| Decheng Capital LLC | 32.14% | New | 5,458,810 | $239.6M |
| TCG Crossover Management, LLC | 12.39% | New | 3,570,206 | $156.7M |
| BlackRock Inc. | 0.00% | New | 2,518,550 | $110.6M |
| Vanguard Group Inc. | 0.00% | New | 2,225,018 | $97.7M |
| BVF Inc. | 2.27% | New | 1,884,191 | $82.7M |
| Janus Henderson Group PLC | 0.04% | New | 1,521,432 | $66.8M |
| Avidity Partners Management LP | 2.27% | New | 1,454,765 | $63.9M |
| Ra Capital Management, L.P. | 0.78% | New | 1,397,433 | $61.3M |
| Perceptive Advisors LLC | 1.01% | New | 1,304,105 | $57.3M |
| Braidwell LP | 2.80% | New | 1,130,235 | $49.6M |
| T. Rowe Price Associates Inc. | 0.01% | New | 992,118 | $43.6M |
| Alliancebernstein L.P. | 0.01% | New | 929,752 | $40.8M |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 96.81% | New | 915,501 | $40.2M |
| Franklin Resources Inc. | 0.01% | New | 848,092 | $37.2M |
| Cormorant Asset Management, LP | 1.55% | New | 800,000 | $35.1M |
| Frazier Life Sciences Management, L.P. | 1.43% | New | 770,000 | $33.8M |
| Holocene Advisors, LP | 0.12% | New | 766,625 | $33.7M |
| Polar Capital Holdings Plc | 0.17% | New | 729,166 | $32.0M |
| T. Rowe Price Investment Management, Inc. | 0.02% | New | 708,711 | $31.1M |
| Avoro Capital Advisors LLC | 0.36% | New | 700,000 | $30.7M |
| Foresite Capital Management V, LLC | 28.54% | New | 692,550 | $30.4M |
| Millennium Management | 0.02% | New | 558,197 | $24.5M |
| Woodline Partners LP | 0.21% | New | 525,199 | $23.1M |
| Geode Capital Management, LLC | 0.00% | New | 504,216 | $22.1M |
| Adage Capital Partners Gp, L.L.C. | 0.04% | New | 455,000 | $20.0M |
| RTW Investments, LP | 0.27% | New | 413,670 | $18.2M |
| State Street Corp. | 0.00% | New | 350,831 | $15.4M |
| Venrock Adviser, LLC | 0.73% | New | 350,000 | $15.4M |
| Ally Bridge Group (NY) LLC | 7.82% | New | 320,378 | $14.1M |
| American International Group, Inc. | 0.05% | New | 306,226 | $13.4M |
| Logos Global Management LP | 1.39% | New | 300,000 | $13.2M |
| Citadel Advisors | 0.01% | New | 276,461 | $12.1M |
| Massachusetts Financial Services Co. | 0.00% | New | 259,888 | $11.4M |
| TimesSquare Capital Management, LLC | 0.14% | New | 224,073 | $9.8M |
| Soleus Capital Management, L.P. | 0.84% | New | 217,871 | $9.6M |
| Wellington Management Group LLP | 0.00% | New | 198,807 | $8.7M |
| ArrowMark Colorado Holdings LLC | 0.10% | New | 196,107 | $8.6M |
| Point72 Asset Management | 0.02% | New | 186,237 | $8.2M |
| Northern Trust Corp. | 0.00% | New | 183,004 | $8.0M |
| Rock Springs Capital Management LP | 0.19% | New | 170,859 | $7.5M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 169,352 | $7.4M |
| Monashee Investment Management LLC | 0.66% | New | 125,000 | $5.5M |
| Driehaus Capital Management LLC | 0.05% | New | 107,957 | $4.7M |
| Walleye Capital LLC | 0.06% | New | 106,319 | $4.7M |
| Jane Street Group, LLC | 0.00% | New | 76,353 | $3.4M |
| Ghost Tree Capital, LLC | 1.06% | New | 75,000 | $3.3M |
