Q32 BioQTTB
13F holders, Q4 2025 (December 31)At the end of Q4 2025, 52 institutions reported holding Q32 Bio Inc. (QTTB) in their 13F filings, down 1 from Q3 2025. 7 opened new positions and 8 sold out. The largest holders were Orbimed Advisors LLC ($7.5M), Atlas Venture Life Science Advisors, LLC ($6.9M) and Carlyle Group Inc. ($3.6M). 3 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Q32 Bio Inc.
- CUSIP
- 746964105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 7 | $980K |
| Exits | 8 | $319K |
All 13F filers, Q3 2025 → Q4 2025: 478,795 shares bought and 863,714 shares sold, net −384,919 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 52 holders
| Orbimed Advisors LLC | 0.15% | No change | 2,252,987 | $7.5M |
| Atlas Venture Life Science Advisors, LLC | 0.80% | No change | 2,092,106 | $6.9M |
| Carlyle Group Inc. | 0.03% | No change | 1,102,741 | $3.6M |
| Acorn Capital Advisors, LLC | 0.56% | Reduce -38.6% | 493,425 | $1.6M |
| Vanguard Group Inc. | 0.00% | Add +8.7% | 321,051 | $1.1M |
| ARCH Venture Management, LLC | 0.16% | No change | 320,482 | $1.1M |
| Pfizer Inc | 0.39% | No change | 277,777 | $922K |
| Sanofi | 0.26% | No change | 244,083 | $810K |
| Opaleye Management Inc. | 0.09% | New | 213,363 | $708K |
| Geode Capital Management, LLC | 0.00% | Add +19.9% | 106,113 | $352K |
| Renaissance Technologies | 0.00% | Add +110.6% | 99,600 | $331K |
| BlackRock, Inc. | 0.00% | Reduce -35.6% | 59,932 | $199K |
| Millennium Management | 0.00% | Reduce -51.1% | 51,268 | $170K |
| Monaco Asset Management SAM | 0.05% | Reduce -83.6% | 50,919 | $169K |
| Acadian Asset Management LLC | 0.00% | Add +62.7% | 48,373 | $159K |
| Two Sigma Investments, LP | 0.00% | Add +48.6% | 46,825 | $155K |
| Citadel Advisors | 0.00% | Add +352.0% | 45,728 | $152K |
| Affinity Asset Advisors, LLC | 0.01% | No change | 27,777 | $92K |
| Jane Street Group, LLC | 0.00% | New | 25,374 | $84K |
| Northern Trust Corp. | 0.00% | Reduce -21.7% | 25,033 | $83K |
| HRT Financial LP | 0.00% | Add +66.5% | 24,698 | $81K |
| State Street Corp. | 0.00% | No change | 21,237 | $71K |
| XTX Topco Ltd | 0.00% | New | 20,353 | $68K |
| ADAR1 Capital Management, LLC | 0.01% | New | 20,000 | $66K |
| Scientech Research LLC | 0.03% | New | 15,510 | $51K |
| UBS Group AG | 0.00% | Add +159.4% | 13,606 | $45K |
| Morgan Stanley | 0.00% | Reduce -51.7% | 5,478 | $18K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -7.7% | 4,640 | $15K |
| FMR LLC | 0.00% | Reduce -78.8% | 3,364 | $11K |
| Federated Hermes, Inc. | 0.00% | Reduce -4.3% | 2,273 | $8K |
| Global Retirement Partners, LLC | 0.00% | Reduce -70.0% | 1,500 | $5K |
| Arax Advisory Partners | 0.00% | Reduce -8.6% | 1,111 | $4K |
| Bank of America Corp. | 0.00% | Reduce -32.1% | 1,035 | $3K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -84.9% | 976 | $3K |
| Rockefeller Capital Management L.P. | 0.00% | No change | 577 | $2K |
| Jones Financial Companies LLLP | 0.00% | New | 500 | $2K |
| Russell Investments Group, Ltd. | 0.00% | No change | 454 | $2K |
| JPMorgan Chase & Co. | 0.00% | Add +8000.0% | 324 | $1K |
| BNP Paribas Financial Markets | 0.00% | Reduce -28.7% | 308 | $1K |
| Royal Bank of Canada | 0.00% | Reduce -77.7% | 235 | $1K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 166 | $551 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -98.1% | 157 | $521 |
| Osaic Holdings, Inc. | 0.00% | Reduce -29.4% | 132 | $437 |
| Allworth Financial LP | 0.00% | Reduce -83.9% | 98 | $326 |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 70 | $231 |
| Group One Trading LLC | 0.00% | No change | 34 | $113 |
| Northwestern Mutual Wealth Management Co. | 0.00% | New | 30 | $100 |
| Barclays PLC | 0.00% | Reduce -97.7% | 19 | $63 |
| Harbour Investments, Inc. | 0.00% | No change | 11 | $37 |
| AdvisorNet Financial, Inc | 0.00% | No change | 2 | $7 |
| Danske Bank A/S | 0.00% | No change | 1 | $3 |
| Cwm, LLC | 0.00% | Reduce -75.3% | 54 | $0 |
"% of holder's portfolio" is QTTB's weight in each manager's 13F, not the share of Q32 Bio Inc. the manager owns.