Spyre TherapeuticsSYRE
13F holders, Q1 2025 (March 31)129holders −2
19new positions
21sold out
2famous investors
$16.17avg. 13F price*
At the end of Q1 2025, 129 institutions reported holding Spyre Therapeutics Inc. (SYRE) in their 13F filings, down 2 from Q4 2024. 19 opened new positions and 21 sold out. The largest holders were FMR LLC ($145.8M), Fairmount Funds Management LLC ($64.8M) and RTW Investments, LP ($58.4M). 2 famous investors held it, including George Soros (0.1% of Soros Fund Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Spyre Therapeutics Inc.
- CUSIP
- 00773J202
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024 → Q1 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 19 | $75.8M |
| Exits | 21 | $39.3M |
All 13F filers, Q4 2024 → Q1 2025: 7,276,083 shares bought and 5,066,456 shares sold, net +2,209,627 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 129 holders
| FMR LLC | 0.01% | Add +2.7% | 9,038,553 | $145.8M |
| Fairmount Funds Management LLC | 10.06% | No change | 4,018,101 | $64.8M |
| RTW Investments, LP | 0.89% | No change | 3,621,996 | $58.4M |
| BlackRock, Inc. | 0.00% | Add +5.1% | 3,572,674 | $57.6M |
| Vanguard Group Inc. | 0.00% | Add +1.8% | 2,898,267 | $46.8M |
| Driehaus Capital Management LLC | 0.42% | Reduce -3.1% | 2,717,312 | $43.8M |
| Venrock Adviser, LLC | 3.69% | No change | 2,685,448 | $43.3M |
| Braidwell LP | 2.17% | No change | 2,578,404 | $41.6M |
| Capital International Investors | 0.01% | New | 2,392,541 | $38.6M |
| Perceptive Advisors LLC | 1.32% | Reduce -10.2% | 2,313,272 | $37.3M |
| Paradigm Biocapital Advisors LP | 1.58% | Add +39.3% | 2,127,205 | $34.3M |
| Tang Capital Management LLC | 1.83% | New | 2,050,000 | $33.1M |
| Commodore Capital LP | 2.36% | No change | 1,988,084 | $32.1M |
| State Street Corp. | 0.00% | Add +1.0% | 1,697,115 | $27.4M |
| Wellington Management Group LLP | 0.01% | Reduce -0.7% | 1,593,678 | $25.7M |
| Jefferies Financial Group Inc. | 0.36% | Add +2.6% | 1,248,854 | $20.2M |
| Janus Henderson Group PLC | 0.01% | Reduce -28.5% | 1,041,410 | $18.7M |
| Pictet Asset Management Holding SA | 0.02% | Reduce -2.1% | 1,068,892 | $17.2M |
| Geode Capital Management, LLC | 0.00% | Add +9.7% | 1,059,563 | $17.1M |
| Polar Capital Holdings Plc | 0.08% | Add +10.0% | 825,000 | $13.3M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | Reduce -22.0% | 803,200 | $13.0M |
| Franklin Resources Inc. | 0.00% | Reduce 0.0% | 760,628 | $12.3M |
| UBS Group AG | 0.00% | Add +40.8% | 552,243 | $8.9M |
| Emerald Advisers, LLC | 0.40% | Add +0.2% | 547,827 | $8.8M |
| Blackstone Inc. | 0.03% | Add +8.9% | 489,248 | $7.9M |
| Affinity Asset Advisors, LLC | 1.29% | Reduce -41.6% | 481,678 | $7.8M |
| Woodline Partners LP | 0.05% | Add +31.8% | 464,808 | $7.5M |
| Deerfield Management Company, L.P. | 0.16% | No change | 450,000 | $7.3M |
| Bank of America Corp. | 0.00% | Add +5879.8% | 427,075 | $6.9M |
| Emerald Mutual Fund Advisers Trust | 0.46% | Add +0.8% | 389,422 | $6.3M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +0.8% | 382,636 | $6.2M |
| Northern Trust Corp. | 0.00% | Add +8.8% | 379,875 | $6.1M |
| Siren, L.L.C. | 0.34% | Reduce -1.4% | 368,598 | $5.9M |
