Sphera Funds Management LTD.
In its 13F for Q4 2024 (holdings as of December 31, 2024, filed February 14, 2025), Sphera Funds Management LTD. reported 102 stock positions worth $541.4 million. Its top holding was Teva Pharmaceutical-SP ADR (TEVA) at 6.4% of the portfolio, followed by Bridgebio Pharma (BBIO, 4.6%) and Sanofi-ADR (SNY, 3.4%). Compared with Q3 2024, it opened 17 new positions, sold out of 22, added to 29 and reduced 36. The biggest buy was a new position in Alphabet Class C (GOOG) and the biggest sale an exit from Apple (AAPL).
- Most Recent 13F
- Q2 2026
- Location
- TEL AVIV, L3
- CIK
- 0001496201
- Portfolio Value
- $541.4M (Q4 2024)
- SEC Filing
- 0001496201-25-000001 ↗ filed Feb 14, 2025
Holdings Value
Holdings 102 stocks · $541.4M
| TEVA Teva Pharmaceutical-SP ADR | 6.39% | 1,569,181 | $34.6M | Reduce -26.3% |
| BBIO Bridgebio Pharma Inc. | 4.59% | 905,279 | $24.8M | Add +7.4% |
| SNY Sanofi-ADR | 3.43% | 384,515 | $18.5M | Reduce -6.1% |
| SNDX Syndax Pharmaceuticals Inc. | 3.37% | 1,381,241 | $18.3M | Add +33.5% |
| AZN Astrazeneca PLC-Spons ADR | 2.72% | 225,060 | $14.7M | Add +18.4% |
| AMZN Amazon.com Inc. | 2.54% | 62,607 | $13.7M | Reduce -40.7% |
| NVMI Nova Ltd. | 2.48% | 68,146 | $13.4M | Add +31.1% |
| META Meta Platforms Inc. Class A | 2.27% | 21,001 | $12.3M | Reduce -28.4% |
| SRPT Sarepta Therapeutics Inc. | 2.22% | 98,921 | $12.0M | Reduce -21.4% |
| CLDX Celldex Therapeutics Inc. | 2.21% | 474,103 | $12.0M | Add +13.1% |
| ELDN Eledon Pharmaceuticals Inc. | 1.94% | 2,551,619 | $10.5M | Add +96.7% |
| LLY Eli Lilly & Co. | 1.88% | 13,190 | $10.2M | No change |
| JNJ Johnson & Johnson | 1.87% | 69,831 | $10.1M | No change |
| RARE Ultragenyx Pharmaceutical Inc. | 1.78% | 228,776 | $9.6M | Add +17.1% |
| MSFT Microsoft Corp. | 1.74% | 22,327 | $9.4M | Reduce -33.2% |
| MRVL Marvell Technology Inc. | 1.60% | 78,611 | $8.7M | Reduce -10.3% |
| TSEM Tower Semiconductor Ltd. | 1.58% | 166,149 | $8.6M | Reduce -20.7% |
| NVO Novo-Nordisk A/S-Spons ADR | 1.56% | 98,080 | $8.4M | Add +25.6% |
| WIX Wix.com Ltd. | 1.56% | 39,253 | $8.4M | Add +14.6% |
| GOOG Alphabet Inc. Class C | 1.53% | 43,500 | $8.3M | New |
| PHVS Pharvaris NV | 1.37% | 388,183 | $7.4M | Reduce -11.6% |
| NICE Nice Ltd. - Spon ADR | 1.33% | 42,500 | $7.2M | Reduce -45.8% |
| CYTK Cytokinetics Inc. | 1.33% | 153,021 | $7.2M | Reduce -32.0% |
| PRAX Praxis Precision Medicines I | 1.30% | 91,583 | $7.0M | Reduce -39.9% |
| CHKP Check Point Software Tech | 1.23% | 35,635 | $6.7M | Reduce -11.4% |
| APLS Apellis Pharmaceuticals Inc. | 1.22% | 206,251 | $6.6M | Reduce -4.5% |
| IMTX Immatics NV | 1.21% | 921,111 | $6.5M | Add +27.7% |
