Vertex PharmaceuticalsVRTX
13F holders, Q4 2025 (December 31)1,672holders +150
162new positions
99sold out
10famous investors
$453.16avg. 13F price*
At the end of Q4 2025, 1,672 institutions reported holding Vertex Pharmaceuticals Inc. (VRTX) in their 13F filings, up 150 from Q3 2025. 162 opened new positions and 99 sold out. The largest holders were Capital World Investors ($11.6B), Vanguard Group Inc. ($10.9B) and BlackRock, Inc. ($10.8B). 10 famous investors held it, including Jim Simons / Peter Brown (0.4% of Renaissance Technologies's portfolio), Ken Griffin (0.1% of Citadel Advisors's portfolio) and Israel Englander (0.1% of Millennium Management's portfolio).
- Company
- Vertex Pharmaceuticals Inc.
- Sector
- Health Care
- CUSIP
- 92532F100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 162 | $680.9M |
| Exits | 99 | $940.3M |
All 13F filers, Q3 2025 → Q4 2025: 17,764,760 shares bought and 12,457,314 shares sold, net +5,307,446 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 1,672 holders
| Capital World Investors | 1.58% | Reduce -1.6% | 25,510,182 | $11.6B |
| Vanguard Group Inc. | 0.16% | Reduce -0.5% | 24,105,823 | $10.9B |
| BlackRock, Inc. | 0.18% | Add +6.7% | 23,751,989 | $10.8B |
| Capital Research Global Investors | 1.45% | Add +4.6% | 17,316,344 | $7.9B |
| State Street Corp. | 0.18% | Add +0.7% | 11,689,539 | $5.3B |
| Invesco Ltd. | 0.34% | Add +274.5% | 7,852,733 | $3.6B |
| JPMorgan Chase & Co. | 0.18% | Reduce -6.1% | 6,039,481 | $2.7B |
| Geode Capital Management, LLC | 0.17% | Add +0.1% | 5,981,905 | $2.7B |
| Capital International Investors | 0.34% | Add +0.9% | 4,733,596 | $2.1B |
| Alliancebernstein L.P. | 0.64% | Reduce -0.6% | 4,496,482 | $2.0B |
| Loomis Sayles & Co. L P | 2.21% | Reduce -2.1% | 4,033,525 | $1.8B |
| Wellington Management Group LLP | 0.30% | Reduce -19.9% | 3,821,731 | $1.7B |
| Victory Capital Management Inc. | 0.87% | Add +49.4% | 3,356,766 | $1.5B |
| Jennison Associates LLC | 0.88% | Reduce -6.0% | 3,249,541 | $1.5B |
| Norges Bank | 0.15% | — | 3,176,613 | $1.4B |
| Morgan Stanley | 0.08% | Add +0.4% | 3,120,310 | $1.4B |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.29% | Add +3.9% | 3,000,778 | $1.4B |
| Bank of America Corp. | 0.10% | Add +3.4% | 2,937,030 | $1.3B |
| Clearbridge Investments, LLC | 1.04% | Add +8.1% | 2,860,176 | $1.3B |
| Northern Trust Corp. | 0.15% | Reduce -1.8% | 2,579,457 | $1.2B |
| T. Rowe Price Associates Inc. | 0.11% | Reduce -25.1% | 2,278,958 | $1.0B |
| Ameriprise Financial Inc. | 0.23% | Reduce -0.6% | 2,263,732 | $1.0B |
| Janus Henderson Group PLC | 0.45% | Add +4.8% | 2,221,953 | $1.0B |
| FMR LLC | 0.05% | Reduce -33.0% | 2,212,596 | $1.0B |
| Legal & General Group Plc | 0.20% | Add +0.9% | 1,970,105 | $893.2M |
| Charles Schwab Investment Management Inc. | 0.13% | Add +1.6% | 1,859,221 | $842.9M |
| Deutsche Bank AG | 0.26% | Add +10.5% | 1,768,881 | $801.9M |
| Goldman Sachs Group Inc. | 0.11% | Add +18.1% | 1,754,118 | $795.2M |
| Bank of New York Mellon Corp | 0.12% | Reduce -2.6% | 1,527,586 | $692.5M |
| Amundi | 0.18% | Add +16.6% | 1,304,161 | $591.3M |
| Royal Bank of Canada | 0.10% | Add +0.1% | 1,194,512 | $541.5M |
| WCM Investment Management, LLC | 1.05% | Reduce -1.8% | 1,129,145 | $512.3M |
| Edgewood Management LLC | 2.29% | Reduce -28.7% | 1,060,075 | $480.6M |
| Nuveen, LLC | 0.12% | Reduce -3.3% | 1,042,397 | $472.6M |
| Dimensional Fund Advisors LP | 0.09% | Add +20.7% | 945,660 | $428.7M |
| Winslow Capital Management, LLC | 1.36% | New | 887,640 | $405.1M |
| American Century Companies Inc. | 0.19% | Add +88.9% | 848,639 | $384.7M |
| Barclays PLC | 0.15% | Add +14.2% | 847,758 | $384.3M |
| Assenagon Asset Management S.A. | 0.57% | Add +9.1% | 832,853 | $377.6M |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0.32% | Reduce -40.1% | 803,773 | $364.4M |
| Pictet Asset Management Holding SA | 0.33% | Reduce -4.9% | 752,425 | $342.2M |
| Wells Fargo & Company | 0.07% | Add +3.4% | 741,813 | $336.3M |
| Swiss National Bank | 0.19% | Reduce -5.1% | 702,600 | $318.5M |
| Bellevue Group AG | 5.85% | Add +34.7% | 681,120 | $308.8M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.35% | Add +46.8% | 669,807 | $303.7M |
