Upstream BioUPB
13F holders, Q3 2025 (September 30)95holders +12
22new positions
9sold out
2famous investors
$18.81avg. 13F price*
At the end of Q3 2025, 95 institutions reported holding Upstream Bio Inc. (UPB) in their 13F filings, up 12 from Q2 2025. 22 opened new positions and 9 sold out. The largest holders were FMR LLC ($152.1M), Orbimed Advisors LLC ($107.1M) and Decheng Capital LLC ($61.8M). 2 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio) and Cliff Asness (0.0% of AQR Capital Management's portfolio).
- Company
- Upstream Bio Inc.
- CUSIP
- 91678A107
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 22 | $26.7M |
| Exits | 9 | $20.8M |
All 13F filers, Q2 2025 → Q3 2025: 4,255,263 shares bought and 7,177,305 shares sold, net −2,922,042 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 95 holders
| FMR LLC | 0.01% | Add +1.9% | 8,086,413 | $152.1M |
| Orbimed Advisors LLC | 2.57% | No change | 5,693,589 | $107.1M |
| Decheng Capital LLC | 10.78% | No change | 3,285,293 | $61.8M |
| BlackRock, Inc. | 0.00% | Add +24.2% | 2,603,706 | $49.0M |
| Enavate Sciences Gp, LLC | 14.13% | No change | 2,459,703 | $46.3M |
| Vanguard Group Inc. | 0.00% | Add +12.5% | 2,442,551 | $45.9M |
| Bain Capital Life Sciences Investors, LLC | 3.05% | No change | 2,439,538 | $45.9M |
| TCG Crossover Management, LLC | 1.96% | Reduce -24.4% | 2,117,103 | $39.8M |
| Altshuler Shaham Ltd | 0.44% | Reduce -58.3% | 1,416,822 | $26.7M |
| Omega Fund Management, LLC | 11.47% | Reduce -33.4% | 1,356,293 | $25.5M |
| Venrock Adviser, LLC | 1.24% | Reduce -49.1% | 1,169,298 | $22.0M |
| Wellington Management Group LLP | 0.00% | Reduce -8.2% | 1,125,395 | $21.2M |
| State Street Corp. | 0.00% | Add +131.5% | 1,114,581 | $21.0M |
| Samsara Biocapital, LLC | 2.36% | Reduce -33.3% | 962,154 | $18.1M |
| Marshall Wace, LLP | 0.02% | Add +198.8% | 867,999 | $16.3M |
| Parkman Healthcare Partners LLC | 1.74% | Add +17.9% | 843,502 | $15.9M |
| Geode Capital Management, LLC | 0.00% | Add +26.4% | 817,109 | $15.4M |
| Siren, L.L.C. | 0.58% | No change | 788,450 | $14.8M |
| Woodline Partners LP | 0.05% | Add +7.9% | 602,252 | $11.3M |
| Nantahala Capital Management, LLC | 0.69% | No change | 594,971 | $11.2M |
| Integral Health Asset Management, LLC | 0.79% | New | 575,000 | $10.8M |
| Great Point Partners LLC | 2.36% | No change | 300,000 | $5.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +59.8% | 284,828 | $5.4M |
| UBS Group AG | 0.00% | Add +16.9% | 272,271 | $5.1M |
| Northern Trust Corp. | 0.00% | Add +11.1% | 254,719 | $4.8M |
| Goldman Sachs Group Inc. | 0.00% | New | 223,214 | $4.2M |
| Schonfeld Strategic Advisors LLC | 0.03% | Reduce -48.0% | 190,244 | $3.6M |
| Ikarian Capital, LLC | 0.61% | New | 161,113 | $3.0M |
| SummitTX Capital, L.P. | 0.09% | New | 112,404 | $2.1M |
| Bank of New York Mellon Corp | 0.00% | Add +14.7% | 91,521 | $1.7M |
| Morgan Stanley | 0.00% | Reduce -11.9% | 87,535 | $1.6M |
| Barclays PLC | 0.00% | Reduce -12.0% | 85,315 | $1.6M |
| Balyasny Asset Management L.P. | 0.00% | New | 73,131 | $1.4M |
| American Century Companies Inc. | 0.00% | Add +219.9% | 71,540 | $1.3M |
| Nuveen, LLC | 0.00% | Reduce -5.5% | 69,882 | $1.3M |
| Boothbay Fund Management, LLC | 0.03% | New | 61,299 | $1.2M |
| Bank of America Corp. | 0.00% | Add +207.7% | 55,473 | $1.0M |
| Exome Asset Management LLC | 0.65% | New | 51,960 | $977K |
| Rhumbline Advisers | 0.00% | Add +2.8% | 49,406 | $929K |
| Verition Fund Management LLC | 0.01% | Add +40.3% | 47,001 | $884K |
| Citigroup Inc. | 0.00% | Add +259.4% | 42,037 | $791K |
