InsmedINSM
13F holders, Q3 2025 (September 30)566holders +50
125new positions
70sold out
11famous investors
$143.81avg. 13F price*
At the end of Q3 2025, 566 institutions reported holding Insmed Inc. (INSM) in their 13F filings, up 50 from Q2 2025. 125 opened new positions and 70 sold out. The largest holders were JPMorgan Chase & Co. ($3.3B), Darwin Global Management, Ltd. ($2.9B) and Vanguard Group Inc. ($2.9B). 11 famous investors held it, including Stanley Druckenmiller (8.9% of Duquesne Family Office's portfolio), Lee Ainslie (1.3% of Maverick Capital's portfolio) and David E. Shaw (0.7% of D. E. Shaw & Co.'s portfolio).
- Company
- Insmed Inc.
- CUSIP
- 457669307
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 125 | $416.8M |
| Exits | 70 | $608.5M |
All 13F filers, Q2 2025 → Q3 2025: 34,213,868 shares bought and 31,890,893 shares sold, net +2,322,975 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 566 holders
| JPMorgan Chase & Co. | 0.21% | Add +47.4% | 23,047,676 | $3.3B |
| Darwin Global Management, Ltd. | 80.54% | Add +5.8% | 20,457,445 | $2.9B |
| Vanguard Group Inc. | 0.04% | Add +13.0% | 19,935,820 | $2.9B |
| BlackRock, Inc. | 0.03% | Add +11.0% | 12,364,904 | $1.8B |
| FMR LLC | 0.07% | Add +80.3% | 9,180,963 | $1.3B |
| Capital International Investors | 0.18% | Add +1.0% | 7,553,853 | $1.1B |
| T. Rowe Price Associates Inc. | 0.11% | Reduce -38.3% | 6,931,466 | $998.2M |
| Baker Bros. Advisors LP | 7.00% | Reduce -13.1% | 6,703,484 | $965.4M |
| D. E. Shaw & Co. | 0.70% | Add +65.3% | 5,657,464 | $814.7M |
| Artisan Partners Limited Partnership | 1.02% | Add +49.0% | 4,937,683 | $711.1M |
| State Street Corp. | 0.02% | Reduce -6.9% | 3,984,354 | $573.8M |
| Geode Capital Management, LLC | 0.03% | Add +12.5% | 3,759,427 | $541.5M |
| Orbis Allan Gray Ltd | 2.01% | Add +113.3% | 3,250,868 | $468.2M |
| RTW Investments, LP | 5.47% | No change | 3,084,558 | $444.2M |
| Ameriprise Financial Inc. | 0.09% | Reduce -8.0% | 2,721,879 | $392.0M |
| Duquesne Family Office | 8.88% | Add +7.5% | 2,423,435 | $349.0M |
| Millennium Management | 0.28% | Add +10.1% | 2,336,112 | $336.4M |
| Franklin Resources Inc. | 0.08% | Reduce -8.9% | 2,139,725 | $308.1M |
| Citadel Advisors | 0.24% | Add +34.2% | 2,057,641 | $296.3M |
| Invesco Ltd. | 0.05% | Add +5.7% | 2,003,871 | $288.6M |
| UBS Group AG | 0.05% | Add +461.0% | 1,646,239 | $237.1M |
| Bank of America Corp. | 0.02% | Add +30.6% | 1,601,806 | $230.7M |
| Integral Health Asset Management, LLC | 16.80% | No change | 1,600,000 | $230.4M |
| William Blair Investment Management, LLC | 0.58% | Reduce -6.6% | 1,555,057 | $223.9M |
| Qube Research & Technologies Ltd | 0.31% | Add +42.7% | 1,544,315 | $222.4M |
| Lord, Abbett & Co. LLC | 0.65% | Reduce -6.5% | 1,444,656 | $208.0M |
