| TARS Tarsus Pharmaceuticals Inc. | 6.98% | 2,454,797 | $126.1M | Add +8.9% |
| LKFT Lakefront Biotherapeutic-ADR filed as GALAPAGOS NV | 5.51% | 3,961,797 | $99.5M | Add +83.3% |
| AUPH Aurinia Pharmaceuticals Inc. | 4.46% | 10,029,500 | $80.6M | Add +19.0% |
| DVAX Dynavax Technologies Corp. | 4.13% | 5,750,000 | $74.6M | Add +210.8% |
| EOLS Evolus Inc. | 3.33% | 4,997,399 | $60.1M | No change |
| KALV Kalvista Pharmaceuticals Inc. | 3.15% | 4,941,798 | $57.0M | Add +1.0% |
| IMCR Immunocore Holdings PLC-ADR | 3.14% | 1,915,708 | $56.8M | Add +23.1% |
| MIRM Mirum Pharmaceuticals Inc. | 3.08% | 1,237,107 | $55.7M | No change |
| PTCT PTC Therapeutics Inc. | 2.82% | 1,000,000 | $51.0M | Add +42.9% |
| KNSA Kiniksa Pharmaceuticals Inte | 2.60% | 2,118,579 | $47.1M | Add +237.0% |
| VRDN Viridian Therapeutics Inc. | 2.08% | 2,792,925 | $37.6M | Add +12.0% |
| SYRE Spyre Therapeutics Inc. | 1.83% | 2,050,000 | $33.1M | New |
| ITCI Intra-Cellular Therapies Inc. | 1.61% | 220,000 | $29.0M | Reduce -26.7% |
| ANAB Anaptysbio Inc. | 1.59% | 1,545,153 | $28.7M | Add +16.1% |
| REPL Replimune Group Inc. | 1.56% | 2,900,000 | $28.3M | Add +7.4% |
| LEGN Legend Biotech Corp.-ADR | 1.56% | 830,000 | $28.2M | Add +84.4% |
| ACAD Acadia Pharmaceuticals Inc. | 1.38% | 1,500,000 | $24.9M | No change |
| BNTX Biontech SE-ADR | 1.36% | 270,000 | $24.6M | No change |
| SLRN Acelyrin Inc. | 1.34% | 9,818,115 | $24.3M | New |
| JAZZ Jazz Pharmaceuticals PLC | 1.30% | 190,000 | $23.6M | Add +35.7% |
| ANIP Ani Pharmaceuticals Inc. | 1.18% | 317,500 | $21.3M | No change |
| RLAY Relay Therapeutics Inc. | 1.17% | 8,068,058 | $21.1M | No change |
| CMPX Compass Therapeutics Inc. | 1.16% | 11,052,632 | $21.0M | Add +87.3% |
| ADMA Adma Biologics Inc. | 1.15% | 1,050,000 | $20.8M | Add +90.9% |
| LENZ Lenz Therapeutics Inc. | 1.09% | 766,940 | $19.7M | No change |
| AZN Astrazeneca PLC-Spons ADR | 1.02% | 250,000 | $18.4M | Add +66.7% |
| LQDA Liquidia Corp. | 0.98% | 1,200,000 | $17.7M | Add +9.1% |
| NBIX Neurocrine Biosciences Inc. | 0.92% | 150,000 | $16.6M | No change |
| AVDL Avadel Pharmaceuticals Ltd. | 0.91% | 2,097,500 | $16.4M | Add +40.1% |
| ITOS Iteos Therapeutics Inc. | 0.89% | 2,689,200 | $16.1M | Add +1112.9% |
| META Meta Platforms Inc. Class A | 0.88% | 27,575 | $15.9M | Add +3.7% |
| GSK GSK PLC-Spon ADR | 0.86% | 400,000 | $15.5M | No change |
| NVDA Nvidia Corp. | 0.85% | 142,569 | $15.5M | No change |
| SNY Sanofi-ADR | 0.83% | 270,000 | $15.0M | No change |
| AVIR Atea Pharmaceuticals Inc. | 0.79% | 4,800,000 | $14.4M | Add +0.2% |
| ALT Altimmune Inc. | 0.76% | 2,750,000 | $13.8M | No change |
| ZYME Zymeworks Inc. | 0.72% | 1,100,000 | $13.1M | No change |
| NKTX Nkarta Inc. | 0.72% | 7,055,576 | $13.0M | Add +207.6% |
