Maze TherapeuticsMAZE
13F holders, Q4 2025 (December 31)143holders +49
51new positions
8sold out
6famous investors
$41.43avg. 13F price*
At the end of Q4 2025, 143 institutions reported holding Maze Therapeutics Inc. (MAZE) in their 13F filings, up 49 from Q3 2025. 51 opened new positions and 8 sold out. The largest holders were Frazier Life Sciences Management, L.P. ($189.2M), TRV GP Iv, LLC ($185.4M) and Deep Track Capital, LP ($175.9M). 6 famous investors held it, including Ken Griffin (0.0% of Citadel Advisors's portfolio), Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio) and Israel Englander (0.0% of Millennium Management's portfolio).
- Company
- Maze Therapeutics Inc.
- CUSIP
- 578784100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 51 | $163.3M |
| Exits | 8 | $10.7M |
All 13F filers, Q3 2025 → Q4 2025: 9,725,619 shares bought and 5,072,203 shares sold, net +4,653,416 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 143 holders
| Frazier Life Sciences Management, L.P. | 5.10% | No change | 4,567,274 | $189.2M |
| TRV GP Iv, LLC | 72.65% | Reduce -26.3% | 4,473,958 | $185.4M |
| Deep Track Capital, LP | 4.01% | Add +7.5% | 4,246,440 | $175.9M |
| ARCH Venture Management, LLC | 26.19% | No change | 4,120,053 | $170.7M |
| Janus Henderson Group PLC | 0.06% | Add +318.0% | 3,142,587 | $130.2M |
| BlackRock, Inc. | 0.00% | Add +73.8% | 2,287,155 | $94.8M |
| a16z Capital Management, L.L.C. | 4.46% | No change | 1,702,225 | $70.5M |
| Vanguard Group Inc. | 0.00% | Add +27.1% | 1,697,015 | $70.3M |
| Venrock Adviser, LLC | 3.17% | Add +25.8% | 1,548,569 | $64.2M |
| Alphabet Inc. | 2.23% | Reduce -42.4% | 1,388,583 | $57.5M |
| General Catalyst Group Management, LLC | 19.35% | No change | 1,035,910 | $42.9M |
| Woodline Partners LP | 0.17% | No change | 1,035,229 | $42.9M |
| TRV GP V, LLC | 9.18% | No change | 950,800 | $39.4M |
| Logos Global Management LP | 2.62% | Reduce -22.6% | 950,000 | $39.4M |
| Bellevue Group AG | 0.70% | New | 887,708 | $36.8M |
| Marshall Wace, LLP | 0.03% | Add +9.0% | 847,472 | $35.1M |
| ArrowMark Colorado Holdings LLC | 0.70% | Add +40.8% | 767,383 | $31.8M |
| Casdin Capital, LLC | 1.95% | No change | 758,857 | $31.4M |
| FMR LLC | 0.00% | Add +11.1% | 728,605 | $30.2M |
| Ikarian Capital, LLC | 3.46% | Reduce -13.0% | 644,680 | $26.7M |
| Caligan Partners LP | 2.09% | New | 550,191 | $22.8M |
| State Street Corp. | 0.00% | Add +38.5% | 533,005 | $22.1M |
| Geode Capital Management, LLC | 0.00% | Add +11.3% | 527,281 | $21.9M |
| Foresite Capital Management IV, LLC | 9.43% | No change | 522,657 | $21.7M |
| Squadron Capital Management LLC | 9.06% | — | 490,000 | $20.3M |
| Bessemer Group Inc. | 0.03% | No change | 481,790 | $20.0M |
| Matrix Capital Management Company, LP | 34.52% | Reduce -71.0% | 480,000 | $19.9M |
| HHLR Advisors, LTD. | 0.61% | No change | 457,535 | $19.0M |
| Citadel Advisors | 0.01% | New | 448,217 | $18.6M |
| Boothbay Fund Management, LLC | 0.45% | Add +16.3% | 409,372 | $17.0M |
| Driehaus Capital Management LLC | 0.11% | No change | 378,015 | $15.7M |
| Eventide Asset Management, LLC | 0.21% | New | 324,041 | $13.4M |
| Washington University | 5.88% | Add +33.3% | 280,802 | $11.6M |
| Morgan Stanley | 0.00% | Add +21.3% | 258,086 | $10.7M |
| Mass General Brigham, Inc | 1.23% | — | 239,994 | $9.9M |
| Parkman Healthcare Partners LLC | 0.83% | Add +4.6% | 209,266 | $8.7M |
| Balyasny Asset Management L.P. | 0.02% | Reduce -54.1% | 199,212 | $8.3M |
| Alyeska Investment Group, L.P. | 0.02% | Add +56.9% | 196,124 | $8.1M |
| Ensign Peak Advisors, Inc | 0.01% | Add +162.9% | 185,794 | $7.7M |
| ADAR1 Capital Management, LLC | 0.56% | Add +589.3% | 179,532 | $7.4M |
| Northern Trust Corp. | 0.00% | Reduce -0.4% | 176,259 | $7.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +4.8% | 175,969 | $7.3M |
