| TRV GP Iv, LLC | 72.02% | New | 6,073,958 | $66.9M |
| Frazier Life Sciences Management, L.P. | 2.08% | New | 4,129,001 | $45.5M |
| ARCH Venture Management, LLC | 22.00% | New | 4,120,053 | $45.4M |
| Deep Track Capital, LP | 1.17% | New | 3,269,126 | $36.0M |
| Matrix Capital Management Company, LP | 7.88% | New | 2,486,184 | $27.4M |
| Alphabet Inc. | 1.68% | New | 2,412,471 | $26.6M |
| Foresite Capital Management IV, LLC | 20.93% | New | 2,111,919 | $23.3M |
| a16z Capital Management, L.L.C. | 2.67% | New | 1,702,225 | $18.7M |
| Janus Henderson Group PLC | 0.01% | New | 1,246,370 | $14.3M |
| General Catalyst Group Management, LLC | 1.29% | New | 1,035,910 | $11.4M |
| Alliancebernstein L.P. | 0.00% | New | 1,016,446 | $11.2M |
| FMR LLC | 0.00% | New | 968,383 | $10.7M |
| TRV GP V, LLC | 8.37% | New | 950,800 | $10.5M |
| Casdin Capital, LLC | 0.85% | New | 946,357 | $10.4M |
| Logos Global Management LP | 1.83% | New | 936,914 | $10.3M |
| Woodline Partners LP | 0.07% | New | 929,102 | $10.2M |
| Vanguard Group Inc. | 0.00% | New | 666,554 | $7.3M |
| Harvard Management Co. Inc. | 0.62% | New | 637,528 | $7.0M |
| BlackRock, Inc. | 0.00% | New | 582,588 | $6.4M |
| Bessemer Group Inc. | 0.01% | New | 481,790 | $5.3M |
| Octagon Capital Advisors LP | 1.12% | New | 468,000 | $5.2M |
| HHLR Advisors, LTD. | 0.14% | New | 457,535 | $5.0M |
| Sphera Funds Management LTD. | 0.97% | New | 355,554 | $3.9M |
| Foresite Capital Management V, LLC | 4.34% | New | 345,191 | $3.8M |
| Ikarian Capital, LLC | 1.16% | New | 322,740 | $3.6M |
| Affinity Asset Advisors, LLC | 0.46% | New | 250,000 | $2.8M |
| Geode Capital Management, LLC | 0.00% | New | 212,464 | $2.3M |
| Driehaus Capital Management LLC | 0.01% | New | 132,115 | $1.5M |
| Alyeska Investment Group, L.P. | 0.01% | New | 125,000 | $1.4M |
| Boothbay Fund Management, LLC | 0.04% | New | 96,968 | $1.1M |
| UBS Group AG | 0.00% | New | 88,064 | $970K |
| Charles Schwab Investment Management Inc. | 0.00% | New | 72,305 | $796K |
| Northern Trust Corp. | 0.00% | New | 70,838 | $780K |
| State Street Corp. | 0.00% | New | 64,713 | $712K |
| Ghisallo Capital Management LLC | 0.03% | New | 30,000 | $330K |
| Morgan Stanley | 0.00% | New | 23,893 | $263K |
| Invesco Ltd. | 0.00% | New | 20,552 | $226K |
| Citadel Advisors | 0.00% | New | 20,000 | $220K |
| Marshall Wace, LLP | 0.00% | New | 19,597 | $216K |
| Bank of New York Mellon Corp | 0.00% | New | 17,233 | $190K |
| Oxford Asset Management LLP | 0.09% | New | 17,000 | $187K |
| Barclays PLC | 0.00% | New | 14,644 | $161K |
| Davidson Kempner Capital Management LP | 0.00% | New | 13,670 | $151K |
| Goldman Sachs Group Inc. | 0.00% | New | 13,129 | $145K |
| Nuveen, LLC | 0.00% | — | 11,375 | $125K |
| Susquehanna International Group, LLP | 0.00% | New | 10,608 | $117K |
| JPMorgan Chase & Co. | 0.00% | New | 10,141 | $112K |
| Deutsche Bank AG | 0.00% | New | 8,885 | $98K |
| Rhumbline Advisers | 0.00% | New | 7,235 | $80K |
| Citigroup Inc. | 0.00% | New | 6,216 | $68K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 5,135 | $57K |
| Wells Fargo & Company | 0.00% | New | 4,693 | $52K |
| Corebridge Financial, Inc. | 0.00% | New | 4,328 | $48K |
| Bank of America Corp. | 0.00% | New | 4,327 | $48K |
| New York State Common Retirement Fund | 0.00% | New | 2,300 | $25K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 2,241 | $25K |
| STRS Ohio | 0.00% | New | 1,600 | $18K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 894 | $10K |
| Legal & General Group Plc | 0.00% | New | 871 | $10K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 834 | $9K |
| Comerica Bank | 0.00% | New | 636 | $7K |
| California State Teachers Retirement System | 0.00% | New | 554 | $6K |
| BNP Paribas Financial Markets | 0.00% | New | 400 | $4K |
| Amalgamated Bank | 0.00% | New | 305 | $3K |
| Royal Bank of Canada | 0.00% | New | 133 | $1K |
| Sterling Capital Management LLC | 0.00% | New | 74 | $815 |
| SBI Securities Co., Ltd. | 0.00% | New | 26 | $286 |
| Nisa Investment Advisors, LLC | 0.00% | New | 18 | $198 |