| Capital World Investors | 0.00% | Reduce -7.3% | 350,774 | $5.7M |
| Morgan Stanley | 0.00% | Add +31.4% | 335,467 | $5.4M |
| Voloridge Investment Management, LLC | 0.02% | Add +122.9% | 257,432 | $4.2M |
| Victory Capital Management Inc. | 0.00% | Reduce -6.0% | 251,846 | $4.1M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -50.9% | 248,542 | $4.0M |
| Candriam S.C.A. | 0.03% | Reduce -0.6% | 246,030 | $4.0M |
| Deep Track Capital, LP | 0.11% | No change | 219,015 | $3.5M |
| Barclays PLC | 0.00% | Add +74.4% | 214,606 | $3.5M |
| Armistice Capital, LLC | 0.09% | No change | 200,000 | $3.2M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -73.6% | 197,068 | $3.2M |
| Nuveen, LLC | 0.00% | — | 140,129 | $2.3M |
| Stempoint Capital LP | 0.70% | New | 136,139 | $2.2M |
| Citadel Advisors | 0.00% | Reduce -87.9% | 130,884 | $2.1M |
| Soros Fund Management | 0.05% | Reduce -50.0% | 125,000 | $2.0M |
| Schroder Investment Management Group | 0.00% | Reduce -4.5% | 108,504 | $1.9M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Reduce -1.5% | 120,321 | $1.9M |
| Bank of New York Mellon Corp | 0.00% | Add +10.2% | 114,240 | $1.8M |
| HighVista Strategies LLC | 0.59% | No change | 95,159 | $1.5M |
| Citigroup Inc. | 0.00% | Add +13.2% | 83,464 | $1.3M |
| EFG Asset Management (North America) Corp. | 0.22% | Reduce -0.4% | 82,472 | $1.3M |
| Prosight Management, LP | 0.40% | Reduce -6.3% | 74,921 | $1.2M |
| Squarepoint Ops LLC | 0.00% | Add +372.8% | 72,011 | $1.2M |
| Rafferty Asset Management, LLC | 0.00% | Reduce -8.4% | 70,323 | $1.1M |
| B Group, Inc. | 0.98% | Add +40.0% | 70,000 | $1.1M |
| Swiss National Bank | 0.00% | No change | 68,600 | $1.1M |
| Susquehanna International Group, LLP | 0.00% | Add +154.2% | 58,696 | $947K |
| Rhumbline Advisers | 0.00% | Reduce -2.8% | 56,023 | $904K |
| BNP Paribas Financial Markets | 0.00% | Add +197.2% | 55,833 | $901K |
| Manufacturers Life Insurance Company, The | 0.00% | Add +2.2% | 53,901 | $870K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +6.5% | 52,138 | $841K |
| F/m Investments LLC | 0.03% | Add +6.2% | 51,844 | $837K |
| JPMorgan Chase & Co. | 0.00% | Add +17.9% | 41,556 | $671K |
| Wexford Capital LP | 0.16% | New | 38,292 | $618K |
| Legal & General Group Plc | 0.00% | Add +0.9% | 37,844 | $611K |
| Alliancebernstein L.P. | 0.00% | No change | 36,230 | $585K |
| State of Wisconsin Investment Board | 0.00% | Add +10.8% | 34,901 | $563K |
| California State Teachers Retirement System | 0.00% | No change | 32,598 | $526K |
| Wells Fargo & Company | 0.00% | Add +21.5% | 30,035 | $485K |
| XTX Topco Ltd | 0.02% | New | 28,499 | $460K |
| Deutsche Bank AG | 0.00% | Reduce -9.3% | 28,483 | $460K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +18.8% | 27,018 | $442K |
| Teachers Retirement System of the State of Kentucky | 0.00% | No change | 25,799 | $416K |
| Invesco Ltd. | 0.00% | Add +28.2% | 25,207 | $407K |
| MetLife Investment Management, LLC | 0.00% | Add +11.0% | 23,733 | $383K |
| Assenagon Asset Management S.A. | 0.00% | Add +0.3% | 22,726 | $367K |
| TD Asset Management Inc | 0.00% | Reduce -65.6% | 22,368 | $361K |
| Intech Investment Management LLC | 0.00% | Add +45.5% | 20,428 | $330K |
