Sectoral Asset Management Inc.
In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 14, 2025), Sectoral Asset Management Inc. reported 82 stock positions worth $162.0 million. Its top holding was Contineum Therapeutics Class A (CTNM) at 5.8% of the portfolio, followed by Eli Lilly (LLY, 4.4%) and Structure Therapeutics (GPCR, 3.8%). Compared with Q2 2025, it opened 4 new positions, sold out of 16, added to 29 and reduced 28. The biggest buy was a new position in Shoulder Innovations (SI) and the biggest sale an exit from Lenz Therapeutics (LENZ).
- Most Recent 13F
- Q2 2026
- Location
- MONTREAL, A8
- CIK
- 0001274413
- Portfolio Value
- $162.0M (Q3 2025)
- SEC Filing
- 0001104659-25-112082 ↗ filed Nov 14, 2025
Holdings Value
Holdings 82 stocks · $162.0M
| CTNM Contineum Therapeutics Inc. Class A | 5.81% | 800,787 | $9.4M | No change |
| LLY Eli Lilly & Co. | 4.42% | 9,376 | $7.2M | Add +4.5% |
| GPCR Structure Therapeutics Inc. | 3.83% | 221,872 | $6.2M | Add +331.9% |
| ANAB Anaptysbio Inc. | 3.68% | 194,485 | $6.0M | Add +131.8% |
| SI Shoulder Innovations Inc. | 3.33% | 430,282 | $5.4M | New |
| RCUS Arcus Biosciences Inc. | 3.09% | 368,070 | $5.0M | Add +43.1% |
| IMTX Immatics NV | 2.95% | 560,494 | $4.8M | Add +68.7% |
| UNH Unitedhealth Group Inc. | 2.89% | 13,545 | $4.7M | Reduce -19.1% |
| BCAX Bicara Therapeutics Inc. | 2.60% | 266,495 | $4.2M | Add +32.3% |
| ORIC Oric Pharmaceuticals Inc. | 2.43% | 328,655 | $3.9M | Add +42.0% |
| SLDB Solid Biosciences Inc. | 2.41% | 633,052 | $3.9M | Add +50.2% |
| KURA Kura Oncology Inc. | 2.16% | 395,872 | $3.5M | Add +22.3% |
| VTYX Ventyx Biosciences Inc. | 2.13% | 1,107,267 | $3.4M | Add +18.9% |
| ABBV Abbvie Inc. | 2.12% | 14,800 | $3.4M | No change |
| MBX MBX Biosciences Inc. | 2.11% | 194,898 | $3.4M | Add +1.6% |
| XBI SS SPDR S&P Biotech ETF | 2.10% | 34,000 | $3.4M | New |
| ZBIO Zenas Biopharma Inc. | 2.08% | 152,025 | $3.4M | Reduce -27.8% |
| PVLA Palvella Therapeutics Inc. | 1.90% | 49,115 | $3.1M | Reduce -48.6% |
| TECX Tectonic Therapeutic Inc. | 1.87% | 192,770 | $3.0M | Add +94.8% |
| VRTX Vertex Pharmaceuticals Inc. | 1.86% | 7,715 | $3.0M | Add +11.1% |
| AMGN Amgen Inc. | 1.80% | 10,340 | $2.9M | Reduce -8.3% |
| TIL Instil Bio Inc. | 1.78% | 161,380 | $2.9M | Add +87.2% |
| ARGX Argenx SE - ADR | 1.77% | 3,890 | $2.9M | Reduce -4.8% |
| JNJ Johnson & Johnson | 1.75% | 15,300 | $2.8M | Reduce -20.7% |
| ISRG Intuitive Surgical Inc. | 1.59% | 5,750 | $2.6M | Add +9.5% |
| ONC Beone Medicines Ltd.-ADR | 1.51% | 7,201 | $2.5M | Reduce -6.7% |
| ABT Abbott Laboratories | 1.42% | 17,198 | $2.3M | Add +13.2% |
| REGN Regeneron Pharmaceuticals | 1.38% | 3,968 | $2.2M | Add +43.1% |
| GILD Gilead Sciences Inc. | 1.34% | 19,550 | $2.2M | Reduce -0.7% |
| BSX Boston Scientific Corp. | 1.33% | 22,126 | $2.2M | Add +4.7% |
| DHR Danaher Corp. | 1.30% | 10,575 | $2.1M | No change |
