Crescent BiopharmaCBIO
13F holders, Q4 2025 (December 31)At the end of Q4 2025, 56 institutions reported holding Crescent Biopharma Inc. (CBIO) in their 13F filings, up 15 from Q3 2025. 20 opened new positions and 6 sold out. The largest holders were FMR LLC ($49.0M), BVF Inc. ($32.6M) and Fairmount Funds Management LLC ($32.6M). 3 famous investors held it, including Steve Cohen (0.0% of Point72 Asset Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Crescent Biopharma Inc.
- CUSIP
- G2545C104
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 20 | $79.8M |
| Exits | 6 | $13.9M |
All 13F filers, Q3 2025 → Q4 2025: 13,441,234 shares bought and 1,391,117 shares sold, net +12,050,117 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 56 holders
| FMR LLC | 0.00% | Add +192.2% | 4,133,514 | $49.0M |
| BVF Inc. | 1.10% | Add +98.1% | 2,748,763 | $32.6M |
| Fairmount Funds Management LLC | 2.48% | Add +98.0% | 2,747,866 | $32.6M |
| Venrock Adviser, LLC | 1.25% | Add +53.7% | 2,133,576 | $25.3M |
| FCPM III Services B.V. | 2.61% | New | 1,677,852 | $19.9M |
| Vestal Point Capital, LP | 0.65% | New | 1,500,000 | $17.8M |
| Opaleye Management Inc. | 1.84% | New | 1,178,300 | $14.0M |
| Tang Capital Management LLC | 0.51% | Add +28.3% | 872,398 | $10.3M |
| ADAR1 Capital Management, LLC | 0.54% | New | 606,000 | $7.2M |
| Logos Global Management LP | 0.47% | No change | 600,000 | $7.1M |
| Vanguard Group Inc. | 0.00% | Reduce -15.3% | 557,506 | $6.6M |
| Boxer Capital Management, LLC | 1.18% | No change | 453,686 | $5.4M |
| Deep Track Capital, LP | 0.12% | No change | 453,686 | $5.4M |
| Perceptive Advisors LLC | 0.10% | No change | 453,686 | $5.4M |
| NEXTBio Capital Management LP | 2.59% | — | 372,856 | $4.4M |
| RTW Investments, LP | 0.04% | New | 372,856 | $4.4M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -11.8% | 338,125 | $4.0M |
| Driehaus Capital Management LLC | 0.02% | No change | 302,457 | $3.6M |
| Point72 Asset Management | 0.01% | New | 300,000 | $3.6M |
| Heights Capital Management, Inc. | 1.20% | New | 264,000 | $3.1M |
| Alyeska Investment Group, L.P. | 0.01% | New | 264,000 | $3.1M |
| Wellington Management Group LLP | 0.00% | Add +710.3% | 143,412 | $1.6M |
| Two Sigma Investments, LP | 0.00% | Add +342.2% | 125,224 | $1.5M |
| Balyasny Asset Management L.P. | 0.00% | New | 111,715 | $1.3M |
| BlackRock, Inc. | 0.00% | Add +0.1% | 109,230 | $1.3M |
| Geode Capital Management, LLC | 0.00% | Add +31.7% | 91,079 | $1.1M |
| Stonepine Capital Management, LLC | 0.82% | New | 87,682 | $1.0M |
| Blackstone Inc. | 0.00% | No change | 75,614 | $897K |
| Woodline Partners LP | 0.00% | New | 74,000 | $878K |
| Burkehill Global Management, LP | 0.06% | New | 74,000 | $844K |
| Jefferies Financial Group Inc. | 0.01% | Reduce -37.5% | 64,244 | $762K |
| Millennium Management | 0.00% | New | 61,882 | $734K |
| Susquehanna International Group, LLP | 0.00% | New | 57,048 | $677K |
| Renaissance Technologies | 0.00% | Add +73.6% | 46,700 | $554K |
| Two Sigma Advisers, LP | 0.00% | New | 32,500 | $385K |
| Morgan Stanley | 0.00% | Add +18880.0% | 27,521 | $326K |
| State Street Corp. | 0.00% | Add +40.8% | 26,217 | $311K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -31.7% | 25,245 | $299K |
| Moore Capital Management, LP | 0.01% | New | 25,000 | $297K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -0.1% | 24,903 | $289K |
| JPMorgan Chase & Co. | 0.00% | Add +137188.2% | 23,339 | $277K |
| Jane Street Group, LLC | 0.00% | New | 22,965 | $272K |
| Marshall Wace, LLP | 0.00% | Reduce -50.0% | 21,826 | $259K |
| Northern Trust Corp. | 0.00% | Add +2.5% | 17,229 | $204K |
| HRT Financial LP | 0.00% | New | 13,083 | $155K |
| OMERS ADMINISTRATION Corp | 0.00% | New | 11,600 | $138K |
| UBS Group AG | 0.00% | Reduce -43.7% | 7,125 | $85K |
| Bank of America Corp. | 0.00% | Add +44.3% | 5,573 | $66K |
| BNP Paribas Financial Markets | 0.00% | Add +89525.0% | 3,585 | $43K |
| Citigroup Inc. | 0.00% | Reduce -21.9% | 623 | $7K |
| Tower Research Capital LLC (TRC) | 0.00% | Add +104.5% | 409 | $5K |
| SBI Securities Co., Ltd. | 0.00% | No change | 68 | $806 |
| Osaic Holdings, Inc. | 0.00% | No change | 26 | $308 |
| Group One Trading LLC | 0.00% | Reduce -95.1% | 4 | $47 |
| Royal Bank of Canada | 0.00% | No change | 20 | $0 |
| Avion Wealth | 0.00% | New | 40 | $0 |
"% of holder's portfolio" is CBIO's weight in each manager's 13F, not the share of Crescent Biopharma Inc. the manager owns.