Prime MedicinePRME
13F holders, Q1 2026 (March 31)192holders +9
30new positions
24sold out
6famous investors
$3.48avg. 13F price*
At the end of Q1 2026, 192 institutions reported holding Prime Medicine Inc. (PRME) in their 13F filings, up 9 from Q4 2025. 30 opened new positions and 24 sold out. The largest holders were Alphabet Inc. ($57.6M), BlackRock, Inc. ($29.6M) and State Street Corp. ($22.1M). 6 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio) and Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio).
- Company
- Prime Medicine Inc.
- CUSIP
- 74168J101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2025 → Q1 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 30 | $16.3M |
| Exits | 24 | $6.4M |
All 13F filers, Q4 2025 → Q1 2026: 10,806,202 shares bought and 6,778,472 shares sold, net +4,027,730 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 192 holders
| Alphabet Inc. | 1.44% | No change | 16,562,498 | $57.6M |
| BlackRock, Inc. | 0.00% | Add +2.8% | 8,501,708 | $29.6M |
| State Street Corp. | 0.00% | Add +24.5% | 6,345,125 | $22.1M |
| ARK Investment Management | 0.17% | Add +16.4% | 6,246,827 | $21.7M |
| T. Rowe Price Investment Management, Inc. | 0.01% | Reduce -8.6% | 5,481,893 | $19.1M |
| Vanguard Capital Management LLC | 0.00% | — | 4,474,162 | $15.6M |
| Balyasny Asset Management L.P. | 0.03% | Add +32.0% | 4,123,365 | $14.3M |
| Casdin Capital, LLC | 0.83% | No change | 3,167,175 | $11.0M |
| Woodline Partners LP | 0.04% | Add +0.0% | 3,003,313 | $10.5M |
| Sumitomo Mitsui Trust Group, Inc. | 0.01% | Reduce -9.4% | 2,940,793 | $10.2M |
| Amova Asset Management Americas, Inc. | 0.14% | Reduce -9.4% | 2,940,793 | $10.2M |
| UBS Group AG | 0.00% | Add +18.4% | 2,888,418 | $10.1M |
| Geode Capital Management, LLC | 0.00% | Add +4.4% | 2,743,700 | $9.6M |
| ADAR1 Capital Management, LLC | 0.42% | New | 1,973,282 | $6.9M |
| FMR LLC | 0.00% | Reduce -18.7% | 1,769,476 | $6.2M |
| Redmile Group, LLC | 0.37% | New | 1,590,832 | $5.5M |
| Two Sigma Investments, LP | 0.00% | Reduce -3.5% | 1,572,811 | $5.5M |
| D. E. Shaw & Co. | 0.00% | Reduce -10.2% | 1,393,621 | $4.8M |
| Farallon Capital Management, L.L.C. | 0.03% | No change | 1,240,843 | $4.3M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -44.7% | 970,425 | $3.4M |
| Charles Schwab Investment Management Inc. | 0.00% | Reduce -2.1% | 917,212 | $3.2M |
| Northern Trust Corp. | 0.00% | Add +5.3% | 886,716 | $3.1M |
| Vanguard Portfolio Management LLC | 0.00% | — | 862,204 | $3.0M |
| JPMorgan Chase & Co. | 0.00% | Add +93.7% | 844,154 | $2.7M |
| Greenwich Wealth Management LLC | 0.11% | Add +1.4% | 750,001 | $2.6M |
| Renaissance Technologies | 0.00% | Reduce -35.5% | 741,039 | $2.6M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 717,002 | $2.5M |
| Susquehanna International Group, LLP | 0.00% | Reduce -39.2% | 715,829 | $2.5M |
| Morgan Stanley | 0.00% | Reduce -45.3% | 639,457 | $2.2M |
| HRT Financial LP | 0.01% | Reduce -6.5% | 612,769 | $2.1M |
| Bank of America Corp. | 0.00% | Reduce -11.0% | 577,004 | $2.0M |
| AQR Capital Management | 0.00% | Add +33.5% | 554,935 | $1.9M |
| Moore Capital Management, LP | 0.07% | No change | 500,000 | $1.7M |
| Chelsea Counsel Co. | 0.72% | Add +103.7% | 462,340 | $1.6M |
| Alessandra Capital Management, LLC | 1.26% | New | 425,510 | $1.5M |
| Bollard Group LLC | 0.04% | No change | 361,136 | $1.3M |
| HighTower Advisors, LLC | 0.00% | Reduce -15.0% | 340,255 | $1.2M |
| Citadel Advisors | 0.00% | Add +198.0% | 336,358 | $1.2M |
| Wells Fargo & Company | 0.00% | Add +8.5% | 319,550 | $1.1M |
| Dimensional Fund Advisors LP | 0.00% | Add +262.3% | 304,522 | $1.1M |
| Wellington Management Group LLP | 0.00% | Add +12.0% | 278,120 | $968K |
| Nuveen, LLC | 0.00% | Add +9.7% | 275,931 | $960K |
| Bank of New York Mellon Corp | 0.00% | Add +8.3% | 267,219 | $930K |
