTYX Ventyx Biosciences Inc. | Reduce -91.2% | 0.70% | −1.42 |
| TECX Tectonic Therapeutic Inc. | Reduce -78.1% | 0.71% | −1.16 |
| ONC Beone Medicines Ltd.-ADR | Reduce -63.0% | 0.65% | −0.87 |
| PFE Pfizer Inc. | Reduce -64.8% | 0.54% | −0.67 |
| MRUS Merus NV | Sold out | 0.00% | −0.67 |
| QURE Uniqure NV | Reduce -0.5% | 0.59% | −0.52 |
| CI The Cigna Group | Sold out | 0.00% | −0.32 |
| BMRN Biomarin Pharmaceutical Inc. | Reduce -56.5% | 0.52% | −0.32 |
| BMY Bristol-Myers Squibb Co. | Sold out | 0.00% | −0.30 |
| ZLAB Zai Lab Ltd.-ADR | Sold out | 0.00% | −0.26 |
| SPRY Ars Pharmaceuticals Inc. | Reduce -63.6% | 0.28% | −0.23 |
| PCVX Vaxcyte Inc. | Sold out | 0.00% | −0.09 |
| ALHC Alignment Healthcare Inc. | Reduce -42.2% | 0.50% | −0.09 |
| FOLD Amicus Therapeutics Inc. | Reduce -63.6% | 0.49% | −0.09 |
| PRVA Privia Health Group Inc. | Reduce -28.8% | 0.49% | −0.07 |
| CYTK Cytokinetics Inc. | Reduce -42.4% | 0.30% | −0.05 |
| MDGL Madrigal Pharmaceuticals Inc. | Reduce -51.8% | 0.16% | −0.04 |
| MLTX Moonlake Immunotherapeutics | Sold out | 0.00% | −0.00 |
| MRNA Moderna Inc. | Reduce -10.6% | 0.12% | +0.03 |
| ALNY Alnylam Pharmaceuticals Inc. | Reduce -8.7% | 0.95% | +0.03 |
| NBIX Neurocrine Biosciences Inc. | Reduce -9.6% | 0.30% | +0.05 |
| INCY Incyte Corp. | Reduce -9.2% | 0.22% | +0.06 |
| RPRX Royalty Pharma PLC Class A | Reduce -8.7% | 0.26% | +0.06 |
| JAZZ Jazz Pharmaceuticals PLC | Reduce -8.7% | 0.28% | +0.10 |
| BIIB Biogen Inc. | Reduce -9.3% | 0.30% | +0.10 |
| ILMN Illumina Inc. | Reduce -9.3% | 0.26% | +0.10 |
| ASND Ascendis Pharma A/S | Reduce -9.6% | 0.56% | +0.11 |
| MLYS Mineralys Therapeutics Inc. | Reduce -6.7% | 0.92% | +0.13 |
| PTCT PTC Therapeutics Inc. | Reduce -9.6% | 0.47% | +0.15 |
| RAPP Rapport Therapeutics Inc. | Reduce -10.5% | 0.95% | +0.15 |
| IONS Ionis Pharmaceuticals Inc. | Reduce -9.1% | 0.53% | +0.16 |
| AVBP Arrivent Biopharma Inc. | Reduce -2.5% | 0.62% | +0.17 |
| ARGX Argenx SE - ADR | Reduce -25.6% | 1.95% | +0.18 |
| AZN Astrazeneca PLC-Spons ADR | Reduce -18.8% | 1.12% | +0.23 |
| BNTX Biontech SE-ADR | Reduce -2.5% | 1.31% | +0.24 |
| TRVI Trevi Therapeutics Inc. | Reduce -20.5% | 0.85% | +0.25 |
| BBIO Bridgebio Pharma Inc. | Reduce -18.2% | 0.68% | +0.25 |
Portfolio Buys Q3 2025 → Q4 2025
| EVMN Evommune Inc. | New | 8.08% | +8.08 |
| SI Shoulder Innovations Inc. | Add +14.4% | 5.64% | +2.31 |
| AMGN Amgen Inc. | Add +26.4% | 3.43% | +1.63 |
| JNJ Johnson & Johnson | Add +32.7% | 3.37% | +1.62 |
| VRTX Vertex Pharmaceuticals Inc. | Add +3.8% | 2.91% | +1.04 |
| ABBV Abbvie Inc. | Add +13.5% | 3.08% | +0.96 |
| VERA Vera Therapeutics Inc. | Add +22.1% | 1.50% | +0.95 |
| MRK Merck & Co. Inc. | Add +30.5% | 1.81% | +0.95 |
| ABT Abbott Laboratories | Add +36.6% | 2.36% | +0.94 |
| COGT Cogent Biosciences Inc. | New | 0.93% | +0.93 |
| SYK Stryker Corp. | Add +52.3% | 1.85% | +0.86 |
| BSX Boston Scientific Corp. | Add +24.9% | 2.11% | +0.78 |
| UNH Unitedhealth Group Inc. | Add +0.4% | 3.60% | +0.71 |
| DXCM Dexcom Inc. | Add +38.6% | 1.53% | +0.67 |
| LENZ Lenz Therapeutics Inc. | New | 0.55% | +0.55 |
| INSP Inspire Medical Systems Inc. | New | 0.53% | +0.53 |
| UTHR United Therapeutics Corp. | Add +125.2% | 0.67% | +0.47 |
| CARL Carlsmed Inc. | New | 0.47% | +0.47 |
| EW Edwards Lifesciences Corp. | Add +15.0% | 1.18% | +0.46 |
| NKTR Nektar Therapeutics | New | 0.46% | +0.46 |
| HNGE Hinge Health Inc. Class A | Add +26.8% | 0.53% | +0.19 |
| AXSM Axsome Therapeutics Inc. | Add +70.6% | 0.25% | +0.18 |
| SMMT Summit Therapeutics Inc. | Add +7.5% | 1.12% | +0.17 |
| RDNT Radnet Inc. | Add +10.0% | 0.63% | +0.16 |
| OMDA Omada Health Inc. | Add +32.7% | 0.46% | +0.09 |
| TEM Tempus AI Inc. Class A | Add +19.7% | 0.21% | +0.03 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 82 | $143.3M | CTNM, SI, LLY, UNH, JNJ |
| Q1 2026 | 77 | $120.7M | EVMN, CTNM, SI, LLY, JNJ |
| Q4 2025 | 74 | $124.8M | EVMN, CTNM, LLY, SI, UNH |
| Q3 2025 | 82 | $162.0M | CTNM, LLY, GPCR, ANAB, SI |
| Q2 2025 | 94 | $151.5M | LENZ, LLY, UNH, MLYS, CTNM |
| Q1 2025 | 84 | $128.5M | LENZ, LLY, UNH, MLYS, CTNM |
| Q4 2024 | 86 | $149.8M | LENZ, CTNM, LLY, UNH, GILD |
| Q3 2024 | 90 | $169.3M | LENZ, CTNM, LLY, UNH, GILD |
| Q2 2024 | 97 | $246.1M | LLY, LENZ, CTNM, UNH, MRK |
| Q1 2024 | 92 | $254.4M | LENZ, LLY, BOLD, UNH, MRK |