Upstream BioUPB
13F holders, Q4 2024 (December 31)70holders
2famous investors
$16.40avg. 13F price*
At the end of Q4 2024, 70 institutions reported holding Upstream Bio Inc. (UPB) in their 13F filings. The largest holders were FMR LLC ($118.0M), Orbimed Advisors LLC ($93.6M) and Decheng Capital LLC ($54.0M). 2 famous investors held it, including George Soros (0.0% of Soros Fund Management's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Upstream Bio Inc.
- CUSIP
- 91678A107
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q4 2024
| Institutions | Total Value | |
|---|---|---|
| New Positions | 68 | $649.7M |
| Exits | 0 | $0 |
Ownership 70 holders
| FMR LLC | 0.01% | New | 7,176,187 | $118.0M |
| Orbimed Advisors LLC | 1.94% | New | 5,693,589 | $93.6M |
| Decheng Capital LLC | 11.59% | New | 3,285,293 | $54.0M |
| TCG Crossover Management, LLC | 4.38% | New | 2,801,763 | $44.9M |
| Enavate Sciences Gp, LLC | 29.04% | — | 2,459,703 | $40.4M |
| Bain Capital Life Sciences Investors, LLC | 4.45% | New | 2,295,322 | $37.7M |
| Venrock Adviser, LLC | 2.59% | New | 2,295,319 | $37.7M |
| Samsara Biocapital, LLC | 5.00% | New | 2,217,146 | $36.4M |
| Omega Fund Management, LLC | 21.71% | New | 2,036,293 | $33.5M |
| Wellington Management Group LLP | 0.00% | New | 1,583,154 | $25.6M |
| BlackRock, Inc. | 0.00% | New | 1,117,800 | $18.4M |
| Alliancebernstein L.P. | 0.01% | New | 1,111,337 | $18.3M |
| Deep Track Capital, LP | 0.62% | New | 1,000,000 | $16.4M |
| Norges Bank | 0.00% | New | 1,000,000 | $16.4M |
| Vanguard Group Inc. | 0.00% | New | 915,021 | $15.0M |
| Siren, L.L.C. | 0.58% | New | 800,000 | $13.2M |
| Nantahala Capital Management, LLC | 0.69% | New | 600,000 | $9.9M |
| Woodline Partners LP | 0.06% | New | 526,511 | $8.7M |
| Geode Capital Management, LLC | 0.00% | New | 363,269 | $6.0M |
| Balyasny Asset Management L.P. | 0.01% | New | 301,152 | $5.0M |
| Great Point Partners LLC | 2.32% | New | 300,000 | $4.9M |
| Marshall Wace, LLP | 0.01% | New | 290,734 | $4.8M |
| State Street Corp. | 0.00% | New | 247,187 | $4.1M |
| Lynx1 Capital Management LP | 1.48% | New | 240,042 | $3.9M |
| Citadel Advisors | 0.00% | New | 180,000 | $3.0M |
| UBS Group AG | 0.00% | New | 161,512 | $2.7M |
| Northern Trust Corp. | 0.00% | New | 143,721 | $2.4M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 135,323 | $2.2M |
| Alyeska Investment Group, L.P. | 0.01% | New | 85,000 | $1.4M |
| Moody Aldrich Partners LLC | 0.23% | New | 74,773 | $1.2M |
| EcoR1 Capital, LLC | 0.04% | New | 60,000 | $986K |
| JPMorgan Chase & Co. | 0.00% | New | 47,792 | $786K |
| Soros Fund Management | 0.02% | New | 46,350 | $762K |
| Jane Street Group, LLC | 0.00% | New | 45,549 | $749K |
| Goldman Sachs Group Inc. | 0.00% | New | 44,490 | $731K |
| Alps Advisors Inc. | 0.00% | New | 43,340 | $713K |
| Morgan Stanley | 0.00% | New | 43,163 | $710K |
| Verition Fund Management LLC | 0.00% | New | 37,379 | $615K |
| Bank of New York Mellon Corp | 0.00% | New | 36,913 | $607K |
| Barclays PLC | 0.00% | New | 27,017 | $444K |
| Citigroup Inc. | 0.00% | New | 26,504 | $436K |
| Nuveen Asset Management, LLC | 0.00% | New | 22,586 | $371K |
| Rhumbline Advisers | 0.00% | New | 16,721 | $275K |
| Invesco Ltd. | 0.00% | New | 15,602 | $256K |
| Deutsche Bank AG | 0.00% | New | 14,851 | $244K |
| Bank of America Corp. | 0.00% | New | 13,963 | $230K |
| Davidson Kempner Capital Management LP | 0.01% | New | 12,500 | $205K |
| MetLife Investment Management, LLC | 0.00% | New | 11,034 | $181K |
| Sandia Investment Management LP | 0.31% | New | 10,000 | $164K |
| Walleye Capital LLC | 0.00% | New | 10,000 | $164K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 9,828 | $162K |
| Wells Fargo & Company | 0.00% | New | 9,047 | $149K |
| Corebridge Financial, Inc. | 0.00% | New | 8,660 | $142K |
| SG Americas Securities, LLC | 0.00% | New | 7,590 | $125K |
| STRS Ohio | 0.00% | New | 3,200 | $53K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 2,846 | $47K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,822 | $30K |
| Legal & General Group Plc | 0.00% | New | 1,734 | $28K |
| US Bancorp \de | 0.00% | New | 1,660 | $27K |
| BNP Paribas Financial Markets | 0.00% | New | 1,511 | $25K |
| California State Teachers Retirement System | 0.00% | New | 1,290 | $21K |
| Royal Bank of Canada | 0.00% | New | 1,282 | $21K |
| Amalgamated Bank | 0.00% | New | 594 | $10K |
| Sterling Capital Management LLC | 0.00% | New | 249 | $4K |
| R Squared Ltd | 0.00% | — | 160 | $3K |
| Aster Capital Management (DIFC) Ltd | 0.00% | New | 134 | $2K |
| Caitong International Asset Management Co., Ltd | 0.00% | — | 44 | $723 |
| Osaic Holdings, Inc. | 0.00% | New | 17 | $279 |
| Principal Securities, Inc. | 0.00% | New | 12 | $197 |
| National Bank of Canada | 0.00% | New | 7 | $115 |
"% of holder's portfolio" is UPB's weight in each manager's 13F, not the share of Upstream Bio Inc. the manager owns.