| Morgan Stanley | 0.00% | New | 73,724 | $3.2M |
| Bank of New York Mellon Corp | 0.00% | New | 64,543 | $2.8M |
| Manufacturers Life Insurance Company, The | 0.00% | New | 63,774 | $2.8M |
| Nuveen Asset Management, LLC | 0.00% | New | 61,866 | $2.7M |
| Deerfield Management Company, L.P. | 0.04% | New | 47,540 | $2.1M |
| Stempoint Capital LP | 0.48% | New | 40,723 | $1.8M |
| Rhumbline Advisers | 0.00% | New | 30,289 | $1.3M |
| Cubist Systematic Strategies, LLC | 0.01% | New | 28,672 | $1.3M |
| Sicart Associates LLC | 0.40% | New | 25,000 | $1.1M |
| Ghisallo Capital Management LLC | 0.14% | New | 25,000 | $1.1M |
| Blackstone Inc. | 0.00% | New | 25,000 | $1.1M |
| Point72 (DIFC) Ltd | 0.08% | — | 24,807 | $1.1M |
| UBS Group AG | 0.00% | New | 23,323 | $1.0M |
| Gilder Gagnon Howe & Co. LLC | 0.01% | New | 18,523 | $813K |
| Capstone Investment Advisors, LLC | 0.03% | New | 18,354 | $806K |
| Barclays PLC | 0.00% | New | 16,353 | $718K |
| Renaissance Technologies | 0.00% | New | 14,200 | $623K |
| Bank of America Corp. | 0.00% | New | 14,147 | $621K |
| LMR Partners LLP | 0.02% | New | 13,616 | $598K |
| Scientech Research LLC | 0.28% | New | 12,194 | $535K |
| Invesco Ltd. | 0.00% | New | 12,183 | $535K |
| MetLife Investment Management, LLC | 0.00% | New | 12,106 | $531K |
| CenterBook Partners LP | 0.04% | New | 11,836 | $520K |
| BNP Paribas Financial Markets | 0.00% | New | 11,198 | $492K |
| Susquehanna International Group, LLP | 0.00% | New | 11,149 | $489K |
| Deutsche Bank AG | 0.00% | New | 10,693 | $469K |
| Wells Fargo & Company | 0.00% | New | 9,623 | $422K |
| M&T Bank Corp | 0.00% | New | 9,580 | $420K |
| JPMorgan Chase & Co. | 0.00% | New | 9,538 | $419K |
| Landscape Capital Management, L.L.C. | 0.03% | New | 7,449 | $327K |
| New York State Common Retirement Fund | 0.00% | New | 7,000 | $307K |
| Voya Investment Management LLC | 0.00% | New | 6,956 | $305K |
| XTX Topco Ltd | 0.03% | New | 5,728 | $251K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.06% | New | 4,933 | $217K |
| Schonfeld Strategic Advisors LLC | 0.00% | New | 4,800 | $211K |
| Citigroup Inc. | 0.00% | New | 4,284 | $188K |
| STRS Ohio | 0.00% | New | 4,100 | $179K |
| California State Teachers Retirement System | 0.00% | New | 2,341 | $103K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 2,320 | $102K |
| Legal & General Group Plc | 0.00% | New | 2,162 | $95K |
| ADAR1 Capital Management, LLC | 0.02% | New | 2,050 | $90K |
| Metropolitan Life Insurance Co | 0.00% | New | 1,246 | $55K |
| AlphaCentric Advisors LLC | 0.03% | New | 1,000 | $44K |
| Amalgamated Bank | 0.00% | New | 781 | $34K |
| Royal Bank of Canada | 0.00% | New | 528 | $23K |
| FMR LLC | 0.00% | New | 157 | $7K |
| Comerica Bank | 0.00% | New | 55 | $2K |
| Washington Trust Advisors, Inc. | 0.00% | New | 49 | $2K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 38 | $2K |
| Nisa Investment Advisors, LLC | 0.00% | New | 5 | $220 |