Prime MedicinePRME
13F holders, Q4 2025 (December 31)183holders +16
41new positions
26sold out
7famous investors
$3.47avg. 13F price*
At the end of Q4 2025, 183 institutions reported holding Prime Medicine Inc. (PRME) in their 13F filings, up 16 from Q3 2025. 41 opened new positions and 26 sold out. The largest holders were Alphabet Inc. ($57.5M), BlackRock, Inc. ($28.7M) and Vanguard Group Inc. ($22.4M). 7 famous investors held it, including Cathie Wood (0.1% of ARK Investment Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Prime Medicine Inc.
- CUSIP
- 74168J101
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 41 | $11.1M |
| Exits | 26 | $41.4M |
All 13F filers, Q3 2025 → Q4 2025: 24,331,317 shares bought and 19,703,585 shares sold, net +4,627,732 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 183 holders
| Alphabet Inc. | 2.23% | No change | 16,562,498 | $57.5M |
| BlackRock, Inc. | 0.00% | Add +46.3% | 8,268,843 | $28.7M |
| Vanguard Group Inc. | 0.00% | Add +31.4% | 6,467,872 | $22.4M |
| T. Rowe Price Investment Management, Inc. | 0.01% | Reduce -35.0% | 5,995,183 | $20.8M |
| ARK Investment Management | 0.12% | Reduce -2.0% | 5,368,526 | $18.6M |
| State Street Corp. | 0.00% | Add +293.0% | 5,095,510 | $17.7M |
| Sumitomo Mitsui Trust Group, Inc. | 0.01% | Reduce -10.6% | 3,245,506 | $11.3M |
| Amova Asset Management Americas, Inc. | 0.13% | Reduce -10.6% | 3,245,506 | $11.2M |
| Casdin Capital, LLC | 0.68% | No change | 3,167,175 | $11.0M |
| Balyasny Asset Management L.P. | 0.02% | Add +6426.4% | 3,124,362 | $10.8M |
| Woodline Partners LP | 0.04% | Add +0.0% | 3,002,844 | $10.4M |
| Geode Capital Management, LLC | 0.00% | Add +48.8% | 2,628,429 | $9.1M |
| UBS Group AG | 0.00% | Add +700.8% | 2,440,583 | $8.5M |
| FMR LLC | 0.00% | Reduce -22.6% | 2,176,646 | $7.6M |
| MWG Caph Ltd | 8.59% | — | 1,792,210 | $6.2M |
| Goldman Sachs Group Inc. | 0.00% | Add +327.5% | 1,755,768 | $6.1M |
| Two Sigma Investments, LP | 0.01% | Add +264.0% | 1,629,324 | $5.7M |
| D. E. Shaw & Co. | 0.00% | Reduce -30.0% | 1,551,369 | $5.4M |
| Farallon Capital Management, L.L.C. | 0.02% | Reduce -73.9% | 1,240,843 | $4.3M |
| Susquehanna International Group, LLP | 0.01% | Add +101.3% | 1,176,727 | $4.1M |
| Morgan Stanley | 0.00% | Add +60.0% | 1,169,898 | $4.1M |
| Renaissance Technologies | 0.01% | Add +1.3% | 1,149,159 | $4.0M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +63.5% | 936,815 | $3.3M |
| Northern Trust Corp. | 0.00% | Add +38.5% | 842,153 | $2.9M |
| Greenwich Wealth Management LLC | 0.11% | Add +2.8% | 740,001 | $2.6M |
| HRT Financial LP | 0.01% | Add +195.9% | 655,351 | $2.3M |
| Bank of America Corp. | 0.00% | Add +484.6% | 648,012 | $2.2M |
| Point72 Asset Management | 0.00% | New | 551,030 | $1.9M |
| Moore Capital Management, LP | 0.04% | No change | 500,000 | $1.7M |
| JPMorgan Chase & Co. | 0.00% | Add +904.2% | 435,710 | $1.5M |
| AQR Capital Management | 0.00% | Add +0.4% | 415,821 | $1.4M |
| HighTower Advisors, LLC | 0.00% | Add +19.9% | 400,110 | $1.4M |
| Two Sigma Advisers, LP | 0.00% | New | 383,500 | $1.3M |
| Barclays PLC | 0.00% | Add +213.9% | 363,826 | $1.3M |
| Bollard Group LLC | 0.03% | No change | 361,136 | $1.3M |
| Wells Fargo & Company | 0.00% | Add +49.5% | 294,496 | $1.0M |
| Verition Fund Management LLC | 0.01% | New | 290,983 | $1.0M |
| Nuveen, LLC | 0.00% | Add +11.4% | 251,636 | $873K |
| Wellington Management Group LLP | 0.00% | Add +20.9% | 248,227 | $861K |
| Bank of New York Mellon Corp | 0.00% | Add +24.8% | 246,770 | $856K |
| Chelsea Counsel Co. | 0.34% | Add +9.0% | 227,000 | $788K |
| Dark Forest Capital Management LP | 0.04% | New | 225,859 | $784K |
| Squarepoint Ops LLC | 0.00% | Add +450.6% | 218,042 | $757K |
| Green Alpha Advisors, LLC | 0.61% | Add +0.3% | 190,883 | $662K |