| TCG Crossover Management, LLC | 0.24% | New | 173,816 | $7.2M |
| HighVista Strategies LLC | 1.82% | New | 170,353 | $7.1M |
| Millennium Management | 0.00% | New | 154,470 | $6.4M |
| Invesco Ltd. | 0.00% | Add +1.5% | 134,033 | $5.6M |
| Stempoint Capital LP | 0.90% | New | 125,877 | $5.2M |
| Freestone Grove Partners LP | 0.04% | New | 118,876 | $4.9M |
| T. Rowe Price Associates Inc. | 0.00% | Add +1004.8% | 115,711 | $4.8M |
| Goldman Sachs Group Inc. | 0.00% | New | 114,455 | $4.7M |
| Integral Health Asset Management, LLC | 0.21% | New | 100,000 | $4.1M |
| Ameriprise Financial Inc. | 0.00% | New | 96,688 | $4.0M |
| Foresite Capital Management V, LLC | 2.17% | No change | 86,291 | $3.6M |
| MPM Bioimpact LLC | 0.38% | New | 81,145 | $3.4M |
| Sphera Funds Management LTD. | 0.62% | Reduce -53.5% | 71,843 | $3.0M |
| SummitTX Capital, L.P. | 0.09% | New | 69,560 | $2.9M |
| Raymond James Financial Inc. | 0.00% | New | 67,718 | $2.8M |
| Wellington Management Group LLP | 0.00% | New | 61,205 | $2.5M |
| Bank of New York Mellon Corp | 0.00% | Add +33.6% | 60,436 | $2.5M |
| Osaic Holdings, Inc. | 0.00% | Add +95.8% | 59,762 | $2.5M |
| Nuveen, LLC | 0.00% | Add +89.0% | 57,258 | $2.4M |
| Franklin Resources Inc. | 0.00% | Add +203.5% | 55,229 | $2.3M |
| Trexquant Investment LP | 0.02% | New | 52,459 | $2.2M |
| Seven Grand Managers, LLC | 0.16% | New | 50,000 | $2.1M |
| Schonfeld Strategic Advisors LLC | 0.01% | Reduce -57.7% | 48,200 | $2.0M |
| Barclays PLC | 0.00% | Add +43.6% | 39,508 | $1.6M |
| D. E. Shaw & Co. | 0.00% | New | 33,694 | $1.4M |
| Alliancebernstein L.P. | 0.00% | Reduce -44.7% | 33,220 | $1.4M |
| XTX Topco Ltd | 0.04% | Add +22.9% | 33,021 | $1.4M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +244.7% | 31,295 | $1.3M |
| Cinctive Capital Management LP | 0.07% | New | 29,134 | $1.2M |
| UBS Group AG | 0.00% | Add +3.3% | 28,698 | $1.2M |
| AQR Capital Management | 0.00% | Reduce -0.6% | 27,439 | $1.1M |
| Renaissance Technologies | 0.00% | Reduce -68.5% | 27,100 | $1.1M |
| Tudor Investment Corporation | 0.01% | New | 24,059 | $997K |
| Wells Fargo & Company | 0.00% | Add +62.5% | 24,008 | $995K |
| Rhumbline Advisers | 0.00% | Add +13.2% | 23,731 | $983K |
| Gilder Gagnon Howe & Co. LLC | 0.01% | New | 23,282 | $965K |
| Russell Investments Group, Ltd. | 0.00% | Add +1082.2% | 22,545 | $934K |
| Verition Fund Management LLC | 0.01% | New | 22,512 | $933K |
| American Century Companies Inc. | 0.00% | New | 21,509 | $891K |
| JPMorgan Chase & Co. | 0.00% | Add +153.6% | 20,007 | $829K |
| Acuta Capital Partners, LLC | 0.56% | New | 20,000 | $829K |
| Bank of America Corp. | 0.00% | Add +92.0% | 18,381 | $762K |
| Deutsche Bank AG | 0.00% | Add +74.7% | 15,522 | $643K |
| Los Angeles Capital Management LLC | 0.00% | New | 19,100 | $635K |
| Two Sigma Advisers, LP | 0.00% | New | 14,800 | $613K |
| PSP Research LLC | 0.46% | — | 12,672 | $525K |
| MetLife Investment Management, LLC | 0.00% | No change | 11,801 | $489K |
| China Universal Asset Management Co., Ltd. | 0.04% | Add +472.1% | 11,441 | $474K |
| Citigroup Inc. | 0.00% | Add +4082.9% | 11,252 | $466K |
| STRS Ohio | 0.00% | Reduce -37.4% | 11,200 | $464K |
| Falcon Wealth Planning | 0.04% | New | 10,030 | $416K |
| SG Americas Securities, LLC | 0.00% | Add +69.3% | 8,493 | $352K |
| Two Sigma Investments, LP | 0.00% | Reduce -35.0% | 7,245 | $300K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 6,897 | $286K |
| Virtus Investment Advisers, LLC | 0.08% | Reduce -18.5% | 6,846 | $284K |
| New York State Common Retirement Fund | 0.00% | No change | 6,700 | $278K |
| Persistent Asset Partners Ltd | 0.13% | New | 6,605 | $274K |
| Intech Investment Management LLC | 0.00% | New | 6,443 | $267K |
"% of holder's portfolio" is MAZE's weight in each manager's 13F, not the share of Maze Therapeutics Inc. the manager owns.