| PFE Pfizer Inc. | 1.21% | 77,150 | $2.0M | No change |
| INSM Insmed Inc. | 1.19% | 13,425 | $1.9M | Reduce -9.8% |
| TMO Thermo Fisher Scientific Inc. | 1.17% | 3,900 | $1.9M | No change |
| QURE Uniqure NV | 1.11% | 30,740 | $1.8M | Reduce -44.6% |
| BNTX Biontech SE-ADR | 1.07% | 17,660 | $1.7M | Add +9.3% |
| SYK Stryker Corp. | 0.98% | 4,300 | $1.6M | Add +10.3% |
| SMMT Summit Therapeutics Inc. | 0.94% | 74,070 | $1.5M | Add +13.6% |
| ALNY Alnylam Pharmaceuticals Inc. | 0.92% | 3,273 | $1.5M | Reduce -1.5% |
| AZN Astrazeneca PLC-Spons ADR | 0.89% | 18,750 | $1.4M | Add +0.6% |
| DXCM Dexcom Inc. | 0.86% | 20,700 | $1.4M | Add +56.8% |
| MRK Merck & Co. Inc. | 0.86% | 16,400 | $1.4M | Reduce -21.5% |
| BMRN Biomarin Pharmaceutical Inc. | 0.84% | 25,030 | $1.4M | Add +6.4% |
| RAPP Rapport Therapeutics Inc. | 0.80% | 43,480 | $1.3M | Reduce -75.8% |
| MLYS Mineralys Therapeutics Inc. | 0.79% | 33,885 | $1.3M | Reduce -91.1% |
| SNDX Syndax Pharmaceuticals Inc. | 0.75% | 79,430 | $1.2M | Add +25.5% |
| EW Edwards Lifesciences Corp. | 0.72% | 15,000 | $1.2M | No change |
| TARS Tarsus Pharmaceuticals Inc. | 0.68% | 18,405 | $1.1M | Reduce -0.7% |
| MRUS Merus NV | 0.67% | 11,545 | $1.1M | Reduce -26.4% |
| TRVI Trevi Therapeutics Inc. | 0.60% | 105,950 | $969K | Reduce -21.0% |
| ALHC Alignment Healthcare Inc. | 0.59% | 54,500 | $951K | New |
| FOLD Amicus Therapeutics Inc. | 0.58% | 119,105 | $939K | Reduce -0.4% |
| PRVA Privia Health Group Inc. | 0.56% | 36,500 | $909K | New |
| VERA Vera Therapeutics Inc. | 0.54% | 30,188 | $877K | Reduce -27.1% |
| BOLD Boundless Bio Inc. | 0.52% | 678,574 | $835K | No change |
| SPRY Ars Pharmaceuticals Inc. | 0.51% | 81,785 | $822K | Add +24.3% |
| RDNT Radnet Inc. | 0.47% | 10,000 | $762K | Reduce -20.0% |
| ROIV Roivant Sciences Ltd. | 0.47% | 50,007 | $757K | No change |
| AVBP Arrivent Biopharma Inc. | 0.45% | 39,235 | $724K | Add +10.3% |
| ASND Ascendis Pharma A/S | 0.44% | 3,601 | $716K | Add +3.8% |
| BBIO Bridgebio Pharma Inc. | 0.44% | 13,650 | $709K | Reduce -15.1% |
| OMDA Omada Health Inc. | 0.38% | 27,500 | $608K | Reduce -20.3% |
| IONS Ionis Pharmaceuticals Inc. | 0.37% | 9,205 | $602K | No change |
| CYTK Cytokinetics Inc. | 0.35% | 10,223 | $562K | Reduce -12.8% |
| HNGE Hinge Health Inc. Class A | 0.34% | 11,206 | $550K | Add +21.7% |
| PTCT PTC Therapeutics Inc. | 0.32% | 8,535 | $524K | No change |
| CI The Cigna Group | 0.32% | 1,800 | $519K | No change |
| BMY Bristol-Myers Squibb Co. | 0.30% | 10,800 | $487K | No change |
| ZLAB Zai Lab Ltd.-ADR | 0.26% | 12,590 | $427K | Reduce -20.5% |
| NBIX Neurocrine Biosciences Inc. | 0.26% | 2,960 | $416K | No change |
| MDGL Madrigal Pharmaceuticals Inc. | 0.21% | 730 | $335K | No change |
| BIIB Biogen Inc. | 0.21% | 2,375 | $333K | No change |
| RPRX Royalty Pharma PLC Class A | 0.20% | 9,280 | $327K | No change |