| CRGX Cargo Therapeutics Inc. | 0.69% | 3,059,630 | $12.5M | Add +378.1% |
| HELP Cybin Inc. | 0.64% | 1,830,097 | $11.6M | Add +37.6% |
| PCVX Vaxcyte Inc. | 0.63% | 300,000 | $11.3M | No change |
| KROS Keros Therapeutics Inc. | 0.62% | 1,100,000 | $11.2M | New |
| TDOC Teladoc Health Inc. | 0.62% | 1,400,000 | $11.1M | No change |
| DERM Journey Medical Corp. | 0.61% | 1,854,596 | $10.9M | Add +7.5% |
| VNDA Vanda Pharmaceuticals Inc. | 0.60% | 2,353,307 | $10.8M | No change |
| ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD | 0.56% | 37,000 | $10.1M | No change |
| ARVN Arvinas Inc. | 0.54% | 1,393,800 | $9.8M | New |
| HRMY Harmony Biosciences Holdings | 0.52% | 281,200 | $9.3M | No change |
| BABA Alibaba Group Holding-SP ADR | 0.51% | 70,000 | $9.3M | New |
| CRSP Crispr Therapeutics AG | 0.50% | 266,500 | $9.1M | No change |
| MRNA Moderna Inc. | 0.48% | 305,300 | $8.7M | Add +1.8% |
| CGEM Cullinan Therapeutics Inc. | 0.47% | 1,121,138 | $8.5M | Add +21.7% |
| ELAN Elanco Animal Health Inc. | 0.46% | 800,100 | $8.4M | Add +0.0% |
| PLRX Pliant Therapeutics Inc. | 0.45% | 6,000,000 | $8.1M | New |
| BLCO Bausch + Lomb Corp. | 0.44% | 550,000 | $8.0M | Add +22.2% |
| INSM Insmed Inc. | 0.42% | 100,000 | $7.6M | No change |
| PHAT Phathom Pharmaceuticals Inc. | 0.42% | 1,200,000 | $7.5M | Add +140.0% |
| APGE Apogee Therapeutics Inc. | 0.41% | 200,000 | $7.5M | Add +100.0% |
| HLVX Hillevax Inc. | 0.39% | 4,920,000 | $7.1M | No change |
| IBRX Immunitybio Inc. | 0.39% | 2,333,333 | $7.0M | Reduce -17.1% |
| NUVB Nuvation Bio Inc. | 0.38% | 3,900,000 | $6.9M | No change |
| EPIX Essa Pharma Inc. | 0.38% | 4,300,000 | $6.8M | No change |
| EWTX Edgewise Therapeutics Inc. | 0.37% | 300,000 | $6.6M | No change |
| VKTX Viking Therapeutics Inc. | 0.36% | 270,000 | $6.5M | Reduce -15.6% |
| DSGN Design Therapeutics Inc. | 0.36% | 1,680,975 | $6.5M | Add +13.5% |
| REGN Regeneron Pharmaceuticals | 0.35% | 10,000 | $6.3M | Add +400.0% |
| ACET Adicet Bio Inc. | 0.34% | 8,223,612 | $6.2M | Add +0.9% |
| BIOA Bioage Labs Inc. | 0.33% | 1,600,000 | $6.0M | Add +21.4% |
| BCRX Biocryst Pharmaceuticals Inc. | 0.33% | 800,000 | $6.0M | No change |
| IOVA Iovance Biotherapeutics Inc. | 0.33% | 1,800,000 | $6.0M | Add +260.0% |
| ABCL Abcellera Biologics Inc. | 0.32% | 2,600,000 | $5.8M | Add +0.7% |
| RCKT Rocket Pharmaceuticals Inc. | 0.31% | 850,000 | $5.7M | Add +13.3% |
| HRTX Heron Therapeutics Inc. | 0.27% | 2,235,459 | $4.9M | Add +4.5% |
| LNTH Lantheus Holdings Inc. | 0.27% | 50,000 | $4.9M | No change |
| DNTH Dianthus Therapeutics Inc. | 0.27% | 264,692 | $4.8M | No change |
| BIIB Biogen Inc. | 0.27% | 35,000 | $4.8M | No change |
| IONS Ionis Pharmaceuticals Inc. | 0.25% | 150,000 | $4.5M | No change |
| CTMX Cytomx Therapeutics Inc. | 0.24% | 6,717,825 | $4.3M | Reduce -8.1% |