| Rafferty Asset Management, LLC | 0.00% | Add +14.8% | 215,582 | $750K |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.05% | Add +15.1% | 205,389 | $715K |
| Green Alpha Advisors, LLC | 0.66% | Add +0.1% | 191,171 | $665K |
| Swiss National Bank | 0.00% | Add +5.0% | 178,600 | $622K |
| Keystone Financial Group | 0.04% | Add +28.0% | 166,010 | $578K |
| Deutsche Bank AG | 0.00% | Add +6.4% | 157,440 | $548K |
| XTX Topco Ltd | 0.01% | Add +115.7% | 157,282 | $547K |
| Elevate Capital Advisors, LLC | 0.34% | Add +254.1% | 151,069 | $526K |
| Marshall Wace, LLP | 0.00% | New | 141,957 | $494K |
| Bridgeway Capital Management, LLC | 0.01% | No change | 134,800 | $469K |
| T. Rowe Price Associates Inc. | 0.00% | Add +27.9% | 133,755 | $466K |
| Alliancebernstein L.P. | 0.00% | Add +12.7% | 122,460 | $425K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +6.4% | 122,463 | $421K |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -0.8% | 117,456 | $409K |
| FIL Ltd | 0.00% | Reduce -0.3% | 115,206 | $401K |
| Rhumbline Advisers | 0.00% | Add +5.4% | 114,269 | $398K |
| Engineers Gate Manager LP | 0.00% | Add +82.4% | 110,348 | $384K |
| Palumbo Wealth Management LLC | 0.09% | Add +19.5% | 102,246 | $356K |
| Invesco Ltd. | 0.00% | Add +70.6% | 96,875 | $337K |
| Profund Advisors LLC | 0.01% | Add +37.6% | 95,806 | $333K |
| TD Asset Management Inc | 0.00% | No change | 94,148 | $328K |
| Squarepoint Ops LLC | 0.00% | Reduce -56.9% | 94,066 | $327K |
| Rockefeller Capital Management L.P. | 0.00% | Reduce -24.7% | 91,401 | $318K |
| California State Teachers Retirement System | 0.00% | Reduce -0.5% | 86,473 | $301K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -13.9% | 85,300 | $297K |
| Mariner, LLC | 0.00% | Add +116.0% | 78,398 | $273K |
| Concurrent Investment Advisors, LLC | 0.00% | New | 74,177 | $258K |
| Ieq Capital, LLC | 0.00% | Add +99.3% | 74,013 | $258K |
| Virtus Investment Advisers, LLC | 0.06% | Add +2.5% | 66,508 | $231K |
| LPL Financial LLC | 0.00% | Add +101.8% | 66,424 | $231K |
| Legal & General Group Plc | 0.00% | Reduce -17.7% | 66,444 | $231K |
| Russell Investments Group, Ltd. | 0.00% | Add +841.5% | 64,273 | $224K |
| Barclays PLC | 0.00% | Reduce -82.5% | 63,773 | $222K |
| Tudor Investment Corporation | 0.00% | New | 61,546 | $214K |
| Janus Henderson Group PLC | 0.00% | No change | 60,900 | $212K |
| &partners | 0.00% | Reduce -1.5% | 59,470 | $207K |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | — | 59,021 | $205K |
| Aquatic Capital Management LLC | 0.01% | New | 54,230 | $189K |
| Los Angeles Capital Management LLC | 0.00% | New | 52,615 | $183K |
| Ameriprise Financial Inc. | 0.00% | Reduce -8.3% | 49,584 | $173K |
| Citigroup Inc. | 0.00% | Reduce -7.8% | 47,232 | $164K |
| Quadrature Capital Ltd | 0.00% | Reduce -11.3% | 46,893 | $163K |
| Mutual Advisors, LLC | 0.00% | No change | 45,200 | $157K |
| Vanguard Global Advisers, LLC | 0.00% | — | 44,269 | $154K |
| MetLife Investment Management, LLC | 0.00% | Reduce -23.2% | 44,208 | $154K |
| VARCOV Co. | 0.05% | New | 41,964 | $146K |
| IvyRock Asset Management (HK) Ltd | 0.08% | No change | 41,800 | $145K |
| DRW Securities, LLC | 0.01% | New | 40,964 | $143K |
| Jones Financial Companies LLLP | 0.00% | Reduce -0.2% | 40,307 | $136K |
| Axq Capital, LP | 0.02% | Add +10.0% | 36,742 | $128K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Add +44.4% | 37,681 | $125K |
| Kingsview Wealth Management, LLC | 0.00% | Add +133.3% | 35,000 | $122K |
| BNP Paribas Financial Markets | 0.00% | Add +250.3% | 34,413 | $120K |
| Cwm, LLC | 0.00% | Add +33.0% | 33,811 | $118K |
| Oppenheimer & Co. Inc. | 0.00% | Add +170.7% | 33,656 | $117K |
| Crestwood Advisors Group, LLC | 0.00% | Add +1.3% | 32,374 | $113K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +8.9% | 32,033 | $111K |
"% of holder's portfolio" is PRME's weight in each manager's 13F, not the share of Prime Medicine Inc. the manager owns.