Prime MedicinePRME
13F holders, Q3 2025 (September 30)167holders +46
52new positions
7sold out
7famous investors
$5.54avg. 13F price*
At the end of Q3 2025, 167 institutions reported holding Prime Medicine Inc. (PRME) in their 13F filings, up 46 from Q2 2025. 52 opened new positions and 7 sold out. The largest holders were Alphabet Inc. ($91.8M), T. Rowe Price Investment Management, Inc. ($51.1M) and BlackRock, Inc. ($31.3M). 7 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Prime Medicine Inc.
- CUSIP
- 74168J101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 52 | $70.3M |
| Exits | 7 | $307K |
All 13F filers, Q2 2025 → Q3 2025: 38,022,774 shares bought and 4,362,063 shares sold, net +33,660,711 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 167 holders
| Alphabet Inc. | 3.81% | Add +10.0% | 16,562,498 | $91.8M |
| T. Rowe Price Investment Management, Inc. | 0.03% | Add +42.1% | 9,217,097 | $51.1M |
| BlackRock, Inc. | 0.00% | Add +26.0% | 5,650,859 | $31.3M |
| ARK Investment Management | 0.18% | Add +135.8% | 5,477,851 | $30.3M |
| Vanguard Group Inc. | 0.00% | Add +35.7% | 4,921,865 | $27.3M |
| Farallon Capital Management, L.L.C. | 0.15% | Add +533.3% | 4,750,000 | $26.3M |
| Sumitomo Mitsui Trust Group, Inc. | 0.01% | Add +127.7% | 3,629,924 | $20.1M |
| Amova Asset Management Americas, Inc. | 0.19% | Add +128.4% | 3,629,924 | $20.0M |
| Casdin Capital, LLC | 1.46% | Add +102.1% | 3,167,175 | $17.5M |
| Woodline Partners LP | 0.08% | New | 3,002,482 | $16.6M |
| Ra Capital Management, L.P. | 0.20% | New | 3,000,000 | $16.6M |
| FMR LLC | 0.00% | Reduce -24.9% | 2,813,075 | $15.6M |
| D. E. Shaw & Co. | 0.01% | New | 2,215,852 | $12.3M |
| MWG Management Ltd. | 12.21% | No change | 1,792,210 | $9.9M |
| Geode Capital Management, LLC | 0.00% | Add +16.9% | 1,766,896 | $9.8M |
| EcoR1 Capital, LLC | 0.41% | New | 1,543,326 | $8.6M |
| Millennium Management | 0.01% | Add +858.5% | 1,418,463 | $7.9M |
| State Street Corp. | 0.00% | Add +4.6% | 1,296,626 | $7.2M |
| Renaissance Technologies | 0.01% | Add +407.9% | 1,134,670 | $6.3M |
| Citadel Advisors | 0.00% | Add +72.6% | 900,142 | $5.0M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | New | 771,361 | $4.3M |
| Invesco Ltd. | 0.00% | Add +5478.1% | 762,078 | $4.2M |
| Morgan Stanley | 0.00% | Add +24.4% | 731,004 | $4.0M |
| Greenwich Wealth Management LLC | 0.20% | Reduce -14.9% | 720,001 | $4.0M |
| Northern Trust Corp. | 0.00% | Add +18.7% | 607,989 | $3.4M |
| Schonfeld Strategic Advisors LLC | 0.02% | Reduce -27.6% | 593,039 | $3.3M |
| Susquehanna International Group, LLP | 0.00% | Add +21.1% | 584,424 | $3.2M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +10.5% | 573,158 | $3.2M |
| Moore Capital Management, LP | 0.06% | No change | 500,000 | $2.8M |
| Two Sigma Investments, LP | 0.00% | Add +73.2% | 447,667 | $2.5M |
| AQR Capital Management | 0.00% | Reduce -2.4% | 414,211 | $2.3M |
| Goldman Sachs Group Inc. | 0.00% | Add +98.4% | 410,736 | $2.3M |
| Bollard Group LLC | 0.05% | No change | 361,136 | $2.0M |
| HighTower Advisors, LLC | 0.00% | Add +1463.0% | 333,755 | $1.8M |
| UBS Group AG | 0.00% | Add +56.0% | 304,773 | $1.7M |
| Nuveen, LLC | 0.00% | Add +8.6% | 225,843 | $1.3M |
| HRT Financial LP | 0.00% | Add +245.1% | 221,464 | $1.2M |
| Chelsea Counsel Co. | 0.51% | No change | 208,210 | $1.2M |
| Wellington Management Group LLP | 0.00% | New | 205,325 | $1.1M |
| Bank of New York Mellon Corp | 0.00% | Add +22.0% | 197,729 | $1.1M |
| Wells Fargo & Company | 0.00% | Add +94.8% | 197,014 | $1.1M |
| Green Alpha Advisors, LLC | 1.02% | Add +141.0% | 190,353 | $1.1M |
| Man Group plc | 0.00% | New | 189,588 | $1.1M |
| JBF Capital, Inc. | 0.15% | New | 188,900 | $1.0M |
| DNB Asset Management AS | 0.00% | New | 182,133 | $1.0M |
