Maze TherapeuticsMAZE
13F holders, Q3 2025 (September 30)94holders +19
23new positions
3sold out
2famous investors
$25.93avg. 13F price*
At the end of Q3 2025, 94 institutions reported holding Maze Therapeutics Inc. (MAZE) in their 13F filings, up 19 from Q2 2025. 23 opened new positions and 3 sold out. The largest holders were TRV GP Iv, LLC ($157.5M), Frazier Life Sciences Management, L.P. ($118.4M) and ARCH Venture Management, LLC ($106.8M). 2 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Maze Therapeutics Inc.
- CUSIP
- 578784100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 23 | $78.9M |
| Exits | 3 | $493K |
All 13F filers, Q2 2025 → Q3 2025: 8,361,073 shares bought and 4,196,642 shares sold, net +4,164,431 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 94 holders
| TRV GP Iv, LLC | 57.49% | No change | 6,073,958 | $157.5M |
| Frazier Life Sciences Management, L.P. | 3.56% | Reduce 0.0% | 4,567,274 | $118.4M |
| ARCH Venture Management, LLC | 21.70% | No change | 4,120,053 | $106.8M |
| Deep Track Capital, LP | 2.86% | No change | 3,948,910 | $102.4M |
| Alphabet Inc. | 2.60% | No change | 2,412,471 | $62.6M |
| a16z Capital Management, L.L.C. | 3.16% | No change | 1,702,225 | $44.1M |
| Matrix Capital Management Company, LP | 40.17% | Reduce -33.5% | 1,653,684 | $42.9M |
| Vanguard Group Inc. | 0.00% | Add +218.1% | 1,334,955 | $34.6M |
| BlackRock, Inc. | 0.00% | Add +114.1% | 1,316,016 | $34.1M |
| Venrock Adviser, LLC | 1.80% | New | 1,230,769 | $31.9M |
| Logos Global Management LP | 3.14% | Add +100.6% | 1,227,300 | $31.8M |
| General Catalyst Group Management, LLC | 0.88% | No change | 1,035,910 | $26.9M |
| Woodline Partners LP | 0.13% | Add +10.1% | 1,035,229 | $26.8M |
| TRV GP V, LLC | 6.97% | No change | 950,800 | $24.7M |
| Marshall Wace, LLP | 0.02% | Add +3868.5% | 777,701 | $20.2M |
| Casdin Capital, LLC | 1.64% | No change | 758,857 | $19.7M |
| Janus Henderson Group PLC | 0.01% | Reduce -46.3% | 751,874 | $19.5M |
| Ikarian Capital, LLC | 3.89% | Add +182.0% | 740,825 | $19.2M |
| FMR LLC | 0.00% | Add +18.2% | 655,614 | $17.0M |
| ArrowMark Colorado Holdings LLC | 0.26% | New | 545,132 | $14.1M |
| Foresite Capital Management IV, LLC | 7.42% | Reduce -75.3% | 522,657 | $13.6M |
| Bessemer Group Inc. | 0.02% | No change | 481,790 | $12.5M |
| Geode Capital Management, LLC | 0.00% | Add +104.8% | 473,549 | $12.3M |
| HHLR Advisors, LTD. | 0.29% | No change | 457,535 | $11.9M |
| Balyasny Asset Management L.P. | 0.02% | New | 433,725 | $11.2M |
| State Street Corp. | 0.00% | Add +165.9% | 384,702 | $10.0M |
| Driehaus Capital Management LLC | 0.07% | Add +95.5% | 378,015 | $9.8M |
| Boothbay Fund Management, LLC | 0.24% | Add +365.9% | 351,875 | $9.1M |
| Morgan Stanley | 0.00% | Add +569.5% | 212,762 | $5.5M |
| Washington University | 3.06% | New | 210,681 | $5.5M |
| Parkman Healthcare Partners LLC | 0.57% | New | 200,000 | $5.2M |
| Octagon Capital Advisors LP | 0.72% | No change | 177,667 | $4.6M |
| Northern Trust Corp. | 0.00% | Add +106.8% | 176,890 | $4.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +123.4% | 167,928 | $4.4M |
| Sphera Funds Management LTD. | 0.95% | Reduce -56.7% | 154,343 | $4.0M |
| Invesco Ltd. | 0.00% | Add +616.6% | 132,062 | $3.4M |
| Alyeska Investment Group, L.P. | 0.01% | No change | 125,000 | $3.2M |
| Schonfeld Strategic Advisors LLC | 0.02% | New | 114,049 | $3.0M |
| Nantahala Capital Management, LLC | 0.15% | New | 93,351 | $2.4M |
| Harvard Management Co. Inc. | 0.11% | Reduce -85.5% | 92,396 | $2.4M |