| ANNX Annexon Inc. | 1.18% | 1,243,039 | $6.4M | New |
| ABBV Abbvie Inc. | 1.12% | 34,256 | $6.1M | Reduce -9.8% |
| MRK Merck & Co. Inc. | 1.10% | 59,600 | $5.9M | No change |
| BHVN Biohaven Ltd. | 1.08% | 156,494 | $5.8M | Add +17.4% |
| RZLT Rezolute Inc. | 1.06% | 1,165,895 | $5.7M | Reduce -2.6% |
| FROG Jfrog Ltd. | 1.03% | 190,381 | $5.6M | Add +58.1% |
| DYN Dyne Therapeutics Inc. | 1.03% | 236,262 | $5.6M | Add +318.1% |
| MRUS Merus NV | 1.01% | 130,532 | $5.5M | Reduce -11.6% |
| NTLA Intellia Therapeutics Inc. | 1.00% | 466,080 | $5.4M | Add +60.1% |
| ORA Ormat Technologies Inc. | 0.99% | 79,000 | $5.3M | New |
| KURA Kura Oncology Inc. | 0.98% | 610,087 | $5.3M | No change |
| ACAD Acadia Pharmaceuticals Inc. | 0.98% | 288,539 | $5.3M | Add +14.3% |
| SEDG Solaredge Technologies Inc. | 0.94% | 375,000 | $5.1M | New |
| ORMAT TECHNOLOGIES INC (ORA 2.5 07/15/27 SEPT) | 0.93% | 5,037,000 | $5.0M | No change |
| NVS Novartis AG-Sponsored ADR | 0.90% | 50,000 | $4.9M | No change |
| HELP Cybin Inc. | 0.88% | 538,111 | $4.7M | Reduce -42.3% |
| SKYE Skye Bioscience Inc. | 0.82% | 1,564,628 | $4.4M | Add +0.1% |
| GSK GSK PLC-Spon ADR | 0.81% | 130,000 | $4.4M | Add +30.0% |
| ETNB 89BIO Inc. | 0.80% | 556,532 | $4.4M | Add +3.7% |
| VIR Vir Biotechnology Inc. | 0.79% | 581,829 | $4.3M | Add +523.4% |
| DAWN Day One Biopharmaceuticals I | 0.78% | 334,987 | $4.2M | Reduce -3.6% |
| VKTX Viking Therapeutics Inc. | 0.77% | 103,270 | $4.2M | Reduce -22.4% |
| PLRX Pliant Therapeutics Inc. | 0.72% | 297,362 | $3.9M | No change |
| AVGO Broadcom Inc. | 0.72% | 16,880 | $3.9M | No change |
| SRRK Scholar Rock Holding Corp. | 0.72% | 90,193 | $3.9M | Reduce -46.0% |
| TVTX Travere Therapeutics Inc. | 0.71% | 220,700 | $3.8M | New |
| ENGN Engene Holdings Inc. | 0.69% | 560,000 | $3.7M | New |
| SVRA Savara Inc. | 0.69% | 1,211,533 | $3.7M | Add +115.2% |
| ARWR Arrowhead Pharmaceuticals Inc. | 0.69% | 197,550 | $3.7M | New |
| JANX Janux Therapeutics Inc. | 0.68% | 68,333 | $3.7M | New |
| ACOG Alpha Cognition Inc. | 0.67% | 620,000 | $3.7M | New |
| SWTX Springworks Therapeutics Inc. | 0.67% | 100,000 | $3.6M | New |
| BIIB Biogen Inc. | 0.64% | 22,738 | $3.5M | Reduce -7.0% |
| ENPH Enphase Energy Inc. | 0.64% | 50,198 | $3.4M | Reduce -21.8% |
| RCKT Rocket Pharmaceuticals Inc. | 0.63% | 271,792 | $3.4M | Add +17.3% |
| INZY Inozyme Pharma Inc. | 0.61% | 1,191,140 | $3.3M | No change |
| CAMT Camtek Ltd. | 0.54% | 36,287 | $2.9M | No change |
| JSPR Jasper Therapeutics Inc. | 0.54% | 135,720 | $2.9M | Reduce -28.3% |
| CRVS Corvus Pharmaceuticals Inc. | 0.49% | 500,491 | $2.7M | New |