| TD Asset Management Inc | 0.00% | Add +690.3% | 181,048 | $1.0M |
| Voloridge Investment Management, LLC | 0.00% | New | 170,021 | $942K |
| Bridgeway Capital Management, LLC | 0.02% | Reduce -23.3% | 164,800 | $913K |
| Simplex Trading, LLC | 0.02% | Reduce -18.4% | 157,897 | $874K |
| Ikarian Capital, LLC | 0.17% | New | 150,000 | $831K |
| Deutsche Bank AG | 0.00% | Add +5.8% | 132,769 | $736K |
| Steward Partners Investment Advisory, LLC | 0.00% | New | 126,387 | $700K |
| Fred Alger Management, LLC | 0.00% | Reduce -68.0% | 122,654 | $680K |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.05% | Add +258.8% | 120,773 | $669K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +0.5% | 120,423 | $667K |
| FIL Ltd | 0.00% | Reduce -0.8% | 116,329 | $644K |
| Barclays PLC | 0.00% | Add +1.0% | 115,900 | $642K |
| Bank of America Corp. | 0.00% | Reduce -23.3% | 110,842 | $614K |
| Rhumbline Advisers | 0.00% | Add +12.1% | 109,787 | $608K |
| Alliancebernstein L.P. | 0.00% | Reduce -35.1% | 108,690 | $602K |
| Palumbo Wealth Management LLC | 0.16% | Reduce -49.5% | 92,535 | $513K |
| Redmile Group, LLC | 0.05% | Reduce -95.8% | 87,118 | $483K |
| Jane Street Group, LLC | 0.00% | Add +216.4% | 85,892 | $476K |
| Diametric Capital, LP | 0.17% | Reduce -23.0% | 81,271 | $450K |
| T. Rowe Price Associates Inc. | 0.00% | Add +14.1% | 74,502 | $413K |
| Keystone Financial Group | 0.03% | New | 70,855 | $393K |
| Commonwealth Equity Services, LLC | 0.00% | Add +322.8% | 63,168 | $350K |
| Tudor Investment Corporation | 0.00% | New | 62,981 | $349K |
| Brevan Howard Capital Management LP | 0.01% | New | 62,242 | $345K |
| Ameriprise Financial Inc. | 0.00% | New | 61,572 | $341K |
| Nisa Investment Advisors, LLC | 0.00% | Add +1327.0% | 60,446 | $335K |
| Engineers Gate Manager LP | 0.00% | New | 55,597 | $308K |
| Boothbay Fund Management, LLC | 0.01% | New | 55,050 | $305K |
| XTX Topco Ltd | 0.01% | Reduce -63.9% | 48,225 | $267K |
| Balyasny Asset Management L.P. | 0.00% | New | 47,873 | $265K |
| Jain Global LLC | 0.00% | New | 44,849 | $248K |
| Axq Capital, LP | 0.10% | Add +19.2% | 44,818 | $248K |
| Mutual Advisors, LLC | 0.01% | No change | 45,200 | $243K |
| JPMorgan Chase & Co. | 0.00% | Add +31.3% | 43,389 | $240K |
| MetLife Investment Management, LLC | 0.00% | Add +10.2% | 42,997 | $238K |
| IvyRock Asset Management (HK) Ltd | 0.10% | New | 41,800 | $232K |
| Squarepoint Ops LLC | 0.00% | Add +10.5% | 39,601 | $219K |
| Corient Private Wealth LP | 0.00% | New | 38,777 | $215K |
| Ieq Capital, LLC | 0.00% | Add +2.3% | 36,667 | $203K |
| PEAK6 LLC | 0.00% | New | 35,063 | $194K |
| ExodusPoint Capital Management, LP | 0.00% | New | 33,494 | $186K |
| Raymond James Financial Inc. | 0.00% | Add +1933.7% | 31,807 | $176K |
| Crestwood Advisors Group, LLC | 0.00% | No change | 31,687 | $176K |
| LPL Financial LLC | 0.00% | New | 31,039 | $172K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +16.2% | 30,650 | $170K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Add +3.0% | 26,778 | $157K |
| Thompson Davis & Co., Inc. | 0.09% | New | 27,573 | $153K |
| Manufacturers Life Insurance Company, The | 0.00% | Add +29.3% | 27,132 | $150K |
| Bank of Nova Scotia | 0.00% | New | 25,500 | $141K |
| Cwm, LLC | 0.00% | Reduce -29.1% | 25,352 | $140K |
| Abacus Planning Group, Inc. | 0.02% | New | 25,188 | $140K |
| Turtle Creek Wealth Advisors, LLC | 0.01% | New | 25,000 | $139K |
| Nomura Holdings Inc. | 0.00% | New | 24,915 | $138K |
| Kingsview Wealth Management, LLC | 0.00% | Reduce -1.0% | 24,750 | $137K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | Add +3.4% | 23,984 | $133K |
"% of holder's portfolio" is PRME's weight in each manager's 13F, not the share of Prime Medicine Inc. the manager owns.