| Corebridge Financial, Inc. | 0.00% | Add +13.8% | 19,595 | $316K |
| NBW Capital LLC | 0.07% | No change | 19,430 | $314K |
| Waverly Advisors, LLC | 0.00% | New | 19,430 | $314K |
| Global Endowment Management, LP | 0.04% | No change | 18,184 | $293K |
| Natixis Advisors, LLC | 0.00% | Reduce -5.2% | 16,401 | $265K |
| ExodusPoint Capital Management, LP | 0.00% | Reduce -9.8% | 15,055 | $243K |
| ADAR1 Capital Management, LLC | 0.05% | New | 15,033 | $243K |
| Profund Advisors LLC | 0.01% | Reduce -1.4% | 14,662 | $237K |
| Aquatic Capital Management LLC | 0.01% | Add +9.7% | 12,903 | $208K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -2.8% | 12,087 | $195K |
| ProShare Advisors LLC | 0.00% | Reduce -9.2% | 11,378 | $184K |
| Voya Investment Management LLC | 0.00% | Reduce -1.4% | 10,348 | $167K |
| New York State Common Retirement Fund | 0.00% | No change | 10,265 | $166K |
| Arizona State Retirement System | 0.00% | Reduce -1.0% | 10,017 | $162K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +18.8% | 8,767 | $141K |
| KLP Kapitalforvaltning As | 0.00% | No change | 7,800 | $126K |
| SG Americas Securities, LLC | 0.00% | New | 7,122 | $115K |
| Virtus Investment Advisers, LLC | 0.03% | New | 6,861 | $111K |
| Ameritas Investment Partners, Inc. | 0.00% | Add +19.3% | 4,046 | $65K |
| AlphaQuest LLC | 0.01% | Add +45.2% | 3,191 | $51K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +3.1% | 2,016 | $36K |
| Royal Bank of Canada | 0.00% | Reduce -46.0% | 2,172 | $35K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -76.2% | 2,044 | $33K |
| Public Employees Retirement Association of Colorado | 0.00% | No change | 1,589 | $26K |
| GF Fund Management Co. LTD. | 0.00% | Add +21.9% | 1,502 | $24K |
| Huntington National Bank | 0.00% | No change | 1,470 | $24K |
| Amalgamated Bank | 0.00% | Add +15.1% | 1,379 | $22K |
| Sterling Capital Management LLC | 0.00% | Reduce -37.7% | 629 | $10K |
| Cwm, LLC | 0.00% | Add +4575.0% | 374 | $6K |
| GAMMA Investing LLC | 0.00% | New | 270 | $4K |
| Osaic Holdings, Inc. | 0.00% | Add +126.7% | 238 | $4K |
| Daiwa Securities Group Inc. | 0.00% | New | 206 | $3K |
| Nisa Investment Advisors, LLC | 0.00% | Add +53.3% | 184 | $3K |
| Aster Capital Management (DIFC) Ltd | 0.00% | New | 126 | $2K |
| Summit Securities Group LLC | 0.00% | New | 133 | $2K |
| IFP Advisors, Inc | 0.00% | No change | 109 | $2K |
| Lindbrook Capital, LLC | 0.00% | New | 78 | $1K |
| Rothschild Investment LLC | 0.00% | Add +25.0% | 50 | $807 |
| Larson Financial Group LLC | 0.00% | New | 44 | $710 |
| CoreCap Advisors, LLC | 0.00% | New | 41 | $662 |
| Caitong International Asset Management Co., Ltd | 0.00% | Add +100.0% | 28 | $452 |
| EverSource Wealth Advisors, LLC | 0.00% | Add +200.0% | 24 | $387 |
| Stephens Consulting, LLC | 0.00% | New | 20 | $323 |
| Parallel Advisors, LLC | 0.00% | New | 14 | $226 |
| Allworth Financial LP | 0.00% | Add +44.4% | 13 | $195 |
| US Bancorp \de | 0.00% | New | 9 | $145 |
| SBI Securities Co., Ltd. | 0.00% | No change | 5 | $81 |
| Amundi | 0.00% | Reduce -84.4% | 5 | $70 |
| Covestor Ltd | 0.00% | No change | 4 | $0 |
"% of holder's portfolio" is SYRE's weight in each manager's 13F, not the share of Spyre Therapeutics Inc. the manager owns.