| CRGX Cargo Therapeutics Inc. | 0.48% | 179,674 | $2.6M | Reduce -5.7% |
| WDAY Workday Inc. Class A | 0.48% | 10,000 | $2.6M | Add +33.3% |
| VIGL Vigil Neuroscience Inc. | 0.47% | 1,502,429 | $2.6M | Reduce -8.8% |
| NTR Nutrien Ltd. | 0.46% | 55,894 | $2.5M | Add +37.2% |
| CGEM Cullinan Therapeutics Inc. | 0.46% | 205,000 | $2.5M | Add +10.3% |
| PFE Pfizer Inc. | 0.44% | 90,000 | $2.4M | No change |
| VTGN Vistagen Therapeutics Inc. | 0.44% | 808,550 | $2.4M | No change |
| MLYS Mineralys Therapeutics Inc. | 0.43% | 190,672 | $2.3M | Reduce -30.0% |
| IONS Ionis Pharmaceuticals Inc. | 0.41% | 63,821 | $2.2M | No change |
| VTYX Ventyx Biosciences Inc. | 0.41% | 1,012,749 | $2.2M | No change |
| ORIC Oric Pharmaceuticals Inc. | 0.41% | 273,213 | $2.2M | Add +112.8% |
| CMMB Chemomab Therapeutics Ltd. | 0.41% | 1,214,575 | $2.2M | No change |
| XENE Xenon Pharmaceuticals Inc. | 0.38% | 52,097 | $2.0M | New |
| PMN Promis Neurosciences Inc. | 0.34% | 1,929,297 | $1.8M | No change |
| UBER Uber Technologies Inc. | 0.33% | 30,000 | $1.8M | New |
| LRMR Larimar Therapeutics Inc. | 0.33% | 455,604 | $1.8M | Add +9.9% |
| ZURA Zura Bio Ltd. | 0.32% | 690,718 | $1.7M | Reduce -6.5% |
| SHLT SHL Telemedicine Ltd.-ADR | 0.31% | 632,456 | $1.7M | No change |
| CATX Perspective Therapeutics Inc. | 0.27% | 460,247 | $1.5M | Reduce -21.9% |
| ATXS Astria Therapeutics Inc. | 0.23% | 139,800 | $1.2M | Add +2.4% |
| BMY Bristol-Myers Squibb Co. | 0.21% | 20,000 | $1.1M | New |
| MERSANA THERAPEUTICS INC | 0.18% | 690,272 | $987K | New |
| ALMS Alumis Inc. | 0.18% | 125,000 | $983K | No change |
| HOWL Werewolf Therapeutics Inc. | 0.17% | 626,810 | $928K | No change |
| APRE Aprea Therapeutics Inc. | 0.16% | 270,000 | $888K | No change |
| PERI Perion Network Ltd. | 0.16% | 102,612 | $869K | Reduce -56.3% |
| OKUR Onkure Therapeutics Inc. Class A | 0.14% | 87,354 | $751K | New |
| KZR Kezar Life Sciences Inc. | 0.13% | 108,473 | $729K | Add +428.7% |
| FATE Fate Therapeutics Inc. | 0.12% | 397,177 | $655K | New |
| ALEC Alector Inc. | 0.11% | 324,639 | $614K | Reduce -47.6% |
| ELEV Elevation Oncology Inc. | 0.11% | 1,018,562 | $573K | Reduce -5.7% |
| CLYM Climb Bio Inc. | 0.08% | 251,935 | $453K | Add +38.5% |
| KYTX Kyverna Therapeutics Inc. | 0.08% | 118,758 | $444K | Reduce -52.2% |
| CGEN Compugen Ltd. | 0.05% | 177,094 | $271K | Reduce -22.0% |
| LVTX Lava Therapeutics NV | 0.02% | 126,328 | $120K | Reduce -13.7% |
| APLT Applied Therapeutics Inc. | 0.01% | 50,000 | $43K | Reduce -84.0% |
Options reported separately and not counted above: PRAX calls ($6.4M), CYTK calls ($2.4M), JSPR puts ($1.7M), JSPR calls ($1.3M).