| Rafferty Asset Management, LLC | 0.00% | New | 187,711 | $651K |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 0.04% | Add +47.8% | 178,519 | $619K |
| Jump Financial, LLC | 0.01% | New | 171,931 | $597K |
| Swiss National Bank | 0.00% | New | 170,100 | $590K |
| Deutsche Bank AG | 0.00% | Add +11.4% | 147,943 | $513K |
| Bridgeway Capital Management, LLC | 0.01% | Reduce -18.2% | 134,800 | $468K |
| Keystone Financial Group | 0.03% | Add +83.0% | 129,665 | $450K |
| Rockefeller Capital Management L.P. | 0.00% | Add +10557.7% | 121,391 | $421K |
| Steward Partners Investment Advisory, LLC | 0.00% | Reduce -6.3% | 118,406 | $411K |
| FIL Ltd | 0.00% | Reduce -0.6% | 115,602 | $401K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -4.5% | 115,060 | $399K |
| Graham Capital Management, L.P. | 0.02% | New | 114,680 | $398K |
| Citadel Advisors | 0.00% | Reduce -87.5% | 112,870 | $392K |
| Alliancebernstein L.P. | 0.00% | No change | 108,690 | $377K |
| Rhumbline Advisers | 0.00% | Reduce -1.3% | 108,409 | $376K |
| T. Rowe Price Associates Inc. | 0.00% | Add +40.3% | 104,553 | $363K |
| Group One Trading LLC | 0.01% | New | 103,213 | $358K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 99,100 | $344K |
| Virtu Financial LLC | 0.01% | Add +701.2% | 94,778 | $329K |
| Qube Research & Technologies Ltd | 0.00% | New | 94,670 | $329K |
| TD Asset Management Inc | 0.00% | Reduce -48.0% | 94,148 | $327K |
| California State Teachers Retirement System | 0.00% | Add +2279.0% | 86,929 | $302K |
| Palumbo Wealth Management LLC | 0.07% | Reduce -7.6% | 85,539 | $297K |
| Dimensional Fund Advisors LP | 0.00% | New | 84,054 | $292K |
| Legal & General Group Plc | 0.00% | Add +1096.1% | 80,749 | $280K |
| XTX Topco Ltd | 0.01% | Add +51.2% | 72,935 | $253K |
| Profund Advisors LLC | 0.01% | New | 69,605 | $242K |
| Virtus Investment Advisers, LLC | 0.06% | New | 64,886 | $225K |
| Janus Henderson Group PLC | 0.00% | New | 60,900 | $210K |
| Engineers Gate Manager LP | 0.00% | Add +8.8% | 60,490 | $210K |
| &partners | 0.00% | Add +409.4% | 60,352 | $209K |
| MetLife Investment Management, LLC | 0.00% | Add +33.9% | 57,570 | $200K |
| Invesco Ltd. | 0.00% | Reduce -92.5% | 56,779 | $197K |
| Brevan Howard Capital Management LP | 0.00% | Reduce -9.9% | 56,088 | $195K |
| Ameriprise Financial Inc. | 0.00% | Reduce -12.2% | 54,082 | $188K |
| Quadrature Capital Ltd | 0.00% | Add +419.2% | 52,866 | $183K |
| Millennium Management | 0.00% | Reduce -96.4% | 51,335 | $178K |
| Citigroup Inc. | 0.00% | Add +894.5% | 51,229 | $178K |
| Tidal Investments LLC | 0.00% | New | 50,244 | $174K |
| Walleye Capital LLC | 0.00% | New | 46,139 | $160K |
| Mutual Advisors, LLC | 0.00% | No change | 45,200 | $157K |
| Elevate Capital Advisors, LLC | 0.10% | New | 42,666 | $148K |
| IvyRock Asset Management (HK) Ltd | 0.08% | No change | 41,800 | $145K |
| Jones Financial Companies LLLP | 0.00% | Add +322.0% | 40,403 | $140K |
| Corient Private Wealth LP | 0.00% | No change | 38,777 | $135K |
| Caitong International Asset Management Co., Ltd | 0.03% | New | 38,696 | $134K |
| Gsa Capital Partners LLP | 0.01% | New | 38,510 | $134K |
| Ieq Capital, LLC | 0.00% | Add +1.3% | 37,136 | $129K |
| Mariner, LLC | 0.00% | Add +99.2% | 36,290 | $126K |
| Polymer Capital Management (US) LLC | 0.02% | Add +73.1% | 35,981 | $125K |
| Intech Investment Management LLC | 0.00% | Add +50.8% | 35,036 | $122K |
| CENTRAL TRUST Co | 0.00% | New | 34,995 | $121K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -45.5% | 34,399 | $119K |
| Axq Capital, LP | 0.03% | Reduce -25.5% | 33,405 | $116K |
| LPL Financial LLC | 0.00% | Add +6.1% | 32,924 | $114K |
| Envestnet Asset Management Inc. | 0.00% | New | 32,576 | $113K |
"% of holder's portfolio" is PRME's weight in each manager's 13F, not the share of Prime Medicine Inc. the manager owns.