| MRUS Merus NV | 0.23% | 100,000 | $4.2M | No change |
| CHRS Coherus Oncology Inc. | 0.23% | 5,097,362 | $4.1M | Add +39.6% |
| JANX Janux Therapeutics Inc. | 0.22% | 150,000 | $4.0M | Add +200.0% |
| CYTK Cytokinetics Inc. | 0.22% | 100,000 | $4.0M | No change |
| CMPS Compass Pathways PLC | 0.22% | 1,400,000 | $4.0M | Add +40.0% |
| TGTX TG Therapeutics Inc. | 0.22% | 100,000 | $3.9M | No change |
| GMAB Genmab A/S -SP ADR | 0.22% | 200,000 | $3.9M | Add +100.0% |
| NVAX Novavax Inc. | 0.21% | 600,000 | $3.8M | No change |
| ARE Alexandria Real Estate Equit | 0.20% | 40,000 | $3.7M | No change |
| VERA Vera Therapeutics Inc. | 0.20% | 150,000 | $3.6M | New |
| SLNO Soleno Therapeutics Inc. | 0.20% | 50,000 | $3.6M | No change |
| VTYX Ventyx Biosciences Inc. | 0.20% | 3,100,000 | $3.6M | No change |
| NUVL Nuvalent Inc. Class A | 0.20% | 50,000 | $3.5M | No change |
| RVMD Revolution Medicines Inc. | 0.20% | 100,000 | $3.5M | No change |
| KZR Kezar Life Sciences Inc. | 0.19% | 720,000 | $3.5M | No change |
| BHVN Biohaven Ltd. | 0.19% | 140,000 | $3.4M | No change |
| STOK Stoke Therapeutics Inc. | 0.18% | 500,000 | $3.3M | Add +66.7% |
| SWTX Springworks Therapeutics Inc. | 0.18% | 74,265 | $3.3M | No change |
| VIR Vir Biotechnology Inc. | 0.18% | 500,000 | $3.2M | New |
| THRD Third Harmonic Bio Inc. | 0.18% | 929,727 | $3.2M | Add +519.8% |
| DTIL Precision Biosciences Inc. | 0.18% | 673,332 | $3.2M | No change |
| BDTX Black Diamond Therapeutics I | 0.18% | 2,070,209 | $3.2M | No change |
| MLYS Mineralys Therapeutics Inc. | 0.18% | 200,000 | $3.2M | New |
| TECX Tectonic Therapeutic Inc. | 0.18% | 179,166 | $3.2M | Add +126.3% |
| KLRS Kalaris Therapeutics Inc. | 0.14% | 309,221 | $2.5M | New |
| SNDX Syndax Pharmaceuticals Inc. | 0.14% | 200,000 | $2.5M | Add +100.0% |
| ZNTL Zentalis Pharmaceuticals Inc. | 0.13% | 1,500,000 | $2.4M | New |
| TBPH Theravance Biopharma Inc. | 0.13% | 262,896 | $2.3M | No change |
| BRK.B Berkshire Hathaway Inc. Class B | 0.13% | 4,401 | $2.3M | Add +42.0% |
| MIND MEDICINE MINDMED INC | 0.13% | 400,200 | $2.3M | Add +100.1% |
| V Visa Inc. Class A | 0.13% | 6,570 | $2.3M | Add +39.3% |
| SEER Seer Inc. | 0.12% | 1,294,423 | $2.2M | Reduce -41.0% |
| JPM JPMorgan Chase & Co. | 0.12% | 8,854 | $2.2M | Add +34.1% |
| VZ Verizon Communications Inc. | 0.12% | 47,153 | $2.1M | Add +52.7% |
| KO The Coca-Cola Co. | 0.12% | 29,762 | $2.1M | Add +51.0% |
| IDXX Idexx Laboratories Inc. | 0.12% | 5,000 | $2.1M | No change |
| WMT Walmart Inc. | 0.12% | 23,802 | $2.1M | Add +36.6% |
| JNJ Johnson & Johnson | 0.11% | 12,243 | $2.0M | Add +53.8% |
| ATYR Atyr Pharma Inc. | 0.11% | 671,134 | $2.0M | No change |
| PG The Procter & Gamble Co. | 0.11% | 11,813 | $2.0M | Add +48.4% |
| ALLK Allakos LLC | 0.11% | 8,693,687 | $2.0M | Add +2196.6% |
