Lexicon PharmaceuticalsLXRX
13F holders, Q2 2025 (June 30)123holders −4
27new positions
32sold out
3famous investors
$0.95avg. 13F price*
At the end of Q2 2025, 123 institutions reported holding Lexicon Pharmaceuticals Inc. (LXRX) in their 13F filings, down 4 from Q1 2025. 27 opened new positions and 32 sold out. The largest holders were Artal Group S.A. ($129.4M), Siren, L.L.C. ($36.8M) and FMR LLC ($36.1M). 3 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Cliff Asness (0.0% of AQR Capital Management's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Lexicon Pharmaceuticals Inc.
- CUSIP
- 528872302
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2025 → Q2 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 27 | $7.3M |
| Exits | 32 | $1.9M |
All 13F filers, Q1 2025 → Q2 2025: 15,230,699 shares bought and 24,728,381 shares sold, net −9,497,682 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 123 holders
| Artal Group S.A. | 13.91% | No change | 136,180,481 | $129.4M |
| Siren, L.L.C. | 1.90% | No change | 38,918,903 | $36.8M |
| FMR LLC | 0.00% | Add +10.4% | 38,137,535 | $36.1M |
| Vanguard Group Inc. | 0.00% | Reduce -7.4% | 8,851,036 | $8.4M |
| Schonfeld Strategic Advisors LLC | 0.03% | Reduce -44.3% | 4,576,152 | $4.3M |
| BlackRock, Inc. | 0.00% | Reduce -66.5% | 3,354,669 | $3.2M |
| Sessa Capital IM, L.P. | 0.09% | New | 3,000,000 | $2.8M |
| Gsa Capital Partners LLP | 0.19% | Add +250.6% | 2,830,659 | $2.7M |
| CIBC Private Wealth Group LLC | 0.00% | Add +9.4% | 2,450,400 | $2.3M |
| Geode Capital Management, LLC | 0.00% | Reduce -35.5% | 2,377,694 | $2.2M |
| Millennium Management | 0.00% | New | 1,643,264 | $1.6M |
| AQR Capital Management | 0.00% | Add +19.5% | 1,402,210 | $1.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -23.3% | 883,227 | $835K |
| State Street Corp. | 0.00% | Reduce -68.6% | 818,621 | $774K |
| Jane Street Group, LLC | 0.00% | New | 804,667 | $761K |
| Hennion & Walsh Asset Management, Inc. | 0.03% | Reduce -4.4% | 793,400 | $750K |
| Royal Bank of Canada | 0.00% | Add +24416.4% | 774,474 | $732K |
| Susquehanna International Group, LLP | 0.00% | Reduce -20.6% | 755,652 | $715K |
| Monaco Asset Management SAM | 0.19% | Reduce -27.6% | 531,600 | $503K |
| HRT Financial LP | 0.00% | New | 488,468 | $461K |
| Wellington Management Group LLP | 0.00% | New | 486,674 | $460K |
| Invesco Ltd. | 0.00% | Add +47.2% | 420,700 | $398K |
| Northern Trust Corp. | 0.00% | Reduce -62.5% | 416,372 | $394K |
| Two Sigma Investments, LP | 0.00% | New | 403,922 | $382K |
| UBS Group AG | 0.00% | Reduce -80.9% | 400,732 | $379K |
| Group One Trading LLC | 0.01% | Reduce -5.2% | 346,752 | $328K |
| Compagnie Lombard Odier SCmA | 0.00% | Add +200.0% | 330,000 | $312K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -8.3% | 325,746 | $308K |
| Cerity Partners LLC | 0.00% | Add +21.1% | 206,279 | $195K |
| Ieq Capital, LLC | 0.00% | Add +8.3% | 192,101 | $182K |
| Ikarian Capital, LLC | 0.06% | Reduce -87.5% | 176,479 | $167K |
| Cubist Systematic Strategies, LLC | 0.00% | Add +1046.7% | 158,204 | $150K |