Other holdings (1): bonds, preferreds, convertibles and warrants · $25K (not counted above)
| Security | Class | Shares / Principal | Value | Change |
|---|---|---|---|---|
| IMTXW Immatics NV -CW | *W EXP 07/01/202 | 100,000 | $25K | No change |
Total filed on the 13F, all lines: $541.4M.
Portfolio Sells Q3 2024 → Q4 2024
| AAPL Apple Inc. | Sold out | 0.00% | −2.32 |
| S Sentinelone Inc. Class A | Sold out | 0.00% | −1.08 |
| CATX Perspective Therapeutics Inc. | Reduce -21.9% | 0.27% | −1.02 |
| NICE Nice Ltd. - Spon ADR | Reduce -45.8% | 1.33% | −0.89 |
| PTCT PTC Therapeutics Inc. | Sold out | 0.00% | −0.72 |
| AMZN Amazon.com Inc. | Reduce -40.7% | 2.54% | −0.68 |
| MSFT Microsoft Corp. | Reduce -33.2% | 1.74% | −0.62 |
| CYTK Cytokinetics Inc. | Reduce -32.0% | 1.33% | −0.62 |
| VKTX Viking Therapeutics Inc. | Reduce -22.4% | 0.77% | −0.61 |
| ENPH Enphase Energy Inc. | Reduce -21.8% | 0.64% | −0.55 |
| CRWD CrowdStrike Holdings Inc. Class A | Sold out | 0.00% | −0.50 |
| NVDA Nvidia Corp. | Sold out | 0.00% | −0.48 |
| HELP Cybin Inc. | Reduce -42.3% | 0.88% | −0.48 |
| META Meta Platforms Inc. Class A | Reduce -28.4% | 2.27% | −0.48 |
| VIGL Vigil Neuroscience Inc. | Reduce -8.8% | 0.47% | −0.45 |
| SNY Sanofi-ADR | Reduce -6.1% | 3.43% | −0.44 |
| APLT Applied Therapeutics Inc. | Reduce -84.0% | 0.01% | −0.43 |
| ENLT Enlight Renewable Energy Ltd. | Sold out | 0.00% | −0.42 |
| GLBE Global-E Online Ltd. | Sold out | 0.00% | −0.41 |
| ASML ASML Holding NV-NY Reg SHS | Sold out | 0.00% | −0.39 |
| OTLK Outlook Therapeutics Inc. | Sold out | 0.00% | −0.36 |
| ALEC Alector Inc. | Reduce -47.6% | 0.11% | −0.36 |
| KLAC KLA Corp. | Sold out | 0.00% | −0.35 |
| SRPT Sarepta Therapeutics Inc. | Reduce -21.4% | 2.22% | −0.35 |
| VRDN Viridian Therapeutics Inc. | Sold out | 0.00% | −0.32 |
| ALNY Alnylam Pharmaceuticals Inc. | Sold out | 0.00% | −0.32 |
| ADI Analog Devices Inc. | Sold out | 0.00% | −0.25 |
| QCOM Qualcomm Inc. | Sold out | 0.00% | −0.22 |
| MRUS Merus NV | Reduce -11.6% | 1.01% | −0.19 |
| ZURA Zura Bio Ltd. | Reduce -6.5% | 0.32% | −0.17 |
| CAPR Capricor Therapeutics Inc. | Sold out | 0.00% | −0.15 |
| PERI Perion Network Ltd. | Reduce -56.3% | 0.16% | −0.14 |
| BIIB Biogen Inc. | Reduce -7.0% | 0.64% | −0.13 |
| PRAX Praxis Precision Medicines I | Reduce -39.9% | 1.30% | −0.13 |
| KYTX Kyverna Therapeutics Inc. | Reduce -52.2% | 0.08% | −0.12 |