| Foresite Capital Management V, LLC | 2.06% | Reduce -75.0% | 86,291 | $2.2M |
| Renaissance Technologies | 0.00% | New | 86,100 | $2.2M |
| Ensign Peak Advisors, Inc | 0.00% | Add +281.2% | 70,665 | $1.8M |
| Alliancebernstein L.P. | 0.00% | Add +89.0% | 60,100 | $1.6M |
| Bank of New York Mellon Corp | 0.00% | Add +110.0% | 45,240 | $1.2M |
| Osaic Holdings, Inc. | 0.00% | Add +56427.8% | 30,525 | $792K |
| Nuveen, LLC | 0.00% | Add +166.4% | 30,304 | $786K |
| UBS Group AG | 0.00% | Reduce -45.9% | 27,793 | $721K |
| AQR Capital Management | 0.00% | Add +0.5% | 27,615 | $716K |
| Barclays PLC | 0.00% | Add +87.9% | 27,516 | $713K |
| XTX Topco Ltd | 0.04% | New | 26,867 | $697K |
| ADAR1 Capital Management, LLC | 0.07% | New | 26,045 | $675K |
| Rhumbline Advisers | 0.00% | Add +171.8% | 20,970 | $544K |
| Franklin Resources Inc. | 0.00% | New | 18,198 | $472K |
| STRS Ohio | 0.00% | Reduce -61.8% | 17,900 | $464K |
| Susquehanna International Group, LLP | 0.00% | Add +53.0% | 16,165 | $419K |
| Wells Fargo & Company | 0.00% | Add +163.2% | 14,779 | $383K |
| WINTON GROUP Ltd | 0.01% | New | 14,487 | $376K |
| Alps Advisors Inc. | 0.00% | Reduce -41.7% | 13,742 | $356K |
| BNP Paribas Financial Markets | 0.00% | Add +1483.4% | 12,018 | $312K |
| MetLife Investment Management, LLC | 0.00% | New | 11,801 | $306K |
| Two Sigma Investments, LP | 0.00% | New | 11,150 | $289K |
| T. Rowe Price Associates Inc. | 0.00% | New | 10,474 | $272K |
| Bank of America Corp. | 0.00% | Add +65.6% | 9,574 | $248K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +85.2% | 9,078 | $235K |
| Deutsche Bank AG | 0.00% | No change | 8,885 | $230K |
| Virtus Investment Advisers, LLC | 0.06% | Add +21.0% | 8,397 | $218K |
| JPMorgan Chase & Co. | 0.00% | Add +80.7% | 7,890 | $205K |
| New York State Common Retirement Fund | 0.00% | Add +191.3% | 6,700 | $174K |
| Legal & General Group Plc | 0.00% | Add +23.0% | 5,219 | $135K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +124.5% | 5,030 | $130K |
| SG Americas Securities, LLC | 0.00% | New | 5,015 | $130K |
| Caption Management, LLC | 0.01% | New | 4,000 | $104K |
| Cwm, LLC | 0.00% | Reduce -5.7% | 2,138 | $55K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -56.3% | 2,012 | $52K |
| China Universal Asset Management Co., Ltd. | 0.00% | New | 2,000 | $52K |
| Russell Investments Group, Ltd. | 0.00% | Add +947.8% | 1,907 | $49K |
| Ameritas Investment Partners, Inc. | 0.00% | Add +82.5% | 1,632 | $42K |
| Sterling Capital Management LLC | 0.00% | Add +462.5% | 1,260 | $33K |
| California State Teachers Retirement System | 0.00% | Add +0.2% | 555 | $14K |
| Farther Finance Advisors, LLC | 0.00% | New | 383 | $10K |
| Amalgamated Bank | 0.00% | No change | 305 | $8K |
| Arax Advisory Partners | 0.00% | New | 307 | $8K |
| Royal Bank of Canada | 0.00% | Reduce -73.9% | 283 | $7K |
| Citigroup Inc. | 0.00% | Reduce -97.9% | 269 | $7K |
| GAMMA Investing LLC | 0.00% | Add +211.8% | 159 | $4K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +30.7% | 149 | $4K |
| PNC Financial Services Group, Inc. | 0.00% | New | 93 | $2K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -87.9% | 61 | $2K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 26 | $674 |
| Sunbelt Securities, Inc. | 0.00% | New | 12 | $311 |
| Rothschild Investment LLC | 0.00% | New | 10 | $259 |
| Essential Partners LLC | 0.00% | No change | 7 | $182 |
| True Wealth Design, LLC | 0.00% | No change | 5 | $130 |
"% of holder's portfolio" is MAZE's weight in each manager's 13F, not the share of Maze Therapeutics Inc. the manager owns.