InsmedINSM
13F holders, Q4 2025 (December 31)678holders +112
165new positions
80sold out
8famous investors
$174.05avg. 13F price*
At the end of Q4 2025, 678 institutions reported holding Insmed Inc. (INSM) in their 13F filings, up 112 from Q3 2025. 165 opened new positions and 80 sold out. The largest holders were JPMorgan Chase & Co. ($4.0B), Vanguard Group Inc. ($3.7B) and Darwin Global Management, Ltd. ($3.6B). 8 famous investors held it, including Stanley Druckenmiller (6.1% of Duquesne Family Office's portfolio), David E. Shaw (0.6% of D. E. Shaw & Co.'s portfolio) and Israel Englander (0.2% of Millennium Management's portfolio).
- Company
- Insmed Inc.
- CUSIP
- 457669307
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 165 | $689.7M |
| Exits | 80 | $966.8M |
All 13F filers, Q3 2025 → Q4 2025: 31,603,248 shares bought and 29,259,633 shares sold, net +2,343,615 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 678 holders
| JPMorgan Chase & Co. | 0.27% | Add +0.7% | 23,199,512 | $4.0B |
| Vanguard Group Inc. | 0.05% | Add +5.7% | 21,076,344 | $3.7B |
| Darwin Global Management, Ltd. | 73.78% | Add +2.3% | 20,933,277 | $3.6B |
| BlackRock, Inc. | 0.04% | Add +21.8% | 15,065,052 | $2.6B |
| FMR LLC | 0.09% | Add +8.1% | 9,927,936 | $1.7B |
| Invesco Ltd. | 0.12% | Add +275.2% | 7,518,338 | $1.3B |
| Baker Bros. Advisors LP | 6.74% | Reduce -1.6% | 6,592,746 | $1.1B |
| State Street Corp. | 0.03% | Add +30.6% | 5,201,744 | $905.3M |
| Capital International Investors | 0.14% | Reduce -31.8% | 5,151,671 | $896.6M |
| Artisan Partners Limited Partnership | 1.29% | Reduce -1.9% | 4,843,749 | $843.0M |
| RTW Investments, LP | 8.44% | Add +57.0% | 4,842,879 | $842.9M |
| D. E. Shaw & Co. | 0.61% | Reduce -23.1% | 4,350,995 | $757.2M |
| Geode Capital Management, LLC | 0.05% | Add +14.3% | 4,299,052 | $751.9M |
| Orbis Allan Gray Ltd | 3.05% | Add +28.6% | 4,179,957 | $727.5M |
| T. Rowe Price Associates Inc. | 0.08% | Reduce -41.7% | 4,039,466 | $703.0M |
| Norges Bank | 0.05% | — | 2,910,971 | $506.6M |
| Franklin Resources Inc. | 0.12% | Add +28.8% | 2,755,536 | $479.6M |
| Ameriprise Financial Inc. | 0.08% | Reduce -27.7% | 1,968,857 | $342.7M |
| UBS Group AG | 0.06% | Add +13.4% | 1,867,635 | $325.0M |
| Bank of America Corp. | 0.02% | Add +7.7% | 1,725,681 | $300.3M |
| Morgan Stanley | 0.02% | Add +69.3% | 1,631,906 | $284.0M |
| Duquesne Family Office | 6.11% | Reduce -38.9% | 1,481,752 | $257.9M |
| Bank of New York Mellon Corp | 0.04% | Add +22.1% | 1,390,042 | $241.9M |
| Millennium Management | 0.17% | Reduce -43.9% | 1,311,654 | $228.3M |
| Castle Hook Partners LP | 3.14% | Add +14.9% | 1,253,568 | $218.2M |
| Integral Health Asset Management, LLC | 11.03% | Reduce -21.9% | 1,250,000 | $217.6M |
| Goldman Sachs Group Inc. | 0.03% | Add +50.1% | 1,244,913 | $216.7M |
| Northern Trust Corp. | 0.03% | Add +15.4% | 1,238,438 | $215.5M |
| William Blair Investment Management, LLC | 0.59% | Reduce -21.5% | 1,221,096 | $212.5M |
| Nomura Asset Management International Inc. | 0.31% | — | 1,183,029 | $205.9M |
| Citadel Advisors | 0.14% | Reduce -43.8% | 1,157,295 | $201.4M |
| Charles Schwab Investment Management Inc. | 0.03% | Add +5.3% | 1,027,355 | $178.8M |
| Fiera Capital Corp | 0.55% | Add +22.7% | 992,892 | $172.8M |
| Nwi Management LP | 10.51% | Reduce -3.2% | 988,460 | $172.0M |
| Two Sigma Investments, LP | 0.26% | Add +24.5% | 962,156 | $167.5M |
| Pictet Asset Management Holding SA | 0.16% | Reduce -15.9% | 958,963 | $167.3M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.03% | Add +84.0% | 943,306 | $164.2M |
| Jefferies Financial Group Inc. | 1.36% | Add +757.0% | 926,339 | $161.2M |
| Amundi | 0.05% | Add +189.2% | 916,998 | $159.6M |
| BNP Paribas Financial Markets | 0.10% | Add +111.3% | 915,419 | $159.3M |
| Summit Partners Public Asset Management, LLC | 4.45% | Reduce -12.7% | 909,080 | $158.2M |
| Sei Investments Co. | 0.15% | Add +49.9% | 890,170 | $154.9M |
| FIL Ltd | 0.11% | Reduce -1.6% | 838,509 | $145.9M |
| Clearbridge Investments, LLC | 0.11% | Reduce -23.3% | 819,011 | $142.5M |