| XOM Exxon Mobil Corp. | 0.11% | 16,597 | $2.0M | Add +50.2% |
| ALXO Alx Oncology Holdings Inc. | 0.11% | 3,158,265 | $2.0M | Reduce -4.2% |
| BLUEBIRD BIO INC | 0.11% | 400,000 | $2.0M | New |
| INTC Intel Corp. | 0.11% | 84,945 | $1.9M | Add +51.7% |
| UNH Unitedhealth Group Inc. | 0.10% | 3,541 | $1.9M | Add +53.4% |
| DIS The Walt Disney Co. filed as DISNEY WALT CO | 0.10% | 18,626 | $1.8M | Add +42.2% |
| MSFT Microsoft Corp. | 0.10% | 4,825 | $1.8M | Add +41.4% |
| HD Home Depot Inc. | 0.10% | 4,850 | $1.8M | Add +44.6% |
| CDNA Caredx Inc. | 0.10% | 100,000 | $1.8M | No change |
| TXN Texas Instruments Inc. | 0.10% | 9,775 | $1.8M | Add +48.8% |
| OKUR Onkure Therapeutics Inc. Class A | 0.10% | 400,000 | $1.7M | Add +35.8% |
| PFE Pfizer Inc. | 0.09% | 66,800 | $1.7M | Add +55.7% |
| ERAS Erasca Inc. | 0.09% | 1,190,012 | $1.6M | Add +97.4% |
| VSTM Verastem Inc. | 0.09% | 270,000 | $1.6M | No change |
| NKE Nike Inc. Class B | 0.09% | 24,764 | $1.6M | Add +56.8% |
| BOLT Bolt Biotherapeutics Inc. | 0.08% | 3,812,773 | $1.5M | No change |
| FATE Fate Therapeutics Inc. | 0.08% | 1,867,773 | $1.5M | Add +0.6% |
| VTRS Viatris Inc. | 0.08% | 168,979 | $1.5M | Add +47.8% |
| PYPL PayPal Holdings Inc. | 0.08% | 22,108 | $1.4M | Add +40.7% |
| CCCC C4 Therapeutics Inc. | 0.08% | 900,000 | $1.4M | No change |
| NMRA Neumora Therapeutics Inc. | 0.08% | 1,400,000 | $1.4M | New |
| ELEV Elevation Oncology Inc. | 0.07% | 4,760,000 | $1.2M | No change |
| CLYM Climb Bio Inc. | 0.07% | 1,000,000 | $1.2M | New |
| NFLX Netflix Inc. | 0.07% | 1,301 | $1.2M | Reduce -3.2% |
| APLT Applied Therapeutics Inc. | 0.07% | 2,428,169 | $1.2M | No change |
| ALGS Aligos Therapeutics Inc. | 0.06% | 141,131 | $1.2M | New |
| TMUS T-Mobile US Inc. | 0.06% | 4,328 | $1.2M | Reduce -4.0% |
| GE General Electric filed as GE AEROSPACE | 0.06% | 5,675 | $1.1M | Reduce -4.0% |
| KRON Kronos Bio Inc. | 0.06% | 1,345,413 | $1.1M | Add +34.1% |
| PYXS Pyxis Oncology Inc. | 0.06% | 1,100,000 | $1.1M | New |
| ALL Allstate Corp. | 0.06% | 5,112 | $1.1M | Reduce -3.9% |
| BA The Boeing Co. | 0.06% | 6,068 | $1.0M | Reduce -3.6% |
| PAYX Paychex Inc. | 0.06% | 6,688 | $1.0M | Reduce -4.1% |
| MCD McDonald's Corp. | 0.06% | 3,228 | $1.0M | Reduce -4.1% |
| AAT American Assets Trust Inc. | 0.06% | 50,000 | $1.0M | New |
| AXP American Express Co. | 0.05% | 3,666 | $986K | Reduce -3.5% |
| BEAM Beam Therapeutics Inc. | 0.05% | 50,000 | $977K | No change |
| ULTA Ulta Beauty Inc. | 0.05% | 2,606 | $955K | Reduce -3.5% |
| CVX Chevron Corp. | 0.05% | 5,697 | $953K | Reduce -4.7% |
| HRL Hormel Foods Corp. | 0.05% | 30,464 | $943K | Reduce -4.0% |
| AMZN Amazon.com Inc. | 0.05% | 4,895 | $931K | Reduce -3.5% |
| SHW The Sherwin-Williams Co. | 0.05% | 2,648 | $925K | Reduce -4.2% |