| Royal Bank of Canada | 0.03% | Add +216.8% | 1,355,331 | $195.2M |
| Adage Capital Partners Gp, L.L.C. | 0.29% | Reduce -56.2% | 1,252,503 | $180.4M |
| Janus Henderson Group PLC | 0.08% | Reduce -47.5% | 1,202,783 | $173.2M |
| Bank of New York Mellon Corp | 0.03% | Reduce -4.9% | 1,138,901 | $164.0M |
| Pictet Asset Management Holding SA | 0.16% | Reduce -26.6% | 1,140,827 | $163.9M |
| Castle Hook Partners LP | 2.38% | Add +141.1% | 1,091,405 | $157.2M |
| Holocene Advisors, LP | 0.36% | Reduce -46.3% | 1,083,681 | $156.1M |
| Northern Trust Corp. | 0.02% | Add +10.6% | 1,072,942 | $154.5M |
| Clearbridge Investments, LLC | 0.12% | Reduce -25.0% | 1,068,018 | $153.8M |
| Summit Partners Public Asset Management, LLC | 4.89% | Add +3.3% | 1,041,845 | $150.0M |
| Nwi Management LP | 14.52% | Add +41.8% | 1,021,000 | $147.0M |
| Eventide Asset Management, LLC | 2.38% | Reduce -16.0% | 1,005,107 | $144.7M |
| Charles Schwab Investment Management Inc. | 0.02% | Reduce -24.9% | 975,279 | $140.4M |
| Morgan Stanley | 0.01% | Reduce -7.7% | 963,631 | $138.8M |
| Hood River Capital Management LLC | 1.50% | Reduce -2.0% | 881,403 | $126.9M |
| Alliancebernstein L.P. | 0.04% | Reduce -35.3% | 868,772 | $125.1M |
| Principal Financial Group Inc. | 0.06% | Reduce -35.9% | 864,294 | $124.5M |
| FIL Ltd | 0.10% | Reduce -26.9% | 851,954 | $122.7M |
| Goldman Sachs Group Inc. | 0.02% | Reduce -54.2% | 829,317 | $119.4M |
| Fiera Capital Corp | 0.38% | Add +8.2% | 809,121 | $116.5M |
| Jane Street Group, LLC | 0.13% | Reduce -41.5% | 791,734 | $114.0M |
| Two Sigma Investments, LP | 0.18% | Add +105.3% | 772,780 | $111.3M |
| Raymond James Financial Inc. | 0.04% | Reduce -3.1% | 759,978 | $109.4M |
| Artia Global Partners LP | 18.55% | Reduce -2.7% | 732,212 | $105.4M |
| Wellington Management Group LLP | 0.02% | Reduce -38.1% | 718,043 | $103.4M |
| Perceptive Advisors LLC | 2.96% | Add +8.0% | 702,130 | $101.1M |
| Marshall Wace, LLP | 0.10% | Reduce -40.8% | 658,647 | $94.9M |
| Maverick Capital | 1.27% | Reduce -18.4% | 656,539 | $94.5M |
| Macquarie Group Ltd. | 0.11% | Reduce -42.5% | 649,847 | $93.6M |
| Ensign Peak Advisors, Inc | 0.15% | Add +13.8% | 642,034 | $92.5M |
| Jennison Associates LLC | 0.05% | Reduce -15.8% | 602,775 | $86.8M |
| GW&K Investment Management, LLC | 0.77% | Reduce -52.8% | 601,803 | $86.7M |
| Sei Investments Co. | 0.09% | Add +37.0% | 593,885 | $85.5M |
| Nuveen, LLC | 0.02% | Reduce -0.1% | 588,122 | $84.7M |
| 1832 Asset Management L.P. | 0.14% | New | 584,800 | $84.2M |
| Wells Fargo & Company | 0.02% | Add +98.2% | 513,849 | $74.0M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Reduce -26.3% | 512,749 | $73.8M |
| Bank of Nova Scotia | 0.13% | New | 506,245 | $72.9M |