| UTHR United Therapeutics Corp. | 0.20% | 765 | $321K | No change |
| TEM Tempus AI Inc. Class A | 0.19% | 3,760 | $303K | No change |
| JAZZ Jazz Pharmaceuticals PLC | 0.18% | 2,244 | $296K | Reduce -1.3% |
| ILMN Illumina Inc. | 0.16% | 2,727 | $259K | Reduce -2.0% |
| INCY Incyte Corp. | 0.16% | 3,030 | $257K | Reduce -50.0% |
| PCVX Vaxcyte Inc. | 0.09% | 4,205 | $151K | No change |
| MRNA Moderna Inc. | 0.09% | 5,600 | $145K | No change |
| AXSM Axsome Therapeutics Inc. | 0.08% | 1,020 | $124K | No change |
| MLTX Moonlake Immunotherapeutics | 0.00% | 956 | $7K | Reduce -93.7% |
Portfolio Sells Q2 2025 → Q3 2025
| LENZ Lenz Therapeutics Inc. | Sold out | 0.00% | −18.91 |
| MLYS Mineralys Therapeutics Inc. | Reduce -91.1% | 0.79% | −2.62 |
| REPL Replimune Group Inc. | Sold out | 0.00% | −1.42 |
| TRML Tourmaline Bio Inc. | Sold out | 0.00% | −1.23 |
| UNH Unitedhealth Group Inc. | Reduce -19.1% | 2.89% | −0.56 |
| RAPP Rapport Therapeutics Inc. | Reduce -75.8% | 0.80% | −0.55 |
| GMED Globus Medical Inc. Class A | Sold out | 0.00% | −0.53 |
| MLTX Moonlake Immunotherapeutics | Reduce -93.7% | 0.00% | −0.47 |
| LEGN Legend Biotech Corp.-ADR | Sold out | 0.00% | −0.46 |
| CNC Centene Corp. | Sold out | 0.00% | −0.45 |
| KMTS Kestra Medical Technologies | Sold out | 0.00% | −0.38 |
| CVRX CVRX Inc. | Sold out | 0.00% | −0.29 |
| AMGN Amgen Inc. | Reduce -8.3% | 1.80% | −0.28 |
| MRK Merck & Co. Inc. | Reduce -21.5% | 0.86% | −0.24 |
| SRRK Scholar Rock Holding Corp. | Sold out | 0.00% | −0.24 |
| JNJ Johnson & Johnson | Reduce -20.7% | 1.75% | −0.20 |
| RVMD Revolution Medicines Inc. | Sold out | 0.00% | −0.15 |
| CAI Caris Life Sciences Inc. | Sold out | 0.00% | −0.15 |
| VTRS Viatris Inc. | Sold out | 0.00% | −0.12 |
| INCY Incyte Corp. | Reduce -50.0% | 0.16% | −0.11 |
| MEDP Medpace Holdings Inc. | Sold out | 0.00% | −0.11 |
| IOBTQ Io Biotech Inc. | Sold out | 0.00% | −0.11 |
| VERA Vera Therapeutics Inc. | Reduce -27.1% | 0.54% | −0.10 |
| ZLAB Zai Lab Ltd.-ADR | Reduce -20.5% | 0.26% | −0.10 |
| GILD Gilead Sciences Inc. | Reduce -0.7% | 1.34% | −0.10 |
| CRSP Crispr Therapeutics AG | Sold out | 0.00% | −0.08 |
| OMDA Omada Health Inc. | Reduce -20.3% | 0.38% | −0.04 |
| RXRX Recursion Pharmaceuticals-A | Sold out | 0.00% | −0.04 |
| BBIO Bridgebio Pharma Inc. | Reduce -15.1% | 0.44% | −0.02 |
| ILMN Illumina Inc. | Reduce -2.0% | 0.16% | −0.02 |
| RDNT Radnet Inc. | Reduce -20.0% | 0.47% | +0.00 |
| JAZZ Jazz Pharmaceuticals PLC | Reduce -1.3% | 0.18% | +0.02 |
| CYTK Cytokinetics Inc. | Reduce -12.8% | 0.35% | +0.09 |
| TRVI Trevi Therapeutics Inc. | Reduce -21.0% | 0.60% | +0.11 |
| MRUS Merus NV | Reduce -26.4% | 0.67% | +0.13 |
| FOLD Amicus Therapeutics Inc. | Reduce -0.4% | 0.58% | +0.13 |
| TARS Tarsus Pharmaceuticals Inc. | Reduce -0.7% | 0.68% | +0.18 |
| INSM Insmed Inc. | Reduce -9.8% | 1.19% | +0.20 |
| ALNY Alnylam Pharmaceuticals Inc. | Reduce -1.5% | 0.92% | +0.21 |