| Millennium Management | 0.00% | New | 40,113 | $755K |
| Rafferty Asset Management, LLC | 0.00% | New | 34,521 | $649K |
| AQR Capital Management | 0.00% | Add +0.7% | 29,954 | $563K |
| JPMorgan Chase & Co. | 0.00% | Add +81.8% | 29,947 | $563K |
| Nomura Holdings Inc. | 0.00% | New | 28,290 | $532K |
| Deutsche Bank AG | 0.00% | Add +14.3% | 26,737 | $503K |
| Alps Advisors Inc. | 0.00% | Reduce -10.4% | 25,962 | $488K |
| Wells Fargo & Company | 0.00% | Add +12.5% | 25,160 | $473K |
| MetLife Investment Management, LLC | 0.00% | No change | 21,691 | $408K |
| Alliancebernstein L.P. | 0.00% | Reduce -19.2% | 19,850 | $373K |
| T. Rowe Price Associates Inc. | 0.00% | Add +6.0% | 18,501 | $349K |
| Caption Management, LLC | 0.02% | New | 18,196 | $342K |
| Invesco Ltd. | 0.00% | Add +5.5% | 17,190 | $323K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -11.6% | 16,863 | $315K |
| Prelude Capital Management, LLC | 0.02% | New | 15,735 | $296K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -0.1% | 15,503 | $292K |
| Quantinno Capital Management LP | 0.00% | Add +40.3% | 14,889 | $280K |
| Creative Planning | 0.00% | Add +1.7% | 14,266 | $268K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -8.3% | 12,092 | $227K |
| Mariner, LLC | 0.00% | New | 10,933 | $206K |
| Two Sigma Investments, LP | 0.00% | New | 10,500 | $198K |
| Intech Investment Management LLC | 0.00% | Reduce -51.2% | 10,396 | $196K |
| Virtus Investment Advisers, LLC | 0.05% | Add +21.0% | 9,843 | $185K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +20.6% | 9,447 | $178K |
| BNP Paribas Financial Markets | 0.00% | Add +110.8% | 6,527 | $123K |
| New York State Common Retirement Fund | 0.00% | Add +34.0% | 6,300 | $119K |
| Cwm, LLC | 0.00% | Add +0.9% | 3,341 | $63K |
| Russell Investments Group, Ltd. | 0.00% | Add +1964.0% | 3,034 | $57K |
| Legal & General Group Plc | 0.00% | Reduce -7.9% | 2,924 | $55K |
| Ameritas Investment Partners, Inc. | 0.00% | Reduce -23.0% | 2,741 | $52K |
| Sterling Capital Management LLC | 0.00% | Add +140.6% | 2,264 | $43K |
| California State Teachers Retirement System | 0.00% | Add +0.1% | 2,176 | $41K |
| Tower Research Capital LLC (TRC) | 0.00% | Reduce -38.8% | 1,868 | $35K |
| Group One Trading LLC | 0.00% | New | 1,305 | $25K |
| Aster Capital Management (DIFC) Ltd | 0.01% | New | 1,141 | $21K |
| GAMMA Investing LLC | 0.00% | Add +28.4% | 890 | $17K |
| Royal Bank of Canada | 0.00% | Reduce -73.1% | 832 | $16K |
| Amalgamated Bank | 0.00% | No change | 594 | $11K |
| Versant Capital Management, Inc | 0.00% | Reduce -1.8% | 548 | $10K |
| US Bancorp \de | 0.00% | Reduce -19.4% | 531 | $10K |
| Global Retirement Partners, LLC | 0.00% | New | 332 | $6K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +0.3% | 310 | $6K |
| Clearstead Advisors, LLC | 0.00% | No change | 163 | $3K |
| Arax Advisory Partners | 0.00% | New | 149 | $3K |
| PNC Financial Services Group, Inc. | 0.00% | New | 130 | $2K |
| J.Safra Asset Management Corp | 0.00% | New | 128 | $2K |
| Essential Partners LLC | 0.00% | No change | 97 | $2K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 96 | $2K |
| Allworth Financial LP | 0.00% | Add +1.5% | 67 | $1K |
| N.E.W. Advisory Services LLC | 0.00% | New | 60 | $1K |
| Signaturefd, LLC | 0.00% | Add +4.1% | 51 | $959 |
| Sunbelt Securities, Inc. | 0.00% | New | 19 | $357 |
| IFP Advisors, Inc | 0.00% | Add +100.0% | 2 | $38 |
| Parallel Advisors, LLC | 0.00% | No change | 2 | $38 |
"% of holder's portfolio" is UPB's weight in each manager's 13F, not the share of Upstream Bio Inc. the manager owns.