| Sumitomo Mitsui Trust Group, Inc. | 0.17% | Reduce -6.6% | 654,470 | $296.7M |
| HSBC Holdings PLC | 0.16% | Reduce -1.1% | 630,289 | $285.9M |
| Arrowstreet Capital, Limited Partnership | 0.16% | Add +55.8% | 593,947 | $269.3M |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.17% | Add +3.9% | 566,227 | $256.0M |
| Voya Investment Management LLC | 0.29% | Add +30.1% | 562,352 | $254.4M |
| BNP Paribas Financial Markets | 0.16% | Add +120.0% | 559,543 | $253.7M |
| Manufacturers Life Insurance Company, The | 0.21% | Add +9.3% | 557,713 | $252.9M |
| California Public Employees Retirement System | 0.14% | Reduce -9.2% | 556,064 | $252.1M |
| UBS Group AG | 0.05% | Reduce -28.1% | 555,982 | $252.1M |
| Franklin Resources Inc. | 0.06% | Add +18.9% | 550,600 | $249.6M |
| Neuberger Berman Group LLC | 0.18% | Add +3.5% | 545,897 | $247.5M |
| Citigroup Inc. | 0.17% | Reduce -0.0% | 539,930 | $244.8M |
| National Pension Service | 0.18% | Add +3.7% | 530,841 | $240.7M |
| Natixis Advisors, LLC | 0.34% | Reduce -1.7% | 527,864 | $239.3M |
| B. Metzler seel. Sohn & Co. AG | 2.04% | Add +63.4% | 515,269 | $233.6M |
| Renaissance Technologies | 0.36% | Reduce -31.4% | 505,048 | $229.0M |
| DekaBank Deutsche Girozentrale | 0.38% | No change | 506,457 | $219.8M |
| Envestnet Asset Management Inc. | 0.06% | Add +0.2% | 471,643 | $213.8M |
| ProShare Advisors LLC | 0.37% | Add +37.0% | 457,046 | $207.2M |
| Nordea Investment Management AB | 0.17% | Add +23.8% | 447,169 | $202.6M |
| Rhumbline Advisers | 0.16% | Reduce -3.7% | 431,262 | $195.5M |
| Manning & Napier Advisors LLC | 2.52% | Reduce -9.9% | 427,603 | $194.0M |
| Bank of Montreal | 0.08% | Add +1.9% | 427,480 | $193.8M |
| Citadel Advisors | 0.13% | Add +146.1% | 427,060 | $193.6M |
| Raymond James Financial Inc. | 0.06% | Reduce -21.9% | 418,131 | $189.6M |
| Principal Financial Group Inc. | 0.10% | Add +2.1% | 415,100 | $188.2M |
| Chevy Chase Trust Holdings, LLC | 0.50% | Reduce -2.4% | 408,363 | $185.1M |
| Robeco Institutional Asset Management B.V. | 0.25% | Add +3.9% | 394,200 | $178.7M |
| Harding Loevner LP | 1.56% | Reduce -14.1% | 391,865 | $177.7M |
| Squarepoint Ops LLC | 0.36% | Reduce -36.0% | 389,020 | $176.4M |
| California State Teachers Retirement System | 0.17% | Reduce -2.2% | 385,751 | $174.9M |
| Russell Investments Group, Ltd. | 0.19% | Add +11.8% | 381,462 | $173.0M |
| Man Group plc | 0.34% | Add +5.0% | 380,735 | $172.6M |
| Life Cycle Investment Partners Ltd | 1.16% | — | 366,854 | $166.3M |
| Bank Julius Baer & Co. Ltd, Zurich | 0.46% | Reduce -2.7% | 366,341 | $166.1M |
| Millennium Management | 0.12% | Add +791.0% | 365,664 | $165.8M |
| Sei Investments Co. | 0.16% | Add +106.2% | 364,023 | $165.0M |
| Alyeska Investment Group, L.P. | 0.45% | Add +32.6% | 354,334 | $160.6M |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.35% | Reduce -9.0% | 353,488 | $160.3M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.41% | Add +56.4% | 345,383 | $156.6M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.25% | Add +4.8% | 334,898 | $151.8M |
| Public Employees Retirement Association of Colorado | 0.55% | Reduce -1.9% | 329,745 | $149.5M |
| Ensign Peak Advisors, Inc | 0.24% | Reduce -2.6% | 303,784 | $137.7M |
| New York State Common Retirement Fund | 0.18% | Reduce -3.6% | 297,414 | $134.8M |
| LPL Financial LLC | 0.03% | Add +4.8% | 276,878 | $125.5M |
| Royal London Asset Management Ltd. | 0.26% | Reduce -1.4% | 273,433 | $124.0M |
| Adage Capital Partners Gp, L.L.C. | 0.19% | Reduce -43.5% | 272,474 | $123.5M |
| Los Angeles Capital Management LLC | 0.42% | Add +726.9% | 293,301 | $123.2M |
| Aberdeen Group plc | 0.18% | Reduce -16.8% | 262,057 | $118.8M |
| Cerity Partners LLC | 0.17% | Add +1.1% | 261,553 | $118.6M |
| Swedbank AB | 0.11% | Add +2.6% | 260,743 | $118.2M |
| National Bank of Canada | 0.11% | Reduce -3.8% | 238,548 | $108.1M |
| State Board of Administration of Florida Retirement System | 0.18% | Reduce -3.3% | 226,000 | $102.5M |
| Candriam S.C.A. | 0.51% | Add +29.1% | 225,292 | $102.1M |
| Welch & Forbes LLC | 1.20% | Reduce -1.0% | 218,198 | $98.9M |
"% of holder's portfolio" is VRTX's weight in each manager's 13F, not the share of Vertex Pharmaceuticals Inc. the manager owns.