| APGE Apogee Therapeutics Inc. | 26.13% | 8,493,321 | $498.9M | No change |
| OCUL Ocular Therapeutix Inc. | 5.82% | 12,762,462 | $111.0M | No change |
| ELVN Enliven Therapeutics Inc. | 5.39% | 4,026,331 | $102.8M | No change |
| VRDN Viridian Therapeutics Inc. | 4.63% | 3,882,709 | $88.3M | Add +0.0% |
| APLT Applied Therapeutics Inc. | 4.37% | 9,825,000 | $83.5M | Add +3.0% |
| SYRE Spyre Therapeutics Inc. | 4.14% | 2,685,448 | $79.0M | No change |
| DYN Dyne Therapeutics Inc. | 4.09% | 2,173,913 | $78.1M | No change |
| ORKA Oruka Therapeutics Inc. | 3.96% | 3,085,620 | $75.6M | New |
| KALV Kalvista Pharmaceuticals Inc. | 3.79% | 6,249,731 | $72.4M | No change |
| PHVS Pharvaris NV | 3.29% | 3,395,606 | $62.9M | No change |
| COGT Cogent Biosciences Inc. | 3.22% | 5,684,167 | $61.4M | No change |
| DNTH Dianthus Therapeutics Inc. | 2.50% | 1,744,373 | $47.8M | Reduce -16.7% |
| FDMT 4D Molecular Therapeutics Inc. | 2.49% | 4,400,000 | $47.6M | No change |
| MRUS Merus NV | 2.38% | 907,963 | $45.4M | Reduce -28.1% |
| ORIC Oric Pharmaceuticals Inc. | 2.36% | 4,394,527 | $45.0M | No change |
| ERAS Erasca Inc. | 2.32% | 16,216,216 | $44.3M | No change |
| PRAX Praxis Precision Medicines I | 2.13% | 706,131 | $40.6M | No change |
| ATXS Astria Therapeutics Inc. | 1.99% | 3,458,645 | $38.1M | Reduce -4.2% |
| TERN Terns Pharmaceuticals Inc. | 1.49% | 3,410,058 | $28.4M | No change |
| AQST Aquestive Therapeutics Inc. | 1.45% | 5,555,555 | $27.7M | No change |
| EWTX Edgewise Therapeutics Inc. | 1.40% | 1,000,000 | $26.7M | Reduce -45.0% |
| ARTV Artiva Biotherapeutics Inc. | 1.30% | 1,609,569 | $24.9M | New |
| ENGN Engene Holdings Inc. | 1.23% | 3,565,841 | $23.5M | Add +26.2% |
| CGEM Cullinan Therapeutics Inc. | 1.21% | 1,379,965 | $23.1M | No change |
| MERSANA THERAPEUTICS INC | 1.12% | 11,328,000 | $21.4M | No change |
| TSHA Taysha Gene Therapies Inc. | 0.95% | 9,000,000 | $18.1M | No change |
| ABVX Abivax SA-ADR | 0.81% | 1,345,780 | $15.5M | No change |
| TRVI Trevi Therapeutics Inc. | 0.60% | 3,422,656 | $11.4M | Add +0.0% |
| ARVN Arvinas Inc. | 0.59% | 454,450 | $11.2M | Reduce -27.6% |
| ADVM Adverum Biotechnologies Inc. | 0.54% | 1,467,048 | $10.3M | No change |
| IPSC Century Therapeutics Inc. | 0.48% | 5,389,259 | $9.2M | No change |
| ZURA Zura Bio Ltd. | 0.43% | 2,023,166 | $8.2M | Reduce -66.4% |
| FRNM Freenome Inc. filed as PERCEPTIVE CAP SOLUTIONS COR | 0.39% | 750,000 | $7.5M | No change |
| CABA Cabaletta Bio Inc. | 0.39% | 1,563,952 | $7.4M | No change |
| CASIF Casi Pharmaceuticals Inc. | 0.32% | 987,259 | $6.1M | Add +784.0% |
| TNYA Tenaya Therapeutics Inc. | 0.16% | 1,555,556 | $3.0M | No change |
| TIL Instil Bio Inc. | 0.12% | 33,177 | $2.2M | New |
| TENX Tenax Therapeutics Inc. | 0.04% | 208,333 | $721K | New |