| Jain Global LLC | 0.00% | New | 151,813 | $144K |
| Virtu Financial LLC | 0.01% | New | 146,805 | $139K |
| Morgan Stanley | 0.00% | Reduce -79.5% | 131,393 | $124K |
| Aster Capital Management (DIFC) Ltd | 0.03% | New | 130,452 | $123K |
| Cwm, LLC | 0.00% | Add +3.6% | 109,330 | $103K |
| LPL Financial LLC | 0.00% | Add +47.2% | 104,433 | $99K |
| Bank of Montreal | 0.00% | No change | 100,000 | $95K |
| Squarepoint Ops LLC | 0.00% | Reduce -51.1% | 95,617 | $90K |
| Commonwealth Equity Services, LLC | 0.00% | No change | 90,864 | $86K |
| Quantessence Capital LLC | 0.02% | New | 84,098 | $80K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +0.6% | 72,943 | $69K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Add +7.6% | 74,454 | $67K |
| Point72 Asia (Singapore) Pte. Ltd. | 0.01% | Reduce -59.1% | 70,045 | $66K |
| XTX Topco Ltd | 0.00% | Add +431.4% | 66,276 | $63K |
| Fortis Group Advisors, LLC | 0.01% | Add +52.9% | 57,800 | $62K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Add +77.8% | 65,330 | $62K |
| Straight Path Wealth Management | 0.02% | No change | 62,666 | $59K |
| Scientech Research LLC | 0.01% | New | 57,862 | $55K |
| Boothbay Fund Management, LLC | 0.00% | Reduce -87.7% | 56,120 | $53K |
| Catalyst Funds Management Pty Ltd | 0.01% | New | 53,700 | $51K |
| Simplex Trading, LLC | 0.00% | Reduce -69.9% | 52,680 | $49K |
| Pinnacle Associates Ltd. | 0.00% | Reduce -6.2% | 50,815 | $48K |
| Citigroup Inc. | 0.00% | Reduce -49.9% | 48,544 | $46K |
| Two Sigma Securities, LLC | 0.01% | New | 42,405 | $40K |
| Wedbush Securities Inc. | 0.00% | No change | 40,850 | $39K |
| Pallas Capital Advisors LLC | 0.00% | Add +1.5% | 36,765 | $35K |
| University of Texas/Texas Am Investment Management Co. | 0.01% | No change | 35,714 | $34K |
| Captrust Financial Advisors | 0.00% | Add +7.2% | 35,582 | $34K |
| Barclays PLC | 0.00% | Reduce -77.9% | 32,270 | $31K |
| Bank of America Corp. | 0.00% | Reduce -66.7% | 32,097 | $30K |
| Pathstone Holdings, LLC | 0.00% | Reduce -4.3% | 30,041 | $28K |
| R Squared Ltd | 0.02% | New | 29,559 | $28K |
| Hudson Bay Capital Management LP | 0.00% | New | 27,010 | $26K |
| Wells Fargo & Company | 0.00% | Reduce -58.7% | 26,423 | $25K |
| JPMorgan Chase & Co. | 0.00% | Reduce -72.0% | 24,684 | $23K |
| D. E. Shaw & Co. | 0.00% | New | 23,723 | $22K |
| Oppenheimer & Co. Inc. | 0.00% | Add +16.9% | 23,500 | $22K |
| Steward Partners Investment Advisory, LLC | 0.00% | Add +0.5% | 21,423 | $20K |
| Cambridge Investment Research Advisors, Inc. | 0.00% | Reduce -2.6% | 21,500 | $20K |
| Victory Capital Management Inc. | 0.00% | Reduce -2.4% | 21,115 | $20K |
| Invera Wealth Advisors, LLC | 0.01% | No change | 20,000 | $19K |
| Tiaa Trust, National Association | 0.00% | No change | 20,000 | $19K |
| KWB Wealth | 0.00% | No change | 40,640 | $19K |
| SBI Securities Co., Ltd. | 0.00% | Add +479.4% | 19,237 | $18K |
| Bank of New York Mellon Corp | 0.00% | Reduce -93.8% | 19,124 | $18K |
| Merit Financial Group, LLC | 0.00% | Add +7.8% | 16,699 | $16K |