| Holocene Advisors, LP | 0.29% | Reduce -26.1% | 801,165 | $139.4M |
| Janus Henderson Group PLC | 0.06% | Reduce -33.4% | 800,555 | $139.3M |
| Raymond James Financial Inc. | 0.04% | Add +2.5% | 779,254 | $135.6M |
| Principal Financial Group Inc. | 0.07% | Reduce -10.8% | 771,358 | $134.2M |
| Lord, Abbett & Co. LLC | 0.40% | Reduce -50.1% | 720,898 | $125.5M |
| Artia Global Partners LP | 19.08% | Reduce -6.8% | 682,212 | $118.7M |
| Nuveen, LLC | 0.03% | Add +10.6% | 650,404 | $113.2M |
| Victory Capital Management Inc. | 0.06% | Add +82.2% | 646,714 | $112.6M |
| Alliancebernstein L.P. | 0.04% | Reduce -26.0% | 642,719 | $111.9M |
| Hood River Capital Management LLC | 1.22% | Reduce -27.7% | 637,577 | $111.0M |
| Federated Hermes, Inc. | 0.18% | Add +92.6% | 632,298 | $110.0M |
| Deutsche Bank AG | 0.03% | Add +188.7% | 590,030 | $102.7M |
| Wells Fargo & Company | 0.02% | Add +14.2% | 586,651 | $102.1M |
| Swiss National Bank | 0.06% | Add +56.0% | 579,112 | $100.8M |
| Jennison Associates LLC | 0.06% | Reduce -6.7% | 562,296 | $97.9M |
| Legal & General Group Plc | 0.02% | Add +159.7% | 540,313 | $94.0M |
| Royal Bank of Canada | 0.02% | Reduce -62.6% | 506,811 | $88.2M |
| Nearwater Capital Markets, Ltd | 1.49% | Add +150.0% | 500,000 | $87.0M |
| TimesSquare Capital Management, LLC | 1.29% | Add +15.4% | 490,506 | $85.4M |
| Palo Alto Investors LP | 11.86% | Reduce -0.5% | 489,482 | $85.2M |
| Wellington Management Group LLP | 0.01% | Reduce -32.3% | 486,138 | $84.6M |
| Eventide Asset Management, LLC | 1.31% | Reduce -51.9% | 483,589 | $84.2M |
| GW&K Investment Management, LLC | 0.73% | Reduce -19.8% | 482,670 | $84.0M |
| AQR Capital Management | 0.04% | Add +63.0% | 468,260 | $81.5M |
| Affinity Asset Advisors, LLC | 5.81% | No change | 450,000 | $78.3M |
| Barclays PLC | 0.03% | Add +289.4% | 444,706 | $77.4M |
| Sumitomo Mitsui Trust Group, Inc. | 0.04% | New | 435,442 | $75.8M |
| Westfield Capital Management Co. LP | 0.31% | Reduce -11.4% | 432,521 | $75.3M |
| Candriam S.C.A. | 0.35% | Add +0.9% | 401,042 | $69.8M |
| Dimensional Fund Advisors LP | 0.01% | Add +3.2% | 399,073 | $69.5M |
| Two Sigma Advisers, LP | 0.13% | Add +670.0% | 395,000 | $68.7M |
| Marshall Wace, LLP | 0.07% | Reduce -40.8% | 389,881 | $67.9M |
| Ensign Peak Advisors, Inc | 0.12% | Reduce -40.5% | 382,202 | $66.5M |
| Balyasny Asset Management L.P. | 0.13% | Add +915.3% | 380,561 | $66.2M |
| Samlyn Capital, LLC | 1.03% | Add +26.3% | 369,575 | $64.3M |
| Gateway Investment Advisers LLC | 0.59% | New | 365,000 | $63.5M |
| California Public Employees Retirement System | 0.04% | Add +14.2% | 354,909 | $61.8M |
| Polar Capital Holdings Plc | 0.27% | Reduce -7.4% | 344,228 | $59.9M |
| ProShare Advisors LLC | 0.10% | Add +4425.1% | 340,740 | $59.3M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.07% | Add +65.2% | 328,328 | $57.2M |
| Rock Springs Capital Management LP | 2.86% | Reduce -17.1% | 319,250 | $55.6M |
| California State Teachers Retirement System | 0.05% | Add +73.0% | 310,330 | $54.0M |
| Adage Capital Partners Gp, L.L.C. | 0.08% | Reduce -76.0% | 300,000 | $52.2M |
| Frontier Capital Management Co. LLC | 0.53% | Reduce -13.4% | 284,844 | $49.6M |
| Zurich Insurance Group Ltd | 0.34% | New | 281,098 | $48.9M |
| National Pension Service | 0.04% | New | 280,442 | $48.8M |
| New York State Common Retirement Fund | 0.06% | Reduce -38.0% | 276,284 | $48.1M |
| Envestnet Asset Management Inc. | 0.01% | Reduce -19.4% | 276,105 | $48.1M |
| Cormorant Asset Management, LP | 2.71% | Reduce -36.0% | 275,000 | $47.9M |
| Rhumbline Advisers | 0.04% | Add +26.0% | 268,326 | $46.7M |
| Patient Square Capital LP | 9.95% | Reduce -18.2% | 267,000 | $46.5M |
| First Turn Management, LLC | 5.26% | Reduce -17.4% | 264,293 | $46.0M |
| TD Asset Management Inc | 0.04% | Reduce -34.1% | 262,478 | $45.7M |
| Axiom Investors LLC | 0.39% | Add +137.5% | 255,849 | $44.5M |
| Aberdeen Group plc | 0.07% | Add +7.9% | 253,112 | $44.1M |
| First Trust Advisors LP | 0.03% | Add +3.0% | 247,940 | $43.2M |
"% of holder's portfolio" is INSM's weight in each manager's 13F, not the share of Insmed Inc. the manager owns.