| OPRX Optimizerx Corp. | 0.05% | 100,000 | $866K | Reduce -54.8% |
| CLX Clorox Company | 0.05% | 5,766 | $849K | Reduce -4.1% |
| UAL United Airlines Holdings Inc. | 0.05% | 11,993 | $828K | Reduce -3.2% |
| TCRX Tscan Therapeutics Inc. | 0.05% | 600,000 | $828K | Add +409.1% |
| F Ford Motor Co. filed as FORD MTR CO | 0.05% | 81,727 | $820K | Reduce -4.7% |
| GEV GE Vernova Inc. | 0.04% | 2,593 | $792K | Reduce -4.3% |
| FDX FedEx Corp. | 0.04% | 3,201 | $780K | Reduce -4.4% |
| SEE Sealed Air Corp. | 0.04% | 26,946 | $779K | Reduce -4.2% |
| FTRE Fortrea Holdings Inc. | 0.04% | 100,000 | $755K | No change |
| CAPR Capricor Therapeutics Inc. | 0.04% | 79,100 | $751K | New |
| WHR Whirlpool Corp. | 0.04% | 8,163 | $736K | Reduce -4.1% |
| OABI Omniab Inc. | 0.04% | 300,000 | $720K | No change |
| CNTA Centessa Pharmaceuticals Ltd. | 0.04% | 50,000 | $719K | New |
| ENTA Enanta Pharmaceuticals Inc. | 0.04% | 126,655 | $699K | No change |
| HPE Hewlett Packard Enterprise | 0.04% | 44,547 | $687K | Reduce -4.0% |
| CRBP Corbus Pharmaceuticals Holdi | 0.04% | 127,520 | $677K | Reduce -47.5% |
| KURA Kura Oncology Inc. | 0.04% | 100,000 | $660K | No change |
| PBYI Puma Biotechnology Inc. | 0.03% | 200,000 | $592K | No change |
| ATXS Astria Therapeutics Inc. | 0.03% | 100,000 | $534K | No change |
| LXRX Lexicon Pharmaceuticals Inc. | 0.03% | 1,150,268 | $530K | Add +35.3% |
| PASG Passage Bio Inc. | 0.03% | 1,500,000 | $530K | No change |
| OTLK Outlook Therapeutics Inc. | 0.03% | 400,000 | $488K | Add +119.2% |
| REVIVA PHARMACEUTCLS HLDGS I | 0.03% | 510,329 | $487K | Add +200.2% |
| BCAB Bioatla Inc. | 0.03% | 1,374,076 | $477K | No change |
| ATRA Atara Biotherapeutics Inc. | 0.02% | 75,196 | $447K | No change |
| LAB Standard Biotools Inc. | 0.02% | 407,755 | $440K | No change |
| IPSC Century Therapeutics Inc. | 0.02% | 900,000 | $428K | No change |
| AMLX Amylyx Pharmaceuticals Inc. | 0.02% | 100,000 | $354K | No change |
| FLNA Filana Therapeutics Inc. filed as CASSAVA SCIENCES INC | 0.02% | 200,000 | $300K | New |
| GRAL Grail Inc. | 0.02% | 11,300 | $289K | Reduce -94.3% |
| KOD Kodiak Sciences Inc. | 0.02% | 100,000 | $281K | New |
| MGNX Macrogenics Inc. | 0.02% | 218,856 | $278K | No change |
| QUINCE THERAPEUTICS INC | 0.01% | 184,383 | $245K | New |
| IVVD Invivyd Inc. | 0.01% | 400,000 | $242K | Add +21.1% |
| NXTC Nextcure Inc. | 0.01% | 404,144 | $194K | Reduce -42.3% |
| MGX Metagenomi Therapeutics Inc. | 0.01% | 134,978 | $184K | New |
| AEROVATE THERAPEUTICS INC | 0.01% | 69,754 | $175K | New |
| ATHIRA PHARMA INC | 0.01% | 600,000 | $171K | No change |
| MCRB Seres Therapeutics Inc. | 0.01% | 203,904 | $143K | New |
| STRO Sutro Biopharma Inc. Com SHS | 0.01% | 200,000 | $130K | New |
| AFMDQ Affimed NV | 0.01% | 148,315 | $107K | No change |