| APGE Apogee Therapeutics Inc. | 27.00% | 8,493,321 | $317.3M | No change |
| MTSR Metsera Inc. | 8.69% | 3,750,662 | $102.1M | New |
| OCUL Ocular Therapeutix Inc. | 7.96% | 12,762,462 | $93.5M | No change |
| ELVN Enliven Therapeutics Inc. | 6.74% | 4,026,331 | $79.2M | No change |
| KALV Kalvista Pharmaceuticals Inc. | 6.58% | 6,703,985 | $77.4M | Add +7.3% |
| VRDN Viridian Therapeutics Inc. | 4.45% | 3,882,709 | $52.3M | No change |
| PHVS Pharvaris NV | 4.16% | 3,112,720 | $48.9M | Reduce -3.3% |
| SYRE Spyre Therapeutics Inc. | 3.69% | 2,685,448 | $43.3M | No change |
| ORKA Oruka Therapeutics Inc. | 3.62% | 4,148,428 | $42.6M | Add +26.3% |
| PRAX Praxis Precision Medicines I | 3.19% | 989,985 | $37.5M | No change |
| COGT Cogent Biosciences Inc. | 2.90% | 5,684,411 | $34.0M | No change |
| DNTH Dianthus Therapeutics Inc. | 2.69% | 1,744,373 | $31.6M | No change |
| DYN Dyne Therapeutics Inc. | 1.93% | 2,173,913 | $22.7M | No change |
| CDTX Cidara Therapeutics Inc. | 1.93% | 1,051,518 | $22.6M | Add +37.3% |
| ENGN Engene Holdings Inc. | 1.92% | 5,046,414 | $22.6M | No change |
| ERAS Erasca Inc. | 1.89% | 16,216,216 | $22.2M | No change |
| ORIC Oric Pharmaceuticals Inc. | 1.51% | 3,182,527 | $17.8M | Reduce -27.6% |
| UPB Upstream Bio Inc. | 1.20% | 2,295,319 | $14.0M | No change |
| ATXS Astria Therapeutics Inc. | 1.12% | 2,457,348 | $13.1M | No change |
| CGEM Cullinan Therapeutics Inc. | 0.89% | 1,379,965 | $10.4M | No change |
| SLDB Solid Biosciences Inc. | 0.78% | 2,481,400 | $9.2M | New |
| SVRA Savara Inc. | 0.77% | 3,257,639 | $9.0M | New |
| ABVX Abivax SA-ADR | 0.72% | 1,345,780 | $8.4M | No change |
| FRNM Freenome Inc. filed as PERCEPTIVE CAP SOLUTIONS COR | 0.66% | 750,000 | $7.7M | No change |
| SRZN Surrozen Inc. | 0.63% | 632,931 | $7.4M | New |
| ZURA Zura Bio Ltd. | 0.55% | 5,023,166 | $6.5M | Add +148.3% |
| ARTV Artiva Biotherapeutics Inc. | 0.41% | 1,609,569 | $4.8M | No change |
| TRVI Trevi Therapeutics Inc. | 0.33% | 615,506 | $3.9M | Reduce -51.4% |
| APLT Applied Therapeutics Inc. | 0.23% | 5,567,709 | $2.7M | Reduce -44.3% |
| FDMT 4D Molecular Therapeutics Inc. | 0.19% | 677,600 | $2.2M | Reduce -77.0% |
| CASIF Casi Pharmaceuticals Inc. | 0.18% | 987,259 | $2.1M | No change |
| TENX Tenax Therapeutics Inc. | 0.12% | 208,333 | $1.4M | No change |
| MERSANA THERAPEUTICS INC | 0.10% | 3,574,325 | $1.2M | Reduce -65.2% |
| IPSC Century Therapeutics Inc. | 0.10% | 2,498,069 | $1.2M | Reduce -36.9% |
| TNYA Tenaya Therapeutics Inc. | 0.08% | 1,555,556 | $887K | No change |
| GLYCOMIMETICS INC | 0.05% | 3,000,000 | $630K | No change |
| TIL Instil Bio Inc. | 0.05% | 33,177 | $576K | No change |