| MLYS Mineralys Therapeutics Inc. | Reduce -30.0% | 0.43% | −0.11 |
| ADCT Adc Therapeutics SA | Sold out | 0.00% | −0.11 |
| ABBV Abbvie Inc. | Reduce -9.8% | 1.12% | −0.10 |
| GLUE Monte Rosa Therapeutics Inc. | Sold out | 0.00% | −0.10 |
| CRGX Cargo Therapeutics Inc. | Reduce -5.7% | 0.48% | −0.10 |
| FDMT 4D Molecular Therapeutics Inc. | Sold out | 0.00% | −0.09 |
| TNGX Tango Therapeutics Inc. | Sold out | 0.00% | −0.06 |
| PRME Prime Medicine Inc. | Sold out | 0.00% | −0.05 |
| JSPR Jasper Therapeutics Inc. | Reduce -28.3% | 0.54% | −0.05 |
| CHKP Check Point Software Tech | Reduce -11.4% | 1.23% | −0.04 |
| LVTX Lava Therapeutics NV | Reduce -13.7% | 0.02% | −0.02 |
| CGEN Compugen Ltd. | Reduce -22.0% | 0.05% | −0.02 |
| TENX Tenax Therapeutics Inc. | Sold out | 0.00% | −0.02 |
| ARBE Arbe Robotics Ltd. | Sold out | 0.00% | −0.01 |
| DAWN Day One Biopharmaceuticals I | Reduce -3.6% | 0.78% | −0.01 |
Portfolio Buys Q3 2024 → Q4 2024
| GOOG Alphabet Inc. Class C | New | 1.53% | +1.53 |
| ELDN Eledon Pharmaceuticals Inc. | Add +96.7% | 1.94% | +1.41 |
| ANNX Annexon Inc. | New | 1.18% | +1.18 |
| BBIO Bridgebio Pharma Inc. | Add +7.4% | 4.59% | +1.08 |
| ORA Ormat Technologies Inc. | New | 0.99% | +0.99 |
| SEDG Solaredge Technologies Inc. | New | 0.94% | +0.94 |
| TVTX Travere Therapeutics Inc. | New | 0.71% | +0.71 |
| NVMI Nova Ltd. | Add +31.1% | 2.48% | +0.71 |
| DYN Dyne Therapeutics Inc. | Add +318.1% | 1.03% | +0.70 |
| ENGN Engene Holdings Inc. | New | 0.69% | +0.69 |
| ARWR Arrowhead Pharmaceuticals Inc. | New | 0.69% | +0.69 |
| JANX Janux Therapeutics Inc. | New | 0.68% | +0.68 |
| ACOG Alpha Cognition Inc. | New | 0.67% | +0.67 |
| VIR Vir Biotechnology Inc. | Add +523.4% | 0.79% | +0.67 |
| SWTX Springworks Therapeutics Inc. | New | 0.67% | +0.67 |
| WIX Wix.com Ltd. | Add +14.6% | 1.56% | +0.62 |
| CRVS Corvus Pharmaceuticals Inc. | New | 0.49% | +0.49 |
| FROG Jfrog Ltd. | Add +58.1% | 1.03% | +0.46 |
| XENE Xenon Pharmaceuticals Inc. | New | 0.38% | +0.38 |
| ACAD Acadia Pharmaceuticals Inc. | Add +14.3% | 0.98% | +0.34 |
| UBER Uber Technologies Inc. | New | 0.33% | +0.33 |
| AZN Astrazeneca PLC-Spons ADR | Add +18.4% | 2.72% | +0.30 |
| SVRA Savara Inc. | Add +115.2% | 0.69% | +0.30 |
| BMY Bristol-Myers Squibb Co. | New | 0.21% | +0.21 |
| ORIC Oric Pharmaceuticals Inc. | Add +112.8% | 0.41% | +0.19 |