| ONC Beone Medicines Ltd.-ADR | Reduce -6.7% | 1.51% | +0.28 |
| ARGX Argenx SE - ADR | Reduce -4.8% | 1.77% | +0.28 |
| PVLA Palvella Therapeutics Inc. | Reduce -48.6% | 1.90% | +0.48 |
| QURE Uniqure NV | Reduce -44.6% | 1.11% | +0.60 |
| ZBIO Zenas Biopharma Inc. | Reduce -27.8% | 2.08% | +0.74 |
Portfolio Buys Q2 2025 → Q3 2025
| SI Shoulder Innovations Inc. | New | 3.33% | +3.33 |
| GPCR Structure Therapeutics Inc. | Add +331.9% | 3.83% | +3.13 |
| ANAB Anaptysbio Inc. | Add +131.8% | 3.68% | +2.45 |
| XBI SS SPDR S&P Biotech ETF | New | 2.10% | +2.10 |
| IMTX Immatics NV | Add +68.7% | 2.95% | +1.77 |
| RCUS Arcus Biosciences Inc. | Add +43.1% | 3.09% | +1.71 |
| BCAX Bicara Therapeutics Inc. | Add +32.3% | 2.60% | +1.36 |
| SLDB Solid Biosciences Inc. | Add +50.2% | 2.41% | +1.06 |
| KURA Kura Oncology Inc. | Add +22.3% | 2.16% | +0.93 |
| ORIC Oric Pharmaceuticals Inc. | Add +42.0% | 2.43% | +0.88 |
| VTYX Ventyx Biosciences Inc. | Add +18.9% | 2.13% | +0.81 |
| MBX MBX Biosciences Inc. | Add +1.6% | 2.11% | +0.66 |
| TIL Instil Bio Inc. | Add +87.2% | 1.78% | +0.59 |
| ALHC Alignment Healthcare Inc. | New | 0.59% | +0.59 |
| TECX Tectonic Therapeutic Inc. | Add +94.8% | 1.87% | +0.57 |
| PRVA Privia Health Group Inc. | New | 0.56% | +0.56 |
| REGN Regeneron Pharmaceuticals | Add +43.1% | 1.38% | +0.42 |
| SNDX Syndax Pharmaceuticals Inc. | Add +25.5% | 0.75% | +0.36 |
| DXCM Dexcom Inc. | Add +56.8% | 0.86% | +0.10 |
| ABT Abbott Laboratories | Add +13.2% | 1.42% | +0.06 |
| ASND Ascendis Pharma A/S | Add +3.8% | 0.44% | +0.05 |
| SMMT Summit Therapeutics Inc. | Add +13.6% | 0.94% | +0.03 |
| AZN Astrazeneca PLC-Spons ADR | Add +0.6% | 0.89% | +0.03 |
| HNGE Hinge Health Inc. Class A | Add +21.7% | 0.34% | +0.02 |
| BMRN Biomarin Pharmaceutical Inc. | Add +6.4% | 0.84% | −0.02 |
| SYK Stryker Corp. | Add +10.3% | 0.98% | −0.04 |
| BNTX Biontech SE-ADR | Add +9.3% | 1.07% | −0.06 |
| AVBP Arrivent Biopharma Inc. | Add +10.3% | 0.45% | −0.06 |
| BSX Boston Scientific Corp. | Add +4.7% | 1.33% | −0.16 |
| VRTX Vertex Pharmaceuticals Inc. | Add +11.1% | 1.86% | −0.18 |
| LLY Eli Lilly & Co. | Add +4.5% | 4.42% | −0.20 |
| SPRY Ars Pharmaceuticals Inc. | Add +24.3% | 0.51% | −0.25 |
| ISRG Intuitive Surgical Inc. | Add +9.5% | 1.59% | −0.30 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 82 | $143.3M | CTNM, SI, LLY, UNH, JNJ |
| Q1 2026 | 77 | $120.7M | EVMN, CTNM, SI, LLY, JNJ |
| Q4 2025 | 74 | $124.8M | EVMN, CTNM, LLY, SI, UNH |
| Q3 2025 | 82 | $162.0M | CTNM, LLY, GPCR, ANAB, SI |
| Q2 2025 | 94 | $151.5M | LENZ, LLY, UNH, MLYS, CTNM |
| Q1 2025 | 84 | $128.5M | LENZ, LLY, UNH, MLYS, CTNM |
| Q4 2024 | 86 | $149.8M | LENZ, CTNM, LLY, UNH, GILD |
| Q3 2024 | 90 | $169.3M | LENZ, CTNM, LLY, UNH, GILD |
| Q2 2024 | 97 | $246.1M | LLY, LENZ, CTNM, UNH, MRK |
| Q1 2024 | 92 | $254.4M | LENZ, LLY, BOLD, UNH, MRK |