| Alkeon Capital Management LLC | 0.33% | No change | 500,000 | $72.0M |
| Loomis Sayles & Co. L P | 0.08% | Reduce -38.0% | 492,296 | $70.9M |
| Palo Alto Investors LP | 13.11% | Reduce -43.1% | 491,805 | $70.8M |
| Westfield Capital Management Co. LP | 0.29% | Reduce -63.6% | 487,927 | $70.3M |
| Voloridge Investment Management, LLC | 0.23% | Add +50.7% | 471,649 | $67.9M |
| Deerfield Management Company, L.P. | 1.12% | Reduce -32.8% | 471,000 | $67.8M |
| Point72 Asset Management | 0.15% | Reduce -5.4% | 464,217 | $66.9M |
| Affinity Asset Advisors, LLC | 6.22% | Reduce -5.3% | 450,000 | $64.8M |
| New York State Common Retirement Fund | 0.08% | Add +4.2% | 445,876 | $64.2M |
| BNP Paribas Financial Markets | 0.05% | Reduce -42.5% | 433,340 | $62.4M |
| Cormorant Asset Management, LP | 4.27% | Reduce -20.4% | 430,000 | $61.9M |
| TimesSquare Capital Management, LLC | 0.88% | Reduce -51.3% | 425,085 | $61.2M |
| TD Asset Management Inc | 0.05% | Add +0.8% | 398,256 | $57.4M |
| Candriam S.C.A. | 0.30% | Reduce -9.4% | 397,588 | $57.3M |
| Dimensional Fund Advisors LP | 0.01% | Reduce -6.1% | 386,671 | $55.7M |
| Rock Springs Capital Management LP | 3.25% | Reduce -26.7% | 385,000 | $55.4M |
| ING Groep NV | 0.29% | New | 373,500 | $53.8M |
| Polar Capital Holdings Plc | 0.26% | Reduce -46.7% | 371,887 | $53.6M |
| Swiss National Bank | 0.03% | Add +6.9% | 371,300 | $53.5M |
| Victory Capital Management Inc. | 0.03% | Add +94.2% | 354,907 | $51.1M |
| Renaissance Technologies | 0.07% | Add +14.3% | 352,887 | $50.8M |
| Amundi | 0.02% | Add +2657.6% | 317,096 | $50.2M |
| Envestnet Asset Management Inc. | 0.01% | Reduce -6.3% | 342,785 | $49.4M |
| Long Focus Capital Management, LLC | 2.78% | Reduce -35.0% | 338,000 | $48.7M |
| Frontier Capital Management Co. LLC | 0.42% | Add +122.5% | 328,884 | $47.4M |
| Federated Hermes, Inc. | 0.08% | Add +202.8% | 328,223 | $47.3M |
| Patient Square Capital LP | 12.57% | Reduce -9.0% | 326,400 | $47.0M |
| First Turn Management, LLC | 6.91% | Reduce -14.2% | 319,773 | $46.1M |
| California Public Employees Retirement System | 0.03% | Add +39.9% | 310,886 | $44.8M |
| Brevan Howard Capital Management LP | 0.62% | Add +45.1% | 294,047 | $42.3M |
| Samlyn Capital, LLC | 0.60% | New | 292,643 | $42.1M |
| AQR Capital Management | 0.03% | Add +477.9% | 287,286 | $40.9M |
| Eagle Health Investments LP | 10.27% | Reduce -36.6% | 271,600 | $39.1M |
| First Trust Advisors LP | 0.03% | Add +407.8% | 240,646 | $34.7M |
| Aberdeen Group plc | 0.05% | Reduce -24.3% | 234,622 | $33.8M |
| Susquehanna International Group, LLP | 0.05% | Add +9.8% | 233,106 | $33.6M |
"% of holder's portfolio" is INSM's weight in each manager's 13F, not the share of Insmed Inc. the manager owns.