| MERSANA THERAPEUTICS INC | New | 0.18% | +0.18 |
| WDAY Workday Inc. Class A | Add +33.3% | 0.48% | +0.18 |
| ETNB 89BIO Inc. | Add +3.7% | 0.80% | +0.15 |
| GSK GSK PLC-Spon ADR | Add +30.0% | 0.81% | +0.14 |
| NTR Nutrien Ltd. | Add +37.2% | 0.46% | +0.14 |
| OKUR Onkure Therapeutics Inc. Class A | New | 0.14% | +0.14 |
| FATE Fate Therapeutics Inc. | New | 0.12% | +0.12 |
| SNDX Syndax Pharmaceuticals Inc. | Add +33.5% | 3.37% | +0.11 |
| NVO Novo-Nordisk A/S-Spons ADR | Add +25.6% | 1.56% | +0.04 |
| NTLA Intellia Therapeutics Inc. | Add +60.1% | 1.00% | +0.02 |
| RARE Ultragenyx Pharmaceutical Inc. | Add +17.1% | 1.78% | +0.00 |
| BHVN Biohaven Ltd. | Add +17.4% | 1.08% | −0.01 |
| ATXS Astria Therapeutics Inc. | Add +2.4% | 0.23% | −0.02 |
| CGEM Cullinan Therapeutics Inc. | Add +10.3% | 0.46% | −0.05 |
| CLYM Climb Bio Inc. | Add +38.5% | 0.08% | −0.07 |
| RCKT Rocket Pharmaceuticals Inc. | Add +17.3% | 0.63% | −0.07 |
| CLDX Celldex Therapeutics Inc. | Add +13.1% | 2.21% | −0.12 |
| LRMR Larimar Therapeutics Inc. | Add +9.9% | 0.33% | −0.12 |
| KZR Kezar Life Sciences Inc. | Add +428.7% | 0.13% | −0.13 |
| IMTX Immatics NV | Add +27.7% | 1.21% | −0.14 |
| SKYE Skye Bioscience Inc. | Add +0.1% | 0.82% | −0.18 |
Options Activity Q3 2024 → Q4 2024
| PRAX Praxis Precision Medicines I | call | Add +107.5% | 83,000 | $6.4M |
| NICE Nice Ltd. - Spon ADR | call | Sold out | 32,100 | $5.6Mbefore exit |
| PRAX Praxis Precision Medicines I | put | Sold out | 52,000 | $3.0Mbefore exit |
| TVTX Travere Therapeutics Inc. | call | Sold out | 170,700 | $2.4Mbefore exit |
| JSPR Jasper Therapeutics Inc. | put | New | 77,500 | $1.7M |
| SRPT Sarepta Therapeutics Inc. | call | Sold out | 1,000 | $125Kbefore exit |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 97 | $698.8M | TEVA, MLYS, TSEM, SNDX, BIIB |
| Q1 2026 | 92 | $581.5M | MLYS, TEVA, TSEM, NVMI, BBIO |
| Q4 2025 | 94 | $478.5M | TEVA, BIIB, MLYS, SNDX, NVMI |
| Q3 2025 | 101 | $421.6M | TEVA, NICE, TSEM, NVMI, QQQ |
| Q2 2025 | 101 | $382.5M | TEVA, NVMI, SNDX, TSEM, CYTK |
| Q1 2025 | 111 | $405.5M | TEVA, SNDX, SNY, NVMI, AZN |
| Q4 2024 | 102 | $541.4M | TEVA, BBIO, SNY, SNDX, AZN |
| Q3 2024 | 107 | $611.0M | TEVA, SNY, BBIO, SNDX, AMZN |
| Q2 2024 | 109 | $613.3M | BBIO, SNY, CYTK, AMZN, SNDX |
| Q1 2024 | 92 | $617.3M | TEVA, SNY, NICE, CYTK, SNDX |