| Integrated Wealth Concepts LLC | 0.00% | New | 16,210 | $15K |
| Jump Financial, LLC | 0.00% | New | 15,993 | $15K |
| HighTower Advisors, LLC | 0.00% | New | 14,910 | $14K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +16.0% | 14,029 | $13K |
| Truist Financial Corp. | 0.00% | No change | 14,000 | $13K |
| Focus Partners Advisor Solutions, LLC | 0.00% | Add +13.6% | 13,746 | $13K |
| SG Americas Securities, LLC | 0.00% | Reduce -79.7% | 13,814 | $13K |
| ProShare Advisors LLC | 0.00% | Reduce -67.0% | 13,561 | $13K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -54.9% | 12,690 | $12K |
| ExodusPoint Capital Management, LP | 0.00% | New | 12,241 | $12K |
| Chemistry Wealth Management LLC | 0.00% | No change | 12,000 | $11K |
| HBK Sorce Advisory LLC | 0.00% | New | 11,786 | $11K |
| Avantax Advisory Services, Inc. | 0.00% | No change | 11,724 | $11K |
| North Star Asset Management Inc. | 0.00% | No change | 11,500 | $11K |
| Perennial Investment Advisors, LLC | 0.00% | New | 10,990 | $10K |
| Berger Financial Group, Inc | 0.00% | No change | 10,929 | $10K |
| NBT Bank, N.A. | 0.00% | New | 10,000 | $9K |
| BNP Paribas Financial Markets | 0.00% | Reduce -90.2% | 8,703 | $8K |
| Point72 (DIFC) Ltd | 0.00% | Reduce -47.6% | 6,982 | $7K |
| Vermillion & White Wealth Management Group, LLC | 0.00% | New | 6,500 | $6K |
| Golden State Wealth Management, LLC | 0.00% | No change | 3,700 | $3K |
| Optiver Holding B.V. | 0.00% | Add +64.7% | 3,035 | $3K |
| Nisa Investment Advisors, LLC | 0.00% | Add +332.0% | 2,592 | $2K |
| Essential Partners LLC | 0.00% | — | 2,134 | $2K |
| Raymond James Financial Inc. | 0.00% | Reduce -82.6% | 2,076 | $2K |
| Quintet Private Bank (Europe) S.A. | 0.00% | No change | 1,928 | $2K |
| Jones Financial Companies LLLP | 0.00% | No change | 2,042 | $2K |
| PNC Financial Services Group, Inc. | 0.00% | No change | 1,461 | $1K |
| Physician Wealth Advisors, Inc. | 0.00% | New | 1,412 | $1K |
| Rialto Wealth Management, LLC | 0.00% | No change | 1,313 | $1K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +25.1% | 1,163 | $1K |
| Avion Wealth | 0.00% | Add +17.6% | 1,333 | $1K |
| Daiwa Securities Group Inc. | 0.00% | No change | 1,369 | $1K |
| Farther Finance Advisors, LLC | 0.00% | Add +50000.0% | 1,002 | $948 |
| Global Retirement Partners, LLC | 0.00% | — | 1,000 | $946 |
| True Wealth Design, LLC | 0.00% | Add +20.0% | 743 | $703 |
| Osaic Holdings, Inc. | 0.00% | Reduce -21.2% | 742 | $697 |
| Fortitude Family Office, LLC | 0.00% | New | 706 | $668 |
| Northwestern Mutual Wealth Management Co. | 0.00% | No change | 500 | $473 |
| Syntax Research, Inc. | 0.00% | No change | 142 | $135 |
| Comerica Bank | 0.00% | No change | 122 | $115 |
| Larson Financial Group LLC | 0.00% | No change | 100 | $95 |
| CBIZ Investment Advisory Services, LLC | 0.00% | No change | 71 | $67 |
| IFP Advisors, Inc | 0.00% | New | 1 | $1 |
| Covestor Ltd | 0.00% | No change | 81 | $0 |
"% of holder's portfolio" is LXRX's weight in each manager's 13F, not the share of Lexicon Pharmaceuticals Inc. the manager owns.